• 디지털융복합연구
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• 제7권3호
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• pp.93-102
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• 2009

Recently, concerns regarding ubiquitous health have been on the increase according to development of ubiquitous technology and growth of health industry. This study suggested a necessity for market segmentation for the creation of new markets of ubiquitous health business under this background. This paper also analyzed possibile health service industry with characteristics of customers by making an analysis of market segmentation. It was grouped into 4 parts by factor analysis and cluster analysis with raw data collected, the results showed that they would be main potential ubiquitous health service industry. However, some are not significant in statistics, which means that since ubiquitous health industry has not yet been experienced, it probably shows uncertainty about its favour. Finally, the study suggested that a future study should build up more detailed market segmentation data with continuous supplementation.

• Bulletin of the Korean Chemical Society
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• 제27권3호
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• pp.395-398
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• 2006

Nerve agents (sarin, tabun, soman and VX) are class of military important substances able to cause many severe intoxications during few minutes. Currently, the threat of misuse of these agents is daily discussed. Unfortunately, there is no single antidote able to treat intoxication caused by all of these agents. Owing to this fact, new generation of antidotes, especially acetylcholinesterase (AChE; EC 3.1.1.7) reactivators, is still developed. In this study, we have tested four newly developed AChE reactivators: 1-(4-hydroxyiminomethylpyridinium)- 5-(4-carbamoylpyridinium)-3-oxa-pentane dibromide (1), 1-(3-hydroxyiminomethylpyridinium)-5-(4-carbamoylpyridinium)-3-oxa-pentane dibromide (2), 1,5-bis(2-hydroxyiminomethylpyridinium)-3-oxa-pentane dichloride (3) and 1,5-bis(4-hydroxyiminomethylpyridinium)-3-oxa-pentane dibromide (4) for their potency to reactivate in vitro tabun and cyclosarin-inhibited AChE. Their reactivation efficacy was compared with currently the most promising oxime HI-6 (1-(2-hydroxyiminomethylpyridinium)-3-(4-carbamoylpyridinium)-2-oxa-propane dichloride). According to obtained results, two AChE reactivators 1 and 4 were able to reactivate tabun-inhibited AChE. On the contrary, there was no better AChE reactivator than HI-6 able to reactivate cyclosarin-inhibited AChE.

• 한국식품영양과학회:학술대회논문집
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• 한국식품영양과학회 2004년도 Annual Meeting and International Symposium
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• pp.271-274
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• 2004

Nutritional genomics is a new field of study of how nutrition interacts with an individual's genome or individual responds to individual diets. Systematic approach of nutritional genomics will likely provide important clues about responders and non-responders. The current interest in personalizing health stems from the breakthroughs emerging in integrative technologies of genomics and epigenomics and the identification of genetic and epigentic diversity in individual's genetic make-up that are associated with variations in many aspects of health, including diet-related diseases. Microarray is a powerful screen system that is being also currently employed in nutritional research. Monitoring of gene expression at genome level is now possible with this technology, which allows the simultaneous assessment of the transcription of tens of thousands of genes and of their relative expression of pathological cells such tumor cells compared with that of normal cells. Epigenetic events such as DNA methylation can result in change of gene expression without involving changes in gene sequence. Recent developed technology of DNAarray-based methylation assay will facilitate wide study of epigenetic process in nutrigenomics. Some of the areas that would benefitfrom these technologies include identifying molecular targets (Biomarkers) for the risk and benefit assessment. These characterized biomarkers can reflect expose, response, and susceptibility to foods and their components. Furthermore the identified new biomarker perhaps can be utilized as a indicator of delivery system fur optimizing health.

• Smart Structures and Systems
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• 제10권4_5호
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• pp.313-329
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• 2012

A challenging issue in design and implementation of an effective structural health monitoring (SHM) system is to determine where a number of sensors are properly installed. In this paper, research on the optimal sensor placement (OSP) is carried out on the Canton Tower (formerly named Guangzhou New Television Tower) of 610 m high. To avoid the intensive computationally-demanding problem caused by tens of thousands of degrees of freedom (DOFs) involved in the dynamic analysis, the three dimension finite element (FE) model of the Canton Tower is first simplified to a system with less DOFs. Considering that the sensors can be physically arranged only in the translational DOFs of the structure, but not in the rotational DOFs, a new method of taking the horizontal DOF as the master DOF and rotational DOF as the slave DOF, and reducing the slave DOF by model reduction is proposed. The reduced model is obtained by IIRS method and compared with the models reduced by Guyan, Kuhar, and IRS methods. Finally, the OSP of the Canton Tower is obtained by a kind of dual-structure coding based generalized genetic algorithm (GGA).

• Journal of Korean Neurosurgical Society
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• 제62권1호
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• pp.10-26
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• 2019

Magnetic resonance-guided focused ultrasound (MRgFUS) is an emerging new technology with considerable potential to treat various neurological diseases. With refinement of ultrasound transducer technology and integration with magnetic resonance imaging guidance, transcranial sonication of precise cerebral targets has become a therapeutic option. Intensity is a key determinant of ultrasound effects. High-intensity focused ultrasound can produce targeted lesions via thermal ablation of tissue. MRgFUS-mediated stereotactic ablation is non-invasive, incision-free, and confers immediate therapeutic effects. Since the US Food and Drug Administration approval of MRgFUS in 2016 for unilateral thalamotomy in medication-refractory essential tremor, studies on novel indications such as Parkinson's disease, psychiatric disease, and brain tumors are underway. MRgFUS is also used in the context of blood-brain barrier (BBB) opening at low intensities, in combination with intravenously-administered microbubbles. Preclinical studies show that MRgFUS-mediated BBB opening safely enhances the delivery of targeted chemotherapeutic agents to the brain and improves tumor control as well as survival. In addition, BBB opening has been shown to activate the innate immune system in animal models of Alzheimer's disease. Amyloid plaque clearance and promotion of neurogenesis in these studies suggest that MRgFUS-mediated BBB opening may be a new paradigm for neurodegenerative disease treatment in the future. Here, we review the current status of preclinical and clinical trials of MRgFUS-mediated thermal ablation and BBB opening, described their mechanisms of action, and discuss future prospects.

• 한국항행학회논문지
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• 제13권4호
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• pp.577-585
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• 2009

최근 정보 통신 기술의 발전과 삶의 질 향상으로 개인의 건강관리 응용 서비스에 대한 다양한 연구가 활발히 진행 되고 있다. 더구나, 유비쿼터스 환경 및 의료 기술의 발달과 더불어 양질의 삶을 위한 u-헬스케어 서비스에 대한 수요가 급증함에 따라 u-헬스케어 분야가 새로운 성장 산업으로 부상하고 있다. 특히 가정을 떠나 많은 시간을 바다에서 보내야 하는 상선승무원은 신체적으로는 물론이고 정신적으로도 다른 직업보다 스트레스가 많고 조속한 시간 내에 적절한 의료 서비스를 받지 못할 확률이 높기 때문에, 선박에서의 u-헬스케어 시스템의 필요성이 대두된다. 본 논문에서는 선원들의 건강을 관리하기 위하여 일반적인 건강관리 지수 모델인 SF-36를 보완하여 보다 객관적이고, 정확한 u-건강 웰빙 지수를 도출하는 방법을 제안한다. 또한 건강 지수에 따라 적당한 운동 프로그램, 식단 컨텐츠를 제공할 수 있는 u-건강 웰빙 지수 서비스 시스템을 설계하였다.

• 대한의용생체공학회:의공학회지
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• 제43권6호
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• pp.417-423
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• 2022

The present study proposed a new interface system for capsule endoscopy by using head mounted display (HMD) device, which can control the orientation of the capsule endoscope with electromagnetic actuator (EMA) system. The orientation information of the HMD user was detected by the gyroscope sensor built into the device and then calculated to as an angle increment using Unity Engine compiler. The measured angle changes from the HMD were converted to the current values of the corresponding coils to be changed in the EMA system. Two experiments were designed to measure the accuracy and the intuitiveness of the HMD interface system. In the angle accuracy measurement, the capsule endoscope driven by HMD interface system showed the averaged errors of 0.68 degrees horizontally and 1.001 degrees vertically for given test angles. In the intuitiveness measurement, HMD interface system showed 1.33 times faster manipulation speed rather than the joystick interface system. In this respect, the HMD interface system for capsule endoscopy was expected to improve the overall diagnostic environment while maintaining comfort of patients and clinicians.

• 센서학회지
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• 제32권5호
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• pp.259-266
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• 2023

The use of various adulterants and harmful chemicals is rapidly increasing in various sectors such as agriculture, food, and pharmaceuticals, and they are also present in our surroundings in the form of pollutants. The regular and repeated intake of harmful chemicals often adversely affects human health. The prolonged exposure of living beings to such adverse components can lead to severe health complications. To avoid the unlimited utilization of these chemical components, a sensing technology that is sensitive and reliable for low-concentration detection is beneficial. Surface-enhanced Raman spectroscopy (SERS) is a powerful method for identifying low-range concentrations of analytes, leading to great applications in molecular identification, including various diagnostic biomarkers. SERS in chemical, gas, and biological sensors can be an excellent approach in the sensing world to achieve rapid and multiple-analyte detection, leading to a new and efficient approach in healthcare monitoring.

• Journal of Plant Biotechnology
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• 제47권2호
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• pp.107-117
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• 2020

Flower industry is now growing due to the development of economy in many countries. Simultaneously, needs from consumers in flower market are varied widely. To satisfy the needs from consumers and deal with a variety of diseases from a lots of pathogens as well as climate change, new elite flower cultivars should be released in flower market. For this purpose, conventional and biotechnological techniques can be employed to make good cultivar. Therefore, this review describes the general overview of flower breeding techniques including cross-hybridization, mutation breeding and genetic transformation systems. Also, breeding systems for ornamentals derived from plant tissue culture such as embryo culture, in vitro fertilization, ovary/ovule culture and haploid production were reviewed. Furthermore, in this study recent development of the generation of new flower cultivars using marker-assisted breeding, plant transformation including particle bombardment and Agrobacterium tumefaciens as well as genome-editing technology were described. This review will be contributed to the development and releasement of new flower cultivars with horticulturally useful traits in the future.

• Child Health Nursing Research
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• 제15권2호
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• pp.210-218
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• 2009

Purpose: The existing web sites for premature babies are operated by non professionals and thus do not provide any medical or professional information necessary for rearing premature babies. The purpose is to construct a new website with lots of medical and professional tips for premature babies. Methods: First, topics of discussions are collected from the bulletin boards of three websites, operated by non professionals, for premature babies. And new website for premature babies is constructed based on the identified topics and also based on professional consultation with six professors. Results: The newly constructed website provides professional tips for the above topics as well as introduction of it's object, general medical information and baby rearing information and the bulletin board for parents of premature babies. Conclusion: By providing professional tips for mothers of premature babies, the new website is expected to provide detailed, accurate and professional information on issues most parents of premature babies concern.