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Four new cyclic peroxides from the Marine Sponge Plakortis simplex  

Hwang, Buyng Su (Department of Oceanography, Kunsan National University)
Rho, Jung-Rae (Department of Oceanography, Kunsan National University)
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Journal of the Korean Magnetic Resonance Society / v.17, no.1, 2013 , pp. 47-53 More about this Journal
Four new cyclic peroxide compounds (1~4) were isolated from the marine sponge Plakortis simplex. Their structures including relative stereochemistry were determined by MS and NMR analysis. All compounds, a side carbon chain with 10 carbons, were very unstable. After transformation into methyl ester analogues, the structure determination was conducted. Compounds 1a and 2a are stereoisomers, assigned as $3S^*$, $4S^*$, $6R^*$ and $3R^*$, $4S^*$, $6R^*$, respectively. Similarly, compounds 3a and 4a, replaced the methoxy group with an aliphatic methyl, are also stereoisomers. Compounds 1a and 2a exhibited the strong antifungal effect against the fungus Candida albicans.
1D and 2D NMR; Plakortis simplex; stereoisomer; cyclic peroxide; antifungal activity;
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