• 한국자기공명학회논문지
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• 제17권1호
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• pp.47-53
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• 2013

Four new cyclic peroxide compounds (1~4) were isolated from the marine sponge Plakortis simplex. Their structures including relative stereochemistry were determined by MS and NMR analysis. All compounds, a side carbon chain with 10 carbons, were very unstable. After transformation into methyl ester analogues, the structure determination was conducted. Compounds 1a and 2a are stereoisomers, assigned as $3S^*$, $4S^*$, $6R^*$ and $3R^*$, $4S^*$, $6R^*$, respectively. Similarly, compounds 3a and 4a, replaced the methoxy group with an aliphatic methyl, are also stereoisomers. Compounds 1a and 2a exhibited the strong antifungal effect against the fungus Candida albicans.

• Fisheries and Aquatic Sciences
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• 제8권1호
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• pp.6-9
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• 2005

Two new cyclic peroxides were isolated from an undescribed sponge of the genus Plakortis sp. collected at Discovery Bay, Jamaica. The molecular structures were elucidated by interpreting ID and 2D NMR and HRMS data. The cyclic peroxides, Compound 1 and 2, exhibited significant antimicrobial activity against pathogenic bacteria and fungi with IC$_${50} values of 0.9-5.0$\mug/mL and 0.7-8.0$\mug/mL, respectively.

• 한국자기공명학회논문지
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• 제27권4호
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• pp.35-41
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• 2023

From a marine sponge Dysidea species, four new furanosesquiterterpenoids were isolated and characterized. Their structural elucidation was achieved through an extensive analysis employing NMR, MS data, and DFT method. Notably, all compounds shared as identical molecular formula. Compound 2 was identified as a derivative of compound 1, while compounds 3 and 4 exhibited an identical planar structure. Determination of the configurations of chiral centers in compounds 1 and 2 involved a comparative analysis between measured and calculated ECD spectra, along with the application of DP4+ probability analysis. Distinctly, the configurations of isomers 3 and 4 were established by scrutinizing proton chemical shifts based on the NOE correlation.

• 한국식품영양과학회지
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• 제32권8호
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• pp.1278-1284
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• 2003

본 연구에서는 김 분말을 첨가하여 기능성 스폰지 케이크를 제조하였을 때의 반죽특성 및 제품의 물리화학적 변화와 상품화 가능성을 조사하였다. 김 스폰지 케이크의 수분함량은 대조구와 김 분말 2,4,6% 첨가시는 차이를 나타내지 않았으나, 8 및 10% 첨가시에는 증가하였으며, 단백질함량, 회분함량도 각각 유의적으로 증가하였다. 비중은 김의 첨가량이 증가할수록 증가하였으며, 김분말 10% 첨가시에는 0.674로서 케이크의 부피가 크게 감소함을 알 수 있었다. 무기질은 Ca와 Na 성분이 가장 많았다. Crust의 L, a, b값은 모두 대조구에 비하여 감소하였으며, crumb의 L과 b값도 유의 적으로 감소하였다. 유리아미노산의 함량은 김분말 첨가량이 증가함에 따라 높게 나타났으며, L-glutamic acid, L-alanine, L aspartic acid 및 L-leucine등의 순으로 검출되었다. 경도(hardness), 탄력성(springiness), 응집성(cohesiveness), 점성(gumminess), 씹힘성(chewiness), 복원성(resilience)은 김분말 첨가량이 증가할수록 높은 값을 나타내었고, 스폰지 케이크의 외관은 작아졌으며, 주사현미경 관찰 결과 기공이 작아지고 큰 입자의 air cell이 나타났다 또한 부착성, 냄새, 입에서의 느낌, 촉촉함 및 종합적인 관능검사 항목으로 보아 스폰지 케이크의 김분말 최적 첨가량은 2%가 적당하였다.

• Archives of Plastic Surgery
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• 제38권2호
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• pp.155-160
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• 2011

Purpose: Fibrillar collagens like type I collagen, are the major constituent of the extracellular matrix and structural protein of bone. Also, it can be a scaffold for osteoblast migration. The purpose of this study is to estimate the effects of absorbable atelo-collagen sponge (Teruplug$^{(R)}$, Terumo biomaterials Co., Tokyo, Japan) insertion in tooth extraction sites on periodontal healing of the second molar, healing of the fractured mandibular bone and new bone formation of third molar socket after the extraction of the impacted third molar with mandibular angle fracture. Methods: In our study of six cases of mandibular angle fractures, all of them underwent the extraction of the third molar tooth & absorbable atelo-collagen sponge insertion in tooth extraction site. Three of them had a intraoral infection & oral opening to fracture site, two of the six had dental caries, and only one had reduction problem due to third molar position. Six consecutive patients with noncomminuted fractures of the mandibular angle were treated by open reduction and internal fixation using one noncompression miniplates and screws placed through a transoral incision. Results: All of the patients have showed good postoperative functions and have not experienced complications requiring second surgical intervention. There was well healing of the mandibular bone and the most new bone formation of third molar socket after the extraction of the impacted third molar with mandibular angle fracture. Conclusion: The results of this study suggest that absorbable atelo-collagen sponge is relatively favorable bone void filler with prevention of tissue collapse, food packing, and enhance periodontal healing. Thus, the use of atelo-collagen sponge and one noncompression miniplate seems to be relatively easy, safe, and effective for the treatment of fractures of the mandibular angle and third molar extraction.

• Bulletin of the Korean Chemical Society
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• 제30권1호
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• pp.188-192
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• 2009

New $\alpha$-pyrones (1 and 2) and cyclohexenones (13 and 14) were isolated along with known analogues (3, 5−12) from the ethyl acetate extract of the whole broth of the fungus Paecilomyces lilacinus, a strain derived from a marine sponge Petrosia sp. Their structures were established by interpretation of 1D and 2D NMR, and FABMS data. It is interesting to isolate cyclohexenone derivatives from the genus Paecilomyces (family Trichocomaceae, order Eurotiales), since these cyclohexenones were previously reported only from far distinct genera, Phoma and Alternaria (family Pleosporaceae, order Pleosporales). Compounds 6, 7, and 9 were evaluated for cytotoxicity against a small panel of human solid tumor cell lines. Their cytotoxicity was insignificant upto a concentration of 30 ${\mu}g/mL$.

• 생약학회지
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• 제44권3호
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• pp.224-229
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• 2013

Bromotopsentin (BSM) is a bisindole alkaloid compound, which is recognized as a metabolite of the marine sponge Spongosorites sp. In this study, the antioxidant activity of BSM was investigated. The 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging assay, the trolox equivalent antioxidant capacity (TEAC) assay, the superoxide radical scavenging (NBT) assay, the lipid peroxidation and hydroxyl radical-induced DNA damage assays were carried out to evaluate the antioxidant activity of BSM. It was found that BSM had stronger scavenging activity on the stable free radical DPPH and superoxide radical than L-ascorbic acid with an $IC_{50}$ value of 62 and 64 ${\mu}M$, respectively. The TEAC value which indicated the total antioxidant capacity of BSM was about 0.8, which was also stronger than L-ascorbic acid. About 1.3 ${\mu}M$ of BSM induced 50% inhibition of lipid peroxidation. 60 nM of BSM exhibited a significant protective activity against DNA strand scission by hydroxyl radical on pBR322 DNA. Taken together, we suggest that BSM possesses strong antioxidant activity, and could be a valuable new addition to the list of anti-aging chemotherapeutic agents.

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 1995년도 춘계학술대회
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• pp.64-64
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• 1995

Cholesteryl Ester Transfer Protein (CETP) mediates the transfer of cholesterol ester and triglyceride between high-density lipoprotein (HDL) and other low-density lipoproteins, therefore, it might influence HDL levels. The levels of HDL is closely related to the atherogenic diseases in human and there were several reports that the trasgenic mice expressing CETP had much worse atherosclerosis than non-expressing control one. Therefore, selective inhibitors of CETP have the potential to be used as antiatherosclerotic agents. Continued screening for potent inhibitors of CETP led to the isolation of Suberitenone B from marine sponge. Suberitenone B, sesterterpenoids of a new skeletal class have been isolated from the sponge Suberites sp. collected from King George Island the Antartic. The structure of the metabolite has been determined by NMR experiments and chemical methods.

• Animal Systematics, Evolution and Diversity
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• nspc2호
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• pp.223-232
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• 1988

한국 남해에서 채집된 성게에 부착한 유병 만각류 1신종 Paralepas phyllacanthusi와 해면속에 사는 무병 만각류 2신종 Acasta paraspinifera 및 A. chejudoensis를 기재한다.

• Animal Systematics, Evolution and Diversity
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• 제14권1호
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• pp.35-42
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• 1998

제주도와 남해도에서 채집된 모래해면속의 3신종, Psammocinia mammiformis, P. mosulpia, 그리고 P. jejuensis를 기재한다. 모래해면속의 특징은 많은 양의 모래입자가 그들의 섬유나 기질안에 포함되어 있거나 또는 해면의 표면에 모래껍질로서 포함되어 있는 것이 특징이다.