Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2002.10a
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- Pages.315.1-315.1
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- 2002
Computer-based screening for novel inhibitors of human topoisomerase I with FlexiDock docking protocol
- Choi, In-Hee (College of Pharmacy, Ewha Womans University) ;
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Kim, Choon-Mi
(College of Pharmacy, Ewha Womans University)
- Published : 2002.10.01
Abstract
DNA topoisomerases I (topo I) and II are essential enzymes that relax DNA supercoiling and relieve torsional strain during DNA processing. including replication. transcription. and repair. Topo I relaxes DNA by cleaving one strand of DNA by attacking a backbone phosphale with a catalytic lyrosine (Tyr723. human topo I). This enzyme has recently been investigated as a new target for antineoplastic drugs. Inhibitors to the enzyme intercalate between the DNA base pairs. interfering religation of cleaved DNA, therefore inhibit the activity of topo I. (omitted)
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