• Journal of Chest Surgery
• /
• v.32 no.8
• /
• pp.722-725
• /
• 1999

Background: To secure a rapid and safe approach which is at the same time cosmetically appealing, we employed the right anterolateral thoracotomy incision for repair of atrial septal defects and valvular heart diseases in the adult. Material and method: Between October 1989 and June 1998, 44 adult patients underwent open heart surgery through right anterolateral thoracotomy at our institution. Operative time, cardiopulmonary bypass time, aortic cross clamp time, blood loss until chest tube removal, length of ICU stay, days to discharge, and survival were compared with those that received cardiac surgery via conventional sternotomy. Result: No significant differences were observed between the two groups. There was no death and no additional morbidity directly related to this approach. Cosmetically satisfying results were obtained with safety using the right anterolateral thoracotomy approach. Conclusion: Our data show that the right anterolateral thoracotomy approach is a safe alternative to conventional median sternotomy as it offers excellent exposure and aesthetically more acceptable wounds while not adding on to the operative risks.

• Korean Institute of Interior Design Journal
• /
• v.22 no.4
• /
• pp.52-61
• /
• 2013

This study set out to compare and analyze the spaces in the images and sets of the representative movies that led the new heyday of Korean film since 1997 and examine the characteristics of contemporary Korean modernism in the movies, thus building an academic foundation for future exchanges between contemporary Korean architecture and contemporary Korean cinema. As for methodologies, the study first examined the film theories on how to utilize spaces projected onto moving images. Secondly, the study made an overall comparison of the characteristics of spaces in the representative movies of contemporary Korean cinema since 1997. Finally, the study compared and analyzed them with the intrinsic characteristics of modernism architecture space. The research findings were as follows: first, the representative movies of contemporary Korean cinema since 1997 either had a backdrop of everyday modernism space in the 1970s and 1980s or created a new space of late or post modernism in them that escaped from daily life for the mise-en-$Sc\grave{e}ne$ composition. Secondly, the contemporary Korean cinemas used the unornamented modernism architecture in Korea as the props of revealing the personalities and emotional aspects of the characters in a prominent fashion. Thirdly, they also used communication between internal and external space and spatial severance via the facade window in modernism architecture as important devices for narration organization. Finally, they selected the camera positions by applying the principle of open space, which allows for the expansion, reduction, and distinction of space according to functions, and thus established a methodology to create a space fit for the personalities of characters and stories.

• Journal of Microbiology and Biotechnology
• /
• v.25 no.11
• /
• pp.1819-1826
• /
• 2015

Poly(ε-ʟ-lysine) (ε-PL) is a novel bioactive polymer secreted by filamentous bacteria. Owing to lack of a genetic system for most ε-PL-producing strains, very little research on enhancing ε-PL biosynthesis by genetic manipulation has been reported. In this study, an effective genetic system was established via intergeneric conjugal transfer for Streptomyces albulus PD-1, a famous ε-PL-producing strain. Using the established genetic system, the Vitreoscilla hemoglobin (VHb) gene was integrated into the chromosome of S. albulus PD-1 to alleviate oxygen limitation and to enhance the biosynthesis of ε-PL in submerged fermentation. Ultimately, the production of ε-PL increased from 22.7 g/l to 34.2 g/l after fed-batch culture in a 5 L bioreactor. Determination of the oxygen uptake rate, transcriptional level of ε-PL synthetase gene, and ATP level unveiled that the expression of VHb in S. albulus PD-1 enhanced ε-PL biosynthesis by improving respiration and ATP supply. To the best of our knowledge, this is the first report on enhancing ε-PL production by chromosomal integration of the VHb gene in an ε-PL-producing strain, and it will open a new avenue for ε-PL production.

• Journal of Animal Science and Technology
• /
• v.60 no.10
• /
• pp.25.1-25.10
• /
• 2018

The central dogma of gene expression propounds that DNA is transcribed to mRNA and finally gets translated into protein. Only 2-3% of the genomic DNA is transcribed to protein-coding mRNA. Interestingly, only a further minuscule part of genomic DNA encodes for long non-coding RNAs (lncRNAs) which are characteristically more than 200 nucleotides long and can be transcribed from both protein-coding (e.g. H19 and TUG1) as well as non-coding DNA by RNA polymerase II. The lncRNAs do not have open reading frames (with some exceptions), 3`-untranslated regions (3'-UTRs) and necessarily these RNAs lack any translation-termination regions, however, these can be spliced, capped and polyadenylated as mRNA molecules. The flexibility of lncRNAs confers them specific 3D-conformations that eventually enable the lncRNAs to interact with proteins, DNA or other RNA molecules via base pairing or by forming networks. The lncRNAs play a major role in gene regulation, cell differentiation, cancer cell invasion and metastasis and chromatin remodeling. Deregulation of lncRNA is also responsible for numerous diseases in mammals. Various studies have revealed their significance as biomarkers for prognosis and diagnosis of cancer. The aim of this review is to overview the salient features, evolution, biogenesis and biological importance of these molecules in the mammalian system.

• Communications of the Korean Mathematical Society
• /
• v.26 no.1
• /
• pp.135-149
• /
• 2011

Using (r, s)-preopen sets [14] and pre-${\omega}_t$-closures [6], a new kind of covering property $P^t_{({\omega}_r,s)}$-closedness is introduced in a bitopological space and several characterizations via filter bases, nets and grills [30] along with various properties of such concept are investigated. Two new types of cluster sets, namely pre-(${\omega}_r$, s)t-${\theta}_f$-cluster sets and (r, s)t-${\theta}_f$-precluster sets of functions and multifunctions between two bitopological spaces are introduced. Several properties of pre-(${\omega}_r$, s)t-${\theta}_f$-cluster sets are investigated and using the degeneracy of such cluster sets, some new characterizations of some separation axioms in topological spaces or in bitopological spaces are obtained. A sufficient condition for $P^t_{({\omega}_r,s)}$-closedness has also been established in terms of pre-(${\omega}_r$, s)t-${\theta}_f$-cluster sets.

• The Korean Journal of Physiology and Pharmacology
• /
• v.18 no.3
• /
• pp.191-200
• /
• 2014

We investigated the anxiolytic-like activity of ${\alpha}$-asarone (AAS) from Acorus gramineus in an experimental rat model of anxiety induced by repeated administration of the exogenous stress hormone corticosterone (CORT). The putative anxiolytic effect of AAS was studied in behavioral tests of anxiety, such as the elevated plus maze (EPM) test and the hole-board test (HBT) in rats. For 21 consecutive days, male rats received 50, 100, or 200 mg/kg AAS (i.p.) 30 min prior to a daily injection of CORT. Dysregulation of the HPA axis in response to the repeated CORT injections was confirmed by measuring serum levels of CORT and the expression of corticotrophin-releasing factor (CRF) in the hypothalamus. Daily AAS (200 mg/kg) administration increased open-arm exploration significantly in the EPM test, and it increased the duration of head dipping activity in the HBT. It also blocked the increase in tyrosine hydroxylase (TH) expression in the locus coeruleus (LC) and decreased mRNA expression of brain-derived neurotrophic factor (BDNF) and its receptor, TrkB, in the hippocampus. These results indicated that the administration of AAS prior to high-dose exogenous CORT significantly improved anxiety-like behaviors, which are associated with modification of the central noradrenergic system and with BDNF function in rats. The current finding may improve understanding of the neurobiological mechanisms responsible for changes in emotions induced by repeated administration of high doses of CORT or by elevated levels of hormones associated with chronic stress. Thus, AAS did exhibit an anxiolytic-like effects in animal models of anxiety.

• Journal of the Korea Academia-Industrial cooperation Society
• /
• v.14 no.12
• /
• pp.6434-6440
• /
• 2013

In this paper, an integrated control system is proposed for automatic control and remote monitoring of pipeline type UV sterilizer. The proposed system can control the cleaning wiper in the sterilizer with various cleaning motions, and periodically check the contamination level of the UV lamps with the UV power sensors. Therefore, sterilizer repair and maintenance can be more effectively done. In addition, the control system based on the open-source processor can communicate with external smart devices via Bluetooth, and thus wirelessly exchange control commands and sensor data. Furthermore, the system is able to flexibly cope with changes of cleaning motions and sensors since its firmware can be wirelessly upgraded by using the smart device. Consequently, the proposed system is suitable to construct a smart sewage treatment system in small towns.

• The Journal of the Korea Contents Association
• /
• v.16 no.9
• /
• pp.667-678
• /
• 2016

National preference enables a nation to achieve more advantageous position regarding international relations. Considering this benefit, the purpose of this study is to explore determinants of national preference between Korean and Japanese college students. To pursue this aim, two versions (translated to Korean and Japanese) of survey were conducted in Korea and Japan in 2015. A total of 370 (206 of Koreans and 164 of Japanese) college students were participated in the survey. Specifically, participants were asked to respond perceptions toward multiculturalism, international experiences, and consumption of media contents. Further, participants were asked to describe their knowledge and perception toward cultural contents of partnered country via open-ended questions. The results implies that Japanese music and books are significant determinants among Korean students in developing national preference toward Japan whereas Koran drama is more an effective factor among Japanese students to build national preference toward Korea. Based on the result, theoretical and practical implications were discussed.

• The Journal of Korean Institute of Communications and Information Sciences
• /
• v.30 no.3B
• /
• pp.138-143
• /
• 2005

This paper aims to optimize an access probe algorithm for the CDMA 2000 system. The incremental value of PWR_STEP increases as NUM_STEP as 1dBm±0.2 for access probe of the area with good receiving sensitivity when the mobile station transmits via access channel and does not receive any ACK message. However, for the area with weak receiving sensitivity, according to the algorithm of open-loop power control, the transmitting power amplifier becomes saturated and PWR_STEP incremental value keeps performing access probe to 0dBm±0.2. Therefore interference and battery consumption increases according to the transmission of the mobile station. We have optimized the access probe algorithm according to the receiving sensitivity. We transmit the incremental value of access probe power, with delaying as much RT slot value as indicated by IS-95C standard in case of good receiving sensitivity and with delaying RT+l slot value in case of weak receiving sensitivity. Simulation results showed that the proposed algorithm contributes to decrease of the interference and battery consumption according to the transmitting power of the mobile station and improves the call duration.

• Informatization Policy
• /
• v.20 no.4
• /
• pp.3-22
• /
• 2013

This study analyzed the research trends and methodologies through meta analysis method on the issues of ICT policy and e-government in Korean major journals and proceedings including Korean Association of Public Administration (KAPA), Korean Association of Policy Studies (KAPS), and Korean Journal of Information Policy of NIA (National Information Agency). The results showed that methodology has changed from explorative study with conceptualization to experimental study with theoretical model and cases. Qualitative approaches including case studies and description with policy implications were employed more as analyses tools. In terms of contents, system effectiveness and e-governance issues prevailed in the early 2000s, and since then, it has changed into ICT-based social changes and looking for generalization of theories including e-democracy, e-service, e-participation, digital divide, and post-information society. Now we are facing another ICT revolution of social network via web3.0 and gov3.0 and it is time to open a new theoretical debate, deconstruction of discourse, and collaborative perspective among different disciplines.