• 대한의용생체공학회:학술대회논문집
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• 대한의용생체공학회 1994년도 추계학술대회
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• pp.147-150
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• 1994

To predict light propagation in biological tissues irradiated by laser, the optical properties such as absorption and scattering coefficients are required. There have been various techniques for measuring these coefficients. One method requires tissue samples, often a slab of thin tissue, is invasive. On the other hand, non-invasive method usually measures back-scattered light from a subject with no physical intervent ions. Advantages and disvantages of using different methods are investigated. A careful attention should be made in order to select the best method for a given experimental condition since, even either for invasive or non-invasive method, accuracy is subject to governing models and sample preparations.

• 대한의용생체공학회:의공학회지
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• 제28권5호
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• pp.676-683
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• 2007

A non-invasive respiratory gated radiotherapy system like those based on external anatomic motion gives better comfortableness to patients than invasive system on treatment. However, higher correlation between the external and internal anatomic motion is required to increase the effectiveness of non-invasive respiratory gated radiotherapy. Both of invasive and non-invasive methods need to track the internal anatomy with the higher precision and rapid response. Especially, the non-invasive method has more difficulty to track the target position successively because of using only image processing. So we developed the system to track the motion for a non-invasive respiratory gated system to accurately find the dynamic position of internal structures such as the diaphragm and tumor. The respiratory organ motion tracking apparatus consists of an image capture board, a fluoroscopy system and a processing computer. After the image board grabs the motion of internal anatomy through the fluoroscopy system, the computer acquires the organ motion tracking data by image processing without any additional physical markers. The patients breathe freely without any forced breath control and coaching, when this experiment was performed. The developed pattern-recognition software could extract the target motion signal in real-time from the acquired fluoroscopic images. The range of mean deviations between the real and acquired target positions was measured for some sample structures in an anatomical model phantom. The mean and max deviation between the real and acquired positions were less than 1mm and 2mm respectively with the standardized movement using a moving stage and an anatomical model phantom. Under the real human body, the mean and maximum distance of the peak to trough was measured 23.5mm and 55.1mm respectively for 13 patients' diaphragm motion. The acquired respiration profile showed that human expiration period was longer than the inspiration period. The above results could be applied to respiratory-gated radiotherapy.

• 약학회지
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• 제48권3호
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• pp.177-181
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• 2004

Non-invasive blood glucose measurement from mouse tail was performed by near-infrared (NIR) spectroscopy. Three groups; normal, type I diabetes (insulin dependent diabetes mellitus, IDDM), type II diabetes (non-insulin dependent diabetes mellitus, NIDDM) group, were studied over a 10 weeks period with the collection of near-infrared (NIR) spectra. Spectral variations from long-term measurement (10 weeks) from dramatic and nonlinear changes in the optical properties of the live tissue sample were compensated by chemometrics techniques such as principle component analysis (PCA) and partial least squares (PLS) regression. The effect from mouse body temperature changes on NIR spectral data was also considered. This study showed that the compensation of variations from long-term measurement and temperature changes improved calibration accuracy of non-invasive blood glucose measurement.

• 대한약학회:학술대회논문집
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• 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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• pp.407.3-408
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• 2002

A portable near infrared (NIR) system which was newly integrated by our lab has been used to develop a non-invasive blood glucose monitoring. The portable NIR system includes a tungsten halogen lamp, a photo diode array type-InGaAs detector, and specialized reflectance fiber optic probes. The shape of probes is composed of two parts. one for illumination into sample and the other for receiving the radiation from sample. Three kinds of probes with different distance between illumination and receiving part. such as 0.03. 0.1. and 0.5mm, were investigated for optimization. (omitted)

• Journal of Species Research
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• 제1권2호
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• pp.240-248
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• 2012

We used a non-invasive technique with microsatellite primers to investigate genetic variation among Eurasian otters Lutra lutra in eastern South Korea. We collected twenty two otter spraints in January and six in August 2008. We used spraints from five dead otters from five different river systems for the present genetic analysis. We extracted DNA from 20 spraints from the January sample. Ten microsatellite primers (Lut435, Lut453, Lut457, Lut604, Lut615, Lut701, Lut715, Lut717, Lut733, and Lut832) for Eurasian otters were tested, and four loci were successfully amplified for further analyses. The results of genotyping the otter population with microsatellite loci lead to the identification of 9 individuals from the Ungokcheon Stream. The Ungokcheon population also showed a genetic structure represented by the Hardy-Weinberg equilibrium.

• Journal of Korean Neurosurgical Society
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• 제42권3호
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• pp.195-199
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• 2007

Objective : Bilateral laminotomy and unilateral laminotomy for bilateral decompression are becoming the minimally invasive procedures for lumbar spinal stenosis (LSS). With the aim of less invasiveness and better preservation of spinal stability. these techniques have been developed. But there are no large randomized studies to show the surgical results between these two techniques. The objective of this study was to examine the safety and efficacy of these two minimally invasive techniques. Methods : A total of 80 patients were included in this study (Group I : bilateral laminotomy, Group II : Unilateral laminotomy for bilateral decompression). Perioperative parameters and complications were analyzed. Symptoms and scores such as visual analog scale (VAS) scores, Oswestry Disability Index (ODI) scores, and SF-36 scores of prospectively accrued patients were assessed preoperatively and at 1 month and 12 months after surgery. Paired-t test, two-sample student-t tests, and non parametric tests were used to determine cross-sectional differences between two groups. Results : No major complications such as spinal instability or deaths occurred during follow-up periods. VAS, ODI scores and SF-36 body pain and physical function scores showed statistically significant improvements in both groups (p<0.001). The significant widening of the spinal canal diameter was also noted in both groups. But, in Group II. there were minor postoperative complications such as dural tear (2 cases 5.0%), fracture of ipsilateral inferior facet (1 case 2.5%), and 5 cases of transient leg symptoms of contralateral side. Conclusion : Both bilateral laminotomy and unilateral laminotomy for bilateral decompression allow achievement of adequate and long-lasting operative results in patients with LSS. But postoperative complications are more frequent in Group II (unilateral laminotomy and bilateral decompression). These results indicate that bilateral laminotomy is the preferred minimally invasive technique to treat symptomatic LSS.

• 대한치과보존학회:학술대회논문집
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• 대한치과보존학회 2003년도 제120회 추계학술대회 제 5차 한ㆍ일 치과보존학회 공동학술대회
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• pp.581-581
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• 2003

The purpose of this study was to search non-invasive and reproductive pulp test. Temperature of the crown surface was measured using the infrared thermography, and the pulp test was investigated with difference of crown temperature of the vital and the non-vital tooth in vitro and in vivo. Twenty extracted human maxillary central incisors were used in this study. Two sample teeth after access cavity preparation were arranged setting with one pair. Then, the each tooth wes estimated as the vital and the non-vital tooth.(중략)

• Tuberculosis and Respiratory Diseases
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• 제86권3호
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• pp.176-182
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• 2023

Since the introduction of low-dose computed tomography (CT) screening for patients at high risk of lung cancer, the detection rate of suspicious lung cancer has increased. In addition, there have been many advances in therapeutics targeting oncogenic drivers in non-small cell lung cancer. Therefore, accurate pathological diagnosis of lung cancer, including molecular diagnosis, is increasingly important. This review examines the problems in the pathological diagnosis of suspected lung cancer. For successful pathological diagnosis of lung cancer, clinicians should determine the appropriate modality of the diagnostic procedure, considering individual patient characteristics, CT findings, and the possibility of complications. Furthermore, clinicians should make efforts to obtain a sufficient amount of tissue sample using non- or less-invasive procedures for pathological diagnosis and biomarker analysis.

• 센서학회지
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• 제10권6호
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• pp.273-278
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• 2001

혈중 헤모글로빈 농도를 비침습적으로 측정하기 위하여 가시광선부터 근적외선 영역인 $400{\sim}2500\;nm$ 영역에서 주요 혈중 성분들의 스펙트럼의 분석에 관하여 연구하였다. 근적외선 영역에서는 물이 주 흡수 성분이 되는데 특정성분의 농도 변화에 따라 물의 상대적인 흡수변화가 수반되므로(water displacement effect) 특정성분의 농도 변화에 따른 물의 농도변화를 고려해줌으로써 보정된 스펙트럼을 얻었고 이로부터 각 흡수 peak을 정확히 얻어내었고 농도변화에 따른 선형적인 증가를 보여주었다 비침습적으로 헤모글로빈 측정을 위한 조직의 산란효과와 타 성분의 영향을 고려하여 파장대역의 선정하였다.

• 환경영향평가
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• 제29권3호
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• pp.230-238
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• 2020

본 연구는 비침습 샘플인 털을 이용하여 영월 한반도습지 내 서식하는 멧돼지(Sus scrofa)의 유전분석을 통하여 그들의 서식 생태를 유추하였다. 털 시료는 2018년 11월부터 2019년 5월까지 한반도습지(2.772㎢) 내에서 비빔목 및 헤어트랩을 이용하여 수집하였다. 털 시료로부터 DNA를 추출하여 개체의 종과 성을 PCR을 통해 파악하였으며 6개의 마이크로새틀라이트 마커를 이용하여 개체 구분과 개체 간 유전적 근연관계를 유추하였다. 수집된 털 시료 중 총 16개의 털이 멧돼지의 시료였으며, 이는 암컷 7마리, 수컷 3마리의 10개체로부터 수집된 것임이 판명되었다. 이 10개체의 유전적 관계를 추정해 본 결과, 이들이 만들어내는 45쌍 중에 9쌍의 개체가 친족관계일 가능성이 높게 나타났다. 개체 쌍의 친족관계와 털 시료가 채집된 위치를 함께 고려하여 본 결과, 한반도습지 일대에서 서식하는 멧돼지는 암컷과 그 자손으로써 모계 가족단위로 생활하는 것으로 추정되며, 이는 기존에 알려진 멧돼지의 습성과도 일치하는 결과이다. 그러나 본 연구에 사용된 샘플과 마이크로새틀라이트 마커의 수가 제한적이므로 향후 추가적인 분석이 필요하다.