• YAKHAK HOEJI
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• v.52 no.2
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• pp.151-159
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• 2008

Consultation program for pharmaceutical development is a new system in which pharmaceutical companies meet and discuss scientific and/or regulatory issues with drug regulatory authority in the research process and before submitting new drug applications. This program helps pharmaceutical companies reduce uncertainties in the research and development and increase the possibilities of getting drug marketing approval. Developed countries such as US, EU, and Japan have implemented various forms of pre-submission meetings or consultation programs since the mid-1990s. The rapid development of technology in pharmaceutical R&D increases the importance of communication between drug development companies and drug regulatory authority in Korea, too. In designing the consultation program, it is desirable to focus on the stages of clinical trials which take the longest period of time and the biggest amount of money in the pharmaceutical R&D process. We suggested that results or recommendations by drug regulatory authorities in pre-submission meetings or consultations be formally documented and considered in review process. Explicit scientific reasons are required for changing the results from consultations.

• The Korean Journal of Emergency Medical Services
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• v.14 no.2
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• pp.57-69
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• 2010

Purpose : The National Registry Exam had some problems on validity of EMT evaluation and verification. The aim of this study was to propose a New EMT National Registry Exam. Methods : Conducted using the Delphi Method(lst meeting March 29 in 2008, 2nd meeting May 31 in 2008, 3rd meeting September 20 in 2008, 4th meeting January 16 in 2009) from questionnaire data(391 from Paramedic, 317 from Basic EMT) collected between June 16-30(lst questionnaire) and October 16-30(2nd questionnaire) in 2008 and a public hearing on February 5 in 2009. Results: The subjects proposed at the request of the National Health Personnel Licensing Examination Board were Introduction, Medical+Trauma Emergencies(Paramedic & Basic) for written examination and scenarios+protocols(Paramedic), protocols(Basic) for practical examination. Conclusion : To be able to response patients' problems in various emergencies, this integrated examination was selected and proposed.

• Journal of Fisheries and Marine Sciences Education
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• v.28 no.4
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• pp.994-1005
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• 2016

Expansion and spreading of marine telemedicine is rather restricted due to the conflict of laws relating to medical service and lack of provisions in the Seafarers' Act, Medical Service Act, etc. Thus, this study is intended to reveal the current status and problems of marine emergency medical advice system for the furtherance of health care of seafarers and emergency medical assistance conditions and deduce relevant proposals for legislative improvements thereof in order to resolve underlying problems and issues. The results of this study can be summated as follows. First, in respect of directions to provide marine emergency service based on marine telemedicine system, emergency radio medical advice system needs to be strengthened to meet domestic and international instrument, marine telemedicine system needs to be provided through integrating u-Health technology and special marine medical center needs to be established. Second, regarding directions to provide health promotion service based on the marine telemedicine system, a new process of health care service for seafarers needs to be devised and provided involving seafarers' life cycle covering from prior to boarding to after leaving a ship. The conclusions of this study can be given as follows. First, the following new provisions need to be introduced in the Seafarers' Act. (1) The Minister of Oceans and Fisheries and a shipowner shall conduct matters pertaining to preventive health promotion and care for seafarers; (2) a provisions regarding establishment of seafarers' health promotion center by the Minister; (3) a special exemption permitting marine telemedicine service and qualification requirements for marine telemedicine assistant; (4) shipowner's obligation of carrying seafarers' health measuring equipment on board. Second, the relevant provisions regarding medical care persons needs to be revised in such a way that master or chief officer shall be appointed to be in charge of medical care on board. Last but not least, it is also essential to amend and update the minimum standards on drug and medicines to be carried on board and medicine chest and equipment on board.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.8 no.2
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• pp.406-423
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• 2014

The recent advances in wireless communication systems and semiconductor technologies are paving the way for new applications over wireless sensor networks. Health-monitoring application (HMA) is one such emerging technology that is focused on sensing and reporting human vital signs through the communication network comprising sensor devices in the vicinity of the human body. The sensed vital signs can be divided into two categories based on the importance and the frequency of occurrence: occasional emergency signs and regular normal signs. The occasional emergency signs are critical, so they have to be delivered by the specified deadlines, whereas the regular normal signs are non-critical and are only required to be delivered with best effort. Handling the occasional emergency sign is one of the most important attributes in HMA because a human life may depend on correct handling of the situation. That is why the underlying network protocol suite for HMA should ensure that the emergency signs will be reported in a timely manner. However, HMA based on IEEE 802.15.4 might not be able to do so owing to the lack of an appropriate emergency-handling mechanism. Hence, in this paper, we propose a new emergency-handling mechanism to reduce the emergency reporting delay in IEEE 802.15.4 through the modified superframe structure. A fraction of an inactive period is modified into three new periods called the emergency reporting period, emergency beacon period, and emergency transmission period, which are used opportunistically only for immediate emergency reporting and reliable data transmission. Extensive simulation is performed to evaluate the performance of the proposed scheme. The results reveal that the proposed scheme achieves improved latency and higher emergency packets delivery ratio compared with the conventional IEEE 802.15.4 MAC.

• Proceedings of the SCSK Conference
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• 2003.09b
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• pp.245-252
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• 2003

There have been many kinds of hair styling sprays with various setting effects. Consumers have used strong setting effect hair sprays to get a long lasting hold. In recent years, however, more and more consumers have come to prefer a "soft ＆ natural" touch feeling, keeping the same long lasting hold. Nonetheless, the existing approaches to this feature could not respond to the consumers′ needs, since products lose the hold strength if the soft feeling is pursued, and vice versa. We have researched and developed a new products to attain a compatible feature with both long lasting hold and natural feeling. Then, we have developed a new multifunctional hair styling material "Poly Amino Acid Derivative (PAAD)." We have focused on the PAAD′s feature that highly diffuses onto a hair and makes thin and even layer on a hair, and have made trials and errors to improve holding strength. "P AAD" excellently makes hair memorize its curl shape which is as the same effect as existing ordinary acrylic resin. Further more, it leaves a soft and natural touch feeling on the hair. We have accomplished a new Poly Amino Acid Derivative with ambivalent features, "soft ＆ natural finish" and "long lasting hold ", and now we report about it.

• Analytical Science and Technology
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• v.32 no.5
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• pp.196-209
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• 2019

As a traditional method to apply fingerprint powder, brush method ("dusting") can create a risk to the health of crime scene investigators due to the inhalation toxicity of harmful and fine powders. Therefore, as a new method of applying powders, we tried to evaluate the potential of a chamber method for the development of latent fingerprint using fans in a closed chamber with a fixed capacity that can prevent the powders from being blown outside and exposed to the users, by comparing with the development results of the conventional brush method. Fingerprints on glass and plastic (PET) were extracted with black powder and green fluorescent powder, and the sharpness and minutiae of the developed fingerprints were compared for each method. The results of the black powder showed similar results, but the effect of the chamber method was slightly decreased when the green fluorescent powder was used. In order to improve the development with the green fluorescent powder, the mixture (50 : 50) of the fluorescent powder with the silica gel was tested and the results were similar to those of the brush method. It is expected that the chamber method has a high potential as a new powder application method considering the health of the crime scene investigator after fine tuning of development conditions with additional studies.

• Journal of Korean society of Dental Hygiene
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• v.11 no.2
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• pp.149-158
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• 2011

Objectives : The objective of this study was to analyze cognition and status of oral health education of dental hygienists who manage the patients visiting dental clinics and to utilize the findings as continuous study data required for development of systematic oral health education program for management of peridontal disease of adults. Methods : Survey was carried out for 261 dental hygienists working in dental clinics who are performing oral health education of patients with peridontal disease living. Results : 1. In the socio-dynamic diagnosis, it was analyzed that, the younger the age is and the lower the career is, the more the work is centered around assisting medical treatment job and, the older the age is and the higher the career is, the work is centered around oral health education job. 2. In the behavioral diagnosis, it was analyzed that, as to source of knowledge acquisition, guide of dentists and senior dental hygienists was the highest and, as to education media, visual education and demonstration education were mainly used. 3. In educational diagnosis, as to the degree of knowledge about oral health education and the degree of practice, it showed that the degree of knowledge was lower than the degree of practice in peridontal disease process and oral prophylaxis as well as scaling part. 4. In both the cases of independent practice and group practice, it showed that the most frequent obstacle was insufficient educational materials and tools and it was analyzed that acquisition of new knowledge and technology is required as a matter to be improved. Conclusions : It seems to be required for the dental hygienists to develop detailed knowledge and professional technology in order to induce actions and motive of patients during oral health education of peridontal patients and to develop and produce data for efficient education of peridontal patients.

• Journal of the Korean Applied Science and Technology
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• v.37 no.5
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• pp.1257-1267
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• 2020

This study was conducted to analyze the differences in negative health behavior, mental health, and self-esteem between tattooed and non-tattooed college students. The subjects of this study were 214 four-year college students located in Seoul and Gyeonggi-do. For data analysis, descriptive statistics, factor analysis, Cronbach's α, crossover analysis, and t-test were conducted using the 25.0 version of the SPSS statistical package. As a result of the study, there was no significant difference in negative health behavior, mental health, and self-esteem between the two groups according to the presence of tattoos. Therefore, it can be said that it has a meaning as a positive aspect of research contrary to previous studies that report negative properties of tattoo. This study is expected to be used as basic data in establishing tattoo culture suitable for the times by reflecting and activating tattoos as a cultural phenomenon in the future.

• International Journal of Advanced Culture Technology
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• v.8 no.4
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• pp.167-176
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• 2020

Recommendation Systems is the top requirements for many people and researchers for the need required by them with the proper suggestion with their personal indeed, sorting and suggesting doctor to the patient. Most of the rating prediction in recommendation systems are based on patient's feedback with their information regarding their treatment. Patient's preferences will be based on the historical behaviour of similar patients. The similarity between the patients is generally measured by the patient's feedback with the information about the doctor with the treatment methods with their success rate. This paper presents a new method of predicting Top Ranked Doctor's in recommendation systems. The proposed Recommendation system starts by identifying the similar doctor based on the patients' health requirements and cluster them using K-Means Efficient Clustering. Our proposed K-Means Clustering with Content Based Doctor Recommendation for Cancer (KMC-CBD) helps users to find an optimal solution. The core component of KMC-CBD Recommended system suggests patients with top recommended doctors similar to the other patients who already treated with that doctor and supports the choice of the doctor and the hospital for the patient requirements and their health condition. The recommendation System first computes K-Means Clustering is an unsupervised learning among Doctors according to their profile and list the Doctors according to their Medical profile. Then the Content based doctor recommendation System generates a Top rated list of doctors for the given patient profile by exploiting health data shared by the crowd internet community. Patients can find the most similar patients, so that they can analyze how they are treated for the similar diseases, and they can send and receive suggestions to solve their health issues. In order to the improve Recommendation system efficiency, the patient can express their health information by a natural-language sentence. The Recommendation system analyze and identifies the most relevant medical area for that specific case and uses this information for the recommendation task. Provided by users as well as the recommended system to suggest the right doctors for a specific health problem. Our proposed system is implemented in Python with necessary functions and dataset.

• The Korean Journal of Physiology and Pharmacology
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• v.21 no.5
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• pp.531-546
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• 2017

Activation of Toll-like receptor-4 (TLR-4) in articular chondrocytes increases the catabolic compartment and leads to matrix degradation during the development of osteoarthritis. In this study, we determined the proteomic and genomic alterations in human chondrocytes during lipopolysaccharide (LPS)-induced inflammation to elucidate the underlying mechanisms and consequences of TLR-4 activation. Human chondrocytes were cultured with LPS for 12, 24, and 36 h to induce TLR-4 activation. The TLR-4-induced inflammatory response was confirmed by real-time PCR analysis of increased interleukin-1 beta ($IL-1{\beta}$), interleukin-6 (IL-6), and tumor necrosis factor alpha ($TNF-{\alpha}$) expression levels. In TLR-4-activated chondrocytes, proteomic changes were determined by two-dimensional electrophoresis and matrix-assisted laser desorption/ionization-mass spectroscopy analysis, and genomic changes were determined by microarray and gene ontology analyses. Proteomics analysis identified 26 proteins with significantly altered expression levels; these proteins were related to the cytoskeleton and oxidative stress responses. Gene ontology analysis indicated that LPS treatment altered specific functional pathways including 'chemotaxis', 'hematopoietic organ development', 'positive regulation of cell proliferation', and 'regulation of cytokine biosynthetic process'. Nine of the 26 identified proteins displayed the same increased expression patterns in both proteomics and genomics analyses. Western blot analysis confirmed the LPS-induced increases in expression levels of lamin A/C and annexins 4/5/6. In conclusion, this study identified the time-dependent genomic, proteomic, and functional pathway alterations that occur in chondrocytes during LPS-induced TLR-4 activation. These results provide valuable new insights into the underlying mechanisms that control the development and progression of osteoarthritis.