• Archives of Pharmacal Research
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• 제22권1호
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• pp.35-43
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• 1999

Overstimulation of both kainate (KA) and N-methyl-D-aspartate (NMDA) receptors has been reported to induce excitatoxicity which can be characterized by neuronal damage and formation of reactive oxygen free radicals. Neuroprotective effect of melatonin against KA-induced excitotoxicity have been documented in vitro and in vivo. It is, however, not clear whether melationin is also neuroportective against excitotoxicity mediated by NMDA receptors. In the present work, we tested the in vivo protective effects of striatally infused melatonin against the oxidative stress and neuronal damage induced by the injection of KA and NMDA receptors into the rat striatum. Melatonin implants consisting of 22-gauge stainless-steel cannule with melatonin fused inside the tip were placed bilaterally in the rat brain one week prior to intrastriatal injection of glutamate receptor subtype agonists. Melatonin showed protective effects against the elevation of lipid peroxidation induced by either KA or NMDA and recovered Cu, Zn-superoxide dismutase activities reduced by both KA and NMDA into the control level. Melatonin also clearly blocked both KA- and NMDA-receptor mediated neuronal damage assessed by the determination of choline acetyltransferase activity in striatal monogenages and by microscopic observation of rat brain section stained with cresyl violet. The protective effects of melatonin are comparable to those of DNQX and MK801 which are the KA- and NMDA-receptor antagonist, respectively. It is suggested that melatonin could protect against striatal oxidative damages mediated by glutamate receptors, both non-NMDA and NMDA receptors.

• Smart Structures and Systems
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• 제13권6호
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• pp.943-957
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• 2014

When subjected to fatigue loading, the main failure mode of partially prestressed concrete (PPC) structure is the fatigue fracture of tensile reinforcement. Therefore, monitoring and evaluation of the steel stresses/strains in the structure are essential issues for structural design and healthy assessment. The current study experimentally investigates the possibility of using fiber Bragg grating (FBG) sensors to measure the steel strains in PPC beams in the process of fatigue loading. Six full-scale post-tensioned PPC beams were exposed to fatigue loading. Within the beams, the FBG and resistance strain gauge (RSG) sensors were independently bonded onto the surface of tensile reinforcements. A good agreement was found between the recorded results from the two different sensors. Moreover, FBG sensors show relatively good resistance to fatigue loading compared with RSG sensors, indicating that FBG sensors possess the capability for long-term health monitoring of the tensile reinforcement in PPC structures. Apart from the above findings, it can also be found that during the fatigue loading, there is stress redistribution between prestressed and non-prestressed reinforcements, and the residual strain emerges in the non-prestressed reinforcement. This phenomenon can bring about an increase of the steel stress in the non-prestressed reinforcement.

• 한국공작기계학회:학술대회논문집
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• 한국공작기계학회 1997년도 추계학술대회 논문집
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• pp.140-145
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• 1997

In case of spot-welded joints, the fatigue cracks generally originate from the weld interfaces of the neighborhood nugget tips, and propagate toward the outer surfaces of the sheets. Generally, because fatigue crack was observed in nugget around, strain gage was attached at nugget zone. Accordingly, it was very difficult to detect the generation time of fatigue crack in spot-welded joints and to measure the propagation speed of fatigue crack. We developed the non-destructive method, according to which th fatigue crack propagation rate can be quantitatively estimated by utilizing information obtained from strain gages bonded on the electrode indentations of spot welds. The results measured by real crack were compared with the data which was measured by strain gauge method in fatigue testing. And so fatigue strength was evaluated by stress intensity factor. In this study behavior of fatigue crack propagation under repeated load were considered.

• Steel and Composite Structures
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• 제51권5호
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• pp.563-573
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• 2024

This research experimentally evaluated the local stress distribution along the cross-section of composite beams under both positive and negative moments. The experiment utilized a large-scale, two-story, two-by-three bay steel gravity frame with a concrete on metal deck floor system. The composite shear connections, which are nominally assumed to be pinned under gravity loading, can develop non-negligible moment-resisting capacity when subjected to lateral loads. This paper discusses the local stress distribution, orshear lag effects, observed near the beam-to-column connections when subjected to combined gravity and lateral loading. Strain gauges were used for measurements along the beam depth at varying distances from the connection. The experimental data showed amplified shear lag effects near the unconnected region of the beam web and bottom flange under the applied loading conditions. These results indicate that strain does not vary linearly across the beam cross-section adjacent to the connection components. This insight has implications for the use of experimental strain gauge data in estimating beam demands near the connections. These findings can be beneficial in informing instrumentation plans for future experimental studies on composite beams.

• 한국구조물진단유지관리공학회 논문집
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• 제23권4호
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• pp.137-144
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• 2019

취성재료인 탄소섬유보강폴리머(CFRP)의 시편시험에서 총변형량과 유효길이로서 유도되는 환산변형률을 도입하고, 환산변형률의 장점을 기술하였다. 일반적으로 재료의 인장물성을 결정하기 위해 스트레인 게이지 측정값을 사용하지만, 취성특성을 가지는 CFRP에서는 항상 유효한 것은 아니다. 그 이유는 취성재료에서는 응력재분배를 할 수 없으며, 스트레인 게이지의 측정값은 국부거동만을 나타기 때문이다. 따라서 환산변형률은 취성재료의 인장인장특성의 평균값을 측정하고 변형률과 측정값을 검증하는 보조지표로서 효과적으로 사용될 수 있다. 또한 환산변형률은 1) 제작 오차(편차) 와 세팅 오차(정렬 불량)에 의해 발생하는 초기 내부 변형률에 기인한 영향과 2) 불균일 변형분포로 인한 부분파단 이후 거동을 명확히 가시화하는 장점이 있다.

• 동의신경정신과학회지
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• 제35권1호
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• pp.15-26
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• 2024

Objectives: The objective of this study is to develop a specialized clinical research protocol for acupuncture treatment specifically designed for disaster survivors based on insights from an expert survey. Methods: An expert panel comprising specialists in neuropsychiatry, acupuncture, and clinical research methodology was assembled. Initial data to inform the clinical research protocol design was collected utilizing open-ended responses, multiple-choice questions, and a 5-point Likert scale to gauge agreement levels. Next, this data was disseminated to a panel of experts. A cohesive clinical research protocol was then formulated during a core panel meeting by integrating insights from a panel of 10 experts. Results: The protocol developed herein entails a non-randomized controlled study involving participants aged 19~64 years old who have been identified as high-risk or cautious according to the National Trauma Center screening test. The study design includes the establishment of an active control group, which allows for the assessment of an additional effect through comparison with conventional therapy. The selected acupuncture approach involves a combination of manual acupuncture and ear acupuncture. For clinical outcome assessment, the Clinician-Administered Posttraumatic Stress Disorder Scale for DSM-5 was proposed to gauge trauma symptoms. Representative scales for various domains such as depression, anxiety, anger, insomnia, pain, and quality of life were also provided for reference. Conclusions: The developed protocol is anticipated to streamline the swift design and initiation of clinical trials during disaster scenarios. It is also designed to be scalable, thereby enabling its application in both non-randomized control group studies and single-group before-and-after comparisons.

• 대한치과보철학회지
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• 제36권4호
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• pp.615-643
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• 1998

The purpose of this study was to evaluate the effect of cantilever length, load, and implant number on the stress distribution of implant supported fixed prosthesis. In the replica of an edentulous human mandible, four or five implants were placed and spaced evenly between the mental foramina and symmetrical gold alloy cast superstructures with cantilever were fabricated. Strain gauges were placed in buccal and lingual side of implants. 9, 15, 21kg of loads at varying cantilever lengths were applied to the occlusal surface of fixed prostheses. The strains were recorded from each gauge and principal stresses were calculated The results were as follows : 1. Increasing the length of the cantilever increased the stresses on the bone supporting implants. and the ratio of increase became high as increasing the load. 2. In the model with four implants, the highest compressive stress was measured on lingual side of the first implants nearest loading point and the highest tensile stress was measured on buccal side of the second implants. 3. In the model with five implants, the highest compressive stress was measured on lingual side of the first implants nearest loading point. And the highest tensile stress was measured on buccal side of the second implants, and lingual side of the third implants. 4. There was no significant change of the magnitude of stress on the most distal imp]ant of non cantilevered side as increasing the cantilever length or load. 5. In general, the superstructure supported by five implants reduced the stress and was less affected by cantilever length compared to the support provided by four implants.

• 한국소음진동공학회:학술대회논문집
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• 한국소음진동공학회 2008년도 춘계학술대회논문집
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• pp.132-139
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• 2008

The blade vibration problem of bladed disk is the most critical subject to consider since it directly affects the stable performance of the engine as well as life of the engine. Especially, due to complicated vibration pattern of the bladed disk, more effort was required for vibration analysis and test. The research of measuring the vibration of the bladed disk, using NSMS(Non-intrusive stress measurement) instead of Aeromechanics testing method requiring slip ring or telemetry system with strain gauge, was successful. These testing can report the actual stresses seen on the blades; detect synchronous resonances that are the source of high cycle fatigue (HCF) in blades; measure individual blade mis-tuning and coupled resonances in bladed disks. In order to minimize the error being created due to heat expansion, the tip timing sensor is installed parallel to the blade trailing edge, yielding optimal result. Also, when working on finite element analysis, the whole bladed disk has gone through three-dimensional analysis, evaluating the family mode. The result of the analysis matched well with the test result.

• 한국추진공학회:학술대회논문집
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• 한국추진공학회 2008년 영문 학술대회
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• pp.871-876
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• 2008

The blade vibration problem of bladed disk is the most critical subject to consider since it directly affects the stable performance of the engine as well as life of the engine. Especially, due to complicated vibration pattern of the bladed disk, more effort was required for vibration analysis and test. The research of measuring the vibration of the bladed disk, using NSMS(Non-intrusive stress measurement) instead of Aeromechanics testing method requiring slip ring or telemetry system with strain gauge, was successful. These testing can report the actual stresses seen on the blades; detect synchronous resonances that are the source of high cycle fatigue(HCF) in blades; measure individual blade mis-tuning and coupled resonances in bladed disks. In order to minimize the error being created due to heat expansion, the tip timing sensor is installed parallel to the blade trailing edge, yielding optimal result. Also, when working on finite element analysis, the whole bladed disk has gone through three-dimensional analysis, evaluating the family mode. The result of the analysis matched well with the test result.

• Earthquakes and Structures
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• 제15권5호
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• pp.463-471
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• 2018

The virtual forces of the original local flexibility method are restricted to inducing stress on the local parts of a structure. To circumvent this restriction, we developed a pseudo local flexibility (PLFM) method that can successfully detect damage to hyperstatic beam structures using fewer modes. For this study, we further developed the PLFM so that it could detect damage in plate structures. We also devised the theoretical background for the PLFM with non-local virtual forces for plate structures, and both the lateral and rotary degree of freedom (DOF) measurements were considered separately. This study investigates the effects of the number of modes, the actual location that sustained damage, multiple damage locations, and noise in modal parameters for the damage detection results obtained from damaged numerical plates. The results revealed that the PLFM can be used for damage detection, localization, and quantification for plate structures, regardless of the use of the lateral DOF and/or rotary DOF.