• Korean Journal of Psychosomatic Medicine
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• v.7 no.2
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• pp.174-183
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• 1999

Objective : This study was designed to evaluate the incidence and characteristics of posttraumatic stress disorder(PTSD) after motor vehicle accidents(MVA) in 44 consecutive MVA victims referred to psychiatry for the diagnosis, treatment and psychiatric assessment. Method : The diagnosis of posttraumatic stress disorder was made on the basis of DSM-IV criteria, and posttraumatic stress symptoms were assessed by the Clinician-Administered PTSD Scale(CAPS). Correlation between the extent of physical injury and the severity of PTSD symptoms using the Abbreviated Injury Scale(AIS) was analyzed and the frequency of psychiatric comorbidity of PTSD was invested. Result : Twenty-two(45.5%) MVA victims met DSM-IV criteria for PTSD, while thirteen(29.5%) showed a subsyndromal form of it. AIS scores significantly related with the development of posttraumatic stress symptoms(r=0.565, p=0.0001). PTSD group showed high percentages of each of the 17 symptoms(criterion B, C, D), while subsyndromal PTSD group showed relatively high percentages of criterion Band D. The most frequent symptom was 'distressing dreams' of criterion B in both group. A high percentages(56%) of the MVA-PTSD group also met the criteria for current major depression. Conclusions : These findings suggest that there is apparently a high likelihood of developing all or part of the PTSD syndrome after motor vehicle accidents. So it does appear that for those MVA victims who seek medical attention and eventually need psychiatric referral, diagnostic possibility of PTSD should be taken into account in treatment planning and early intervention.

• Nutrition Research and Practice
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• v.9 no.4
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• pp.379-384
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• 2015

BACKGROUND/OBJECTIVE: Apolipoprotein A5 gene promoter region T-1131C polymorphism (APOA5 T-1131C) is known to be associated with elevated plasma TG levels, although little is known of the influence of the interaction between APOA5 T-1131C and lifestyle modification on TG levels. To investigate this matter, we studied APOA5 T-1131C and plasma TG levels of subjects participating in a three-month lifestyle modification program. SUBJECTS/METHODS: A three-month lifestyle modification program was conducted with 297 participants (Age: $57{\pm}8years$) in Izumo City, Japan, from 2001-2007. Changes in energy balance (the difference between energy intake and energy expenditure) and BMI were used to evaluate the participants' responses to the lifestyle modification. RESULTS: Even after adjusting for confounding factors, plasma TG levels were significantly different at baseline among three genotype subgroups: TT, $126{\pm}68mg/dl$; TC, $134{\pm}74mg/dl$; and CC, $172{\pm}101mg/dl$. Lifestyle modification resulted in significant reductions in plasma TG levels in the TT, TC, and CC genotype subgroups: $-21.9{\pm}61.0mg/dl$, $-20.9{\pm}51.0mg/dl$, and $-42.6{\pm}78.5mg/dl$, respectively, with no significant differences between them. In a stepwise regression analysis, age, APOA5 T-1131C, body mass index (BMI), homeostasis model assessment-insulin resistance (HOMA-IR), and the 18:1/18:0 ratio showed independent association with plasma TG levels at baseline. In a general linear model analysis, APOA5 T-1131C C-allele carriers showed significantly greater TG reduction with decreased energy balance than wild type carriers after adjustment for age, gender, and baseline plasma TG levels. CONCLUSIONS: The genetic effects of APOA5 T-1131C independently affected plasma TG levels. However, lifestyle modification was effective in significantly reducing plasma TG levels despite the APOA5 T-1131C genotype background.

• Journal of Korean Neurosurgical Society
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• v.63 no.5
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• pp.649-656
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• 2020

Objective : Unclear mental state is one of the major factors contributing to diagnostic failure of occult skeletal trauma in patients with traumatic brain injury (TBI). The aim of this study was to evaluate the overlooked co-occurring skeletal trauma through whole body bone scan (WBBS) in TBI. Methods : A retrospective study of 547 TBI patients admitted between 2015 and 2017 was performed to investigate their cooccurring skeletal injuries detected by WBBS. The patients were divided into three groups based on the timing of suspecting skeletal trauma confirmed : 1) before WBBS (pre-WBBS); 2) after the routine WBBS (post-WBBS) with good mental state and no initial musculoskeletal complaints; and 3) after the routine WBBS with poor mental state (poor MS). The skeletal trauma detected by WBBS was classified into six skeletal categories : spine, upper and lower extremities, pelvis, chest wall, and clavicles. The skeletal injuries identified by WBBS were confirmed to be simple contusion or fractures by other imaging modalities such as X-ray or computed tomography (CT) scans. Of the six categorizations of skeletal trauma detected as hot uptake lesions in WBBS, the lesions of spine, upper and lower extremities were further statistically analyzed to calculate the incidence rates of actual fractures (AF) and actual surgery (AS) cases over the total number of hot uptake lesions in WBBS. Results : Of 547 patients with TBI, 112 patients (20.4 %) were presented with TBI alone. Four hundred and thirty-five patients with TBI had co-occurring skeletal injuries confirmed by WBBS. The incidences were as follows : chest wall (27.4%), spine (22.9%), lower extremities (20.2%), upper extremities (13.5%), pelvis (9.4%), and clavicles (6.3%). It is notable that relatively larger number of positive hot uptakes were observed in the groups of post-WBBS and poor MS. The percentage of post-WBBS group over the total hot uptake lesions in upper and lower extremities, and spines were 51.0%, 43.8%, and 41.7%, respectively, while their percentages of AS were 2.73%, 1.1%, and 0%, respectively. The percentages of poor MS group in the upper and lower extremities, and spines were 10.4%, 17.4%, and 7.8%, respectively, while their percentages of AS were 26.7%, 14.2%, and 11.1%, respectively. There was a statistical difference in the percentage of AS between the groups of post-WBBS and poor MS (p=0.000). Conclusion : WBBS is a potential diagnostic tool in understanding the skeletal conditions of patients with head injuries which may be undetected during the initial assessment.

• Nutrition Research and Practice
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• v.8 no.3
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• pp.257-266
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• 2014

BACKGROUND/OBJECTIVE: Licorice has been shown to possess cancer chemopreventive effects. However, glycyrrhizin, a major component in licorice, was found to interfere with steroid metabolism and cause edema and hypertension. The roasting process of licorice modifies the chemical composition and converts glycyrrhizin to glycyrrhetinic acid. The purpose of this study was to examine the anti-carcinogenic effects of the ethanol extract of roasted licorice (EERL) and to identify the active compound in EERL. MATERIALS/METHODS: Ethanol and aqueous extracts of roasted and un-roasted licorice were prepared. The active fraction was separated from the methylene chloride (MC)-soluble fraction of EERL and the structure of the purified compound was determined by nuclear magnetic resonance spectroscopy. The anti-carcinogenic effects of licorice extracts and licochalcone A was evaluated using a MTT assay, Western blot, flow cytometry, and two-stage skin carcinogenesis model. RESULTS: EERL was determined to be more potent and efficacious than the ethanol extract of un-roasted licorice in inhibiting the growth of DU145 and MLL prostate cancer cells, as well as HT-29 colon cancer cells. The aqueous extracts of un-roasted and roasted licorice showed minimal effects on cell growth. EERL potently inhibited growth of MCF-7 and MDA-MB-231 breast, B16-F10 melanoma, and A375 and A2058 skin cancer cells, whereas EERL slightly stimulated the growth of normal IEC-6 intestinal epithelial cells and CCD118SK fibroblasts. The MC-soluble fraction was more efficacious than EERL in inhibiting DU145 cell growth. Licochalcone A was isolated from the MC fraction and identified as the active compound of EERL. Both EERL and licochalcone A induced apoptosis of DU145 cells. EERL potently inhibited chemically-induced skin papilloma formation in mice. CONCLUSIONS: Non-polar compounds in EERL exert potent anti-carcinogenic effects, and that roasted rather than un-roasted licorice should be favored as a cancer preventive agent, whether being used as an additive to food or medicine preparations.

• Journal of Korean Neurosurgical Society
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• v.60 no.6
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• pp.635-643
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• 2017

Objective : Acute basilar artery occlusion (BAO) is associated with severe neurological dysfunction and high mortality rates. The benefits of mechanical thrombectomy in BAO have not been explored in recent clinical trials. Therefore, we analyzed outcomes of stent retriever mechanical thrombectomy for BAO, and compared with anterior circulation occlusions (ACO). Methods : In total, 161 consecutive patients (24 BAO, 137 ACO) who underwent mechanical thrombectomy with the stent retriever between January 2013 and August 2016 enrolled in our study. All patients underwent clinical assessment with the National Institutes of Health Stroke Scale (NIHSS) and modified Rankin scale (mRS). Radiological results were used to evaluate thrombolysis in cerebral infarction (TICI) scores and successful recanalization was defined by TICI 2b or 3. Results : Mean NIHSS scores at 24 hours and 30 days were significantly higher in the BAO group than the ACO group (p=0.021, p=0.001). mRS at 90 days was significantly higher in the BAO group (4.2) compared with the ACO group (3.0) (p=0.003). The BAO group (2.0) performed fewer stent retriever passages than the ACO group (2.7) (p=0.049). There were no significant differences between the two groups in terms of complications, but the BAO patients experienced a higher mortality (16.6%) rate than ACO patients (5.8%) (p=0.001). In subgroup analysis of BAO, patients with short procedure times achieved successful recanalization (p=0.001) and successfully recanalized patients exhibited more favorable mRS at 90 days (p=0.027). Conclusion : In our study, mechanical thrombectomy of BAO patients showed worse clinical outcome and higher mortality rate than ACO patients. However, mechanical thrombectomy with a stent retriever in BAO is an effective treatment, because successfully recanalized patients showed good clinical outcome in BAO patients.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.17 no.12
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• pp.532-541
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• 2016

The objective of this paper is to support accurate pavement condition assessment and decision of proper maintenance method and time by conducting visual inspection and calculating the remaining life of pavement from falling weight deflectometer(FWD) data. Each was implemented in the same long-term performance pavement(LTPP) sections. Visual inspection was executed to measure pavement condition indices such as crack, rutting and international roughness index(IRI) and the Seoul Pavement Index(SPI) was calculated based on these results. The dynamic modulus was back-calculated from the FWD data. The remaining pavement lives were determined from equivalent single axle loading(ESAL) and FWD data. Correlation of maintenance priority by each result value was examined. Consequently, the correlation between remaining life to Crack and Rutting was higher than the other factors or indicesbecause IRI is not related to FWD value and SPI value consists with IRI value and other indices. The R-square value of correlation of FWD with Crack and Rutting was 0.65, which indicated an insufficient correlation. Consequently, when decision of maintenance of method, time, etc. is determined, FWD data have to be considered with Crack and Rutting because of those relations.

• Journal of Korean Society of Rural Planning
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• v.21 no.2
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• pp.63-77
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• 2015

Improve the rural views of the Government and the municipalities with the intention of rural landscape planning. However, rural scenery evaluation of landscape types and element categories, landscape scenes, such as the valuation of resources selected, form a coherent system and ecological point of view is not only a Visual perspective of evaluation, or evaluation is made. This study evaluates the rural landscape through the rural landscape for rurality is implemented can explain the image. Rural amenity 100 represented the rural landscape in rurality with photos of photos, and scenes, photos, location-based rural Vista rurality landscapes drawn components. Selected landscape photography scenic landscapes in the u.s. survey and image vocabularies through surveys is representative of the landscape in rurality of each Vista location-specific photos and images began extracted factors. As a result, the Distant view is a town and village in the rolling hills of the surrounding environment is an image behind the Vista Skyline, Farmland Rural village forests, Behind the hills, Individual housing roof, Housing arrangement, The number of household includes landscape components. Factor analysis 'openness', 'intimacy', 'activity', 'complexity', 'safety' was down to five factors, such as a description of the overall factors that force was 66.45 percent. Middle distance view is close to being out of town houses and village environment, an image in the skyline hills Vista, farmlands, village forests, rolling hills, behind the scenes of the housing component of the neck, the sperm will honor an individual factor analysis results are 'intimacy', 'safety', 'openness', 'specificity', 'complexity' five factors the whole description of the capacity factors compared to 67.24 percent. Close-range view is mainly in Vista village embraced the individual elements and an image of a harmonious location in the surroundings of the sperm, individual houses, fences, gates, courtyard, Garden, garage, agricultural facilities, including, but not limited to, factors assay but an 'intimacy', 'complexity', 'safety', 'activity', 'openness' five factors, such as a description of the overall factors that force was 65.29%. This research seeks to determine the extent to which rurality of rural landscape Vista by location attributes and elements and representative officer in photo selection and rurality to extract the image. To date, followed by a comprehensive study, which was presented through the readjustment could not overlook the Visual elements. The future rural development officer for the evaluation of rural landscape classification and quantitative and objective assessment will have to come up with ways to do.

• Journal of Korean Society of Rural Planning
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• v.21 no.2
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• pp.79-90
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• 2015

In empirical studies on rural development projects, differentiation tends to be considered a strategy aimed at increasing the number of visitors. Rural development projects include the improvement of living environment, and the discussion about project goals and evaluation of project results are often focused on the aspect of rural tourism. Thus, subjective benefits of such projects for residents are omitted. This study examines the meaning of differentiation from the perspective of residents and explores the validity of the number of visitors and the possibility of reflecting residents' subjective score as evaluation indicators for a project. To achieve such an objective, this study uses survey data collected from 153 people in 38 comprehensive development projects in areas of Eup and Myeon, Korea. The results of this study show that differentiation is viewed as a by-product of positive improvement from a rural development project, from the perspective of residents. The effects of rural development are classified into two dimensions: socioeconomic effects and living environmental effects. Landscape improvement is included in the dimension of living environmental effects and an increase in the number of visitors is included in the dimension of socioeconomic effects. As such, they are confirmed to be the factors that determine the level of differentiation. For example, the increase in the number of visitors is confirmed to be a valid indicator of project success, in which two-dimensional characters are reflected. The level of differentiation evaluated by residents is a result of the workings of the above two factors. Unlike in previous studies, the possibility of evaluation based on the perception of residents is confirmed in the evaluation of results. When the level of differentiation is interpreted as the direct result of a project, the number of visitors has an impact on socioeconomic effects, and the project content of landscape improvement has an impact on living environmental effects. The goal of policy and residents is the same in terms of the effort residents may make in maximizing results of a project by themselves; thus, the government's goal is achieved even when a project is carried out under the autonomy of residents. Ultimately, the government should focus on providing conditions in which active citizen participation can not only occur but help to establish a policy direction, which subsequently strengthens the substantial rights of residents.

• Journal of Sasang Constitutional Medicine
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• v.23 no.3
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• pp.351-360
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• 2011

1. Objective: This study was designed to analyze the characteristics of each Sasang constitutional type using the Temperament and Character Inventory (TCI). 2. Methods: A total of 135 healthy subjects (age 19-30) participated in this study, consisting of 35 Soyang-type, 66 Taeeum-type, 30 Soeum-type, and 4 Taeyang-type subjects. A Sasang Constitutional Medicine specialist determined each subject's Sasang constitutional type based on the Two Step Questionnaire for Sasang Constitution Diagnosis (TS-QSCD) and comprehensive constitutional assessment. The subjects were also asked to complete the TCI. 3. Results: Among the four temperament dimensions, the Soyang- and Taeeum-type subjects showed significantly higher scores than the Soeum-type subjects in Novelty Seeking (NS). The Soeum-type subjects showed significantly higher scores than the Taeum- and Soyang-type subjects in Harm Avoidance (HA) (Soeum type > Taeeum type > Soyang type). The Soyang-type subjects showed significantly higher scores than the Soeum-type subjects in Reward Dependence (RD). The Soyang- and Taeeum-type subjects showed significantly higher scores than the Soeum-type subjects in Persistence (P). Among the three character dimensions, the Soyang-type subjects showed significantly higher score than the Taeeumand Soeum-type subjects in Self-Directedness (SD) (Soyang type > Taeeum type > Soeum type). The Soyang-type showed significantly higher scores than the Taeeum-type in Cooperativeness (C). 4. Conclusions: Differences in temperament and character were discovered across the Sasang constitutional types. The Sasang constitutional characteristics should be investigated in larger studies in the future. Similar studies could add to the growing knowledge of Sasang constitutional typology and contribute to a more accurate Sasang constitutional diagnosis.

• Journal of Korea Water Resources Association
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• v.44 no.9
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• pp.721-730
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• 2011

The objective of this study is to assess the availability of streamflow simulation using Radar-AWS Rain rate (RAR) data which is produced by KMA on real-time. Chuncheon dam upstream basin is selected as study area and total area is 4859.73 $km^2$. Mean Areal Precipitation (MAP) using AWS and RAR are calculated on 5 subbasin. The correlationship of hourly MAPs between AWS and RAR is weak on ungauged subbasins but that is relatively high on gauged ones. We evaluated the simulated discharge using the MAPs derived from two data types during flood season from 2006 to 2009. The simulated discharges using AWS on Chuncheon dam (gauged basin) are well fitted with measured ones. In some cases, however, discharges using AWS on Hwacheon dam and Pyeonghwa dam with some ungauged subbasins are overestimated on the other hand, ones using RAR in the same case are well fitted with measured ones. The hourly RAR data is useful for the real-time river forecast on the ungauged basin in view of the results.