• Asian Pacific Journal of Cancer Prevention
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• v.16 no.15
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• pp.6429-6438
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• 2015

Glutathione S-transferases (GSTs) play an important role in detoxification of carcinogenic electrophiles. The null genotypes in GSTM1 and GSTT1 have been implicated in carcinogenesis. Present study was planned to evaluate the influence of genetic polymorphisms of GSTM1 and GSTT1 gene loci in cervical carcinogenesis. The study was conducted in Lok Nayak hospital, New Delhi. DNA from clinical scrapes of 482 women with minor gynaecologic complaints attending Gynaecology OPD and tumor biopsies of 135 cervical cancer cases attending the cancer clinic was extracted. HPV DNA was detected by standard polymerase chain reaction (PCR) using L1 consensus primer pair. Polymorphisms of GSTM1 and GSTT1 were analysed by multiplex PCR procedures. Differences in proportions were tested using Pearson's Chi-square test with Odds ratio (OR) and 95% confidence interval (CI). The risk of cervical cancer was almost three times in women with GSTM1 homozygous null genotype (OR-2.62, 95%CI, 1.77-3.88; p<0.0001). No association of GSTM1 or GSTT1 homozygous null genotypes was observed in women with normal, precancerous and cervical cancerous lesions among ${\leq}35$ or >35 years of age groups. Smokers with null GSTT1 genotype had a higher risk of cervical cancer as compared to non-smokers (OR-3.01, 95% CI, 1.10-8.23; p=0.03). The results further showed that a significant increased risk of cervical cancer was observed in HPV positive smoker women with GSTT1 (OR-4.36, 95% CI, 1.27-15.03; p=0.02) and GSTM1T1 (OR-3.87, 95% CI, 1.05-14.23; p=0.04) homozygous null genotypes as compared to HPV positive non smokers. The results demonstrate that the GST null genotypes were alone not associated with the development of cervical cancer, but interacted with smoking and HPV to exert effects in our Delhi population.

• Communications for Statistical Applications and Methods
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• v.4 no.2
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• pp.427-434
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• 1997

The purpose of this paper is to discuss distribution-free tests of hypothesis that the random samples are identically distributed against the epidemic alternative. But most tests that have been considered are depended only on specific null distribution. Two nonparametric tests are considered and compared with a likelihood ratio test by the empirical powers.

• Journal of the Korean Institute of Telematics and Electronics
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• v.9 no.1
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• pp.1-6
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• 1972

The ftatistica1 correlation method for estimating impulse response using maximum period null sequence as test signal was studied and in describing some preliminary experimental work, the author discussed the problms of mechanization supported by analytical considerations. Experiments were performed on the 2nd order oscillatory system and the results were in good coincidence with the theoretical values.

• Communications for Statistical Applications and Methods
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• v.5 no.1
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• pp.35-42
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• 1998

Once a contingency table is constructed, the first interest will be the hypotheses of either homogeneity or independence depending on the sampling scheme. The most widely used test statistic in practice is the classical Pearson's $\chi^2$ statistic. When the null hypothesis is rejected, another natural interest becomes which cell contributed to the rejection of the null hypothesis more than others. For this purpose, so called cell $\chi^2$ components are investigated. In this paper, the influence function of a cell to the $\chi^2$ statistic is derived, which can be used for the same purpose. This function measures the effect of each cell to the $\chi$$^2$ statistic. A numerical example is given to demonstrate the role of the new function.

• International Journal of Aeronautical and Space Sciences
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• v.2 no.1
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• pp.44-54
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• 2001

This paper describes the antenna alignment method of the tracking antenna system for LEO satellite. The purpose of the antenna alignment is to reduce the angular error due to the structural alignment and the monopulse null point alignment error. The angular error of 3 axis tracking system is the key performance parameter that should be minimized to accurately track satellite movement. The angular error is analyzed via a simulation and boresight measurement. The simulation is done with formulas to be derived from vector concept for 3-axis movement. The formulas of the structural alignment are verified by comparing the formula result with the field measurement. Also, the angular error due to monopulse null shift is obtained via boresight measurement. Based on the analyzed and measured results, the antenna alignment was performed and was verified via tracking test of operating LEO satellite.

• Communications for Statistical Applications and Methods
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• v.19 no.2
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• pp.267-276
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• 2012

Bagai et al. (1989) proposed a distribution-free test for stochastic ordering in the competing risk model, and recently Murakami (2009) utilized a standard saddlepoint approximation to provide tail probabilities for the Bagai statistic under finite sample sizes. In the present paper, we consider the Gaussian-polynomial approximation proposed in Ha and Provost (2007) and compare it to the saddlepoint approximation in terms of approximating the percentiles of the Bagai statistic. We make numerical comparisons of these approximations for moderate sample sizes as was done in Murakami (2009). From the numerical results, it was observed that the Gaussianpolynomial approximation provides comparable or greater accuracy in the tail probabilities than the saddlepoint approximation. Unlike saddlepoint approximation, the Gaussian-polynomial approximation provides a simple explicit representation of the approximated density function. We also discuss the details of computations.

• Transactions of The Korea Fluid Power Systems Society
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• v.6 no.2
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• pp.22-30
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• 2009

An in-process method of diagnosing the spool wear of hydraulic servovalves was explored. The diagnostic method discussed in this paper is for force-control hydraulic servo systems. The key principle used is that pressure sensitivity of a servovalve drops as the valve spool wears out so that it is possible to determine the spool condition by monitoring pressure sensitivity. A diagnostic algorithm was developed and evaluated through numerical simulation and experiments. Two major steps of diagnosis are the evaluation of null bias of the servovalve and the approximation of pressure sensitivity, both of which could be successfully done during normal operation of a servo system. The difference between a new servovalve and a worn valve could be clearly detected in-process, and the diagnostic test was found to be repeatable.

• Proceedings of the Computational Structural Engineering Institute Conference
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• 2011.04a
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• pp.419-423
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• 2011

Unlike other non-destructive inspection method, AE Structural defects that are likely to grow in the operation status can be detected, and the advantage of being due to the continuous monitoring of large structures has been widely used to evaluate the stability. AE sensor used to detect sound wave that occurs between 20kHz to 20MHz. and Sound wave result may vary depending on sensor's sensitivity. In this paper, Tensile test conducted on STS 304 and SS400, and tries to detect the crack signal. In tensile test, specimens were conducted using different sensor sensitivity to the same tensile test condition. The crack signal parameters divided into 4 types of communities by conducting cluster analysis. It was demonstrated that crack signal of two sensor is not different by statistical analysis of null hypotheses. Based on the results, waveform of this tension test is crack signal.

• International Journal of Fluid Machinery and Systems
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• v.10 no.2
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• pp.176-188
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• 2017

The nozzle-flapper valves are widely applied as a pilot stage in aerospace and military system. A subject of the analysis presented in this work is to find out a reasonable range of null clearance between the nozzle and flapper. This paper has presented a numerical flow coefficient simulation. In every design point, a parameterized model is created for flow coefficient simulation and cavitation under different conditions with varying gap width and inlet pressure. Moreover, a new test device has been designed to measure the flow coefficient and for visualized cavitation. The numerical simulation and test results both indicate that cavitation intensity gets fierce initially and shrinks finally as the gap width varies from small to large. From the curve, the flow coefficient mostly has experienced three stages: linear throttle section, transition section and saturation section. The appropriate deflection of flapper is recommended to make the gap width drop into the linear throttle section. The flapper-nozzle null clearance is optionally recommended near the range of $D_N/16$. Finally through simulation it is also concluded that the inlet pressure plays a little role in the influence on the flow coefficient.

• The Korean Journal of Applied Statistics
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• v.26 no.6
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• pp.889-902
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• 2013

Several goodness-of-fit test statistics have been proposed for a multinomial logit regression model; however, the properties of the proposed tests were not adequately studied. This paper evaluates three different goodness-of-fit tests using grouping strategies, proposed by Fagerland et al. (2008), Bull (1994), and Pigeon and Heyse (1999). In addition, Pearson (1900)'s method is also examined as a reference. Simulation studies were conducted to evaluate the four methods in terms of null distribution and power. A real data example is presented to illustrate the methods.