• YAKHAK HOEJI
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• v.18 no.3
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• pp.190-196
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• 1974

A new colorimetric method established for the determination of ampicillin was based on the reductions of phosphomolybdic acid by ampicillin to be resutled in a molybdenum blue which showed a mezimal absorbance at 770nm. The pH effects on a molybodenum blue solution was dependent significantly on temeprature, but the wave-length shift was not effected by the molybdenum blue.

• 한국데이터정보과학회:학술대회논문집
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• 2006.11a
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• pp.43-48
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• 2006

In 2001 US FDA proposed a draft guidance for future in vivo bioequivalence studies. The guidance suggested specific criteria for new drug sponsors to show prescribability and switchability in bioequivalence testing for approval of generic drugs. However, there is less acceptance of the need to change statistical procedures and study designs from those currently used to assess the current criterion of average bioequivalence. The measures of population and individual bioequivalence testing are introduced and statistical procedures for them are discussed.

• Archives of Pharmacal Research
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• v.1 no.1
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• pp.41-54
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• 1978

Aspirin is one of the oldest synthetic drugs and remains the most widely used medical agent. It is a household remedy effective in treating such common ailments as headache, minor muscular pain and fever. Aspirin is the drug choice for rheumatic fever and arthritis which some five million Americans suffer. Lately it has been established by double-blind and randomized clinical studies that regular aspirin intake reduces the incidence of mild strokes and heart attackes.

• KSBB Journal
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• v.16 no.2
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• pp.107-114
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• 2001

The dynamic evolution process has resulted in the myriad shapes, functions, and systems evident in every living organism. For centuries, people have been harnessing the power of evolution to produce new varieties of plants and animals, such as producing tomatoes from berries and Chihuahuas from wolves. Now scientists are using it to produce better molecules, ranging from drugs to industrial chemicals, and doing it in days or weeks rather than eons. The ingenious process, which creates genetic diversity and selects those with desired features in the laboratory, is called directed evolution or test tube evolution. In this paper, concepts of directed molecular evolution and some examples will be discussed.

• Natural Product Sciences
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• v.16 no.2
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• pp.59-67
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• 2010

Flavonoids are well-known anti-inflammatory agents that exert their effects via a variety of mechanisms including antioxidative action, inhibition of eicosanoid metabolizing enzymes and regulation of theexpression of proinflammatory molecules. In this review, synthetic approaches to obtain more useful flavonoid derivatives are summarized. Human clinical trials of flavonoid therapy are discussed. Through continual investigation to identify more potent and comparable flavonoids, new anti-inflammatory flavonoid therapy will be successfully launched, especially for the treatment of chronic inflammatory disorders.

• Proceedings of the Korean Society of Applied Pharmacology
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• 2007.11a
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• pp.67-73
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• 2007

There have been various inflammatory skin disorders in humans including atopic dermatitis, eczema and psoriasis. Although some drugs have been used for these disorders, there is an urgent need for safer and more effective topical anti-inflammatory agents. Plant flavonoids possess anti-inflammatory activity and some of them have multiple pharmacological mechanisms, inhibition of eicosanoid metabolizing enzymes, histamine release and/or down-regulation of pro inflammatory gene expression. These properties of flavonoids may be suitable for treating chronic skin inflammatory disorders. Especially, wogonin, some prenylated flavonoids and biflavonoids have a strong potential as new anti-inflammatory agents by topical application.

• Proceedings of the PSK Conference
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• 2003.10a
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• pp.79-80
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• 2003

A lot of polyketide antibiotics have been isolated from natural sources like microorganism, fungi and plant. The polyketide natural products have biologically and medically important activities, including antibacterial, anticancer, antiparasitic, and immunosuppressant properties. The diversified activities of polyketides are originated from their structural variety of which have been took advantage by several research groups for development of new drugs. (omitted)

• Proceedings of the PSK Conference
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• 2002.10a
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• pp.358.3-358.3
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• 2002

We recently synthesized new platinum(II) complex analogs containing trans-1 and cis-l.2-diaminocyclohexane (DACH) as carrier ligands and L -3-phenyllactic acid(PLA) as a leaving group. Our platinum-based drug discovery program has been aimed at developing drugs capable of diminishing toxicity and improving selective cytotoxicity. (omitted)

• Proceedings of the PSK Conference
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• 2003.04a
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• pp.246.1-246.1
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• 2003

Hetero chain compounds have high possibilities of being good medicinal candidate because of their well-known medicinal activity and relatively low subtitled carbon. By constructing the method of making this compound library, this research has the purpose to create a new medicinal candidate materials based on an easy medicinal search. The first step is to construct an Indole library in a compounding process with the design of a linker connecting a solid-state resin and a substrate. (omitted)

• Proceedings of the PSK Conference
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• 2002.10a
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• pp.315.1-315.1
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• 2002

DNA topoisomerases I (topo I) and II are essential enzymes that relax DNA supercoiling and relieve torsional strain during DNA processing. including replication. transcription. and repair. Topo I relaxes DNA by cleaving one strand of DNA by attacking a backbone phosphale with a catalytic lyrosine (Tyr723. human topo I). This enzyme has recently been investigated as a new target for antineoplastic drugs. Inhibitors to the enzyme intercalate between the DNA base pairs. interfering religation of cleaved DNA, therefore inhibit the activity of topo I. (omitted)