• Title/Summary/Keyword: nicotine patch

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A Preliminary Comparison of the Efficacy of Auricular Acupuncture, Transdermal Nicotine Patch and Combination Therapy for Smoking Cessation (금연 이침과 경피적 니코틴 패치 및 병용 요법 간의 금연 효과에 대한 예비적 비교 연구)

  • Kang, Hee-Chul
    • Journal of Oriental Neuropsychiatry
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    • v.24 no.2
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    • pp.179-188
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    • 2013
  • Objectives : The purpose of this study was to compare three therapies - auricular acupuncture, transdermal nicotine patch and therapy - in combination with auricular acupuncture and nicotine patch. Methods : The subjects of this study included 188 male smokers in their 20s, 30s, 40s and 50s, who visited Wonmi Public Health Center. They were evaluated with the Fagerstrom test for nicotine dependence, amounts of daily smoking and success rate of smoking cessation. The subjects decided on a therapy method strictly of their own choice. They were divided into three groups according to the therapy; auricular acupuncture group (62 persons), nicotine patch group (69 persons) and combination therapy group (57 persons). Results : All three groups resulted in statistically significant reducing effects of nicotine dependence and amounts of daily smoking. In the combination therapy group, nicotine dependence was significantly decreased by more than those of the other groups. There were no statistically significant differences in decrements of daily smoking and success rate of smoking cessation among the three groups. Conclusions : The above results suggest that auricular acupuncture and transdermal nicotine patch have significant effects of smoking cessation. If they are combined, it is expected that therapies for smoking cessation would be developed.

In Vivo Prediction and Biopharmaceutical Evaluation of Nicotine Transdermal Patch (생체내 예측 및 흰쥐를 이용한 니코틴 패취의 약물동력학적 평가)

  • Lee, Woo-Young;Baek, Seung-Hee;Park, Eun-Seok;Chi, Sang-Cheol
    • Journal of Pharmaceutical Investigation
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    • v.35 no.4
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    • pp.273-278
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    • 2005
  • Nicotine transdermal therapeutic systems $(TTS_S)$ have been regarded as an effective mean to aid smoking cessation. However, most of nicotine $TTS_S$ in the market have some problems such as unpleasant side effects and skin irritation due to the excess amount of the drug permeated and the properties of the additives employed. In order to solve these problems, new nicotine $TTS_S$ were formulated using biocompatible additives. The optimized formula of the drug layer consisted of nicotine, propylene glycol and poloxamer 188 at the ratio of 1.2: 17.0: 2.0. The drug layer had the sickness of $1,250\;{\mu}m$, the pH of 8.12. The skin permeation rate of nicotine from optimized nicotine patch (NP) was $21.5\;{\mu}g/cm^2/h$. Transdermal administration of nicotine patch has been carried out for the determination of pharmacokinetic parameters in rats. Steady-state plasma concentration of nicotine following transdermal application of NP (area of patch = $15\;cm^2$) on the dorsal skin of rats was 143.2 ng/ml and AUC for 24 hrs was 3,022 ng h/ml. In case of $EXODUS^{\circledR}$ and Nicotinell $TTS^{\circledR}$, the steady-state plasma concentration of nicotine and ACU for 24 hrs were 428.9 ng/ml, $9,121\;ng{\cdot}hr/ml$ and 155.3 ng/ml, $3,152\;ng{\cdot}h/ml$, respectively. NP showed the experimental plasma nicotine concentration profile was very similar to the simulated one and had an appropriate skin permeation rate and a steady-state concentration of nicotine, which can show therapeutic blood levels of the drug for 24 hrs without severe side effects.

Bioequivalence of Nicotine Patches (니코틴 패취제의 생물학적 동등성 평가)

  • 배준호;박은석;지상철
    • Biomolecules & Therapeutics
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    • v.5 no.3
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    • pp.260-264
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    • 1997
  • The bioequivalence of two nicotine patches was evaluated in 16 normal male volunteers (age 21 ~ 27 yrs) following single transdermal application. Test product was "Nicostop patch" made by Sam Yang Co. and reference product was "Nicotinell TTS patch" made by Korean Searle Ciba-Geigy Co. After nicotine patches were applied onto the inside of the forearm, blood was taken at predetermined time intervals and the nicotine concentration in plasma was determined with a sensitive GC method using NPD detector. AUC and Cm\ulcorner were calculated and statistically analyzed for the bioequivalence of the two products. The results showed that the differences in AUC and $C_{msx}$between two products were 5.47% and 2.70%, respectively. The powers (1-$\beta$) for AUC and $C_{max}$. were >90% and 88.76%, respectively. Detectable differences($\Delta$) and confidence intervals were all less than 20%. All of these parameters met the criteria of KFDA for bioequivalence, indicating that "Nicostop patch" is bioequivalent to "Nicotinell TTS patch" . . .

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The Effects of Smoking Cessation and Antioxidant Vitamins on Oxidative Stress

  • Ha, Aewha
    • Nutritional Sciences
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    • v.9 no.4
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    • pp.288-294
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    • 2006
  • In this study, the effects of smoking cessation and relative antioxidant activities on the oxidative stress were determined by using in vitro method. Thirty healthy smokers who were free of any disease and smoked more than 1 pack per day for the past 10 years participated in this study. For smoking cessation, smokers were asked to wear nicotine patch (21mg nicotine/ patch) everyday for 30 days and then to replace at the same time of the day. Smoking cessation program in conjunction with nicotine patch replacement was also conducted every week, one hour/each session, for 4 weeks. Canthaxanthin, $\beta-carotene$, and $\alpha-tocopherol$ were added into red blood cells at pre and post smoking cessation. As indicators of oxidative stress, hemoglobin degradation, lipid peroxidation, and percent hemolysis were determined at both pre and post smoking cessation. After 30 days of smoking cessation, the subjects gained an average of 5 pounds, varying 2 to 8 pounds, by suggesting that behavioral problems rather than nicotine itself are more important for gaining weight in ex-smokers. The total hemoglobin concentrations in blood were similar in pre and post smoking cessation, but smoking cessation resulted in a decrease in the percentage of methemoglobin from 0.96% to 0.85% Smoking cessation also caused to decease malondialdehyde (MDA) values ($26.7{\pm}7.8$ vs. $23.6{\pm}4.5$ (without oxidation), $179.3{\pm}21$ vs. $161.2{\pm}28$ nmol/ml (with oxidation) (p<0.05)), not percent hemolysis. Various antioxidants with smoking cessation significantly decreased MDA values(p<0.05), in contrast to marginal decrease of MDA in smoking cessation only. Three antioxidants used in this stu study were similarly effective in inhibiting MDA production, but relative effectiveness of canthaxanthin or $\alpha-tocopherol$ was greater than that of $\beta-carotene$ (p<0.05), in case of oxidation induced. The percent hemolysis was greatly decreased when antioxidants were added into the blood of ex-smokers (p<0.05) but no statistical significance in relative effectiveness of antioxidants was observed.

Progressive nicotine poisoning by multiple transdermal nicotine patches

  • Kang, Jeong Ho;Lee, Sung Kgun
    • Journal of Medicine and Life Science
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    • v.18 no.2
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    • pp.31-34
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    • 2021
  • The pharmacokinetic properties of transdermal nicotine patches (TNPs) are different from those of other routes of nicotine administration; further, acute nicotine poisoning by TNPs may present with different clinical features. In the present report, we describe the case of a 23-year-old woman who was admitted to emergency department (ED) at Jeju National University Hospital with loss of consciousness. Five hours before the ED visit, she used multiple TNPs to attempt suicide. Initially, nausea and vomiting occurred, and the symptoms worsened over time. We immediately removed the TNPs, and the application sites were gently washed with sterile water. The patient's level of consciousness gradually improved, and she fully recovered an altered mental status 5 hours later. Her initial urinary cotinine level was 324 ng/mL. Physicians should be aware that acute nicotine poisoning by TNPs can cause various toxic symptoms.

Factors Related to the Recognition and Behavioral Intention for Smoking Cessation Programs (금연프로그램에 대한 인지도, 이용의도 및 영향요인)

  • 장혜정;노맹석
    • Korean Journal of Health Education and Promotion
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    • v.20 no.3
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    • pp.1-18
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    • 2003
  • This study was conducted to evaluate factors related to the recogniton and behavioral intention for smoking cessation programs. Five effective smoking cessation programs were considered: acupuncture, nicotine patch, clinic program, mass education, and alliance programs. To explain the health behavior for smoking and smoking cessation programs, a five-stage behavioral intention model was built, and 500 questionnaires were completed through a telephone survey. Stages of the model included recogniton of the programs, past experiences, present smoking status, intention for smoking, and behavioral intention for smoking cessation programs. The results showed that the recogniton rate of the programs were low in general, therefore strategies of education, public relations, and advertisement need to be pursued. Nicotine dependency resulted in the fact that success rates were low although trial rates of smoking cessation were high among smokers. The necessity for smoking cessation programs was suggested. And the significant factors related to the intention for smoking cessation were individual attitude and reluctancy to pay time and money. Others' attitude was insignificant to subjects' smoking cessation. Purchase rates for nicotine patches were 11.3% for male and 27.3% for female, those for acupunture were 7.6% for male and 10.0% for female. There were very low purchase rates for clinic, mass education, and alliance programs. In conclusion, evidence-based and effective smoking cessation programs need to be promoted by medical doctors. Strategies in education, public relations, and advertisement also need development. In addition, continuing legal and systematic support for smoking cessation would lower the smoking rate and ultimately contribute to the nation's health.

Effects of Smoking Cessation Program for Male University Students: Perceived Nicotine Dependency and Self-efficacy (남자 대학생을 위한 금연프로그램의 효과 - 니코틴 의존도와 자기효능감을 중심으로 -)

  • Chaung, Seung-Kyo;Kim, Chun-Gill
    • Korean Journal of Adult Nursing
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    • v.17 no.2
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    • pp.219-229
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    • 2005
  • Purpose: The purpose of this study was to evaluate the effectiveness of 8 weeks smoking cessation program(SCP) developed by researchers. Method: One group pretest-posttest design was used in this study. The subjects were 88 male university students who consented to participate in the 8 weeks SCP. The SCP in this study consisted of a stop-smoking class, e-mail, SMS(short message service), cellular phone, internet cafe, displayed panel, and patch or acupuncture for quitting smoking. Korean version of questionnaire for nicotine dependency by Ahn et al.(2002), the smoking self-efficacy scale translated by Choi(1999) and subjects' opinion about the SCP were measured. The data were analyzed by using frequency, Chi-Square test, paired t-test and repeated measures ANOVA with SPSS WIN 10.1 Program. Results: 1) The rate of quitting smoking was 31.8% after 8 weeks SCP. 2) There was no significant decrease in the nicotine dependency score among smoking subjects after SCP. 3) There was a significant increase in self-efficacy after SCP. The mean score of self -efficacy in the quitting smoking group increased significantly, but did not significantly change in the smoking group. 4) The stop-smoking class was the most helpful among contents of the SCP. Contents of the SCP except for internet cafe were useful for quitting smoking in this study. Conclusion: The above results indicated that the 8 weeks SCP would be a helpful intervention to quit smoking for male university students.

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Erratum

  • 대한한방신경정신과학회
    • Journal of Oriental Neuropsychiatry
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    • v.24 no.3
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    • pp.321-330
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    • 2013
  • Voice Handicap Index and Voice-Related Quality of Life in Idiopathic Parkinson's Disease 10.7231/jon.2013.24.2.155, The Differences of Learning Characteristics in Sasang Constitution 10.7231/jon.2013.24.2.163, A Preliminary Comparison of the Efficacy of Auricular Acupuncture, Transdermal Nicotine Patch and Combination Therapy for Smoking Cessation 10.7231/jon.2013.24.2.179, The Effects of OnDam-tang-Kami-bang (ODK) in Antioxidant and Serotonin Metabolism Testing on P815 Cell 10.7231/jon.2013.24.2.189

The Satisfaction Study on a Specialized Treatment Type Smoking Cessation Camp Conducted by a Korean Medicine Hospital (한방병원에서 시행한 전문치료형 금연캠프 프로그램에 대한 만족도 연구)

  • Jeon, Cheon-hoo;Lyu, Yee-ran;Park, Ji-hye;Lee, Jin-yong;Ahn, Woo-sang;Park, Yang-chun;Cho, Chung-sik
    • The Journal of Internal Korean Medicine
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    • v.39 no.4
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    • pp.741-750
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    • 2018
  • Objectives: To evaluate the degree of satisfaction about a specialized treatment type smoking cessation camp conducted by a Korean medicine hospital. Methods: The subjects of this study were 112 patients who enrolled smoking cessation camp from September 2015 to December 2017 at ${\bigcirc}{\bigcirc}$ Korean medicine hospital of ${\bigcirc}{\bigcirc}$ University. Patients received Korean medical treatment, including acupuncture, herbal medicine, counseling, education, stretching, hand and foot baths, and hiking. Each patient filled in a satisfaction survey after completion of the camp. Results: Drug satisfaction of the nicotine patch was $8.0{\pm}1.9$ points, nicotine gum was $7.5{\pm}2.6$ points, Cheongpye-tang was $7.8{\pm}2.5$ points, and Bopye-tang was $7.6{\pm}2.8$ points. Acupuncture was the most favorable treatment among the 12 programs, followed by education and herbal medicine. Confidence after the camp was $8.8{\pm}1.4$ points compared to $6.6{\pm}2.4$ points before the camp. An appropriate period for the camp was 7 days (40%). Conclusions: After participating in the smoking cessation camp, most patients feel considerable satisfaction. Further study is required.

Factors Associated with Success of Smoking Cessation during 6 Months (6개월 금연 성공의 영향 요인 연구 - 인천광역시 보건소 금연클리닉을 방문한 흡연자를 중심으로 -)

  • Lee Kun-Ja;Chang Chun-Ja;Kim Myung-Soon;Lee Myung-Hee;Cho Young-Hee
    • Journal of Korean Academy of Nursing
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    • v.36 no.5
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    • pp.742-750
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    • 2006
  • Purpose: This study was to identify which factors are likely to influence the effectiveness of smoking cessation on adults who smoke in Metropolitan Incheon. Method: Data from 9,083 smokers, who visited a smoking cessation clinic of a public health center from Jan. to Oct. 2005, were provided by the Korean Health Research Society, Among 9,083 smokers, 1,495 people were selected for follow up care at 6 months in order to analyze the differences between two groups one is a successful group and the other is a failure group. Results: The successful group included 639 people and the failure group 856 people. In the demographic profiles such as sex, age and motive registration, there was a significant difference between the two groups. In the view of smoking pattern and factors such as the expiratory CO level, the age of starting to smoke, the duration of smoking, alcohol, and dependence on alcohol use and nicotine, there were significant differences between the two groups. The smoking cessation method, results of uni variate analysis, the total number of visits to the smoking cessation clinics, and the use of nicotine gum or a patch(stage 1, stage 2) were significantly different in the two groups. Conclusion: The results of multi variate analysis have shown that the factors associated with the success for smoking cessation is the total number of visits to the smoking cessation clinic, and the dependence on alcohol.