• Proceedings of the ESK Conference
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• 1996.04a
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• pp.264-269
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• 1996

Facial expression is innate communication skill of human. Human can recognize theri psychological state by facial parameters which contain surface movement, color, humidity and etc. This study is to quantify or qualify human emotion by measurement of facial electromyography (EMG) and facial movement. The measurement is taken at the facial area of frontalis and zygomaticus The results is indicative to discriminate the positive and negative respond of emotion and to extract the parameter sensitive to positive and negative facial-expression. The facial movement according to EMG shows the possibility of non-invasive technique of human emotion.

• Journal of the Korean Society of Costume
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• v.54 no.8
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• pp.147-162
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• 2004

The purpose of this study is to investigate the characteristics of Grotesque in Contemporary Fashion. The study selected the 1990's or after fashion material by the material of both $pr{\hat{e}}t-{\grave{a}}-porter$ collection and haute couture collection based on Europe. These days, the characteristics of grotesque have been categorized into four groups based on the theory of representative scholars of the Post Modernism era. The results are as follows. ${\cdot}$ The devilism creates shocking and destructive cruelty and fear by using frightening object and mysterious and devilish motif which symbolize the death of fashion ${\cdot}$ Hatred produces physical destroy of human body, anatomical expression inside human body, cruelty by naked sex expression, pains, cruel treatment, disillusion and unpleasantness, which have been caused by the disturbance and ideological confrontation of the society, and is said to be a kind of self-confession against dislike and fear of the disclosure of human existence. ${\cdot}$ Playfulness distorts and exaggerates clothes and human body forms, and produces abnormality and mystery because of vague sex identity. The playfulness of fashion can open fixed and closed world and lead it flexibly. ${\cdot}$ Heterogeneity is divided into both primitiveness and virtuality The primitiveness distorts or transforms human body through the human body decoration of primitive race, and expresses a grotesque form combining human being and other animals. It gives a question to the existence of alienated and suppressed life through the world. in which everything is mixed and not separated. The virtuality introduces not only cyborg form combining human being and machines but also state of the art technology factors, so that it emphasizes non-mechanical and non-human grotesque images.

• Journal of Korea Game Society
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• v.9 no.2
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• pp.81-93
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• 2009

This study aims to investigate human capital in Korea's online game industry (as the representative of IT-based creative services) under the knowledge-based economy paradigm. In recognition of the importance of intellectual capital closely intertwined with human capital and the economic potential of the online game industry, Korean government has begun to show active support. In this context, this study measures the human capital efficiency in online game business by using non-parametric analysis (Data Envelopment Analysis, DEA). Most previous studies (human capital theory, knowledge based economy theory, economic growth theory) have proved that human capital has a very positive effect on sustainable growth of corporate management and wealth of nations. As such, this paper uses the DEA to obtain the efficiency of the human capital (scale, investment, education, compensation). The results of this study will suggest strategic implications on maximizing the human capital in online game corporations and provide a reference frame for government policies.

• Korean Journal of Human Ecology
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• v.13 no.6
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• pp.891-901
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• 2004

This study is to investigate the degree of consumers' non-ethical perceptions and behaviors, and to explore related variables such as demographic variables, idealism and relativism. The data used in this study were obtained by surveying 237 college students from 10th through 24th of October, 2002 in Kimhae city. We conducted a statistical analysis of the data, using percentiles, frequencies, means, t-test, ANOVA, and Multiple Regression. Consumers' non-ethical perceptions and behaviors were measured by modifying Consumer Ethics Scale(CES, Muncy & Vitell, 1992). The CES scale comprises 4 sub-factors: actively benefiting from illegal activity(CES1), passively benefiting(CES2), actively benefiting from questionable action(CES3), no harm/no foul(CES4). Average scores of consumers' non-ethical perceptions and behaviors marked below a mid-value, which means that most of the students are basically ethical. The related variable of consumers' non-ethical perceptions was idealism. The related variables of consumers' non-ethical behaviors were idealism and the amount of discretionary money. The results show that most of the participants are basically ethical as a consumer. However, the results related with the CES4 sub-factor which includes consumer attitudes toward copyrights of consumer softwares and music CDs tell us that they are relatively non-ethical. This claims an importance of consumer education to college students in regards to intellectual property.

• The Korean Journal of Physiology and Pharmacology
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• v.24 no.6
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• pp.441-452
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• 2020

In vivo animal models are limited in their ability to mimic the extremely complex systems of the human body, and there is increasing disquiet about the ethics of animal research. Many authorities in different geographical areas are considering implementing a ban on animal testing, including testing for cosmetics and pharmaceuticals. Therefore, there is a need for research into systems that can replicate the responses of laboratory animals and simulate environments similar to the human body in a laboratory. An in vitro two-dimensional cell culture model is widely used, because such a system is relatively inexpensive, easy to implement, and can gather considerable amounts of reference data. However, these models lack a real physiological extracellular environment. Recent advances in stem cell biology, tissue engineering, and microfabrication techniques have facilitated the development of various 3D cell culture models. These include multicellular spheroids, organoids, and organs-on-chips, each of which has its own advantages and limitations. Organoids are organ-specific cell clusters created by aggregating cells derived from pluripotent, adult, and cancer stem cells. Patient-derived organoids can be used as models of human disease in a culture dish. Biomimetic organ chips are models that replicate the physiological and mechanical functions of human organs. Many organoids and organ-on-a-chips have been developed for drug screening and testing, so competition for patents between countries is also intensifying. We analyzed the scientific and technological trends underlying these cutting-edge models, which are developed for use as non-animal models for testing safety and efficacy at the nonclinical stages of drug development.

• Journal of Nutrition and Health
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• v.56 no.1
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• pp.12-23
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• 2023

Purpose: This study investigates the alterations in A549 human non-small-cell lung cancer (NSCLC) cells exposed to Citrus junos extract (CJE). We further examine the antiproliferative and apoptotic effects of CJE on NSCLC cells. Methods: Inhibition of proliferation was examined by applying the 3-(4,5-dimethylthiazol-2-yl)-2,5- diphenyltetrazolium bromide (MTT) colorimetric assay on CJE-treated A549 NSCLC cells. The lactate dehydrogenase (LDH) assay was performed to measure the degree of toxicity of CJE on NSCLC cells. The effect on migratory proliferation was confirmed using the scratch wound healing assay. The antiproliferative effect of the CJE on human lung cancer cells was verified through morphological observation, fluorescence microscopy, and caspase-3 colorimetry. Results: Exposure of NSCLC cells to CJE resulted in a dose- and time-dependent decrease in cell activity and increased toxicity to the cells. In addition, microscopic observation revealed a reduced ability of the cancer cells to migrate and proliferate after exposure to the CJE, with simultaneous morphological apoptotic changes. Fluorescence staining and microscopic examination revealed that this death was a process of self-programmed cell death of NSCLC cells. Compared to unexposed NSCLC cells, the expression of caspase-3 was significantly increased in cells exposed to CJE. Conclusion: Exposure of A549 human NSCLC cells to CJE inhibits the proliferation, increases the cytotoxicity, and decreases the ability of cells to migrate and grow. Moreover, the expression of caspase-3 increases after CJE treatment, suggesting that the apoptosis of NSCLC cells is induced by a chain reaction initiated by caspase-3. These results indicate that Citrus junos is a potential therapeutic agent for human non-small-cell lung cancer.

• Journal of Pharmaceutical Investigation
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• v.34 no.5
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• pp.351-362
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• 2004

The basic concept underlying gene therapy is that human diseases may be treated by the transfer of genetics material into specific cells of a patient in order to correct or supplement defective genes responsible for disease development. There are several systems that can be used to transfer foreign genetic material into the human body. Both viral and non-viral vectors are developed and evaluated for delivering therapeutic genes. Viral vectors are biological systems derived from naturally evolved viruses capable of transferring their genetics materials into host cells. However, the limitations associated with viral vectors, in terms of their safety, particularly immunogenecity, and their limited capacity of transgenic materials, have encouraged researchers to increasingly focus on non-viral vectors as an alternative to viral vectors. Although non-viral vectors are less efficient than viral ones, they have the advantages of safety, simplicity of preparation and high gene encapsulation capability. This article reviews the most recent studies highlighting the advantages and the limitation of gene delivery systems focused on non-viral systems compared to viral systems.

• Korean Journal of Human Ecology
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• v.23 no.6
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• pp.1231-1247
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• 2014

The purpose of this study was to explore housing cost burden and financial support from parents to afford housing costs of college students from Capital and non-Capital regions. On-site and on-line questionnaire surveys were conducted to college students between March 3 and April 4, 2014, and total 241 useable responses were collected. Findings are as follow: (1) Jeon-se renters and monthly renters with deposit in Capital region were found to have paid greater housing costs than those in non-Capital region; (2) 86% of Jeon-se renters, 95% of monthly renters with deposit, and 80% of monthly renters without deposits were found to have received parental supports to pay housing costs; (3) respondents in Capital region tended to perceive influence of housing costs on housing choices greater than those in non-Capital region; and (4) more than a quarter of the respondents thought it would be proper to receive parental supports for all expenses until college graduation.

• Journal of Community Nutrition
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• v.8 no.2
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• pp.69-75
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• 2006

Adipose tissue has now been recognized as a rich source of metabolically active molecules that include leptin and angiotensinogen (AGT), the precursor of angiotensin II (Ang II). Both of which have been implicated in the pathogenesis of metabolic alteration and hypertension associated with obesity. In this study, we examined the relationship between body mass index (BMI), adipocyte size, leptin, Ang II secretion and mRNA expression in human adipose tissue obtained from female subjects. Leptin and Ang II were analyzed using specific radioimmunoassay kits following a 48hour tissue culture. Leptin and Ang II secretion varied from 1.4 - 72.1ng/g and 0.8 - 57.3pg/g of tissue respectively. These large individual variations limit significant correlation between BMI, leptin and Ang II secretion. Ang II secretion was significantly higher in the obese than the non-obese (p < 0.05) and positively correlated with BMI. However, no difference in leptin secretion between the obese and the non-obese was observed and leptin secretion showed negative correlation with BMI. No difference in leptin and AGT mRNA expression in adipose tissue between the obese and the non-obese was observed. Although several limitations of this study, we found increased Ang II secretion in obese patients compared with non-obese patients, and positive correlation between AGT and BMI. Observed difference in AGT expression between the obese and the non-obese in this study might be of importance in relation with obesity related hypertension. (J Community Nutrition 8(2): 69-75, 2006)

• Clinical and Experimental Reproductive Medicine
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• v.45 no.4
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• pp.189-194
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• 2018

Objective: The aim of this study was to compare the rate of maturation, fertilization, and embryo development of in vitro-matured human oocytes derived from pregnant and non-pregnant women. Methods: Immature oocytes were obtained by needle aspiration from 49 pregnant women (group 1) who underwent a cesarean section at term and 77 non-pregnant women (group 2) who underwent a gynecological operation during the same period (8 months). Healthy immature oocytes (530 in group 1 and 539 in group 2) were cultured and assessed for maturation 36 hours later. Mature oocytes were inseminated by intracytoplasmic sperm injection and cultured up to 144 hours. Results: The percentage of degenerated oocytes was significantly higher (12.1% vs. 6.3%; p<0.001) in group 1 than in group 2. There was no significant difference in the maturation rate (66.8% vs. 68.1%; p=0.698), fertilization rate (66.7% vs. 67.6%; p=0.857), or the rate of formation of good-quality blastocysts (46.2% vs. 47.2%; p=0.898) in oocytes obtained from pregnant and non-pregnant women. Conclusion: The developmental competence of immature oocytes did not differ between pregnant and non-pregnant women.