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http://dx.doi.org/10.5012/bkcs.2009.30.1.188

α-Pyrones and Yellow Pigments from the Sponge-Derived Fungus Paecilomyces lilacinus  

Elbandy, Mohamed (College of Pharmacy, Pusan National University,Department of Food Sciences and Technology, Faculty of Environmental Agricultural Sciences, Suez Canal University)
Shinde, Pramod B. (College of Pharmacy, Pusan National University)
Hong, Jong-Ki (College of Pharmacy, Kyung Hee University)
Bae, Kyung-Sook (Korea Research Institute of Chemical Technology)
Kim, Mi-Ae (College of Pharmacy, Pusan National University)
Lee, Sang-Mong (College of Natural Resources and Life Science, Pusan National University)
Jung, Jee H. (College of Pharmacy, Pusan National University)
Publication Information
Bulletin of the Korean Chemical Society / v.30, no.1, 2009 , pp. 188-192 More about this Journal
Abstract
New $\alpha$-pyrones (1 and 2) and cyclohexenones (13 and 14) were isolated along with known analogues (3, 5−12) from the ethyl acetate extract of the whole broth of the fungus Paecilomyces lilacinus, a strain derived from a marine sponge Petrosia sp. Their structures were established by interpretation of 1D and 2D NMR, and FABMS data. It is interesting to isolate cyclohexenone derivatives from the genus Paecilomyces (family Trichocomaceae, order Eurotiales), since these cyclohexenones were previously reported only from far distinct genera, Phoma and Alternaria (family Pleosporaceae, order Pleosporales). Compounds 6, 7, and 9 were evaluated for cytotoxicity against a small panel of human solid tumor cell lines. Their cytotoxicity was insignificant upto a concentration of 30 ${\mu}g/mL$.
Keywords
Sponge-derived fungus; Paecilomyces lilacinus; Pyrones; Cyclohexenones;
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