• Title/Summary/Keyword: numerical stability

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A Case Series of Snake Venom Pharmacopuncture for Chemotherapy-Induced Peripheral Neuropathy: A Retrospective Observational Study

  • Song, Si Yeon;Bae, Kyeore;Shin, Kwhang Ho;Yoo, Hwa-Seung
    • Journal of Pharmacopuncture
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    • v.20 no.4
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    • pp.280-286
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    • 2017
  • Objective: This case series aims to report the efficacy and the safety of using snake venom pharmacopuncture (SVP) for chemotherapy-induced peripheral neuropathy (CIPN). Methods: Three heterogeneous cancer (1 endometrium, 1 cervix, and 1 prostate cancer) patients were referred to the East-West Cancer Center (EWCC), Dunsan Korean Medicine Hospital of Daejeon University, from August 02, 2017, to September 15, 2017, for treatment with SVP, and they were treated with SVP 4 times, 6 times, and 8 times, respectively. During the treatment period, the efficacy of SVP therapy was assessed by using the Numerical Rating Scale (NRS) and the Common Terminology Criteria for Adverse Events (CTCAE), and the stability was evaluated by using blood tests. Following each session, all patients were examined closely for any allergenic responses or adverse effects. Results: All patients showed noticeable improvements of their NRS and CTCAE scores. Except for bleeding and bruising at the SVP injection site, no major side effects were noted. One of the patients reported mild chilling and a sore throat after receiving the second treatment; those symptoms went away after a few hours. No hematologic toxicity, hepatotoxicity, or nephrotoxicity was found on the blood test. Conclusion: The results of this research suggest positive potential benefits of using SVP for treating patients with CIPN. Also, the excellent safety results of SVP seen in this research should lead to larger clinical trials aimed at developing SVP into a potential intervention for managing patients with the symptoms of CIPN.

Back Analysis for the Properties of Cut and Cover Tunnel using Optimization Algorithms (최적화 알고리즘을 이용한 복개터널 물성값의 역해석)

  • Park, Byung-Soo;Jun, Sang-Hyun
    • Journal of the Korean Society of Hazard Mitigation
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    • v.8 no.1
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    • pp.81-87
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    • 2008
  • This study is about the back analysis to optimize the uncertain parameters of geotechnical properties used in stability analysis of cut and cover tunnel. The Simplex algorithm, Powell algorithm, Rosenbrock algorithm, and Levenberg-Marquardt algorithm are applied for artificial problems of ground excavation. Furthermore, results are compared in the matter of the reliability of optimal solutions with a certain accuracy and the computation speed for evaluations of variables. As shown in results of numerical analysis, all of four algorithms are converged to exact solution satisfying the allowable criteria. And Levenberg-Marquardt's and Rosenbrock's algorithms are identified to be the more efficient methods in the evaluations of functions. After the back analysis for Poisson ratio and Young's modulus for cut and cover tunnel has been performed, design parameters have been correctly estimated and computation time has been improved while the number of measure points is increased.

VIRTUAL PREDICTION OF A RADIAL-PLY TIRE'S IN-PLANE FREE VIBRATION MODES TRANSMISSIBILITY

  • CHANG Y. P.;EL-GINDY M.
    • International Journal of Automotive Technology
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    • v.6 no.2
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    • pp.149-159
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    • 2005
  • A full nonlinear finite element P185/70Rl4 passenger car radial-ply tire model was developed and run on a 1.7-meter-diameter spinning test drum/cleat model at a constant speed of 50 km/h in order to investigate the tire transient response characteristics, i.e. the tire in-plane free vibration modes transmissibility. The virtual tire/drum finite element model was constructed and tested using the nonlinear finite element analysis software, PAM-SHOCK, a nonlinear finite element analysis code. The tire model was constructed in extreme detail with three-dimensional solid, layered membrane, and beam finite elements, incorporating over 18,000 nodes and 24 different types of materials. The reaction forces of the tire axle in vertical (Z axis) and longitudinal (X axis) directions were recorded when the tire rolled over a cleat on the drum, and then the FFT algorithm was applied to examine the transient response information in the frequency domain. The result showed that this PI 85/70Rl4 tire has clear peaks of 84 and 45 Hz transmissibility in the vertical and longitudinal directions. This result was validated against more than 10 previous studies by either theoretical or experimental approaches and showed excellent agreement. The tire's post-impact response was also investigated to verify the numerical convergence and computational stability of this FEA tire model and simulation strategy, the extraordinarily stable scenario was confirmed. The tire in-plane free vibration modes transmissibility was successfully detected. This approach was never before attempted in investigations of tire in-plane free vibration modes transmission phenomena; this work is believed to be the first of its kind.

A Study on Active Suspension Robust Control with Sensor and Actuator Location (센서위치를 고려한 능동 서스펜션 강인제어에 관한 연구)

  • Park Jung-Hyen;Jang Seung-Jae
    • Journal of the Korea Institute of Information and Communication Engineering
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    • v.10 no.6
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    • pp.1147-1152
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    • 2006
  • This paper proposed modelling and design method in suspension system design to analyze sky hook damper system by adopting active robust control theory. Recent in the field of suspension system design it is general to adopt active control scheme for stiffness and damping, and connection with other vehicle stability control equipment is also intricate, it is required for control system scheme to design more robust, higher response and precision control equipment. It is known that sky hook suspension system is better than passive spring-damper system in designing suspension equipment. We analyze location of sensor and actuator in sky hook system and its motion equation, then design robust control system. Numerical example is shown for validity of robust control system design in active sky hook suspension system.

Parameter Optimization of the Marine Gyrocompass Follow-up System (자이로콤파스 추종계통의 최적조정)

  • 이상집
    • Journal of the Korean Institute of Navigation
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    • v.5 no.2
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    • pp.49-58
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    • 1981
  • One of the main purposes of the marine gyrocompass follow-up system is to preserve the sensitive part from the wandering error due to the frictional or torsional torque around the vertical axis. This error can be diminished through the rapid follow-up action, which minimizes the relative azimuthal angular displacement between the sensitive and follow-up parts and shortens the duration of the same displacement. But an excessive rapidity of the follow-up action would result in a sustained oscillation to the system. Therefore, to design a new type of the follow-up system, the theoretical annlysis of the problems concerned should be studied systematically by introducing the control theory. This paper suggest a concrete procedure for the optimal adjustment of the gyrocompass follow-up system, utilizing the mathematic model and the stability informations formerly investiaged by the author. For theoptimal determination of the adjustable paramfter K, the performance index(P.I.), ITSE(Intergral of the Time multiplied by the Squared Error) is proposed, namely, P.I. = $\int_{0}^{\infty} t \cdot e^{2}(t)dt$ where t is time and e(t) means control error. Then, the optimal parameter minimizing the performance index is calculated by means of Parseval's theorem and numerical computation, and the validity of the obtained optimal value of the parameter Ka is examined and confirmed through the simulations and experiments. By using, the proposed method, the optimal adjustment can be performed deterministically. But, this can not be expected in the conventional frequency domain analysis. While the Mps of the original system vary to the extent of from 0.98 to 46.27, Mp of the optimal system is evaluated as 1.1 which satisfies the generally accepted frequency domain specification.

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A Suggestion of Blasting Patterns of a Mine closed to Railway Line for Securing Safety of High Speed Train (고속철도 안전확보를 위한 노선 인접 광산의 발파패턴 제안)

  • Kim, Hyun-Ki;Lee, Sung-Hyeok;Lee, Jin-Wook;Choi, Chan-Yong
    • Journal of the Korea institute for structural maintenance and inspection
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    • v.19 no.5
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    • pp.1-9
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    • 2015
  • Recently Honam high-speed railroad line is constructed in southern part of Korea. This line is for next generation HST named HEMU-430X. But there is a limestone mine near this line and this mine will make a process to dig a passageway under the railway line. In this case, safety of railroad system and stability of mine are crucial problems on both sides. By measuring mine blasting vibration and calculating regression equation, effect of mine blasting to train running is investigated quantitatively. 0.5 kine (cm/sec) is applied as a management specification of vibration based on field measurement. In this study, changes of blasting patterns are suggested to control vibration of mine blasting. And the effect of train vibration to mine is also invesitigated by numerical analysis.

A Study on the Improvement of Forward Blocking Characteristics in the Static Induction Transistor (Static Induction Transistor의 순방향 블로킹 특성 개선에 관한 연구)

  • Kim, Je-Yoon;Jung, Min-Chul;Yoon, Jee-Young;Kim, Sang-Sik;Sung, Man-Young;Kang, Ey-Goo
    • Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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    • 2004.07a
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    • pp.292-295
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    • 2004
  • The SIT was introduced by Nishizawa. in 1972. When compared with high-voltage, power bipolar junction transistors, SITs have several advantages as power switching devices. They have a higher input impedance than do bipolar transistors and a negative temperature coefficient for the drain current that prevents thermal runaway, thus allowing the coupling of many devices in parallel to increase the current handling capability. Furthermore, the SIT is majority carrier device with a higher inherent switching speed because of the absence of minority carrier recombination, which limits the speed of bipolar transistors. This also eliminates the stringent lifetime control requirements that are essential during the fabrication of high-speed bipolar transistors. This results in a much larger safe operating area(SOA) in comparison to bipolar transistors. In this paper, vertical SIT structures are proposed to improve their electrical characteristics including the blocking voltage. Besides, the two dimensional numerical simulations were carried out using ISE-TCAD to verify the validity of the device and examine the electrical characteristics. A trench gate region oxide power SIT device is proposed to improve forward blocking characteristics. The proposed devices have superior electrical characteristics when compared to conventional device. Consequently, the fabrication of trench oxide power SIT with superior stability and electrical characteristics is simplified.

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A numerical study of adjusted parameter estimation in normal inverse Gaussian distribution (Normal inverse Gaussian 분포에서 모수추정의 보정 방법 연구)

  • Yoon, Jeongyoen;Song, Seongjoo
    • The Korean Journal of Applied Statistics
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    • v.29 no.4
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    • pp.741-752
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    • 2016
  • Numerous studies have shown that normal inverse Gaussian (NIG) distribution adequately fits the empirical return distribution of financial securities. The estimation of parameters can also be done relatively easily, which makes the NIG distribution more useful in financial markets. The maximum likelihood estimation and the method of moments estimation are easy to implement; however, we may encounter a problem in practice when a relationship among the moments is violated. In this paper, we investigate this problem in the parameter estimation and try to find a simple solution through simulations. We examine the effect of our adjusted estimation method with real data: daily log returns of KOSPI, S&P500, FTSE and HANG SENG. We also checked the performance of our method by computing the value at risk of daily log return data. The results show that our method improves the stability of parameter estimation, while it retains a comparable performance in goodness-of-fit.

Comparison of Numerical Results for Stability Assessment of Revetments in Meandering Channel (만곡부 사석보호공 안정성 평가를 위한 수치모의결과 비교)

  • Kim, Hyung-Jun;Bae, Deok-Won;Yoon, Kwang-Seok
    • Proceedings of the Korea Water Resources Association Conference
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    • 2012.05a
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    • pp.605-605
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    • 2012
  • 최근 통계자료에 의하면 국내 제방붕괴 유형 중 11.5%가 제체 불안정에 의한 붕괴로 보고되고 있다. 홍수시 노후화된 제방이 붕괴하여 발생하는 인명 및 재산피해는 점차 증가하고 있는 상황이어서, 이에 대한 제방 시설물의 보강 및 안전관리 대책이 필요한 상황이다. 하천시설물 주변의 흐름특성에 의하여 세굴이 발생할 수 있는 지점에는 보호공을 설치하여 시설물의 안정성을 확보하도록 하천설계기준 해설(2009)에서 제안하고 있다. 그러나 구조물을 보완하는 보호공의 공종 및 규격 등을 설계하기 위한 세부적인 설계지침이 미흡하여 외국의 연구 또는 설계사례를 참고하여 국내 하천에 적용하고 있는 상황이다. 해외의 연구사례를 살펴보면, 설계공식에 적용된 설계인자인 유속 및 수심 등을 1차원 단면평균값을 활용하는 경우가 많아서 복잡한 하천의 흐름특성을 반영하기에 미흡한 상황이다. 본 연구에서는 국내 하천해석에서 주로 활용되고 있는 수치모형을 이용하여 실험수로의 흐름을 재현하고 수리실험을 통하여 관측한 유속 및 수위분포 결과와 비교하였다. 2차원 수치모형으로는 RMA2, CCHE2D, FLUMEN 등의 상용모형과 최근 연구가 활발히 진행되고 있는 Approximate Riemann 기법을 적용하여 개발된 유한체적모형을 적용하였다. 제방 부근에서 형성되는 흐름을 상세하게 모의하기 위하여 국내 하천시설물 설계에서 많이 활용되고 있는 FLOW-3D 모형을 적용하여 3차원 모의결과와 수리실험결과를 비교하였다. 수리실험에서 관측된 사석호안공의 이탈시 흐름현상을 재현하여 호안공 이탈에 영향을 미치는 국부유속 및 전단응력을 산정하여 호안설계에 적합한 설계인자를 분석하였다. 연구결과를 활용하여 사석호안공 설계 기법에 적용되는 수치모형을 통하여 산정되는 설계인자의 정확성을 향상시킴으로써, 정량적이고 합리적인 사석호안공 설계기법개발에 도움이 될 것으로 판단된다.

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Numerical Analysis for Advection Equation Based on the Method of Moments (모멘트법에 의한 이송방정식의 수치해석)

  • Baek, Jung-Cheol;Jo, Won-Cheol;Heo, Jun-Haeng
    • Journal of Korea Water Resources Association
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    • v.32 no.2
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    • pp.99-110
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    • 1999
  • The method of moments, a Lagrangian scheme, considers the zeroth, first, and second moments of the grid cell spatial distributions of the concentration and then advects the concentration by maintaining conservation of the moments. The reasonable inital description of the first and second moments as well as the mean concentration, the zeroth moments, in grid element is important in the method of moments. In this study, the description methods of each initial moment are reviewed, and the method of moments is extended to overcome the restrictions of Courant number. Its performance is compared with those of available Eulerian and Lagrangian schemes. As the results, the method is successfully extended to overcome the stability restriction and is an accurate scheme for the advection simulation of concentration distribution, especially of which the gradient is steep. In addition, the method is very promising scheme in terms of computational efficiency when the mixing is confined in a relatively small region to the entire domain in two-dimensional problem.

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