• Ocean and Polar Research
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• v.42 no.3
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• pp.195-210
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• 2020

The observed time series from the Korea Ocean Research Stations (KORS) in the Yellow and East China Seas (YECS) have various sources of noise, including bio-fouling on the underwater sensors, intermittent depletion of power, cable leakage, and interference between the sensors' signals. Besides these technical issues, intricate waves associated with background tidal currents tend to result in substantial oscillations in oceanic time series. Such technical and environmental issues require a regionally optimized automatic quality control (QC) procedure. Before the achievement of this ultimate goal, we examined the approach of the Ocean Observatories Initiative (OOI)'s standard QC to investigate whether this procedure is pertinent to the KORS. The OOI QC consists of three categorized tests of global/local range of data, temporal variation including spike and gradient, and sensor-related issues associated with its stuck and drift. These OOI QC algorithms have been applied to the water temperature time series from the Ieodo station, one of the KORS. Obvious outliers are flagged successfully by the global/local range checks and the spike check. Both stuck and drift checks barely detected sensor-related errors, owing to frequent sensor cleaning and maintenance. The gradient check, however, fails to flag the remained outliers that tend to stick together closely, as well as often tend to mark probably good data as wrong data, especially data characterized by considerable fluctuations near the thermocline. These results suggest that the gradient check might not be relevant to observations involving considerable natural fluctuations as well as technical issues. Our study highlights the necessity of a new algorithm such as a standard deviation-based outlier check using multiple moving windows to replace the gradient check and an additional algorithm of an inter-consistency check with a related variable to build a standard QC procedure for the KORS.

• Asian-Australasian Journal of Animal Sciences
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• v.33 no.6
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• pp.965-972
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• 2020

Objective: Astragalus membranaceus root is a well-known traditional Chinese herbal medicine with many biological active constituents. This study was conducted to examine the effects of Astragalus membranaceus root powder (AMP) on growth performance, serum antioxidant and immune response in finishing lambs. Methods: A total of thirty-six Guangling fat-tailed ram lambs (body weight = 19±2 kg, mean±standard deviation) were randomly assigned to one of six treatments for a 40 d feeding period, with the first 10 d for adaptation. Treatments consisted of the lambs' basal diets with addition of 0, 5, 10, 15, 20, and 30 g/kg of diet of AMP. Results: Response to supplementation level of AMP was quadratic (p≤0.032) for final weight and ADG with the greatest at 10 g/kg of diet, but dry matter intake was not affected (p≥0.227) by treatments. The increase of AMP supplementation resulted in a quadratic response in contents of triglyceride and creatinine (p<0.05), with the lowest values for 10 and 20 g/kg of diet, respectively. A linear and quadratic decrease was observed in activity of alkaline phosphatase in serum of lambs. As the AMP supplementation increased, the activities of total superoxide dismutase and total antioxidant capacity increased linearly (p≤0.018) and hydroxyl radical (OH^-) decreased linearly (p = 0.002). For catalase (CAT) and malondialdehyde (MDA), quadratic (p≤0.001) effects were observed among treatments, with the greatest CAT and lowest MDA values at 10 g/kg AMP. Additionally, supplementing AMP up to a level of 10 or 15 g/kg of diet quadratically increased immunoglobulin and interleukin contents in the serum. Conclusion: The results indicated that AMP can be used as natural feed additive in the ration of lambs to improve ADG, antioxidant status, and immune functions, and the optimal dose was 10 g/kg of diet under the condition of this experiment.

• Archives of Plastic Surgery
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• v.44 no.3
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• pp.202-209
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• 2017

Background No consensus exists on the optimal treatment protocol for orofacial clefts or the optimal timing of cleft palate closure. This study investigated factors influencing speech outcomes after two-stage palate repair in adults with a non-syndromal complete unilateral cleft lip and palate (UCLP). Methods This was a retrospective analysis of adult patients with a UCLP who underwent two-stage palate closure and were treated at our tertiary cleft centre. Patients ${\geq}17$ years of age were invited for a final speech assessment. Their medical history was obtained from their medical files, and speech outcomes were assessed by a speech pathologist during the follow-up consultation. Results Forty-eight patients were included in the analysis, with a mean age of 21 years (standard deviation, 3.4 years). Their mean age at the time of hard and soft palate closure was 3 years and 8.0 months, respectively. In 40% of the patients, a pharyngoplasty was performed. On a 5-point intelligibility scale, 84.4% received a score of 1 or 2; meaning that their speech was intelligible. We observed a significant correlation between intelligibility scores and the incidence of articulation errors (P<0.001). In total, 36% showed mild to moderate hypernasality during the speech assessment, and 11%-17% of the patients exhibited increased nasalance scores, assessed through nasometry. Conclusions The present study describes long-term speech outcomes after two-stage palatoplasty with hard palate closure at a mean age of 3 years old. We observed moderate long-term intelligibility scores, a relatively high incidence of persistent hypernasality, and a high pharyngoplasty incidence.

• Journal of Radiation Protection and Research
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• v.26 no.2
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• pp.101-111
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• 2001

To study the relationship between the DNA content of human chromosomes and their involvement in radiation-induced structural chromosome aberrations, the frequencies of translocations and dicentrics induced in human lymphocytes after in vitro exposure to 2Gy of x-tay were analysed by fluorescence in situ hybridization(FISH). Single whole chromosome probes(WCP), specific for chromosomes 1, 2, 4, 7, 8, 9, and 21 and triple combination of probes tot chromosome 1, 2 & 4 were used separately. A significant deviation of the frequency of symmetrical translocation and dicentrics from a DNA-proportional distribution was observed. Chromosomes 2, 7, 8, 9 and 21 were less frequently involved in the formation of symmetrical translocations and dicentrics than expected, whereas chromosomes 1 and 4 were more frequently involved. Chromosome 2 and 4 showed a higher frequency of acentric fragments. When triple combination probe for chromosome 1, 2 & 4 was used, no differences were found between the observed and expected frequency of exchange type aberrations. The results showed that the frequency of radiation-induced chromosome aberrations was not proportional to DNA contents, suggesting the difference in the susceptibility to specific aberrations among individual chromosomes. The results also indicated that the FISH technique with combination of probes for chromosome 1, 2 & 4 was useful for radiation biodosimetry.

• Journal of Food Hygiene and Safety
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• v.35 no.3
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• pp.213-218
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• 2020

This study was conducted to develop a method of analysis for 4-hydroxy-L-isoleucine in the seed extract of fenugreek (Trigonella foenum graecum), a health functional food that contains dietary fiber. The analytical method for 4-hydroxy-L-isoleucine was derived with O-phthaldialdehyde reagent (OPA) and determined by HPLC-PDA. The method was performed on a Capcell Pak C₁₈ UG 120 column (4.6×250 mm, 5 ㎛) in isocratic elution mode using disodium phosphate and acetonitrile. The validation of the developed analytical method was conducted by evaluating several parameters; selectivity, linearity, limit of detection (LOD), limit of quantification (LOQ), accuracy and repeatability. Excellent linearity (R²=0.999) was observed for 4-hydroxy-L-isoleucine in the concentration range (5-100 ㎍/mL). Observed recoveries of these compounds were found to be between 91.7 and 96.4%. Precision was between 0.2 and 2.4% relative standard deviation (%RSD).

• Journal of Nutrition and Health
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• v.37 no.10
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• pp.917-927
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• 2004

This study was performed to examine component of variance in nutrient intakes and to estimate the level of accuracy with varying degree of precision in order to achieve estimates of usual nutrient intakes. Three-day dietary records including both weekdays and weekends were collected every 4 season over a I-year period from 36 males and 93 females aged 40 - 65 y. For each nutrient, we partitioned total intake variance into weekly (weekday vs weekend), seasonal, within- and between- individual variation as components of variance, using analysis of variance. It was found that major components of variance were within- and between-individual variation. Particularly, within-individual variation (57.2 - 87.1 %) was greater than between-individual variation (12.2 - 37.4%) for all nutrients. Weekly and seasonal variation contributed small components of variance for most nutrients. For protein, fat and carbohydrate, there were a little significant weekly variation (0.00 - 1.35%) in females but not in males. For some micronutrients, there were moderately significant seasonal variation (0.15 - 5.48%) in both sexes. Ratio of within- to between- individual variation ranged 1.4 (vitamin B$_2$) -4.5 (vitamin B$_1$) in males and 1.6 (carbohydrate) -2.9 (fat) in females. With total 12-day dietary records data, the maximum percentage deviation of observed intakes from usual (true) intakes ranged 12-37%. To estimate usual individual intakes within 20% of the true mean with 90% confidence level, 3 - 9 days of dietary survey were required for energy, protein, carbohydrate, phosphorus and iron, 13 - 19 days for fat and calcium, 25 - 29 days for vitamin A and vitamin C. Correlation coefficients between observed and true nutrient intakes were 0.71 - 0.91 for males, 0.81-0.91 for females. In conclusion, mean intakes of several nutrients can be reliably measured with the record method, using a limited number of days. Both nutrients of interest and the primary objectives should be taken account when planning method of assessment and number of replicates.

• Journal of Korea Water Resources Association
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• v.38 no.12 s.161
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• pp.1039-1049
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• 2005

The objective of this study is to produce optimal radar-derived rainfall for hydrologic utilization. The ground clutter and beam blockage effects from Mt. Kwanak station (E.L 608m) are removed from radar reflectivities by POD analysis. The reflectivities are used to produce radar rainfall data in the form of rain rates (mm/h) by the application of the Marshall-Palmer reflectivity versus rainfall relationship. However, these radar-derived rainfall are underestimated in temporal and spatial scale compared with observed one, so it is necessary to hire a correction scheme based on the gauge-to-radar (G/R) statistical adjustment technique. The selected watershed for studying the real-time correction of radar-rainfall estimation is the Soyang dam site, which is located approximately 100km east of Kwanak radar station. The results indicate that adjusted radar rainfall with the gauge measurement have reasonal G/R ratio ranged on 0.95-1.32 and less uncertainty with that mean standard deviation of G/R ratio are decreased by $9-28\%$. Mean areal precipitation from adjusted radar rainfall are well agreed to the observed one on the Soyang River watershed. It is concluded that the real-time bias adjustment scheme is useful to estimate accurate basin-based radar rainfall for hydrologic application.

• Journal of Korean Society of Environmental Engineers
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• v.33 no.8
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• pp.583-590
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• 2011

The effect of the physical parameters in the reactor (aeration depth, bubble size, and surface area) and the alkalinity of the solution on the ammonia stripping by bubbling were evaluated. When an airflow of 30 L/min was bubbled below the solution surface in the range 6-53 cm, the ammonia removal rate were observed to be the same regardless of the bubbling depths. At pH 10.0 and a temperature of $30^{\circ}C$, the average rate constant and the standard deviation were $0.178h^{-1}$ and 0.004. No appreciable changes in the ammonia removal rate were also observed with varying the bubble size and the air-contacting surface area. Alkalinity of the solution was found to affect the ammonia removal rate indirectly. This is expected because the pH of the solution would vary with dissolution of gaseous $CO_2$ by air bubbling. The real wastewaters from landfill site and domestic wastewater treatment plant were tested. In the case of domestic wastewater (pH = 7.1, alkalinity = 75 mg/L), the ammonia removal rate was poor even with the control of pH to 9.3. The raw landfill leachate (pH = 8.0, alkalinity = 6,525 mg/L), however, showed the appreciable removal rate with increasing pH during aeration. When the initial pH of the leachate was adjusted 9.4, the removal rate was significantly increased without changing the pH during aeration.

• Journal of The Korean Society of Grassland and Forage Science
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• v.28 no.3
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• pp.185-192
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• 2008

We have studied effect of water treatment sludge (WTS) on trace metals of sorghum hybrid (Sorghum bicolor (L.) Moench). In the present report it was for cadmium (Cd) content on background correction (BGC) mode with an atomic absorption spectrophotometer. The four treatments were Control, Compost, Alum + nitrogen, phosphorus, potassium (NPK), Compost + NPK. In the analysis, burner height of the atomic absorption spectrophotometer was adjusted to three levels; 3 mm, 6 mm, 9 mm. As a conclusion, 3 mm and 6 mm burner height conditions were better than 9 mm height for Cd analysis. And the conditions for widening the range, the mean, and the standard deviation (SD) values of observed absorbances as well as the condition for lessening the mean of observed background values are necessary for getting the better measuring of Cd. At the present experiment, 6 mm burner height condition is the best among the three burner heights.

• Clinical and Experimental Reproductive Medicine
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• v.32 no.4
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• pp.301-314
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• 2005

Objective: Rebamipide is a propionic acid derivative that has an action of the inhibition of superoxide production and removal of hydroxyl radical with the sperm incubation and cryopreservation. In the present study, to investigate whether rebamipide is useful to treat male infertility and sterility, the author observed the antioxidative effects in patient with male infertility and also examined its absorption and distribution in rat genital organ. Methods: To measure the distribution of rebamipide in reproductive organ in the rat, carbon indicated rebamipide, $^{14}C-OPC-12759$, was orally administered to 10 Spraque-Dawley rats and its organ concentration in serum, liver, kidney, stomach, duodenum, colon, urinary bladder, seminal vesicle, epididymis and testicle were measured each time after 0.5, 1, 2, 4, 8 and 24 hours by using HPLC fluorescent method. The concentrations in semen were measured by HPLC fluorescent method in a sample of 50 infertile males who took 900 mg of rebamipide daily for 3 months. To measure the antioxidative effect and fertility rate for 3 months, each month before and after the treatment, sperm motility, vitality, the oxygen free radical formation, level of peroxidation, fetilizing capacity of semen sample which were obtained from infertile male patients by masturbation after at least 48 hours abstinence were analyzed by computer assisted semen analyzer, eosin-nigrosin stain, chemiluminescence, thiobarbituric acid method and hypo-osmotic swelling test. Simultaneously in a sample that wanted baby, both pregnancy and delivery were researched. Results: The $^{14}C-OPC-12759$ concentration in the body of white rats was highest in gastrointestinal organ like stomach, smal intestine and duodenum and followed by genital organ like seminal vesicle, testis and epididymis. The rebamipide concentration in semen of infertile males was $220.77{\pm}327.84ng/mL$ (SD) which showed a large deviation but it was higher than serum which was $126{\pm}76ng/mL$ (SD). In the infertile males, after the treatment with rebamipide, the level of seminal reactive oxygen species (ROS) and lipid peroxidation have significantly decreased in duration of the treatment (p<0.05) and sperm vitality and fertilizing capacity except sperm motility significantly improved on post treatment of 2~3 months (p<0.05). Out of the 41 cases who hoped for pregnancy, 15 cases (36.6%) became pregnant and 12 cases had childbrith, 2 cases had miscarriage and one case is ongoing. The side effect was observed in 1 case (2%) which experienced diarrhea but it was lost spontaneously. Conclusions: We conclude from this study that rebamipide showed relatively high tendancy of absorption and excretion in the genital organ. In infertile males who had elevated ROS in semen, by specifically inhibiting the cell damage from the antioxidation, a way to preserve sperm motility, vitality and fertilizing capacity was confirmed.