• 한국식품위생안전성학회지
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• 제2권2호
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• pp.75-81
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• 1987

Bifunctional monoterpene 유도체의 향의 유무는 분자내에 존재하는 두 개의 관능기인, proton donor(AH)와 proton acceptor(B)가 olfaction과 구조활성 상호작용(SAR)과 밀접한 관계가 있다. 일반적으로 Ohloff가설에 의하면, p-menthane monoterpene 분자내의 AH와 B의 입체배위적 최소거리가 3${\AA}$ 이하인 경우 향을 갖고, 3${\AA}$ 이상인 경우는 향을 갖지 않는다. Bifunctional pinanone, thujane, carane, carvomenthone 및 기타 menthone 유도체 등을 이용하여 이 가설을 확대 연구하였다. Bifunctional monoterpene인 (원문이미지참조) 등은 분자내에 각각 AH (OH 혹은 COOH)와 B (C=O)의 입체배위적 최소 거리가 항상 3${\AA}$ 이하여서 향을 가지며, 이들은 olfactory three point attachment에 의한 구조활성 상관관계를 가지는 것으로 사료된다. 상기 화합물의 proton donor인 OH, 혹은 COOH가 각각 acetylation이나 methylation되는 경우에는 proton donor로서의 기능 상실로 향이 사라지게 되었다.

• KSBB Journal
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• 제13권6호
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• pp.631-637
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• 1998

후각은 가장 민감한 감각 기관으로 다른 감각에 비해 아직 많은 연구가 이루어져 있지 않다. 후각의 이론적 접근은 100년도 안되는 역사를 가지고 있고, 후각세포에서 일어나는 전기적 신호를 측정한 것은 50년 전의 일이었다. 최근들어 후각의 산업적 응용에 대한 관심으로 인해 많은 연구가 진행중이다. 본 고에서는 후각의 신호 전달 과정을 이해하기 위해 포유 동물과 곤충의 후각 기관의 구조를 비교하고 각각의 인지 과정을 분자 수준에서 살펴보았다. 또한 후각 기관의 냄새 인지 과정을 이해하여 후각 센서로의 이용 가능성에 대해 검토하고, 현재 후각 센서의 개발 현황을 알아보았다. 후각에 대한 연구는 앞으로 센서산업에 많은 기여를 할 것으로 기대된다.

• 동의생리병리학회지
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• 제28권5호
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• pp.478-485
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• 2014

In order to the excellent differentiation of syndromes, we study on the individual characteristic factor by the inspection of face colour and tongue & the auscultation and olfaction. To the subject of diagnosis special books and diagnostics textbook of korean medicine, we arrange the individual characteristic factor by the inspection of face colour and tongue & the auscultation and olfaction. The inspection on the individual characteristic factor was analyzed the face colour, inspection of tongue. The auscultation and olfaction on the individual characteristic factor was analyzed the 25 types by the five-voice (五音) in Huang Di Nei Jing (黃帝內經). As the results, the individual characteristic factor is very important item of the four methods of diagnosis and the differentiation of syndromes. And Therefore the process on four methods of diagnosis and differentiation of syndromesis is necessary to divide the signs of individual characteristic factor and the signs of disease.

• 한국양식학회지
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• 제12권1호
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• pp.63-69
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• 1999

A series of experiments were conducted to examine on what stimulus giant danio (Danio malabaricus) were mainly responsible for detecting alarm substance. When 0.15 ml alarm substance (10 ppm) was introduced into the tank, fish showed no notable change in swimming pattern. However, the introduction of 1.5 ml alarm substance (100 ppm) could induce fright reaction about in 6 minutes. Further, when 15 ml alarm substance (1,000 ppm) was introduced into the tank, fish showed the following fright reaction in a few seconds; suppressing to feed diet, no swimming, strong chasing, and visual alertness. In detecting alarm substance, fish were mainly depending on the chemical stimulus (nares) rather than the vision stimulus (eyes) because fish detected alarm substance by the chemical cue showed the significantly stronger fright reaction than by the visual cue. The time for fish to show the initial fright reaction after detecting alarm substance by the chemical cue was shorter than by the visual cue. Also after alarm substance was introduced into the tank, olfaction-deprived fish showed significantly weaker fright reaction and less frequency of chasing than the normal fish which detected alarm substance by both olfaction and gustation stimulus. These results indicated that chemical stimulus, especially olfaction might be the primary sensory modality used in the detection of the alarm substance for giant danio.

• 한국의류학회지
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• 제34권6호
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• pp.1033-1041
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• 2010

This study investigates the combined effect of clothing interest and fashion innovativeness on dimensions of scent quality (pleasantness, intensity, familiarity, and congruency) to understand which dimensions of scent quality have significant positive effects on the appeal of scented apparel products. The survey data were statistically analyzed. A structural equation modeling using LISREL was conducted to test the model. Results indicate that clothing interest has a significant impact on scent quality attitude. Positive evaluations of the product were most strongly influenced by the pleasantness quality of the scent. Intensity and familiarity were factors that affected the approach of consumer responses toward scented products. Congruency was not a significant scent quality in generating positive responses for apparel products among consumers.

• 한양메디칼리뷰
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• 제34권3호
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• pp.130-136
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• 2014

Animals find nutritious foods to survive, while avoiding aversive and toxic chemicals through the chemosensory faculties of olfaction and taste. The olfaction is comparatively well characterized, but the studies of taste are only recently developing since after 2000. Genetic, immunohistochemistry, and electrophysiological studies with knock-out transgenic mice opened up the taste field in mammals. Taste in insects has been only recently been studied after mammalian taste receptors were identified. Flies also discriminate the differences of sweet, salty and sour food, while being able to detect and reject potential foods contaminated with toxins or detrimental chemicals. These discriminatory abilities indicate that flies house basic taste receptors in their taste organs like humans. For the last decade, the sweet and bitter gustatory receptors in Drosophila have been characterized. In this review, we compare the taste anatomy between humans and insects. We also introduce five canonical taste sensations in Drosophila. In addition, we introduce new taste repertoires, that fruit flies can sense water and fatty acids as well as the carbonation buffer in beverage. These studies on simple model organisms will open up a new potential for scientists to further investigate these characteristics in vertebrates.

• 한국감성과학회:학술대회논문집
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• 한국감성과학회 1999년도 춘계학술발표논문집 논문집
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• pp.175-176
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• 1999

• 센서학회지
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• 제26권5호
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• pp.297-300
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• 2017

Realistic media comprised of metadata of the five senses to provide enhanced experiences by stimulating our memory and sensations have had an increasingly pervading effect in our daily lives. Many researchers and companies are in the process of developing their own authoring systems running on different platforms to serve realistic media, resulting in compatibility issues among the systems. To tackle these issues, the International Organization for Standardization have standardized the interface, data format, protocol, API, etc. required to provide the realistic media. In particular, the ISO/IEC 23005 standard, which is called MPEG-V in SC29/WG 11, has defined XML schemas for olfaction interaction based on electronic nose (E-Nose), and scent display. In this paper, the MPEG-V standard for olfaction interaction is reviewed, and a data flow diagram that can be used for olfactory interaction based on the MPEG-V standard was designed. In addition, the necessary schemas related to the E-Nose sensor for olfactory interaction was provided.

• Journal of Rhinology
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• 제25권2호
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• pp.63-68
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• 2018

본 종설에서는 부비동 수술 후 후각 회복에 영향을 미치는 인자들에 대해 서술 하였으며, 이들을 숙지함으로써 술 전에 후각 회복 여부를 예측할 수 있고, 술 후 후각 회복율을 높이는데 도움을 주고자 하였다. 부비동 내시경 수술 후 후각 기능은 다양한 치료 결과를 나타내고, 호전되었다고 하더라도 저후각증 상태로 남아있는 경우도 많은데, 이는 반복적인 감염과 상피조직의 손상이 후각신경세포들의 불가역적인 손상이나 편평상피화 및 섬유화를 초래함으로써 기인할 수 있다. 수술 후에도 지속되는 점막의 부종이나 후열 부위의 염증도 후각 회복을 저해할수 있다. 술 전 후각이 무후각증 일수록, 비용종이 있을수록, CT상 후열 혼탁이 경도일수록, 부비동 수술 과거력이 없을수록, 후각장애 기간이 짧을수록, 비호산구성 부비동염, 상처 회복이 순조로울수록 수술 후 후각 회복율이 높다고 할 수 있다. 만성부비동염에 동반되는 후각 장애는 환자나 의사 모두에게 해결이 힘든 문제이자 수술 후 결과를 정확하게 예측하기 어려운 문제로 남아있으며, 향후 더 많은 연구가 필요할 것으로 생각한다.

• BMB Reports
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• 제54권6호
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• pp.295-304
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• 2021

Olfactory neuropathology is a cause of olfactory loss in Alzheimer's disease (AD). Olfactory dysfunction is also associated with memory and cognitive dysfunction and is an incidental finding of AD dementia. Here we review neuropathological research on the olfactory system in AD, considering both structural and functional evidence. Experimental and clinical findings identify olfactory dysfunction as an early indicator of AD. In keeping with this, amyloid-β production and neuroinflammation are related to underlying causes of impaired olfaction. Notably, physiological features of the spatial map in the olfactory system suggest the evidence of ongoing neurodegeneration. Our aim in this review is to examine olfactory pathology findings essential to identifying mechanisms of olfactory dysfunction in the development of AD in hopes of supporting investigations leading towards revealing potential diagnostic methods and causes of early pathogenesis in the olfactory system.