• Korean Journal of Microbiology
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• v.44 no.4
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• pp.282-288
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• 2008

Tissue ischemia resulting from the constriction or obstruction of blood vessels leads to an illness that may affect many organs including the heart, brain, and legs. In recent years, considerable progress has been made in the field of therapeutic angiogenesis and the new approaches are expected to cure those "no-option patients" who are unsuited to conventional therapies. Although single angiogenic growth factor may be successful in inducing angiogenesis, combination of multiple growth factors is increasingly sought these days to augment the therapeutic responses. This trend is proper in light of the fact that blood vessel formation is a complex and multi-step process that requires the actions of many different factors. To meet the growing need for functionally significant blood flow recovery in the ischemic tissues, a novel strategy that can provide concerted actions of multiple factors is required. One way to achieve such a goal is to use a transcription factor that can orchestrate the expression of multiple target genes in the ischemic region and thus induce significant level of angiogenesis. Here, a putative transcription factor, cardiac ankyrin repeat protein (CARP), was evaluated in adenoviral vector context for angiogenic activity in human umbilical vein endothelial cells. The results indicated significant increase in proliferation, capillary-like structure formation, and induction of vascular endothelial growth factor, a typical angiogenic gene. Taken together, these results suggest that CARP represents itself as a novel target for therapeutic angiogenesis and warrants further investigation.

• Korean Journal of Construction Engineering and Management
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• v.14 no.3
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• pp.134-145
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• 2013

Road construction projects are parcelled into sub-sections which are then tendered to individual contractors for construction. The type of work and equipments used are similar for each sub-section. However, such equipment are not shared on a regular basis among the contractors and only partially performed in an informal and ad hoc manner. Consequently, road construction equipment suffer from low utilization and increased leasing costs. Lean construction and Program Management approaches stress the importance of collaboration among individual participants in a way that increases the collective cost savings of the entire project. This research attempts to apply such theories with the notion that under utilization of expensive equipment can be improved by formalizing a way to enable the sharing of equipment in large, public sponsored, multi-sectioned road construction projects. A system was developed consisting of a set of criteria and processes that enables automatic allocation of equipment to multiple sites on daily basis, in a way that minimizes equipment costs and improves their individual utility. The system was then applied in allocating three different types of equipment to an actual road construction project with four sub-sections for three months. A new metric, nDPR showed that utilization improved for all equipment and also equipment related costs were decreased by 4.45%. Results also showed that increased shared opportunities of equipment correspond to an increase in utilization and cost savings.

• Journal of the Economic Geographical Society of Korea
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• v.13 no.1
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• pp.111-125
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• 2010

For a shift to a new paradigm that allows restoring solidarity among class, gender, and race, it is necessary to closely investigate the differences between Marxist view and poststructuralist view which provide theoretical basis for labor movement and for feminist movement, respectively. However, little effort has been devoted to this task. This paper critically compares two best wellknown geographers; Harvey's class-centered theory and Gibson-Graham's post-structuralist feminist approach by focusing on their understandings of "difference". David Harvey argues that racial/gender discrimination is another form of class-exploitation and puts priority on the solidarity based on the commonality of labor. On the contrary Gibson-Graham argues that the privileging of class above all else marginalizes other political dimension, and proposes the deconstruction of hegemonic discourse of capitalism and the construction of "community economies", Based on the critical survey of both theories, I propose that understanding the role that spatiality plays in capital accumulation process is the key to compromise two different approaches.

• Archives of design research
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• v.17 no.4
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• pp.233-240
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• 2004

Living in the modern age with well-developed scientific technologies, all of us are enjoying convenient lives because of 'energy'. Korea, poor in resources, is importing a large portion of its energy sources from abroad but energy consumption shows an upward tendency due to the continuing economic growth and the improvement of living conditions. The atomic energy is considered a self-reliant, alternative energy source like our country. However, it is necessary to educate the people on and publicize atomic power generation in the face of the widespread negative recognition that the atomic power plant is a hazardous facility. The study approaches to these matters with a human-friendly and environment-friendly coloring plan in the perspective of environment coloring plan. The study aims to minimize negative images of the atomic power, while highlighting its friendly and positive images so as to enhance the confidence of the people on the atomic power and to create a clean image for the atomic power. For this goal, the study examined and analyzed cases of Japanese nuclear power plants and domestic nuclear power plants, and also carried out an on-site survey in the sites in which nuclear power plants would be constructed to extract concrete colors through the analyses of their natural environment and actual conditions. The study also carried out a survey of residents in the regions to induce their participation, and reflected the survey results to the coloring plan. The study is expected to create a stable and friendly image of the nuclear power plant through materializing its environment-friendly image and remove negative recognition that the people have on the nuclear power plant. It also attempted an external environment-coloring plan a s a strategic means for positive publicity and through this, is expected to ultimately contribute to the creation of the new images of nuclear ower plants.

• Journal of the Korean Institute of Gas
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• v.19 no.4
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• pp.1-7
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• 2015

As the interest on the air pollution is gradually rising up at home and abroad, automotive and fuel researchers have been working on the exhaust emission reduction from vehicles through a lot of approaches, which consist of new engine design, innovative after-treatment systems, using clean (eco-friendly alternative) fuels and fuel quality improvement. This research has brought forward various main issues : whether PM emissions should be regulated for diesel and gasoline vehicles and whether gasoline and LPG powered vehicles can be further neglected from PM emission inventories. Finally, the greenhouse gas regulation has been discussed including automotive emission regulation. The greenhouse gas and emissions of automotive had many problem that cause of ambient pollution, health effects. Based on various test modes and ambient conditions, this paper discusses the characteristics of LPG on exhaust emissions and greenhouse gases. Also, this paper assessed emission characteristics due to the test temperature. These test temperature were performed by dividing the temperature of the test mode and the lowest local temperature in winter. Through this study, the correlation of vehicle test mode and ambient condition, exhaust emission, greenhouse gas emission was analyzed.

• Journal of KIISE:Computer Systems and Theory
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• v.33 no.5
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• pp.257-266
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• 2006

Recently TCP/IP Offload Engine (TOE) technology, which processes TCP/IP on a network adapter instead of the host CPU, has become an important approach to reduce TCP/IP processing overhead in the host CPU. There have been two approaches to implementing TOE: software TOE, in which TCP/IP is processed by an embedded processor on a network adapter; and hardware TOE, in which all TCP/IP functions are implemented by hardware. This paper proposes a hybrid TOE that combines software and hardware functions in the TOE. In the hybrid TOE, functions that cannot have guaranteed performance on an embedded processor because of heavy load are implemented by hardware. Other functions that do not impose as much load are implemented by software on embedded processors. The hybrid TOE guarantees network performance near that of hardware TOE and it has the advantage of flexibility, because it is easy to add new functions or offload upper-level protocols of TCP/IP. In this paper, we developed a prototype board with an FPGA and an ARM processor to implement a hybrid TOE prototype. We implemented the hardware modules on the FPGA and the software modules on the ARM processor. We also developed a coprocessing mechanism between the hardware and software modules. Experimental results proved that the hybrid TOE prototype can greatly reduce the load on a host CPU and we analyzed the effects of the coprocessing mechanism. Finally, we analyzed important features that are required to implement a complete hybrid TOE and we predict its performance.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.41 no.1
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• pp.122-131
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• 2016

In the smart societies, such as the current unlike in the past, the voice that listeners will feel favor is changing through the development of ICT technologies and infrastructure. In other words, in the past, loud, intensive and fast voice is a favorite but now a new social and cultural situation that is changing them with ICT technologies. Now, this becomes one of the important things that we clarify 'Is it a voice that feels a favor?'. For this, in this paper, we identified what voice that listeners feel favor by applying ICT technologies. Studies were carried out to proceed largely divided into two categories. Firstly, as the quantified data, we extracted the impact on favorable feeling of listeners which related with emotional speech by empirical analysis work. To do this, we performed the experiment for the public. Secondly, we identified what kind of voice which listeners feel a good impression. For this, we identified voice characteristics that there are people who are influential in the real society. Also, we extracted both the voice characteristics of each influential people and common voice characteristics. In addition, we want to overcome the problems of qualitative methods that have originally limitations in objective respects which is significant to the voice analysis. For this, we performed the experiments of the voice analysis by numerical and visual approaches.

• Journal of the Korean association of regional geographers
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• v.4 no.1
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• pp.27-41
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• 1998

The communication model has been accepted as the basic research paradigm of cartography since Board(1967) discussed the map/model analogy. In that paradigm, the function of maps was limited to the media of communication, and the functionality of maps was extremely emphasized. Therefore the model could not play its own role under the new environments such as computer, GIS, scientific visualization. Nowadays, the model has been attacked on several grounds and several alternatives have been suggested. Among the objections raised are (1) geographic visualization in which maps are considered as the tool of scientific visualization, (2) the contributions of art which are ignored in the positivist cartographic research, and (3) deconstructionist arguments which deny the scientific epistemology of map as an objective form of knowledge and recognize the textuality of maps including their metaphorical and rhetorical nature. Since a publication by McCormick et al, the scientific visualization based on the powerful computer graphics is used in a wide context. Maps are treated as the tools of scientific visualization and emphasis is on exploration of the geographic data to gain understanding and insight in the geographic visualization processes. The research on geographic visualization have stayed in the early stage of developing the conceptual model and the basic visualization tools. But, it is expected that the geographic or visual thinking which is emphasized in the geographic visualization will contribute the reestablishment of links between cartography and geography. Also, the development of scientific visualization tools and strategies will offer the opportunities to suggest a fresh idea, to synthesize information and develop holistic approaches to geographical problems.

• Journal of the Korean association of regional geographers
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• v.4 no.2
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• pp.79-94
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• 1998

This study begins with emphasis on the approach to public policy development and the extent to which a GIS framework can be used to evaluate projects objectively. This paper relates to public policy making and the use of GIS as a strategic management tool rather than the development of GIS technologies which has been the focus of attention since the advent of the first generation GIS systems in the 1960s. In order to consolidate a view towards public policy, the aim of this study is to show the advantages of using GIS to generate results which could be evaluated by cost and benefit analysis giving options of the alternative methods to estimate the feasibility of projects (both tangible and intangible) in a real public policy scenario. This study also reports that the tangible benefits associated with the GIS projects are better information processing, the easy analysis of data and the cost savings of map updates and printing, whilst the intangible benefits include quality decision making, and precise management of data through computing networks. In GIS context, the task of analysing and evaluating GIS projects is assumed in order to facilitate scientific and quantitative cost-benefit analysis. Previous methods of the cost-benefit analysis has not fully supported the evaluation of the intangible benefits and it has not been possible to make public policy realistic or scientifically understandable limiting decision makers in public domain. With the GIS decision makers are able to explore the potential of projects with this powerful decision supporting tool in practical application. On the basis of its potentials and limitations to cost-benefit analysis, therefore, it can be concluded that more flexible analysis and evaluation methodologies are needed to extend into the intangible benefits. In order to balance the evaluation of both quantitative and qualitative approaches on the cost-benefit analysis new or additional utilities will be required for the next GIS generation appraisal tool.

• Journal of Embryo Transfer
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• v.18 no.3
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• pp.243-248
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• 2003

Sperrnatogenesis, the process by which the male germ-line stem cells(GSCs; type A spermatogonia) divide and differentiate to produce the mature spermatozoa, occurs in the seminiferous tubules of the testis. The GSCs proliferate actively to produce two types of cells: other GSCs and differentiating spermatogonia. GSCs have unipotentcy, devoted solely to the generation of sperm. The function of GSCs has broad implications for development, disease, and evolution. Spermatogenesis is fundamental for propagation of species and the defects of this system can result in infertility or disease. The ability to identify, isolate, culture, and alter GSCs will allow powerful new approaches in animal transgenesis and human gene therapy relating to infertility. Until recently, research on stem cells in the testis has been limited because of technical difficulties in isolating and identifying these cell populations. Here, we were trying to find out optimal conditions for in vitro culture of GSCs for identifying and isolating GSCs. We collected mouse GSCs from 3-days old mouse by two-step enzyme digestion method. GSCs were plated and grown on mouse embryonic fibroblasts in Dulbecco's modified Eagle's medium (DMEM) containing 15％ fatal bovine serum, 10 mM 2-mercaptoethanol, 1％ non-essential amino acids, 1 ng/$m\ell$ bFGF, 10 $\mu$M forskolin, 1500 U/$m\ell$ human recombinant leukemia inhibitory factor (LIF). Over a period 3∼5 days, GSCs gave rise to large multicellular colonies resembling those of mouse pluripotent stem cells. After 5th passages, cells within the colonies continued to be alkaline phosphatase and Oct-4 positive and tested positive against a panel of two immunological markers(Integrin $\alpha$ 6 and Integrin $\beta$ 1) that have been recognized generally to characterize GSCs. SSEA-1, SSEA-3, and SSEA-4 also showed positive signals. Based on our data, these GSCs-derived cultures meet the criteria for GSCs itself and even other pluripotent stem cells. We reported here the establishment of in vitro cultures from mouse male GSCs.