• Clinical and Experimental Pediatrics
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• v.63 no.6
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• pp.195-202
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• 2020

Developments in next-generation sequencing (NGS) techogies have assisted in clarifying the diagnosis and treatment of developmental delay/intellectual disability (DD/ID) via molecular genetic testing. Advances in DNA sequencing technology have not only allowed the evolution of targeted panels but also, and more currently enabled genome-wide analyses to progress from research era to clinical practice. Broad acceptance of accuracy-guided targeted gene panel, whole-exome sequencing (WES), and whole-genome sequencing (WGS) for DD/ID need prospective analyses of the increasing cost-effectiveness versus conventional genetic testing. Choosing the appropriate sequencing method requires individual planning. Data are required to guide best-practice recommendations for genomic testing, regarding various clinical phenotypes in an etiologic approach. Targeted panel testing may be recommended as a firsttier testing approach for children with DD/ID. Family-based trio testing by WES/WGS can be used as a second test for DD/ID in undiagnosed children who previously tested negative on a targeted panel. The role of NGS in molecular diagnostics, treatment, prediction of prognosis will continue to increase further in the coming years. Given the rapid pace of changes in the past 10 years, all medical providers should be aware of the changes in the transformative genetics field.

• Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
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• v.24 no.8
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• pp.70-77
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• 2010

This paper presents the current and speed controller design procedure and their performance for the IPMSM based next generation high speed railway traction system. The next generation high speed railway system is a power distributed type and uses vector control method for a motor speed control. Since the speed and current controller gains of the vector control system directly affects to the transient characteristics and speed control capability, the systematic design of the controllers are required. In this paper the controllers are designed using the IPMSM based next generation high speed railway system parameters. Simulation programs based on Matlab/Simulink is developed. Finally the controller characteristics are analyzed by the simulation results.

• Proceedings of the Korean Institute Of Construction Engineering and Management
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• 2007.11a
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• pp.943-946
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• 2007

Recently, lots of research are going on relation to Improving the Flexibility through all of construction I industry in that space, materials, structure, construction method, etc. The style , space and pattern of housing have been changing by reason that satisfying change of residential environment at the needs of the times, transformation of future-oriented construction trend and recognition of demand-oriented. Therefore, this study should suggest alternations through comparing and analyzing to construction factor of improving the Flexibility, and then should show direction and guideline for realizing actual a long life housing at the next generation through applicable and various classification examples in apartment housing.

• Advances in Computational Design
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• v.8 no.1
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• pp.1-12
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• 2023

To consider the effects of the increasing speed of next-generation high-speed trains, the existing traffic safety code for railway bridges needs to be improved. This study suggests a numerical method of evaluating the new effects of this increasing speed on railway bridges. A prestressed concrete (PSC) box bridge with a 40 m span length on the Gyeongbu track sector is selected as a representative example of high-speed railway bridges in Korea. Numerical models considering the inertial mass forces of a 38-degree-of-freedom train and the interaction forces with the bridge as well as track irregularities are presented in detail. The vertical deflections and accelerations of the deck are calculated and compared to find the new effects on the bridge arising with increasing speed under simply and continuously supported boundary conditions. The ratios between the static and dynamic responses are calculated as the dynamic amplification factors (DAFs) under different running speeds to evaluate the traffic safety. The maximum deflection and acceleration caused by the running speed are indicated, and regression equations for predicting these quantities based on the speed are also proposed.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.48 no.1
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• pp.3-12
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• 2022

Selection of potential disease-specific biomarkers from saliva or epithelial tissues through next generation sequencing (NGS)-based protein studies has recently become possible. The early diagnosis of oral squamous cell carcinoma (OSCC) has been difficult, if not impossible, until now due to the lack of an effective OSCC biomarker and efficient molecular validation method. The aim of this study was to summarize the advances in the application of NGS in cancer research and to propose potential proteomic and genomic saliva biomarkers for NGS-based study in OSCC screening and diagnosis programs. We have reviewed four categories including definitions and use of NGS, salivary biomarkers and OSCC, current biomarkers using the NGS-based technique, and potential salivary biomarker candidates in OSCC using NGS.

• Journal of Chest Surgery
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• v.57 no.4
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• pp.408-412
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• 2024

Fetal lung interstitial tumor (FLIT), which is characterized by immature interstitial cells resembling the fetal lung parenchyma of 20 to 24 weeks of gestation, is a rare respiratory neoplasm. This study presents the first reported FLIT in Korea. It also aims to refine the diagnostic method of FLIT and increase the accuracy of prognostic assessment by using next-generation sequencing to check for anaplastic lymphoma receptor tyrosine kinase (anaplastic lymphoma kinase) gene rearrangement. Although the initial prognosis for FLIT has been promising since its first report in 2010, certain pathological features are associated with poorer outcomes. Therefore, achieving an accurate diagnosis of FLIT is crucial for avoiding unnecessary treatments beyond surgical resection.

• Archives of Metallurgy and Materials
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• v.65 no.3
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• pp.1035-1039
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• 2020

U-10wt.%Zr-5wt.%RE fuel slugs for a sodium-cooled fast reactor (SFR) were conventionally prepared by a modified injection casting method, which had the drawback of a low fabrication yield rate of approximately 60% because of the formation of many metallic fuel scraps, such as melt residue and unsuitable fuel slug butts. Moreover, the metallic fuel scraps were classified as a radioactive waste and stored in temporary storage without recycling. It is necessary to develop a recycling process technology for scrap wastes in order to reduce the radioactive wastes of the fuel scraps and improve the fabrication yield of the fuel slugs. In this study, the additive recycling process of the metallic fuel scraps was introduced to re-fabricate the U-10wt.%Zr-5wt.%RE fuel slugs. The U-10wt.%Zr-5wt.%RE fuel scraps were cleaned on the surface impurity layers with a mechanical treatment that used an electric brush under an Ar atmosphere. The U-10wt.%Zr-5wt.%RE fuel slugs were soundly re-fabricated and examined to evaluate the feasibility of the additive process compared with the metallic fuel slugs that used pure metals.

• Proceedings of the Korean Magnestics Society Conference
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• 2008.12a
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• pp.183.1-183.1
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• 2008

• Proceedings of the Korean Institute of Navigation and Port Research Conference
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• 2017.11a
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• pp.115-116
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• 2017

In this paper, we propose a standardization strategy for next generation electronic navigational chart which can be classified as S-100 Universal Hydrographic Data Model, to accept various requirements arising from various marine information and services as well as support e-navigation service strategies. IMO uses the next generation electronic chart standard, S-100 as Common Maritime Data Structure. It means that a common data model is needed as a key element for realization of e-Navigation and also points out that a new ICT convergence paradigm is needed not only for marine safety but also for maritime information and services. this paper considers he model-based data representation and reference model in order to understand the content and use of the S-100 standard and also considers the interconnectivity and role of the ISO/TC211 standards, which are being used as base standards for profiling to develop S-100 standard. Finally, we look at what standardization items are required for standardization of next generation electronic navigational chart supporting multi-purpose and how they are used mutually.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.28 no.5A
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• pp.284-293
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• 2003

Location service is usually provided by the GPS method using satellites. In the next generation mobile communication systems which use smart antennas, location service can be accomplished using direction of arrival (DOA) estimation techniques. In this paper, we propose a DOA estimation technique for the location service of the next generation mobile communication systems and investigate the validity of the proposed technique through computer simulation. First, DOA estimation problems of distributed sources are considered using vortical and horizontal array processors which are orthogonal to each other. The DOA of the elevation angle is estimated by the vertical array processor and then that of the azimuth angle is estimated by the horizontal array processor. Finally, the procedures of the location service for specific signal sources using three smart antennas are exhibited by computer simulation to show that the proposed DOA estimation technique can be used for the location service in the next generation mobile communication systems.