• Tuberculosis and Respiratory Diseases
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• 제45권4호
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• pp.723-735
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• 1998

Background : Vitamin C has been reported to have a role in the decrease of airway hyperresponsiveness in animal models. This data is based on some metabolic actions of vitamin C, such as promotion of histamine degradation, producing more $PGE_2$ than $PGF_{2\alpha}$ in cyclooxygenase pathway, decrease of smooth muscle contraction, and acting as reducing agent of oxidant. It has been also known that heavy smokers have lower blood levels of vitamin C than nonsmokers and this deficiency in heavy smokers have been explained by several mechanisms, such as increased oxidation by oxidants and free radicals, increased biosynthesis of catecholamine and serotonin released by nicotine, and inadequate dietary intake. In this study, We attempted to assess effect of vitamin C on bronchial hyperresponsiveness in heavy smokers who have bronchial hyperresponsiveness and role of vitamin C on bronchial hyperresponsiveness. Method: To assess acute effect of vitamin C on airway hyperresponsiveness, blood sample for vitamin C level and spirometry, methacholine challenge test were done in 17 smokers and 8 nonsmokers, and one hour after oral administration of vitamin C 3 g, blood sample for vitamin C level and spirometry, methacholine challenge test were repeated. To assess chronic effect of vitamin C on airway hyperresponsiveness, after daily administration of vitamin C 1 g for one week in 17 smokers, blood sample for vitamin C level and spirometry, methacholine challenge test were done. To assess role of vitamin C, after oral administration of vitamin C 3 g plus indomethacin 100 mg in 12 of 15 smokers who were reactive to methacholine challenge test, spirometry and methacholine challenge test were done and after oral intake of indomethacin 100 mg in 12 smokers who were reactive to methacholine challenge test, spirometry and methacholine challenge test were repeated. Result: There were no significant differences in whole blood vitamin C levels between smokers($1.17{\pm}0.22$ mg/dL) and nonsmcikers($1.14{\pm}0.19$ mg/dL) (p>0.05). Fifteen of the 17 smokers(88.2%) were reactive to methacholine challenge test and 10 of the 15 smokers who were reactive to methacholine challenge test were less than 8 mg/dL in $PC_{20}FEV-2$, and 7 of the 8 nonsmokers(87.5%) were nonreactive to methacholine challenge test There were significant decrease in bronchial responsiveness after oral administration of vitamin C 3 g in 13 of the 15 smokers who were reactive to methacholine challenge test This significant decrease persisted with maintenance daily administration of 1 g for one week. $PC_{20}FEV-2$ were not correlated to vitamin C levels in smokers. After oral administration of indomethacin 100 mg, significant reduction of bronchial responsiveness that occured after oral administration of vitamin C 3 g in smokers were attenuated. Conclusion: Although there were no significant differences in whole blood vitamin C levels between smokers and nonsmokers. heavy smokers have significant increase in bronchial responsiveness than nonsmokers. This bronchial hyperresponsiveness of heavy smokers can be attenuated by vitamin C supplement. Disappearance of vitamin C effect by indomethacin supplement may suggest that vitamin C exert its effect via alteration of arachidonic acid metabolism.

• The Journal of Korean Physical Therapy
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• 제13권2호
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• pp.347-357
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• 2001

It is well known that there is an adverse effect of long-term cigarette smoking on pulmonary function. Therefor we attempted to consider the vital capacity for position changes in a smokers and non-smokers. The pulmonary functions on sitting and supine positions were measured in 28 young healthy students fer the change of vital capacity. Forced expiratory flow-volume curve were performed sitting position and supine position and smoking. The results were summarized as follows; 1) The spirometric values(VC, FVC, FEV$_{1}$) were progressively decreased from sitting position to 30minutes after supine position in a non-smoking group(p<.05). 2) The VC, FVC. FEV$_{1}$, FEF25 ${\sim}$ 75% were decreased from sitting position to 30minutes after supine position in a smoking group(p< .01). The PEF and FEF25% were decreased from supine position to after smoking(p< .05). 3) non-smoking group and smoking group not showed significant change(p> .05). But the spirometric values were more decreased nonsmokers than smokers.

• Environmental Sciences Bulletin of The Korean Environmental Sciences Society
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• 제4권1호
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• pp.25-29
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• 2000

The present study evaluated the body burden of aromatic VOCs in roadside and underground storekeepers. The Method Detection Limit(MDL) of the analytical system ranged from 0.2 to 0.4$\mu\textrm{g}$/m3 for the target VOCs. The recovery of the sampling system for the compounds was above 80%. For all the target compounds, the breath concentrations of the smokes were similar to or slightly higher than those of the nonsmokers for both the roadside and underground storekeepers. For Ethylbenzene, p-Xylene, and o-Xylene, the breath concentrations of the underground storekeepers were somewhat higher than those of the roadside storekeepers. In contrast, the breath m-xylene concentration of underground storekeepers was similar to that of roadside storekeepers. For both the roadside and underground storekeepers, the breath concentrations prior to and after work were not significantly different.

• Biomedical Science Letters
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• 제12권4호
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• pp.371-374
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• 2006

This study was carried out to investigate the relationship of the cadmium and lead levels in blood by age, gender and smoking status among 181 students in Gyeongnam province from June 2005 to July 2006. The cadmium and lead levels in blood was analyzed by atomic absorption spectrophotometer. Subjects were classified for the investigation according to smoking status as smokers and nonsmokers, age and gender. Mean blood cadmium level in male and female was $1.65{\mu}g/dl,\;1.10{\mu}g/dl$ respectively. Male was significantly higher than that of female. Blood cadmium levels in heavy smokers ($11{\sim}20\;ea/day$) and light smokers ($1{\sim}10\;ea/day$) were $2.34{\mu}g/dl,\;1.10{\mu}g/dl$ respectively. Heavy smokers were significantly higher than those of light smokers. In the comparison of age, gender and smoking status in blood Lead levels were no significant differences. In conclusion, heavy smoking was the most significant risk factor to increase blood cadmium levels. The further study will need analysis of the other factors related to the elevation of the cadmium and lead levels.

• The Korean Journal of Physiology and Pharmacology
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• 제3권2호
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• pp.207-213
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• 1999

To examine individual variation in drug metabolism catalyzed by flavin-containing monooxygenase (FMO), 179 Korean volunteers' urinary molar concentration ratio of theobromine (TB) and caffeine (CA) was determined. Their urine was collected for 1 hr (between 4 and 5 hrs) after they drank a cup of coffee containing 115 mg CA and analyzed by an HPLC system. The lowest TB/CA ratio obtained was 0.40, the highest ratio was 15.17 (38-fold difference), and the median ratio for all subjects was 1.87. The mean was 2.66 with 2.36 S.D.. In 134 nonsmokers, the mean ratio was $2.35{\pm}1.93,$ that of 51 males was $2.30{\pm}2.26$ and 83 females was $2.37{\pm}1.85,$ respectively. There was no significant gender difference in the obtained TB/CA ratio (Mann-Whitney test; p=0.518). There were no smokers among the 83 female volunteers. In the remaining 96 male subjects, the ratio obtained in 51 nonsmokers was $2.30{\pm}2.06$ and that of 45 smokers was $3.62{\pm}3.19.$ This indicated that the TB/CA ratio was increased significantly in smokers (p=0.007). However, when the TB/CA ratios (FMO activity) obtained in all 179 Korean volunteers are compared with the urinary concentration ratios of paraxanthine (PX) plus 1,7-dimethylurate (17U) to CA (CYP1A2 activity), there was a weak but significant correlation (Pearson's correlation coefficient test; $r^2=0.28,$ p＜0.0001). This indicates that, although the urinary TB/CA ratio mostly represents FMO activity, minor contribution by CYP1A2 activity cannot be ignored. In conclusion, the FMO activity measured by taking the urinary TB/CA ratio from normal healthy Korean volunteers shows marked individual variations without significant gender differences and the increased TB/CA ratio observed in cigarette smokers may have been caused by the increased CYP1A2 activity.

• Journal of Preventive Medicine and Public Health
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• 제42권3호
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• pp.160-164
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• 2009

Objectives : The objective of this study was to determine the relationship between past smoking and the risk factors for metabolic syndrome. Methods : From January 2007 to December 2007, a total of 3,916 over thirty years old male health screen examinees were divided into the nonsmoking, smoking, ex-smoking groups. The diagnosis of metabolic syndrome was based on the criteria of the NCEP ATP III(Executive Summary of The Third Report of The National Cholesterol Education Program). Metabolic syndrome was defined as the presence of three or more of the following: a blood pressure $\geq$ 130/85 mmHg, a fasting glucose level $\geq$ 110 mg/dL, a HDL-C (High Density Lipoprotein Cholesterol) level < 40 mg/dL, a triglyceride level $\geq$ 150 mg/dL and, a waist circumference men $\geq$ 102 cm, but a waist to hip ratio > 0.90 was used as a surrogate for the waist circumference. Results : After adjustment for age, alcohol consumption and, exercise in the smokers, for the ex-smokers compared with the nonsmokers, the odds ratio (OR) of a lower HDL cholesterol level (<40 mg/dL) was 1.29 (95% CI=1.03-1.61) in the smokers, the ORs of a higher triglyceride level were 1.35 (95% CI=1.09-1.66) in the ex-smokers and, 2.12 (95% CI=1.75-2.57) in the smokers, and the OR of a waist to hip ratio was 1.25 (95% CI=1.03-1.52) in the ex-smokers. When there were over three components of metabolic syndrome in the ex-smokers and smokers as compared with the nonsmokers, the odds ratio against the risk of metabolic syndrome were 2.39 (95% CI=1.00-6.63) and 2.37 (95% CI=1.02-6.46), respectively. Conclusions : The present study suggested that there is an association of smoking with metabolic syndrome in men.

• Korean journal of communication and information
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• 제44권
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• pp.223-247
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• 2008

The purpose of this study is to explore the anti-smoking message effects and smoking status on smoking belief attributes. Based on the health behavior theories such as theory of reasoned action, health belief model, and social cognitive theory, three factors are selected to investigate the effects of anti-smoking campaign messages. The balance of benefits and barriers, self-efficacy, and social pressure are selected as independent variables. Three two-way ANOVA were conducted. Results showed that the main effect of social pressure were found with the social smoking attributes. Interaction effects were found on the nonsmoker-social pressure group and the non-smoker-two sided message group. It is found that nonsmokers accepted these two anti-smoking messages easily as compared to smoker groups. No main smoking status was found in this study; it is believed that smoking is a habitual that is not changed easily because attitude formation takes time. Results revealed that the two-sided message video releases and the social pressure video releases were favored by both smokers and nonsmokers. This study contributes the theoretical framework that can be transferred to the practices of anti-smoking campaign. Also, the researcher produced the televised stimuli which is not common in health message studies. By using the televised message material, the research tried to solve the validity problem which is common in experimental design.

• Journal of Korean Public Health Nursing
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• 제20권1호
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• pp.39-56
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• 2006

Objectives: To investigate the drinking and smoking habits among the community residents of a city. Methods: We surveyed 1.973 adults from October 1, 2005 to November 16, 2005. The data collected on alcohol drinking habits involved frequency, age of initiation, amount of alcohol consumed, number of attempts to reduce consumption and reasons for reducing it. The data collected on smoking habits involved amount, age of initiation, duration, situations, and the number of attempts to quit smoking. These were analyzed with frequency, percentage, mean, standard deviation, $x^2$-test, t-test and ANOVA. Results: The rate of drinking was 67.4%; 83.1% among males, and 52.5%among females. Among all drinkers, the largest group (29.8%) drank once or twice a week. The mean age of initiation was 21.2 years; 19.9 among males, and 22.8 among females. The average consumed amount was 5.8 glasses; males consumed 7.4 glasses, and females 3.3 glasses. The consumption was the highest among those in fifties. The rate of attempts to reduce drinking was 33.4%, mainly for health reasons. The rate of smoking was 38.0%; 72.4% among males, and 5.5% among females. Among all smokers, the largest group (44.1%) smoked between 11 and 20 cigarettes per day. The mean of the age of initiation was 20.7 years; 20.3 among males, 25.6 among females. The mean smoking duration was 20.9 years; 21.3 years among males, and 16.2 years among females. The main reason for the initial attempt was curiosity. The most common situation for smoking was after dinner. The rate of attempts to quit smoking was 77.1%, mainly out of concern for one's health. Alcohol consumption among smokers was higher than among any other group of nonsmokers. Also, the age of drinking initiation among smokers was lower than among any other group of nonsmokers. Conclusion: This study highlighted the actual data on drinking and smoking habits among community residents. The study can be utilized for creating programs aiming at reducing the consumption of alcohol and tobacco or stopping it altogether. Therefore, it is now possible to assess the indicators for interventions in each population group. Finally, the groups of heavy drinkers and smokers are expected to be given priority for intervention program.

• Korean Journal of Community Nutrition
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• 제10권3호
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• pp.281-289
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• 2005

Hyperlipidemia and related heart disease will be growing public health problems as the population ages. It is therefore of great importance to identify modifiable risk factors. So this research investigated associations among life style, nutrient intake, and blood lipids in middle-aged men with borderline hyperlipidemia. Dietary intakes were assessed by food-frequency questionnaire and convenient method. The subject's histories of alcohol use and smoking were assessed via a questionnaire. Current smokers were classified as smokers, whereas past smokers and subjects who never smoked were classified as nonsmokers. With regard to alcohol intake, the subjects were stratified into drinkers and nondrinkers. In drinkers the frequency were measured. Frequency of alcohol intake and weight were associated with high blood lipids and blood pressure. The highest quartile of calcium intake had lower triglyceride concentration than did those in the lower three quartiles. High calcium intake was associated with low blood triglyceride concentration. These results suggest that healthy weight and high calcium intake and less alcohol intake can contribute to maintenance of healthy blood lipids in men.

• Journal of Nutrition and Health
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• 제31권3호
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• pp.289-296
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• 1998

A large body of epidemiologic evidence suggests inverse relationships between ischemic heart disease and plasma vitamin C and E concentrations. Smokers have lower plasma concentrations of these vitamins than do nonsmokers. Smokers therefore need antioxidant vitamin supplementation . The purpose of study was to investigate the effect of antioxidant vitamin supplementation on blood composition in smoking college men. 24 subjects were divided into 3 groups of which were the vitamin C supplementation group(n=8), the vitamin E supplementation group(n=8), and the vitamin C+E supplementation group(n=8). The vitamin supplementation group consumed 500mg of ascorbic acid, the vitamin E supplementation group consumed 200IU of D-$\alpha$-tocopherol , and the vitamin C+E supplementation group consumed 500mg of ascorbic acid +200IU of D-$\alpha$-tocopherol for 4 weeks. We examined the blood compositions of the volunteers bofore and after vitamins were supplemented . The results obtained were as follows ; intakes of energy , carbohydrate , fat protein , vitamin C and vitamin E were not significantly affected by vitamin supplementation in all groups. Blood glucose concentrations were not significantly affected by vitamin supplementation in all groups. Concentrations of plasma uric acid and alkaline phosphatase activity were decreased significantly (p<0.05) with vitamin E supplementation. The results of this study show that antioxidant vitamin supplementation in smokers has a tendency to decrease coronary heart disease risk.