OPB, a water extract from Rehmannia glutinosa Libosch and Eleutherococcus senticosus Max, inhibits osteoclast differentiation and function |
Kim, Jung-Keun
(Department of Pharmacology and Mechanism, Research Institute, Oscotec Inc.)
Kim, Se-Won (Department of Pharmacology and Mechanism, Research Institute, Oscotec Inc.) Kim, Hae-Young (Department of Pharmacokinetics, Research Institute, Oscotec Inc.) Lee, Byung-Eui (Department of Herbal medicine, Research Institute, Oscotec Inc.) Ko, Seon-Yle (Department of Pharmacology and Mechanism, Research Institute, Oscotec Inc.) |
1 | Awang, D.V.C.: Siberian ginseng toxicity may be a case of mistaken identity. Can. Med. Assoc. J. 155:1237, 1996 |
2 | Baron, R., Neff, L., Van, P.T., Nefussi, J.R. and Vignery, A.: Kinetic and cytochemical identification of osteoclast precursors and their differentiation into multinucleated osteoclasts. Am. J. Pathol. 122:363-378, 1986 |
3 | Heaney, R.P.: Calcium. in Principles of Bone biology. edited by Bilezikian, J.P., Raisz, L.G. and Rodan, G.A. pp 1007-1017, Academic Press, 1996 |
4 | Kim, S.S., Son, Y.O., Chun, J.C., Kim, S.E., Chung, G.H., Hwang, K.J. and Lee, J.C.: Antioxidant property of an active component purified from the leaves of paraquat-tolerant Rehmannia glutinosa. Redox. Rep. 10:311-318, 2005 DOI ScienceOn |
5 | Martin, J.H. and Matthews, J.L.: Mitochondrial granules in chondrocytes, osteoblasts and osteocytes. An ultrastructural and microincineration study. Clin. Orthop. 68:273-278, 1970 |
6 | Minkin, C.: Bone acid phosphatase: Tartrate-resistant acid phosphatase as a marker of osteoclast function. Calcif. Tissue Int. 34:285-290, 1982 DOI |
7 | Mundy, G.R. and Roodman, G.D.: Osteoclast ontogeny and function, in Bone and Mineral Research, vol. 5, edited by Peck, W.A., pp 209-279, Elsevier, Amsterdam, 1987 |
8 | Pixley, F.J. and Stanley, E.R.: CSF-1 regulation of the wandering macrophage: Complexity in action. Trends Cell Biol. 14:628-638, 2004 DOI ScienceOn |
9 | Reginster, J.Y.: Treatment of bone in elderly subjects: calcium, vitamin D, fluor, bisphosphonates, calcitonin. Horm. Res. 43:83-88, 1995 DOI |
10 |
Sasaki, T., Takahashi, N., Higashi, S. and Suda, T. Multinucleated cells formed on calcified dentin from mouse bone marrow cells treated with 1a,25-dihydroxyvitamin |
11 | Suda, T., Takahashi, N., Udagawa, N., Jimi, E., Gillespie, M.T. and Martin, T.J.: Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families. Endocr. Rev. 20:345-57, 1999 DOI ScienceOn |
12 | Wasnich, R.: What is an osteoporotic fracture? in Osteoporosis: Diagnotic and Therapeutic Principles, edited by Rosen, C.J., pp 79-88, Humana Press, Totowa, NJ, 1996 |
13 | Recker, R.P.: Current therapy for osteoporosis. J. Clin. Endocrinol. Metab. 76:14-16, 1993 DOI |
14 | Chang, H.M. and But, P.P.H.: Pharmacology and applications of Chinese amteria medica. vol 1, edited by Yao, S.C., Wang, L.L. and Shem, C.S. p 461, 1986 |
15 | Rodan, G.A.: Emerging therapies in osteoporosis. Ann. Rep. Med. Chem. 29:275-285, 1994 DOI |
16 | Wang, J.Z., Tsumura, H., Shimura, K. and Ito, H.: Antitumor activity of polysaccharide form a Chinese medicinal herb, Acnthopanax giraldii Harms. Cancer Lett. 65:79-84, 1992 DOI ScienceOn |
17 | Fleisch, H.: Bisphosphonates: Mechanism of action and clinical use. in Principles of Bone biology. edited by Bilezikian, J.P., Raisz, L.G. and Rodan, G.A. pp 1037-1052, Academic Press, 1996 |
18 | Scheven, B.A.A., Visser, J.W.M. and Nijweide, P.J.: In vitro osteoclast generation from different bone marrow fractions, including a highly enriched hematopoietic stem cell population. Nature 321:79-81, 1986 DOI ScienceOn |
19 | Canalis, E.: Effect of growth factors on bone cell replication and differentiation. Clin. Orthop. Rel. Res. 193:246-263, 1985 |
20 | Raju, B.L., Lin, S.J., Hou, W.C., Lai, Z.Y., Liu P.C. and Hsu, F.L.: Antioxidant iridoid glucosides from Wendlandia formosana, Natural Product Res. 8:357-364, 2004 |
21 | Ben-Hur, E. and Fulder, S.: Effect of Panax ginseng saponins and Eleutherococcus senticosus on survival of cultured mammalian cells after ionizing radiation. Am. J. Chin. Med. 9:48-56, 1981 DOI ScienceOn |
22 | Chao, J.C., Chiang, S.W., Wang, C.C., Tsai, Y.H. and Wu, M.S.: Hot water-extracted Lycium barbarum and Rehmannia glutinosa inhibit proliferation and induce apoptosis of hepatocellular carcinoma cells. World J. Gastroenterol. 12:4478-4484, 2006 DOI |
23 | Jin, U.H., Kim, D.I., Lee, T.K., Lee, D.N., Kim, J.K., Lee, I.S. and Kim, C.H.: Herbal formulation, Yukmi-jihang-tang- Jahage, regulates bone resorption by inhibition of phosphorylation mediated by tyrosine kinase Src and cyclooxygenase expression. J. Ethnopharmacol. 106:333- 343, 2006 DOI ScienceOn |
24 | Nelson, H.D., Humphrey, L.L., Nygren, P., Teutsch, S.M. and Allan, J.D.: Postmenopausal hormone replacement therapy: scientific review. JAMA 288:872-881, 2002 DOI ScienceOn |
25 | Shan, B.E., Yoshita, Y., Sugiura, T. and Yamashita, U.: Suppressive effect of Chinese medicinal herb, Acanthopanax gracilistylus, extract on human lympocytes in vitro. Clin. Exp. Immunol.118:41-48, 1999 DOI |
26 | Takasugi, N., Moriguchi, T., Fuwa, T., Sanada, S., Ida, Y., Shofi, J. and Saito, H.: Effect of Eleutherococcus senticosus and its rectal temperature, body and grip tones, mortor coordination, and exploratory and spontaneous movements in acute stressed mice. Shoyakugaku Zasshi. 39:232-237, 1985 |
27 | Tang, W. and Eisenbrand, G.: Chinese Drugs of Plant Origin: in Chemistry, Pharmacolgy, and Use in Traditional Modern Medicine, pp 849-854, Springer-Verlag, Berlin 1992 |
28 | Kormosh, N., Laktionov, K. and Antoshechkina, M.: Effect of a combination of extract from several plants on cellmediated and humoral immunity of patients with advanced ovarian cancer. Phytother. Res. 20:424-425, 2006 DOI ScienceOn |
29 | 生藥學硏究會 : 現代生藥學, PP263-265, 학창사, 서울 1998 |
30 | Fujikawa, T., Yamaguchi, A., Morita, I., Takeda, H. and Nishibe, S.: Protective effects of Acanthopanax senticosus Harms from Hokkaido and its components on gastric ulcer inrestrained cold water stressed rats. Biol. Pharm. Bull. 19:1227-1230, 1996 DOI |
31 | Kostenuik, P.J. and Shalhoub, V: Osteoprotegerin: A physiological and pharmacological inhibitor of bone resorption. Curr. Pharm. Des. 7:613-635, 2001 DOI ScienceOn |
32 | Owen, M.E.: Lineage of osteogenic cells and their relationship to the stromal system. in Bone and Mineral Research, edited by Peck, W.A., pp 1-25, Elsevier Science Publisher, Amsterdam, 1985 |
33 | Raisz, L.G.: Hormonal regulation of bone growth and remodeling. in Cell and Molecular Biology of Vertebrate Hard Tissue CIBA Foundation Symposium 136, pp 226- 238, Wiley, NY, 1988 |
34 | Boyle, W.J., Simonet, W.S. and Lacey. D.L.: Osteoclast differentiation and activation. Nature 423:337-342, 2003 DOI ScienceOn |
35 | Takahashi, N., Yamana, H., Yoshiki, S., Roodman, G.D., Mundy, G.R., Jones, S.J., Boyde, A. and Suda, T.: Osteoclast-like cell formation and its regulation by osteotropic hormones in mouse bone marrow cultures. Endocrinol. 122:1373-1382, 1988a DOI ScienceOn |
36 | Nijweide, P.J., Burger, E.H. and Feyen, J.H.M.: Cells of bone: Proliferation, differentiation, and hormonal regulation. Physiol. Rev. 66:855-886, 1986 DOI |
37 | Shen, M.L., Zhai, S.K., Chen, H.L., Luo, Y.D., Tu, G.R. and Ou, D.W.: Immunopharmacological effects of polysaccharides from Acanthopanax senticosus on experimental animals. Int. J. Immunopharmacol. 13:549- 554, 1991 DOI ScienceOn |
38 | Sridhar, C., Subbaraju, G.V., Venkateswarlu, Y. and Venugopal, R.T.: New acylated iridoid glucosides from Products 67:Vitex altissima. J. Natural 2012-2016, 2004 DOI ScienceOn |
39 | Yu, H.H., Seo, S.J., Kim, Y.H., Lee, H.Y., Park, R.K., So, H.S., Jang, S.L. and You, Y.O.: Protective effect of Rehmannia glutinosa on the cisplatin-induced damage of HEI-OC1 auditory cells through scavenging free radicals. J. Ethnopharmacol. 107:383-388, 2006 DOI ScienceOn |
40 | Zhao, Y., Wen, X.S., Cui, J. and Wu, W.H.: Extraction and salting-out purification of alpha-galactosidase and betaglucosidase from fresh roots of Rehmannia glutinosa. Zhong. Yao. Cai. 29:137-139, 2006 |
41 | Canalis, E., McCarthy, T. and Centrella, M.: Growth factors and the regulation of bone remodeling. J. Clin. Invest. 81:277-281, 1988 DOI ScienceOn |
42 | Stock, J.L.: Drug therapy. in Osteoporosis: Diagnotic and Therapeutic Principles, edited by Rosen, C.J., pp 173-187, Humana Press, Totowa, NJ, 1996 |
43 |
Takahashi, N., Akastu, T., Sasaki, T., Nicholson, G.C., Moseley, J.M., Martin, T.J. and Suda, T.: Induction of calcitonin receptors by 1a,25-dihydroxyvitamin |
44 | Wang, J.Z., Mao, X.J., Ito, H. and Shimura, K.: Immunomodulatory activity of polysaccharide from Acanthopanax obovatus roots. Planta. Med. 57:335-336, 1991 DOI ScienceOn |
![]() |