• Journal of Acupuncture Research
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• v.22 no.3
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• pp.137-144
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• 2005

Objective : This study was designed to assess the heart rate variablitv of patients with Parkinson's disease according to Hoehn-Yahr stage. Methods : Subjects were voluntarily recruited by newspapers and internet. All the subjects are confirmed as idiopathic parkinson's disease by a neurologist. The patients were grouped by Hoehn-Yahr(H-Y) stage. Heart rate variability was measured for 5 minutes after 5 minutes' bed rest. Subjects were comprised of 3 groups which were H-Y stage I (n=14), H-Y stage H(n=9), H-Y stage III(n=7). We compared the heart rate variability of each groups by one-way ANOVA test. We also studied the relationship between UPDRS score and Heat rate variability components (SDNN, RMS-SD and TP) by pearson correlation analysis and simple linear regressin analysis Results: Age, duration was matched among groups. SDNN, RMS-SD, TP were significantly decreased as H-Y stage increased(p<0.05). Especially there was significant difference between H-Y stage I and III group(p<0.05). But other components(Heart rate, LF, HF, LF/HF ratio) were not showed significant difference. SDNN, RMS-SD and TP were significantly decreased as UPDRS scores increase(p<0.05). Conclusion : This study suggests that the function of the autonomic nervous system decreases as Parkinson`s disease progresses.

• Journal of Physiology & Pathology in Korean Medicine
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• v.21 no.1
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• pp.126-135
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• 2007

This study was conducted to identify the effects of the oriental medicine Qigong Exercise on the brain power, HRV, pulsation, live blood condition among young boys and girls. The study was performed with two group(control group and experimental group) in a pre-test/post-test design. The subjects were 44 young boys and girls selected by a some middle school in Busan. The oriental medicine Qigong Exercise program consists of 80-minute sessions three times a week over 5 months. All of the subjects were examined on the congnition assessment tool, stress assessment tool, oriental medicine pulsation 3-D MAC, live blood condition analyzer Prior and post surveys were measured before and after the experiment. In the cognition assessment, the amplitude of ERS were increased afer Qigong Exercise. The Success and the Concentration were significantly increased afer Qigong Exercise, the Error was significantly decreased afer Qigong Exercise. The Cognition strength was significantly increased, but the Reponse time was not significantly decreased afer Qigong Exercise. And the Workload was not significantly decreased, the Total Score was not significantly increased afer Qigong Exercise. Among the stress assessment, RRV tachogram's ‘mean RR’ was significantly increased, ‘mean HRV’ was significantly decreased afer Qigong Exercise. SDNN was not significantly increased, Complexity was not significantly increased afer Qigong Exercise. And TP(RRV power's total power) was not significantly increased, VLF and HF was significantly increased, and LF was significantly decreased afer Qigong Exercise. ANS's norm LF was not significantly decreased, but norm HF was significantly increased afer Qigong Exercise. In the RRV's Phase Plot, RMSSD and SDSD were not significantly increased, pnn50 was not significantly decreased afer Qigong Exercise. On the whole, Parasympathetic Activity and Stress Endurance were significantly increased, but Cardiac Activity and Physical Arousal were not significantly increased afer Qigong Exercise. Cardiac Aging was not significantly decreased afer Qigong Exercise. Sympathetic Activity, Autonomic Nervous System Balance and Heart-load were not significantly decreased afer Qigong Exercise. In the pulsation, press power was increased(15%), and w/t(pressurization time / pulsation time) was decreased(20%) afer Oigong Exercise. And the live blood condition was not changed afer Qigong Exercise. As mentioned above; the oriental medicine Qigong Exercise program was identified the effects of the inspiration of the brain power, heart rate and anti-stress.

• The Journal of Internal Korean Medicine
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• v.30 no.3
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• pp.510-524
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• 2009

Objective : This study was designed to find the correlation between Sasang Constitution and heart rate variability(HRV). Method : There were 665 subjects (280 men and 385 women), between 39 and 72 years old. in a rural community. Sasang Constitution was diagnosed by a Sasang constitutional specialist using PSSC (Phonetic System for Sasang Constitution), face and tongue photo and checkup-list. A structured-questionnaire was used to assess the general characteristics. HRV was recorded using SA-2000 (medi-core). HRV was assessed by time domain and by frequency domain analysis. Metabolic syndrome was defined on the basis of clustering of risk factors, when three or more of the following cardiovascular risk factors were included : blood pressure, fasting blood sugar, triglyceride HDL-cholesterol, and abdominal obesity (waist). Because of the skewness of the data, logarithmic transformation was performed on the absolute units of the spectral components of HRV, and the resulting logarithmic values and normalized units were compared between the groups by a logistic regression. The 95% confidence interval (CI) of the odds ratio was used and calculated from the data laid out for a cross sectional study. Results : 1. Odds ratios of Taeeumin and Soeumin in female adults below 60 years old were significantly lower than that of Soyangin in LF norm and LF/HF ratio. Odds ratios of Taeeumin and Soeumin in female adults below 60 years old were significantly higher than that of Soyangin in HF norm. 2. There was no significant correlation between HRV and Sasang Constitution in female adults from 60 years old and over. 3. There was no significant correlation between HRV and Sasang Constitution in male adults. Conclusion : There is a statistically significant correlation between the HRV and Sasang Constitution. There is a tendency of increase in the sympathetic activity in Soyangin. There is a tendency of decrease in the parasympathetic activity in Taeeumin and Soeumin.

• Journal of Biomedical Engineering Research
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• v.24 no.1
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• pp.1-8
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• 2003

The job of long distance driving is likely to be fatiguing and requires long period alertness and attention, which make considerable demands of the driver. Driving fatigue contributes to driver related with accidents and fatalities. In this study, we investigated the relationship between the number of hours of driving and driving fatigue using heart rate variability(HRV) signal. With a more traditional measure of overall variability (standard deviation, mean, spectral values of heart rate). Nonlinear characteristics of HRV signal were analyzed using Approximate Entropy (ApEn) and Poincare plot. Five subjects drive the four passenger vehicle twice. All experiment number was 40. The test route was about 300Km continuous long highway circuit and driving time was about 3 hours. During the driving, measures of electrocardiogram(ECG) were performed at intervals of 30min. HRV signal, derived from the ECG, was analyzed using time, frequency domain parameters and nonlinear characteristic. The significance of differences on the response to driving fatigue was determined by Student's t-test. Differences were considered significant when a p value < 0.05 was observed. In the results, mean heart rate(HRmean) decreased consistently with driving time, standard deviation of RR intervals(SDRR), standard deviation of the successive difference of the RR intervals(SDSD) increased until 90min. Hereafter, they were almost unchanging until the end of the test. Normalized low frequency component $(LF_{norm})$, ratio of low to high frequency component (LF/HF) increased. We used the Approximate Entropy(ApEn), Poincare plot method to describe the nonlinear characteristics of HRV signal. Nonlinear characteristics of HRV signals decreased with driving time. Statistical significant is appeared after 60 min in all parameters.

• Journal of Acupuncture Research
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• v.23 no.1
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• pp.25-38
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• 2006

Objectives : Acupuncture has been widely used in oriental medicine. The aim of this research is to study how does the interaction between reinforcement-reduction by twirling nine and six and subject's cold or heat tendency effect on Heart Rate Variability. Methods : We divided our subjects into 3 groups at random and classified subjects by their cold or heat tendency using questionnaire for cold-heat patternization. Group 1 is acupuncture at shinmun(HT7) reinforcement group, 2 is acupuncture at shinmun(HT7) reduction group, 3 in acupuncture at hapkok(LI4) group. According to their group, we acupunctured. Before and after acupuncture Heart Rate Variability raw data were measured during 5 minutes. LF, HF, LF norm HF norm were calculated. We analyzed these data using 3-way repeated ANOVA, Paired student T-Test. Results : 3-way repeated ANOVA showed significant interaction among LF, each group and subject's cold heat tendency(p<0.05). Paired student T-Test showed significant differences between before and after acupuncture at shinmun(HT7) reinforcement method in cold tendency men and acupuncture at shinmun(HT7) reduction method in heat tendency men(p<0.05). Conclusion : These results suggest that acupuncture at Shinmun(HT7) has an effect on declining sympathetic nerve function and has an effect on stabilizing mind through Interaction between reinforcement-reduction by twirling nine and six and subject's cold or heat tendency. We propose that more prudent care is needed about subject's cold or heat tendency and acupuncture technique of reinforcement-reduction to achieve the most suitable treatment effect.

• Journal of Oriental Neuropsychiatry
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• v.21 no.4
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• pp.163-173
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• 2010

Objectives : The objective of this study was to assess the effects of acupuncture applied at 114 and Liv3 points on heart rate variability (HRV) in normal subjects under mental stress. Methods: 36 healthy male and female subjects were recruited and randomized to a treatment group(18 subjects) or a control group (18 subjects). After 10-minutes rest period and instrumentation, both groups performed a mental stress test(Stroop color word test, Arithmetic test. four rule of arithmetic task) for l6-minutes. HRV was recorded before and after the mental stress. And then acupuncture needles were inserted on 114 and Liv3 for the study group. In the control group, they rested for l5-minutes. And Heart rate variability(HRV) was measured. Results: In the both groups, low frequency(LF) power, normalized low frequency power(LF(norm)) and ratio of low frequency to high frequency(LF/HF) was significantly increased after mental stress. Acupuncture induced significant decrease in low frequency(LF) power, normalized low frequency power(LF(norm)) and ratio of low frequency to high frequency (LF/HF) which was increased after mental stress test. In contrast, control group induced no changes. Conclusions : Acupuncture on 114 and Liv3 could be useful to decrease sympathetic activity and prevent the alteration of autonomic nervous system due to mental stress.

• Journal of Acupuncture Research
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• v.21 no.6
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• pp.37-50
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• 2004

Objective : In this study, we investigated the effects of Hwangryunhaedoktang Herbal-acupuncture(HHT) at a acupoint, $G_{21}$(Kyonjong) on the Heart Rate Variability(HRV) in adults, as well as we tried to observe how HHT affects on the balance of the autonomic nervous system. Methods : The subject were comprised of 20 healthy adults, who didn't take any drugs which affected on the autonomic nervous system and had normal sinus rhythm in electrocardiogram. The control group was comprised of 9 subjects, who were injected normal saline at $G_{21}$(Kyonjong). The experiment group consisted of 10 subjects, who were injected HHT at $G_{21}$(Kyonjong). We measured HRV by CANS 3000 on three times : before, immediately after, and 20 minutes after injection. The SPSS 10.0 for windows was used to analyze the date and the Wilcoxon signed rank test (in group) and Mann-Whitney U-test(between two groups) were used to verify the results. Results : The following results were obtained ; 1. In each group, Mean-HRV and Mean-RR showed a significant change during 20 minutes after injection. But there were no significant difference between two groups(p>0.05). 2. In experiment group, 20 minutes after injection, norm LF and LHR showed a significant decrease and norm HF showed a significant increase. There were significant difference between two groups(p<0.05). Conclusions : The findings suggest that HHT at $G_{21}$(Kyonjong) in adults relatively activate parasympathetic nervous system and inactivate sympathetic nervous system.

• Journal of Biomedical Engineering Research
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• v.43 no.1
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• pp.27-34
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• 2022

Drunk driving defines a driver as unable to drive a vehicle safely due to drinking. To crack down on drunk driving, alcohol concentration evaluates through breathing and crack down on drinking using S-shaped courses. A method for assessing drunk driving without using BAC or BrAC is measurement via biosignal. Depending on the individual specificity of drinking, alcohol evaluation studies through various biosignals need to be conducted. In this study, we measure biosignals that are related to alcohol concentration, predict BrAC through SVM, and verify the effectiveness of the S-shaped course. Participants were 8 men who have a driving license. Subjects conducted a d2 test and a scenario evaluation of driving an S-shaped course when they attained BrAC's certain criteria. We utilized SVR to predict BrAC via biosignals. Statistical analysis used a one-way Anova test. Depending on the amount of drinking, there was a tendency to increase pupil size, HR, normLF, skin conductivity, body temperature, SE, and speed, while normHF tended to decrease. There was no apparent change in the respiratory rate and TN-E. The result of the D2 test tended to increase from 0.03% and decrease from 0.08%. Measured biosignals have enabled BrAC predictions using SVR models to obtain high Figs in primary and secondary cross-validations. In this study, we were able to predict BrAC through changes in biosignals and SVMs depending on alcohol concentration and verified the effectiveness of the S-shaped course drinking control method.

• Journal of Oriental Neuropsychiatry
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• v.21 no.2
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• pp.87-101
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• 2010

Objectives : The aim of this experiment was to investigate the influences of Autonomic Nervous System and EEG by conducting Reinforcement-Reduction(補瀉) acupuncture stimulation to compare the changes in acupoints on the body before and after treatment of acupuncture at Xingjian(LR2) being referred as Fire-point(火穴) and Ququan(LR8) being referred as Water-point(水穴) of Yin Liver Meridian(足厥陰肝經). Methods : This study was carried out on 30 healthy female volunteers in their 20's. There were four tests conducted throughout and the period for each test was between 2 to 5days. HRV and EEG were measured for 5 minutes before acupuncture stimulation was conducted on LR2-Reinforcement, LR2-Reduction, LR8-Reinforcement and LR8-Reduction at random. During the 20 minutes of acupuncture treatment, same subjects were measured simultaneously to observe any significant changes in acupoints. Again, the same subjects were measured for 5 minutes after removing the acupuncture in order to perform a comparative analysis. Results : The measurement of HRV showed that LF, LFnorm and LF/HF ratio increased significantly(p<0.05) while HF, HF norm decreased significantly in case of LR2-Reinforcement & LR8-Reduction. Both LR2-Reduction and LR8-Reinforcement induced a significant increase in HFnorm. EEG measurement indicated low $\alpha$ wave decreased and high $\beta$ wave increased significantly at LR2-Reinforcement during post-acupuncture period compared with acupuncture stimulation period. Both LR2-Reduction and LR8-Reinforcement developed significantly low $\alpha$ wave and high $\alpha$ wave. High $\beta$ wave increased significantly at LR8-Reduction during the acupuncture stimulation in comparison with pre-acupuncture period. Conclusions : The manipulation of acupuncture stimulation at LR2-Reinforcement and LR8-Reduction enhanced the activity of sympathetic nerves and the state of arousal while that of para sympathetic nerves declined. On the other hand, LR2-Reduction and LR8-Reinforcement developed the levels of para sympathetic nerves and relaxation.

• Journal of Oriental Neuropsychiatry
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• v.26 no.2
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• pp.89-102
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• 2015

Objectives: To examine the medical effectiveness of meditation programs ($\alpha$ version) by psychological types. Methods: MBTI, which was created by Katharine Cook Briggs and Isabel Briggs Myers, was used as the Psychological Type test and to investigate psychological temperament and functions and psychological preferences. Heart rate variability was used to test the effectiveness of meditation by investigating time domains (mean HR, SDNN, PSI) and frequence domain parameters (TP, LF, HF, LF or HF norm, Ln (TP or VLF or LF or HF). Results: 1. The autonomic nervous system became active, and both time domains and frequency domains showed positive responses to meditation in heart rate variability tests, without distinction of Psychological Types. 2. In Psychological Types using sensing over intuition for perception, there were positive responses as well as an increase of the parasympathetic nervous system's activeness to meditation for heart rate variability tests, depending on psychological temperaments and psychological functions. 3. In heart rate variability tests by preferences, there was no difference. Extroversion and Introversion types, Sensing over Intuition Types, Thinking over Feeling Types, Judging over Perception Types had an increase of activeness of the parasympathetic nervous system. Therefore, meditation has a positive physical and psychological relaxing effect. Conclusions: A complex meditation program has a positive effect on overall meditation. Especially in the MBTI test, sensing was superior to intuition when people recognized objects. The Sensing, Thinking and Judging type was more advantageous than Intuition, Feeling and Perception, respectively. In the future, a well-designed control study is needed, to develop a suitable meditation for each personality type.