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http://dx.doi.org/10.5125/jkaoms.2022.48.1.3

Next generation sequencing-based salivary biomarkers in oral squamous cell carcinoma  

Sodnom-Ish, Buyanbileg (Department of Oral and Maxillofacial Surgery, School of Dentistry, Dental Research Institute, Seoul National University)
Eo, Mi Young (Department of Oral and Maxillofacial Surgery, School of Dentistry, Dental Research Institute, Seoul National University)
Myoung, Hoon (Department of Oral and Maxillofacial Surgery, School of Dentistry, Dental Research Institute, Seoul National University)
Lee, Jong Ho (Department of Oral and Maxillofacial Surgery, School of Dentistry, Dental Research Institute, Seoul National University)
Kim, Soung Min (Department of Oral and Maxillofacial Surgery, School of Dentistry, Dental Research Institute, Seoul National University)
Publication Information
Journal of the Korean Association of Oral and Maxillofacial Surgeons / v.48, no.1, 2022 , pp. 3-12 More about this Journal
Abstract
Selection of potential disease-specific biomarkers from saliva or epithelial tissues through next generation sequencing (NGS)-based protein studies has recently become possible. The early diagnosis of oral squamous cell carcinoma (OSCC) has been difficult, if not impossible, until now due to the lack of an effective OSCC biomarker and efficient molecular validation method. The aim of this study was to summarize the advances in the application of NGS in cancer research and to propose potential proteomic and genomic saliva biomarkers for NGS-based study in OSCC screening and diagnosis programs. We have reviewed four categories including definitions and use of NGS, salivary biomarkers and OSCC, current biomarkers using the NGS-based technique, and potential salivary biomarker candidates in OSCC using NGS.
Keywords
Next generation sequencing; Saliva; Biomarkers; Early diagnosis; Oral squamous cell carcinoma;
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