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OPB, a water extract from Rehmannia glutinosa Libosch and Eleutherococcus senticosus Max, inhibits osteoclast differentiation and function

  • Kim, Jung-Keun;Kim, Se-Won;Kim, Hae-Young;Lee, Byung-Eui;Ko, Seon-Yle
    • International Journal of Oral Biology
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    • v.32 no.1
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    • pp.23-34
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    • 2007
  • We performed the present study to investigate whether Rehmannia glutinosa Libosch (RG) extracts (RGX) and Eleutherococcus senticosus Max (ES) extracts (ESX) play any roles in bone metabolism. We examined cellular activities of bone cells by measurement of osteoblastic cell viability, osteoprotegerin (OPG) secretion from osteoblasts, osteoclastogenesis, and osteoclastic activity. There is no cytotoxicity from osteoblasts after treatment with RGX and ESX. The secretion of OPG from the osteoblasts showed marked increases after treatment with RGX and ESX. In addition, RGX and ESX treatment decreased the number of tartrate-resistant acid phosphatase-positive multinucleated cells and the resorption areas. RGX and ESX, when mixed at optimal ratios, induced synergic effects, in vitro. OPB, which showed synergic effects, is the extract of natural ingredients RG and ES mixed at a raw material weight ratio of 4 : 1. It can be suspected that extracts of RG and ES mixtures contains active ingredients involved in bone tissue metabolism and may be effective in improving osteoporosis.

Flavonols, Flavones, Flavanoues and Human Health: Epidemiological Evidence

  • Graf Brigitte A.;Milbury Paul E.;Blumberg Jeffrey B.
    • Proceedings of the Korean Society of Food Science and Nutrition Conference
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    • 2004.11a
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    • pp.24-36
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    • 2004
  • Polyphenolic flavonoids are among a wide variety of phytochemicals present in the human diet. Basic research, animal model, and human studies suggest flavonoid intake may reduce the risk of several age-related chronic diseases. The vast number of flavonoids and mixtures of their subclasses, including flavonols, flavones and flavanones, and the variety of agricultural practices that affect their concentration in foods have presented a challenge to the development of adequate food composition databases for these com-pounds. Nonetheless, dietary assessments have been applied to cohort and case-control epidemiological studies and several reveal an inverse association with risk of some forms of cancer, cardiovascular disease, and other chronic conditions. Those observational studies that have examined these relationships with regard to flavonols, flavones, and flavanones are reviewed. The requirement for caution in interpreting these studies is discussed with regard to the limited information available on the bioavailability and biotransformation of these flavonoids. As the totality of the available evidence on these flavonoids suggests a role in the prevention of cancer and cardiovascular disease, further research is warranted, particularly in controlled clinical trials.

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Effect of Various Mixtures of Used Perlite and Rockwool Slabs on Growth of Euphorbia pulcherrima 'Freedom Red' in a Mat Subirrigation System (폐펄라이트와 폐암면을 재활용한 혼합배지가 포인세티아 'Freedom Red'의 생육에 미치는 영향)

  • 김영회;황승재;정병룡
    • Journal of Bio-Environment Control
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    • v.13 no.2
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    • pp.107-111
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    • 2004
  • This study was conducted to examine the possibility of producing poinsettia with various growing media containing used perlite and rockwool slabs as medium components. Pot plants of Euphorbia pulcherrima 'Freedom Red' were grown in 10 media containing used perlite and particles of rockwool slabs at various ratios including 1:1 and 1:3 (v/v). Medium containing used perlite and peatmoss at 1:3 (v/v) was employed as the control treatment. Height, root length, length of the longest branch, number of roots, leaf area, and width and length of the largest bract of plants grown in media containing used perlite were significantly greater than those in the control. Stem diameter and bract count were not affected by the medium composition. From the results, used perlite and rockwool slabs were proved to be a practically useful materials as medium components for pot production of poinsettia plants.

Stabilization Characteristics of DME-Air Diffusion Flames Depending on the Configuration of the Fuel-Air Tubes in Half Closed Combustion Spaces (반밀폐 연소공간 내 동축관 형상에 따른 DME-공기 확산화염의 안정화 특성)

  • Kim, Go-Tae;Kim, Nam-Il
    • Transactions of the Korean Society of Mechanical Engineers B
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    • v.33 no.11
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    • pp.916-923
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    • 2009
  • The effects of configuration of fuel and air tubes on the flame stabilization were experimentally investigated in half-closed combustors. Flame behaviors and stabilities of methane, propane, and DME flames were compared by changing tube diameters and the locations of the fuel and air tubes. It was found that flammability limits are significantly affected by the outlet boundary condition, which disturbs compositions of burned and unburned mixtures near the flame base. And it was found that there exist critical inner tube heights, over which flame stability is determined only by the fuel flow rate. Conclusively, flame stabilization is governed by the flame propagation velocity in an ordinary mixing flow and the non-uniform mixture concentration in the combustion space which is affected by flow recirculation and the combustor configuration. The compositions of $NO_x$ and CO were compared to know basic characteristics of methane, propane, and DME flames.

Prediction of workability of concrete using design of experiments for mixtures

  • Yeh, I-Cheng
    • Computers and Concrete
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    • v.5 no.1
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    • pp.1-20
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    • 2008
  • In this study, the effects and the interactions of water content, SP-binder ratio, and water-binder ratio on the workability performance of concrete were investigated. The experiments were designed based on flatted simplex-centroid experiment design modified from standard simplex-centroid one. The data gotten from the design was used to build the concrete slump model using neural networks. Research reported in this paper shows that a small number of slump experiments can be performed and meaningful data obtained with the experiment design. Such data would be suitable for building slump model using neural networks. The trained network can be satisfactorily used for exploring the effects of the components and their interactions on the workability of concrete. It has found that a high water content and a high SP/b ratio is essential for high workability, but achieving this by increasing these parameters will not in itself guarantee high workability. The w/b played a very important role in producing workability and had rather profound effects; however, the medium value about 0.4 is the best w/b to reach high slump without too much effort on trying to find the appropriate water content and SP/b.

Growth Characteristics of Azotobacter vinelandii UWD Using Glucose and Organic Acids as Substrates (포도당 및 유기산을 이용한 Azotobacter vinelandii UWD 의 생장 특성)

  • 김태용;박창호
    • KSBB Journal
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    • v.15 no.6
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    • pp.670-672
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    • 2000
  • Azotobacter vinelandii UWD synthesizes poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV), one of the biodegradable polymers, when odd and even number carbon sources are simultaneously added to a medium. In this study, we investigated the specific growth rate of Azotobacter vinelandii UWD on propionic acid and valeric acid. The specific growth rates were $0.183 hr^{-1} and 0.137 hr^{-1}$ at 1.0∼1.5 g/L of propionic acid and 1.0 g/L of valeric acid, respectively. When a mixture of 0.75 g/L of propionic acid and 0.5 g/L of valeric acid was added to the medium, the specific growth rate was 0.196 hr(sup)-1, which was equal to or higher than those of the individual organic acids. Among 10∼50 g/L of glucose cell growth was best at 20 g/L.

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γ-Ray Shielding Behaviors of Some Nuclear Engineering Materials

  • Mann, Kulwinder Singh
    • Nuclear Engineering and Technology
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    • v.49 no.4
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    • pp.792-800
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    • 2017
  • The essential requirement of a material to be used for engineering purposes at nuclear establishments is its ability to attenuate the most penetrating ionizing radiations, gamma $({\gamma})-rays$. Mostly, high-Z materials such as heavy concrete, lead, mercury, and their mixtures or alloys have been used in the construction of nuclear establishments and thus termed as nuclear engineering materials (NEM). The NEM are classified into two categories, namely opaque and transparent, depending on their behavior towards the visible spectrum of EM waves. The majority of NEM are opaque. By contrast, various types of glass, which are transparent to visible light, are necessary at certain places in the nuclear establishments. In the present study, ${\gamma}-ray$ shielding behaviors (GSB) of six glass samples (transparent NEM) were evaluated and compared with some opaque NEM in a wide range of energy (15 keV-15 MeV) and optical thickness (OT). The study was performed by computing various ${\gamma}-ray$ shielding parameters (GSP) such as the mass attenuation coefficient, equivalent atomic number, and buildup factor. A self-designed and validated computer-program, the buildup factor-tool, was used for various computations. It has been established that some glass samples show good GSB, thus can safely be used in the construction of nuclear establishments in conjunction with the opaque NEM as well.

Effect of coarse aggregates and sand contents on workability and static stability of self-compacting concrete

  • Mohamed, Sahraoui;Taye, Bouziani
    • Advances in concrete construction
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    • v.7 no.2
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    • pp.97-105
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    • 2019
  • In this paper, the workability and static stability were evaluated using a proposed test method. Workability and static stability represent a key property of self-compacting concrete (SCC) in fresh state. A number of standardized test methods were developed to assess these properties. However, no accelerated test method reliably predicts both workability and static stability of SCC. In the present work, a modified K-slump test method was developed to evaluate workability and static stability of SCC. In order to take implicit mixture variations of SCC constituents that can affect fresh SCC properties, a central composite design was adopted to highlight the effect of gravel to sand ratio (G/S), gravel 3/8 to gravel 8/15 ratio (G1/G2), water to cement ratio (W/C), marble powder to cement ratio (MP/C) and superplasticizer content (SP) on workability measured with slump and flow time (T50) tests and static stability measured with sieve stability test (Pi), segregation test index (SSI), Penetration test (Pd) and the proposed K-slump test (Km). The obtained results show that G/S ratio close to 1 and G1/G2 ratio close to 60% can be considered as optimal values to achieve a good workability while ensuring a sufficient static stability of SCC. Acceptable relationships were obtained between Slump flow, Pi, Pd and Km. Results show that the proposed K-slump test allow to assess both workability and static stability of fresh SCC mixtures.

Characteristics of Edge Flames for Premixed Flames in a Counterflow Slot Burner (대향류 슬롯 버너에서 예혼합 선단화염의 전파특성)

  • Clayton, David B.;Cha, Min-Suk;Ronney, Paul D.
    • 한국연소학회:학술대회논문집
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    • 2006.04a
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    • pp.7-12
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    • 2006
  • The propagation rates ($U_{edge}$) of various premixed edge-flames were measured as a function of global strain rate (${ \sigma}$), mixture strength, and Lewis number (Le). Using a counterflow slot-jet burner with electrical heaters at each end, both advancing (positive $U_{edge}$) and retreating (negative $U_{edge}$) edges can be studied as they propagate along the long dimension of the burner. Preliminary results are presented for single and twin premixed hydrocarbon edge-flames in terms of the effects on $U_{edge}$. A low-${\sigma}$ extinction limit has been discovered for all mixtures tested but further analysis is necessary for full characterization since sufficiently $high-{\sigma}$ leads to an apparent stability limit. Propagation rates clearly show a strong dependence on Le. Future work will focus on completing the premixed hydrocarbon edge-flame analysis and include investigations into non-premixed edge-flames and edge-flames composed of fuels such as hydrogen ($H_2$) with significantly lower Le.

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Improvement and Evaluation of the Korean Large Vocabulary Continuous Speech Recognition Platform (ECHOS) (한국어 음성인식 플랫폼(ECHOS)의 개선 및 평가)

  • Kwon, Suk-Bong;Yun, Sung-Rack;Jang, Gyu-Cheol;Kim, Yong-Rae;Kim, Bong-Wan;Kim, Hoi-Rin;Yoo, Chang-Dong;Lee, Yong-Ju;Kwon, Oh-Wook
    • MALSORI
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    • no.59
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    • pp.53-68
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    • 2006
  • We report the evaluation results of the Korean speech recognition platform called ECHOS. The platform has an object-oriented and reusable architecture so that researchers can easily evaluate their own algorithms. The platform has all intrinsic modules to build a large vocabulary speech recognizer: Noise reduction, end-point detection, feature extraction, hidden Markov model (HMM)-based acoustic modeling, cross-word modeling, n-gram language modeling, n-best search, word graph generation, and Korean-specific language processing. The platform supports both lexical search trees and finite-state networks. It performs word-dependent n-best search with bigram in the forward search stage, and rescores the lattice with trigram in the backward stage. In an 8000-word continuous speech recognition task, the platform with a lexical tree increases 40% of word errors but decreases 50% of recognition time compared to the HTK platform with flat lexicon. ECHOS reduces 40% of recognition errors through incorporation of cross-word modeling. With the number of Gaussian mixtures increasing to 16, it yields word accuracy comparable to the previous lexical tree-based platform, Julius.

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