• Preventive Nutrition and Food Science
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• 제8권1호
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• pp.24-28
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• 2003

There is evidence to suggest that cranberry juice supplements improve the health of the urinary tract by inhibiting the binding of fimbriated uropathogenic E. coli to the bladder mucosa. In patients with neurogenic bladders, urinary tract infections (UTI) are particularly common and often poorly managed by antibiotic treatment. A double-blind, randomized, placebo-controlled trial was undertaken on 29 geriatric and spinal cord injured patients with dysfunctional bladders. They received three times daily at mealtimes a 4 oz bottle of cranberry juice (Ocean Spray Cranberries, USA) or a specially prepared synthetic placebo drink. Two episodes of UTI arose in week one of cranberry intake and none thereafter, compared to four episodes of UTI in 4 placebo patients in weeks four, six and 10. Mean bacterial adhesion counts on bladder cells of the patients rose during the first month of treatment in 71 % of the placebo patients compared to only 31 % of cranberry patients (p < 0.001). The difference persisted to some extent for the second and third months. Bacterial adhesion levels correlated with culture findings (higher adhesion and higher viable counts in urine) (p < 0.001), positive leukocyte nitrite tests (136$\pm$131 bacteria per cell versus 52$\pm$86 in negative tests) (p < 0.001), and higher white blood cell counts (> 10) per high power field (126$\pm$125 versus 48$\pm$85 bacteria per cell) (p<0.001). E. coli was the most frequently isolated organism (40% samples) followed by K. pneumoniae (17%) and a number of other uropathogens. Group B Streptococci, and coagulase negative Staphylococcus were recovered from urine in 4 samples but were not associated with any red blood cell presence. The daily intake of cranberry juice, in amounts which are not detrimental to long term compliance, appeared to have a role in reducing the risk of bladder colonization and infection in a highly susceptible patient population.

• 대한간호학회지
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• 제46권3호
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• pp.400-408
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• 2016

Purpose: This study was done to identify frequency, intensity of urinary dysfunction and daily life distress in women after a radical hysterectomy for cervical cancer. Methods: One hundred and fifty seven women who had undergone a radical hysterectomy and one hundred and sixty five women as healthy controls completed questionnaires on intensity of urinary dysfunction and daily life distress caused by urinary dysfunction. Results: Women with cervical cancer showed higher frequency of urinary dysfunction than healthy controls. Major urinary dysfunction for women with cervical cancer in order of frequency were night-time incontinence (odds ratio=10.39, p<.001), difficulty in starting urination, weak urine stream and sense of incomplete emptying of bladder. The highest score on intensity was difficulty in starting urination, followed by urgency, weak urine stream, daytime frequency and sense of incomplete emptying. Night-time incontinence was the urinary symptom causing the most daily life distress for cervical cancer women followed by difficulty in starting urination, urgency, sense of incomplete emptying, and night-time frequency. Conclusion: Results suggest that nurses should address the potential postoperative urinary complications and develop long term interventions to decrease urinary dysfunction and daily life distress for women who have had a radical hysterectomy for cervical cancer.

• Investigative and Clinical Urology
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• 제59권6호
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• pp.410-415
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• 2018

Purpose: Despite meticulous techniques, surgical complications continue to be problematic in kidney transplant recipients. Role of routine stenting to reduce complications is controversial. In this study, we compare incidence of early urological complications, lymphoceles, urinary tract infections (UTI) and graft function; with or without double-J stenting. Materials and Methods: All patients who underwent live related donor renal transplantation from February 2014 to February 2016 were included. Transplants prior to February 2015 were without routine stenting; subsequent transplants were with routine stenting. Patients with neurogenic bladder, previously operated bladder and delayed or low urinary output were excluded. Followup was for at least three months. Descriptive statistics was performed for all parameters. Chi square test and Fisher's Exact test were used for qualitative variables. For quantitative variables, Mann-Whitney test was used to test median difference and independent samples t-test for mean difference. The p-value ${\leq}0.05$ was considered significant. Results: We analysed 74 patients (34 stented and 40 non-stented). There was no difference in the incidence of urinary leak, anastomotic obstruction, lymphoceles or UTI (p>0.4 for all comparisons). However, mean estimated glomerular filtration rate at sixth day, 14th day, one month and two months were 76.1 vs. 61.5 (p=0.025), 72.1 vs. 56.6 (p=0.005), 79.4 vs. 63.1 (p=0.002) and 82.0 vs. 63.3 (p=0.001) in the stented versus non-stented groups. Conclusions: Placement of ureteral stent in renal transplant does not significantly affect the incidence of early urinary complications or UTI. However, graft function is significantly better in stented recipients, at least in the short term.

• Journal of Acupuncture Research
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• 제22권3호
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• pp.123-135
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• 2005

국내외 학술지중 배뇨장애에 대한 침치료의 연구 동향을 문헌고찰 연구, 생리적 기전 연구, 임상효과 연구로 나누어 분석한 결과 다음과 같은 결과를 얻었다. 1. 23 편의 논문 중 review study가 3편, experimental study 6편, clinical study가 14 편이었다. 다양한 Journal에 발표되고 있었는데, review study는 모두 국내 학술지에 게재 된 논문이었고, 2000년 이후로 점차 연구의 양과 관심이 증대되고 있는 추세였다. 2. 배뇨장애는 하부요로증상의 다양한 증상을 포괄하는 것으로 한의학적인 측면에서는 융폐, 소편부금(小便不禁), 빈요(頻尿), 급박요(急迫尿), 요실금(尿失禁), 림증(淋證), 야뇨(夜尿), 난요(難尿), 점적요(點滴尿), 지연요(遲延尿)등에 해당하는데, 그 대부분의 유발 원인은 신기부족(腎氣不足)등의 하초허한(下焦虛寒)에 기인하는 것으로 판단되며, 간기울결(肝氣鬱結)등의 정서적 자극과 습열(濕熱) 및 어혈(瘀血)등의 원인에 의해서도 발생할 수 있다. 3. 배뇨장애에 대한 침구치료의 생리적 기전을 대략적으로 요약한다면 침자극에 의해 부교감 신경, 대뇌의 수면-각성 체계, 뇌교 및 척추 배뇨 센타, 음부신경/골반신경을 통해 방광에 영향을 주어 방광용량의 확장 또는 배뇨 수축의 억제작용을 하는 한편, 척추 환상 회로 나 신경연접부의 지속성 흥분을 통하여 요도주의 근육에 영향을 주는 것으로 생각되어 진다. 4. 배뇨장애에 대한 침구치료의 임상효과를 요약 한다면, 융폐, 소편부통(小便不通)에 속하는 신경인성 방광(Neurogenic Bladder), 소편부금(小便不禁), 빈요(頻尿), 급박뇨(急迫尿)에 해당하는 요실금(尿失禁)(Incontinence), 림증(淋證)에 해당하는 방광염(Cycitis), 액요(液尿) (Nocturnal Enuresis), 잡요(雜尿), 점적요(點滴尿), 지연요(遲延尿)에 해당하는 전립선염/골반통 증후군 (Prostatitis/Pelvic Pain Syndrom)등의 하부 요로증상에 침구치료는 유의미한 효과가 있다. 이상으로 국내 및 해외 연구는 최근들어 더욱 활발히 연구되고 있는데, 특히 해외연구는 배뇨 장애의 침구치료의 생리적 기전 분야에서 다양 하게 시도되고 있었다. 향후 고령화 사회로 진입 하는등 사회여건상 이와같은 다양한 배뇨장애 환자의 증가는 물론 치료욕구의 증대가 예상되는 바 이러한 생리적 치료기전의 연구 및 다양한 질환에 대한 임상연구를 시도함으로써 표준적인 치료기술의 개발이 필요할 것으로 사료된다.

• 한국전문물리치료학회지
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• 제12권2호
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• pp.98-104
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• 2005

This study was done to research the general information, causes of stroke, risk factors, complications during admission of geriatric CVA inpatients. We retrospectively studied 208 above 65 years old geriatric CVA inpatients treated in Ajou university hospital from 1994 to 2003 by medical record. These were divided into two groups by following years. We were gathered information about sex, onset age, cause of stroke, number of stroke, complications, housing, family, insurance, smoking, alcohol. Most of incidence of the stroke was noted in the group of young old age (65~74 years old) and old age (75~84 years old). The occurrence rate of male stroke (38.5%) was less than of female stroke (61.5%) and the ratio of male to female was 1:1.6. The occurrence rate of ischemic stroke (72.6%) was higher than of hemorrhagic stroke. The occurrence rate of ischemic stroke increased more and more at the late stage. The most common risk factors for stroke was hypertension and complications during hospitalization were neurogenic bowl and bladder. These results of epidemiologic study may help above 65 years old geriatric CVA early treatment and prevention, rehabilitation and use basic data for multiple prospective study using stroke registry.

• 한방재활의학과학회지
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• 제33권4호
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• pp.225-233
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• 2023

This case study reports the clinical effect of Korean medicine treatment on vascular disease of spinal cord. A 58-year-old female patient was diagnosed as vascular disease of spinal cord and treated with combined Korean medicine treatment such as acupuncture, electro-acupuncture, herbal medication, and physical therapy for 16 days. The patient was assessed for International Standard for Neurological Classification of Spinal Cord Injury (ISNCSCI), Berg Balance Scale (BBS), and Numeral Rating Scale (NRS). After treatment, total scores of ISNCSCI, BBS, and NRS were numerically improved. Also symptoms of neurogenic bladder were improved. This study suggests that Korean medicine treatment could be effective treatment for vascular disease of spinal cord.

• 대한유전성대사질환학회지
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• 제23권1호
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• pp.25-30
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• 2023

아미노아실-tRNA 합성효소는 단백질을 만드는 번역(translation)단계에서 아미노산을 활성화시키고 적절한 아미노산을 해당 tRNA에 결합을 시키는 중요한 효소이며, IARS2 유전자는 미토콘드리아에서 작용하는 isoleucylt-RNA 합성효소를 코딩하는 핵의 유전자이다. IARS2 유전자의 돌연변이는 백내장, 성장 호르몬 결핍, 감각 신경병증, 감각신경성 난청, 골격 형성 이상 증후군의 특징을 보이는 CAGSSS (MIM#616007)라는 희귀 질환의 원인으로 상염색체 열성으로 유전된다. 현재까지 이 증례 보고를 포함하여 29명의 환자만이 보고가 되었음에도 단지 백내장의 증상만 나타냈던 환자, 그리고 신경학적 증상이 두드러지는 Leigh 증후군을 유발하면서 여러 장기에 영향을 주는 환자 등 다양한 임상 증상의 환자가 보고되었다. Leigh 증후군은 드문 진행성 신경 퇴행성 미토콘드리아 질환이다. 이 연구는 IARS2 연관된 Leigh 증후군의 환자에서 방광 기능의 이상의 표현형을 보고하는 첫 증례 보고로 의미가 있다. 5세의 한국인 여아는 복부 팽만을 동반한 복통으로 응급실에 내원하였으며, 복부CT에서 명백한 폐쇄 증상, 급성 신장염, 요로감염의 징후가 보이지 않으면서 현저하게 팽창된 방광이 확인 되었다. 여아의 발달 상태는 발달 저하를 보이면서, 6개월에 뒤집기가 가능하였지만 이후는 신경학적 퇴행으로 내원당시에는 목 가누기도 되지 않고, 의미 있는 단어를 말하지도 못하는 전반적인 발달 지연 상태였다. 2세에는 양쪽 눈의 백내장이 발생하여 수술한 과거력이 있었다. 뇌 MRI T2 강조영상에서는 양쪽에 대칭적으로 기저핵(basal ganglia)에 고신호를 보였고, 이는 Leigh 증후군에 전형적인 영상의 특징이다. Whole mitochondrial genome의 유전자검사를 시행했지만 의미 있는 돌연변이가 확인되지 않았으므로, Whole exome sequencing 검사를 시행했으며, IARS2 유전자의 이중대립유전자 돌연변이(biallelic mutation), c.2446C>T (p. Arg816Ter)와 c.2450G>A (p. Arg817His)가 확인이 되었고 부모님은 보인자였다. 현재까지 IARS2 유전자의 돌연변이를 가지는 환자 중에서 신경학적 발달 저하, 인지장애 등의 증상이 동반된 환자는 신체의 다중장기질환의 증상으로 심비대, 부정맥, 빈혈, 측만증, 청력 저하, 뇌전증, 부갑상선저하증이 알려졌으나, 이 연구에서 IARS2 유전자 돌연변이를 가진 환자에서 배뇨근의 이상을 동반한 과민성방광증상을 확인하여 방광이상증상을 처음 보고를 한다. IARS2 유전자의 이상이 확인된 환자에서는 하부요로이상증상이 동반 가능성에 대해서 인지하는 것이 필요하고, 증상이 보이면 배뇨 일지나 요역동학검사를 통해서 조기에 진단 및 치료가 환자의 관리에 필요할 수 있다. 이 증례 보고는 IARS2 유전자의 임상 양상의 확대 및 유전자의 이해를 넓히는데 기여할 것으로 기대된다.

• 대한약리학회지
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• 제16권2호
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• pp.77-83
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• 1980

The effectiveness of Cefoperazone in the treatment of urinary tract infection was evaluated in the Department of Urology, St. Mary's hospital from December 1. 1979 to April 30. 1980. In this studies, the cusative organisms were divided into 2 groups; 1) Single form. E. coli (8), Staphylococcus aureus(7), Proteus vulgaris (4), P. morganii(3), S. epidermis (1), Enterococcus(1), Klebsiella (2), N. gonococcus(1). 2) Mixed from: Proteus+E. coli(4), E. coli+other(1), Pseudomonas+Enterococcus(1), Klebsiella+other(1). Effectiveness on urological diseases. 1) Neurogenic bladder: Results were excellent in 3 cases, good in 4 cases and negative effect in 4 cases. 2) Non-gonococcal urethritis: In this group, the therapeutic results were favorable in 88.9% of all cases. (Excellent in 2, Fail in1) 3) Pyelonephritis: All(4 cases) were excellent. 4) Renal stone: Among the 4 cases of renal stone, only one case was responded to cefoperazone. 5) Two cases of urethral stricture, two cases of cystitis, one case of B.P.H. and one case of gonococcal urethritis were all excellent. No serious side effects were observed except slight dizziness in one case.

• 대한한방내과학회지
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• 제23권2호
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• pp.286-291
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• 2002

Urinary tract infection(UTI) is one of the common complications in stroke patients. As it has negative effect on the recovery of stroke, it should be cured out immediately. But antibiotics might cause some adverse reactions such as diarrhea, eruption, anorexia, nausea and vomiting. so there have been several reports about treating urinary tract infection with Traditional Korean Medication. We treated a 54-year-old male patient with cerebral hemorrhage, who had had neurogenic bladder after stroke and had been urinated by intermittent catheterization. About 10 days later, he could void by himself without catheter, but showing the symptoms of UTI; Voiding pain, hematuria and yellowish pus. The pus culture grew Staphylococcus spp., which was resistant to most of antibiotics except vancomycin and teicoplanin. Based on accompanying symptoms of intermittent dizziness, headache, insomnia, nocturnal sweating, weak pulse, red tongue and urinary problem, we differentiated him as the deficiency of Yin of the Kidney[腎陰虛] and treated with Gagamyookmijihwang-tang (Jia-Jian-Liu-Wei-De- Huang-Tang), which improved his urinary symptoms and other general conditions without any side effect. In next follow-up culture, there was no pathogen. We conclude that Traditional Korean Medicine based on differentiation is useful in the treatment of urinary tract infection.

• Journal of Acupuncture Research
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• 제25권1호
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• pp.233-245
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• 2008

Multiple Myeloma is malignant tumor that malignant proliferous plasma cell to originate from bone marrow invades bone multiply. Objectives : Therapy for Multiple Myeloma includes chemotherapy, radiation therapy and self-stem cell transplantation, but it has no effect for a majority of Multiple Myeloma patients. So we diagnosed it as Wei symptom, oliguria, or dysuria(遺尿) in Oriental medicine, and treated it using the Oriental medical system. Methods : The patient was treated using acupuncture, electroacupuncture, herbal acupuncture treatment, moxibustion, physical treatment and western medicine. We observed 12 kinds of symptoms in the patient when admitted to the hospital. Results : 1. Paraplegia, urination desire, voluntary urination, and other symptoms improved except for a period of complication. 2. Defecation desire, sensory disturbance of the body and lower extremities, self-made changes, maintenance of body posture, and other symptoms improved during admitting days. 3. Voluntary defecation, pains of the neck and lower extremities, and other symptoms had irregular changes during admitting days. Conclusions : This study demonstrates the necessity of having more clinical study about Mutiple Myeloma.