• Proceedings of the Korean Society of Life Science Conference
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• 2007.10a
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• pp.57.1-57.1
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• 2007

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• Proceedings of the Korean Society of Life Science Conference
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• 2007.10a
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• pp.71.1-71.1
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• 2007

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• Proceedings of the PSK Conference
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• 2001.10a
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• pp.143.2-143.2
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• 2001

• Proceedings of the Ginseng society Conference
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• 2007.12a
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• pp.66-67
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• 2007

• 한국약용작물학회:학술대회논문집
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• 2008.05a
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• pp.152-153
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• 2008

• Archives of Reconstructive Microsurgery
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• v.8 no.2
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• pp.170-175
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• 1999

Objective : Extracranial-intracranial(EC-IC) microvascular anastomosis was performed in 18 patients with hemodynamic cerebral ischemia and traumatic cerebral aneurysm, the aim of this retrospective study was to assess its value in neurosurgical field. Method : Of 18 cases, 17 case were hemodynamic cerebral ischemia and one was traumatic cerebral aneurysm. There were 14 superficial temporal artery(STA)-to-middle cerebral artery(MCA) anastomosis, 3 saphenous vein graft bypass(2 external carotid artery(ECA)-to-MCA, 1main trunk of the STA-to-MCA) and 1 radial artery bypass(ECA-to-MCA). Results : Bypass patency was confirmed by postoperative angiography in all cases except for two cases, postoperative cerebral blood flow of ischemic brain showed significant increased in all cases with good patency through bypass. Conclusion : Revascularization by EC-IC microvascular anastomosis to the ischemic brain eliminated ischemia and was associated with excellent good outcome and good patency rates.

• Biomolecules & Therapeutics
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• v.27 no.6
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• pp.530-539
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• 2019

Brain aging is an inevitable process characterized by structural and functional changes and is a major risk factor for neurodegenerative diseases. Most brain aging studies are focused on neurons and less on astrocytes which are the most abundant cells in the brain known to be in charge of various functions including the maintenance of brain physical formation, ion homeostasis, and secretion of various extracellular matrix proteins. Altered mitochondrial dynamics, defective mitophagy or mitochondrial damages are causative factors of mitochondrial dysfunction, which is linked to age-related disorders. Etoposide is an anti-cancer reagent which can induce DNA stress and cellular senescence of cancer cell lines. In this study, we investigated whether etoposide induces senescence and functional alterations in cultured rat astrocytes. Senescence-associated ${\beta}$-galactosidase (SA-${\beta}$-gal) activity was used as a cellular senescence marker. The results indicated that etoposide-treated astrocytes showed cellular senescence phenotypes including increased SA-${\beta}$-gal-positive cells number, increased nuclear size and increased senescence-associated secretory phenotypes (SASP) such as IL-6. We also observed a decreased expression of cell cycle markers, including PhosphoHistone H3/Histone H3 and CDK2, and dysregulation of cellular functions based on wound-healing, neuronal protection, and phagocytosis assays. Finally, mitochondrial dysfunction was noted through the determination of mitochondrial membrane potential using tetramethylrhodamine methyl ester (TMRM) and the measurement of mitochondrial oxygen consumption rate (OCR). These data suggest that etoposide can induce cellular senescence and mitochondrial dysfunction in astrocytes which may have implications in brain aging and neurodegenerative conditions.

• Journal of The Korea Institute of Healthcare Architecture
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• v.20 no.3
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• pp.27-40
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• 2014

Purpose: As the nation is becoming an aging society, there is an increasing number of the patient who has Neuroscience disease. So it is necessary to build a facility which provides specialized health care. Methods: Field surveys to facilities and analysis to the floor plan have been conducted in order to suggest adequate architectural composition to the specialized neuroscience center and the dimensions of rooms. Results: The result of this study can be summarized into six points which contain guide to how to organize the specialized neuroscience center. One of the most important things in this study is to suggest the architectural type which provides efficient collaborating system between the outpatient and angiography unit. Implications: It can be said that this paper can be useful research material when the architect tries to plan the specialized neuroscience center.

• Proceedings of the PSK Conference
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• 2002.10a
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• pp.257.2-257.2
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• 2002

This research was performed to investigate the protective effect of Yangguksanwha-tang(YST) agaist ischemic damage in PC 12 cells. To elucidate the mechanism of the protective effect of YST on ischemic insult. cell viability and changes in activities of Superoxide dismutase. Glutathione Peroxidase. Catalase. capase 3 and the production of Malondialdehyde were observed after treating PC12 cells with YSt which was metabolized by rat liver homogenate. (omitted)

• 대한약리학회:학술대회논문집
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• 2006.10a
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• pp.106.2-106.2
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• 2006