• Restorative Dentistry and Endodontics
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• v.15 no.2
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• pp.17-33
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• 1990

The purpose of this study was to evaluate the fracture toughness of dental composite resins and to investigate the filler factor affecting the fracture behaviour on which the degree of fracture toughness depends. Six kinds of commercially available composite resin;, including two of each macrofilled, microfilled, and hybrid type were used for this study, The plane strain fracture toughness ($K_{10}$) was determined by three-point bending test using the single edge notch specimen according to the ASTM-E399. The specimens were fabricated with visible light curing or self curing of each composite resin previously inserted into a metal mold, and three-point bending test was conducted with cross-head speed of 0.1mm/min following a day's storage of the specimens in $37^{\circ}C$ distilled water. The filler volume fractions were determined by the standard ashing test according to the ISO-4049. Acoustic Emission(AE), a nondestructive testing method detecting the elastic wave released from the localized sources In material under a certain stress, was detected during three-point bending test and its analyzed data was compared with, canning electron fractographs of each specimen. The results were as follows : 1. The filler content of composite resin material was found to be highest in the hybrid type followed by the macrofilled type, and the microfilled type. 2. It was found that the value of plane strain fracture toughness of composite resin material was in the range from 0.69 MPa$\sqrt{m}$ to 1 46 MPa$\sqrt{m}$ and highest In the macrofilled type followed by the hybrid type, and the microfilled type. 3. The consequence of Acoustic Emission analysis revealed that the plane strain fracture toughness increased according as the count of Acoustic Emission events increased. 4. The higher the plane strain fracture toughness became, the higher degree of surface roughness and irregularity the fractographs demonstrated.

• The Journal of Korean Academy of Prosthodontics
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• v.34 no.2
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• pp.363-372
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• 1996

A common site of fracture in maxillary complete denture is on the anteroposterior midline that coincides with the notch for relief of the labial frenum. Various approaches to reduce the incidence of this type of fracture have been suggested. The most widely used technique is the reinforcement of acrylic resin denture base with several solid metal forms. But few comparative studies on the efficacy of metal reinforcements have been reported. This study was conducted to compare reinforcing effects of commonly available metal reinforcements, which include wire, metal mesh embedded in the denture base and metal plate affixed to the impression surface of denture base by silicoating technique. This was load on the posterior. The strain gauges were oriented perpendicular to the anteroposterior midline of maxillary polished denture surface at one labial and the four palatal sites Non-renforced denture was used as control. The results were as follows : 1. In the non-reinforced denture group, only tensile strains on the palatal polished surface were observed. The tensile strains decreased in the order of incisive papilla, posterior denture border area, mid palatal area and rugae area. Compressive strain was observed on the labial polished surface. 2. As compared with the non-reinforced denture group, the metal plate or the metal mesh reinforced denture groups showed reduced palatal tensile strains,and the metal mesh reinforcement had a better reinforcing effect than the metal plate. But both reinforced denture groups showed no difference in the amount of compressive strain on the labial polished surface when compared to the non-reinforced denture group. 3. The metal wire positioned just above the labial notch decreased the compressive strain on the labial polished surface. But the presence of metal wires in the palatal polished surface caused increase in tensile strains in the area.

• Journal of the Korean Institute of Gas
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• v.17 no.1
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• pp.19-25
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• 2013

The joining methods of steel structures of gas facilities, bridges, ships etc. by welding are composed mostly of T-type or cruciform fillet welding and full penetration or partial penetration according to the uses and the shape of the structures. In this study, it was examined the characteristics of fatigue crack according to penetration depth in relation to material thickness in the cruciform fillet welded joints. From the results, it was investigated the safe design stresses within the range of infinite life. When the LOP length is long the range of infinite life is small with root failure and when the LOP length is short the range of infinite life is large with teo failure. For the specimen of material thickness, 20mm welded by 3 pass compared with 10mm, 15mm welded by 2 pass, the fatigue strength and the range of infinite life was more improved by increasing of notch toughness from formation of micro-ferrite acicular structure.

• Proceedings of the KWS Conference
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• 2002.10a
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• pp.583-588
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• 2002

The purpose of the study is to evaluate fracture toughness on the Laser and the electron beam welded joints of high tensile steels (HT500, HT550, HT650) by using 3-point bend CTOD and Charpy impact test. WM (weld metal) CTOD tests have been carried out using two kinds of CTOD specimen, the Laser beam welding (108mm length, and 24mm width, and 12mm thickness) and the electron beam welding (l71mm length, and 38mm width, and 19mm thickness). WM Charpy impact specimen is a standard V-notch type, and the temperature of the experiment is changed from -45 to 20 degree of centigrade. FE-analysis is also performed in order to investigate the effect of stress-strain fields on fracture characteristics. Results of the standard V-notch Charpy test are influenced by strength mis-match effect and the absorbed energy vE depends on crack path, and The transition temperature of Laser beam welded joints is more higher than that of electron beam welded joints. Results of the 3-point bend test give low critical CTOD and the crack path is in the weld metal of al specimens. These results indicate fracture toughness characteristics of the welded joints and transition temperature of HT500 are similar both a Laser beam welded joint and an electron beam welded joint. But the fracture toughness and the transition temperature of the electron beam welded joints of HT550 and HT650 are higher than those o the Laser beam welded joints.

• International Journal of Concrete Structures and Materials
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• v.9 no.4
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• pp.475-486
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• 2015

Mode II fracture toughness ($K_{IIc}$) of fiber reinforced concrete (FRC) has been widely investigated under various patterns of test specimen geometries. Most of these studies were focused on single type fiber reinforced concrete. There is a lack in such studies for hybrid fiber reinforced concrete. In the current study, an experimental investigation of evaluating mode II fracture toughness ($K_{IIc}$) of hybrid fiber embedded in high strength concrete matrix has been reported. Three different types of fibers; namely steel (S), glass (G), and polypropylene (PP) fibers were mixed together in four hybridization patterns (S/G), (S/PP), (G/PP), (S/G/PP) with constant cumulative volume fraction ($V_f$) of 1.5 %. The concrete matrix properties were kept the same for all hybrid FRC patterns. In an attempt to estimate a fairly accepted value of fracture toughness $K_{IIc}$, four testing geometries and loading types are employed in this investigation. Three different ratios of notch depth to specimen width (a/w) 0.3, 0.4, and 0.5 were implemented in this study. Mode II fracture toughness of concrete $K_{IIc}$ was found to decrease with the increment of a/w ratio for all concretes and test geometries. Mode II fracture toughness $K_{IIc}$ was sensitive to the hybridization patterns of fiber. The (S/PP) hybridization pattern showed higher values than all other patterns, while the (S/G/PP) showed insignificant enhancement on mode II fracture toughness ($K_{IIc}$). The four point shear test set up reflected the lowest values of mode II fracture toughness $K_{IIc}$ of concrete. The non damage defect concept proved that, double edge notch prism test setup is the most reliable test to measure pure mode II of concrete.

• Biomolecules & Therapeutics
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• v.22 no.5
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• pp.371-383
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• 2014

The nematode Caenorhabditis elegans (C. elegans) offers a unique opportunity for biological and basic medical researches due to its genetic tractability and well-defined developmental lineage. It also provides an exceptional model for genetic, molecular, and cellular analysis of human disease-related genes. Recently, C. elegans has been used as an ideal model for the identification and functional analysis of drugs (or small-molecules) in vivo. In this review, we describe conserved oncogenic signaling pathways (Wnt, Notch, and Ras) and their potential roles in the development of cancer stem cells. During C. elegans germline development, these signaling pathways regulate multiple cellular processes such as germline stem cell niche specification, germline stem cell maintenance, and germ cell fate specification. Therefore, the aberrant regulations of these signaling pathways can cause either loss of germline stem cells or overproliferation of a specific cell type, resulting in sterility. This sterility phenotype allows us to identify drugs that can modulate the oncogenic signaling pathways directly or indirectly through a high-throughput screening. Current in vivo or in vitro screening methods are largely focused on the specific core signaling components. However, this phenotype-based screening will identify drugs that possibly target upstream or downstream of core signaling pathways as well as exclude toxic effects. Although phenotype-based drug screening is ideal, the identification of drug targets is a major challenge. We here introduce a new technique, called Drug Affinity Responsive Target Stability (DARTS). This innovative method is able to identify the target of the identified drug. Importantly, signaling pathways and their regulators in C. elegans are highly conserved in most vertebrates, including humans. Therefore, C. elegans will provide a great opportunity to identify therapeutic drugs and their targets, as well as to understand mechanisms underlying the formation of cancer.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.36 no.12
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• pp.1619-1625
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• 2012

An electrical steel strip is commonly used as a core material in all types of electric transformers and motors. It is produced by a cold rolling process. In this paper, a damage-mechanics-based approach that predicts the edge fracture of an electrical steel strip during cold rolling is presented. We adopted the normal tensile stress criterion and the fracture energy method as a damage initiation criterion and a damage evolution scheme, respectively. We employed finite element analysis (FEA) to simulate crack initiation and propagation at the initial notch located at the edges of the strip. The material constants required in FEA were experimentally obtained by tensile tests using a standard and a notched sheet-type specimen. The results reveal that the edge crack was initiated at the entrance of the roll bite and that it rapidly evolved at the exit. The evolution length of the edge crack increased as the length of the initial notch as well as the front tension reel force of the strip increased.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.34 no.3
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• pp.291-298
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• 2010

A conventional EGR cooler, which is used in an EGR system of an automobile diesel engine, has a low heat-exchange efficiency. To maximize the heat transfer between the exhaust gas and coolant, dimples are formed on the surface of heat exchange tubes. When designing the dimpled EGR cooler, the net heat transfer areas in the conventional and dimpled tube-type EGR coolers are compared. Structural integrity evaluations are also performed by combining finite element analysis with a homogenization method. Subsequently, the process of manufacturing the dimpled tube, i.e., the formation of dimples, edge bending, center v-notch bending, compression, and plasma welding, is established and carried out. Thus, the dimpled EGR cooler is developed, and its performance is verified.

• Journal of Microbiology and Biotechnology
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• v.32 no.3
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• pp.365-377
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• 2022

Mammalian target of rapamycin (mTOR) is a serine-threonine kinase member of the cellular phosphatidylinositol 3-kinase (PI3K) pathway, which is involved in multiple biological functions by transcriptional and translational control. mTOR is a downstream mediator in the PI3K/Akt signaling pathway and plays a critical role in cell survival. In cancer, this pathway can be activated by membrane receptors, including the HER (or ErbB) family of growth factor receptors, the insulin-like growth factor receptor, and the estrogen receptor. In the present work, we congregated an electronic network of mTORC1 built on an assembly of data using natural language processing, consisting of 470 edges (activations/interactions and/or inhibitions) and 206 nodes representing genes/proteins, using the Cytoscape 3.6.0 editor and its plugins for analysis. The experimental design included the extraction of gene expression data related to five distinct types of cancers, namely, pancreatic ductal adenocarcinoma, hepatic cirrhosis, cervical cancer, glioblastoma, and anaplastic thyroid cancer from Gene Expression Omnibus (NCBI GEO) followed by pre-processing and normalization of the data using R & Bioconductor. ExprEssence plugin was used for network condensation to identify differentially expressed genes across the gene expression samples. Gene Ontology (GO) analysis was performed to find out the over-represented GO terms in the network. In addition, pathway enrichment and functional module analysis of the protein-protein interaction (PPI) network were also conducted. Our results indicated NOTCH1, NOTCH3, FLCN, SOD1, SOD2, NF1, and TLR4 as upregulated proteins in different cancer types highlighting their role in cancer progression. The MCODE analysis identified gene clusters for each cancer type with MYC, PCNA, PARP1, IDH1, FGF10, PTEN, and CCND1 as hub genes with high connectivity. MYC for cervical cancer, IDH1 for hepatic cirrhosis, MGMT for glioblastoma and CCND1 for anaplastic thyroid cancer were identified as genes with prognostic importance using survival analysis.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.23 no.5
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• pp.103-108
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• 2023

In this paper, a performance enhancement study of an AESA antenna that can be applied to a seeker that serves as the eye of a missile was conducted, and the performance of the antenna was verified through actual measurement. When designing an AESA antenna, the optimization of the active reflection coefficient must be considered during transmission due to the mutual coupling between radiators that inevitably occurs, and the selection of a radiator that can overcome the space limitation of the seeker with a small size/light weight is an important design consideration. Accordingly, optimization in terms of electrical performance and low-profile structure is required through research on array antennas for application to the AESA structure. The radiator designed and measured in this paper was designed as an SFN that can satisfy the low-profile structure while enhancing the performance of a general vivaldi antenna. Through this paper, it was confirmed that SFN has the same broadband characteristics as general vivaldi antennas and has optimized characteristics required for AESA antennas. The structure optimized through simulation confirmed the pattern characteristics and active reflection coefficient characteristics through the fabrication of actual proto-type antennas.