Journal of Chest Surgery

The Korean Society for Thoracic and Cardiovascular Surgery (대한심장혈관흉부외과학회)
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Fetal Lung Interstitial Tumor: A Comprehensive Case Study with an Emphasis on Next-Generation Sequencing

  • Yoo Jin Jung (Department of Thoracic and Cardiovascular Surgery, Seoul National University Hospital, Seoul National University College of Medicine) ;
  • Seongyeon Jung (Department of Pathology, Seoul National University Hospital, Seoul National University College of Medicine) ;
  • Jiwon Koh (Department of Pathology, Seoul National University Hospital, Seoul National University College of Medicine) ;
  • Jaemoon Koh (Department of Pathology, Seoul National University Hospital, Seoul National University College of Medicine) ;
  • Yoon Kyung Jeon (Department of Pathology, Seoul National University Hospital, Seoul National University College of Medicine) ;
  • Sung-Hye Park (Department of Pathology, Seoul National University Hospital, Seoul National University College of Medicine) ;
  • Eun Na Kim (Department of Pathology, Seoul National University Hospital, Seoul National University College of Medicine) ;
  • Chang Hyun Kang (Department of Thoracic and Cardiovascular Surgery, Seoul National University Hospital, Seoul National University College of Medicine)
  • Received : 2023.11.06
  • Accepted : 2023.12.26
  • Published : 2024.07.05
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Abstract

Fetal lung interstitial tumor (FLIT), which is characterized by immature interstitial cells resembling the fetal lung parenchyma of 20 to 24 weeks of gestation, is a rare respiratory neoplasm. This study presents the first reported FLIT in Korea. It also aims to refine the diagnostic method of FLIT and increase the accuracy of prognostic assessment by using next-generation sequencing to check for anaplastic lymphoma receptor tyrosine kinase (anaplastic lymphoma kinase) gene rearrangement. Although the initial prognosis for FLIT has been promising since its first report in 2010, certain pathological features are associated with poorer outcomes. Therefore, achieving an accurate diagnosis of FLIT is crucial for avoiding unnecessary treatments beyond surgical resection.

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References

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