• Journal of Preventive Medicine and Public Health
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• 제27권3호
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• pp.557-567
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• 1994

This study was conducted to examine the effect of chronic low dose organic solvent exposures in the industries towards then neurobehavioral functions of workers. Subjective symptoms on neurobehavioral function as well as a visual reaction time test (Flicker test) were administered to 94 exposed and 162 unexposed workers in a oil refinery and some other auto-repair shops. The results obtained were as follows : 1. Symptom complaints were higher and Flicker test values were lower in exposed workers than in unexposed workers. 2. Flicker valus were Inversely correlated with urinary Hippuric acid concentration in exposed workers(r=-0.26, p<0.05). 3. Flicker valus were inversely co..elated with Subjective symptom score(r=-0.15, p<0.05). Low Flicker value were also related with some subjetive symptoms such as 'Dimmed vision', 'Nightmare', 'Weakness on extrimity' in workers as a whole. While symptoms of 'Dimmed vision ', 'Nightmare' only observed among exposed workers.

• Journal of Korean Neurosurgical Society
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• 제63권2호
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• pp.163-170
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• 2020

Objective : Milk fat globule-epidermal growth factor VIII (MFG-E8) may play a key role in inflammatory responses and has the potential to function as a neuroprotective agent for ameliorating brain injury in cerebral infarction. This study aimed to determine the role of MFG-E8 in brain injury in the subacute phase of cerebral ischemia in a rat model. Methods : Focal cerebral ischemia was induced in rats by occluding the middle cerebral artery with the modified intraluminal filament technique. Twenty-four hours after ischemia induction, rats were randomly assigned to two groups and treated with either recombinant human MFG-E8 or saline. Functional outcomes were assessed using the modified Neurological Severity Score (mNSS), and infarct volumes were evaluated using histology. Anti-inflammation, angiogenesis, and neurogenesis were assessed using immunohistochemistry with antibodies against ionized calcium-binding adapter molecule 1 (Iba-1), rat endothelial cell antigen-1 (RECA-1), and bromodeoxyuridine (BrdU)/doublecortin (DCX), respectively. Results : Our results showed that intravenous MFG-E8 treatment did not reduce the infarct volume; however, the mNSS test revealed that neurobehavioral deficits were significantly improved in the MFG-E8-treated group than in the vehicle group. Immunofluorescence staining revealed a significantly lower number of Iba-1-positive cells and higher number of RECA-1 in the periinfarcted brain region, and significantly higher numbers of BrdU- and DCX-positive cells in the subventricular zone in the MFG-E8-treated group than in the vehicle group. Conclusion : Our findings suggest that MFG-E8 improves neurological function by suppressing inflammation and enhancing angiogenesis and neuronal proliferation in the subacute phase of cerebral infarction.

• 대한통합의학회지
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• 제7권3호
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• pp.33-40
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• 2019

Purpose : The purpose of this randomized controlled trial study was to examine the effect of transcranial direct current stimulation (tDCS) on cognitive function and depression in stroke patients. Methods : Thirty stroke patients were randomly divided into an experimental group (n = 15) and a control group (n = 15). The experimental group received tDCS while performing computerized cognitive rehabilitation programs, and the control group was provided with sham tDCS while operating the same programs. The 30-minute intervention was implemented five times per week for six weeks. To assess cognitive function before and after the intervention, the Neurobehavioral Cognitive Status Examination was conducted; the Beck Depression Inventory BDI was employed to assess depression. Results : The experimental group showed statistically significant increases in cognitive function and decreases in depression (p < .05 ). Comparing the amount of variation between the groups after arbitration also showed significant differences in cognitive function and depression between the two groups (p > .05). Conclusion : The application of tDCS and computerized cognitive rehabilitation programs for stroke patients may positively affect their cognitive function and depression. Therefore, tDCS used with computerized cognitive rehabilitation programs is positively applicable to the enhancement of cognitive function in stroke patients and reduction of depression.

• Clinical and Experimental Pediatrics
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• 제51권9호
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• pp.935-943
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• 2008

Attention deficit hyperactivity disorder (ADHD) is a neurobehavioral developmental disorder characterized by a persistent pattern of inattention and/or hyperactivity, as well as forgetfulness, poor impulse control or impulsivity, and distractibility. The recommended evaluation includes documenting the type and severity of ADHD symptoms, verifying the presence of normal vision and hearing, screening for comorbid psychological conditions, reviewing the child's developmental history and school performance, and applying objective measures of cognitive function. Prevailing opinion characterizes ADHD as a disorder of executive function attributable to abnormal dopamine transmission in the frontal lobes and frontostriatal circuitry. A clearly defined etiology remains unknown, but studies suggest a strong genetic link. The aim of treatment is to decrease symptoms, enhance functionality, and improve well-being for the child and his or her close contacts. Stimulants remain the pharmacological agents of first choice for the management of ADHD, and psychosocial, behavioral and educational strategies that enhance specific behaviors may improve educational and social functioning in children with ADHD.

• Journal of Yeungnam Medical Science
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• 제14권1호
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• pp.183-196
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• 1997

유기용제가 신경행동기능에 미치는 영향을 평가하기 위하여 에탄올을 이용하여 저농도의 유기용제가 신경행동기능에 미치는 영향을 정량적으로 평가하고 신경행동기능 영역중 에탄올에 민감한 기능영역을 선별하기 위하여 실험연구를 시행하였다. 영남대학교 의과대학 학생중 20명을 대상으로 설문조사 및 신경행동학적 검사를 1996년 8월동안 실시하였다. 대상자의 체중 kg당 100% 알코올 0.5g을 섭취하고 개인용 컴퓨터를 이용하여 단순반응시간, 색단어구분, 숫자구분, 손가락두드리기, 숫자더하기, 부호숫자짝짓기, 숫자외우기를 시행하였다. 알코올 섭취 전과 후의 신경행동기능의 변화량은 단순반응시간(반응시간 237.4 : 269 msec, p<0.01), 숫자구분(반응시간 490.4 : 553.9 msec, p<0.01), 우수의 손가락두드리기(반응시간 66.7 : 63.3, p<0.05)와 부호숫자짝짓기(반응시간 1958.7 : 2066.6 msec, p<0.05)에서 통계적으로 매우 유의하였다. 평소 음주량이 많을수록 단순반응시간, 열수의 손가락두드리기, 부호숫자짝짓기에서는 반응시간이 길어지고, 우수의 손가락두드리기에서 두드린 수가 적어지는 경향을 보였다. 흡연량이 많을수록 열수의 손가락두드리기에서 두드린 횟수가 증가하는 경향을 보였다(p<0.05). 알코올의 급성폭로 후 나타난 결과로 만성적 폭로의 영향을 평가하는데 이용하기에는 다소 무리가 있으나 향후 유기용제의 만성효과에 관한 역학적 연구를 위한 신경행동학적 검사항목의 선택에 도움을 줄 수 있을 것으로 생각된다.

• 한국콘텐츠학회논문지
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• 제13권6호
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• pp.339-349
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• 2013

뇌손상 환자들을 대상으로 한국판 간이정신상태검사(MMSE-K)와 한국형 컴퓨터 신경행동검사(KCNT)를 실시하여 관련성을 평가하고, 확정적 정상군과 치매 의심군을 구분하는데 있어서 KCNT의 유용성을 평가하기 위하여 수행되었다. 뇌손상 환자 50명 중 확정적 정상군과 치매 의심군의 KCNT 결과는 정규성 검정을 만족하여 두 군간 비교는 t 검정을, MMSE-K와 KCNT 결과간에는 이변량 상관분석을 실시하였다. 두 군의 특성은 유의한 차이가 없었으며, KCNT 결과는 두 군간 모든 항목에서 유의한 차이가 있었다(p<.05). 두 검사간 Pearson 상관계수는 단순반응시간(r=-.580), 선택반응시간(r=-.341), 글자색 맞추기(r=-.661), 숫자구분(r=-.703), 두 자리 숫자더하기(r=-.582), 세 자리 숫자더하기(r=-.610), 부호숫자 짝짓기(r=-.642), 숫자외우기(r=.807)로 유의한 상관관계가 있었다(p<.05). 이 중 단순반응시간, 두 자리 숫자더하기는 확정적 정상군과 치매 의심군에서 서로 다른 부호의 상관계수를 나타내 두 군을 구분하는 검사로 사용할 수 있을 것으로 생각되며, 제안된 KCNT 항목들을 검사 목적에 따라 선택하여 사용하면 두 군의 인지기능을 관찰하기 위한 검사로 유용하게 사용할 수 있을 것으로 생각된다.

• Parasites, Hosts and Diseases
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• 제58권4호
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• pp.461-466
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• 2020

Toxoplasma gondii is an obligate intracellular protozoan parasite that can invade various organs in the host body, including the central nervous system. Chronic intracranial T. gondii is known to be associated with neuroprotection against neurodegenerative diseases through interaction with host brain cells in various ways. The present study investigated the neuroprotective effects of chronic T. gondii infection in mice with cerebral ischemia experimentally produced by middle cerebral artery occlusion (MCAO) surgery. The neurobehavioral effects of cerebral ischemia were assessed by measurement of Garcia score and Rotarod behavior tests. The volume of brain ischemia was measured by triphenyltetrazolium chloride staining. The expression levels of related genes and proteins were determined. After cerebral ischemia, corrected infarction volume was significantly reduced in T. gondii infected mice, and their neurobehavioral function was significantly better than that of the uninfection control group. Chronic T. gondii infection induced the expression of hypoxia-inducible factor 1-alpha (HIF-1α) in the brain before MCAO. T. gondii infection also increased the expression of vascular endothelial growth factor after the cerebral ischemia. It is suggested that chronic intracerebral infection of T. gondii may be a potential preconditioning strategy to reduce neural deficits associated with cerebral ischemia and induce brain ischemic tolerance through the regulation of HIF-1α expression.

• 생물정신의학
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• 제2권1호
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• pp.28-37
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• 1995

Clinical neuropsychology which belongs to the necuroscience field is concerned with relationship between human behaviors and the brain structure. Clinical neuropsychology has grown to be a specialized separate field within psychology over the last twenty years. Clinical neuropsychology offers an objective methodology to consider the mind-body interaction and evaluate the behavioral consequences and functional deficits associated with brain lesions. Clinical neuropsychological assessment is composed of cognitive, perceptual, motor and emotional function through various neuropsychological examinations such as Halsted-Reitan and Luria-Nebraska batteries, and computerized neuropsychological test such as PCIS Vienna Test System and Stim. The goals of neuropsychological evaluation are to identify of neuropsychological dysfuncitions, to develop execute and monitor treatment plans, and to make rehabilitation programs. Recently, the neuropsychiatric patients are increasing in number and 15-20% of acute psychiatric patients suffer from organic mental problems. Moreover, clinical neuropsychology has an increasingly important role in both neurobehavioral foundation and clinical application. So, psychiatrists must play a major role in the development of clinical neuropsychology in psychiatry.

• 대한통합의학회지
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• 제8권2호
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• pp.121-130
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• 2020

Purpose : The objective of the current study was to evaluate the impact of the Computer-Based Cognitive Rehabilitation Program (CoTras) on the cognitive function and daily living activities of elderly and adult stroke patients. Methods : Twenty stroke patients were divided into two groups comprising 10 elderly stroke patients and 10 adult stroke patients. The CoTras was applied as the intervention for 30 minutes at a time, three times a week, for nine weeks (i.e., a total of 27 times), to both groups. The Neurobehavioral Cognitive Status Examination was used to assess cognitive function, and the Functional Independence Measure was utilized to evaluate daily living activities, prior to, during, and after the intervention. Results : The CoTras was demonstrated to have a statistically significant and positive effect on the cognitive function and daily living activities of stroke patients. However, the effect of the program on the restoration of weight-shifting capacity, as a component of the daily living activities of stroke patients, was without statistical significance. The program had a greater influence on improving the cognitive function and daily living activities of elderly stroke patients than adult stroke patients. Conclusion : This study makes a meaningful contribution to the literature on the topic as the intervention was demonstrated to lead to a more significant recovery of cognitive function and daily living activities in elderly stroke patients, compared to adult patients. Therefore, it is proposed that the CoTras should be used as a clinical intervention for elderly stroke patients. Future studies that evaluate the application of the CoTras, along with other occupation-based intervention programs, are warranted.

• 대한통합의학회지
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• 제9권4호
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• pp.49-58
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• 2021

Purpose : This study investigates the effects of the application of traditional occupational therapy and the korean computerized cognition training system on the cognitive function and performance of daily activities of stroke patients with cognitive impairment. Methods : From inpatients referred for rehabilitation treatment at L Rehabilitation Hospital located in Busan, 20 patients diagnosed with stroke from April 05. 2021 to May 02. 2021 (study period) were selected, They were divided into two, an experimental group consisting of 10 subjects who underwent a computerized cognitive rehabilitation program and traditional occupational therapy in combination and a control group of 10 subjects who underwent traditional occupational therapy alone. In order to measure the cognitive function of the subjects before the intervention, two assessment tests were conducted: a Neurobehavioral Cognitive Status Examination (NCSE), which evaluates stroke-related cognitive ability, and a Functional Independence Measure (FIM) test, which evaluates life activities. Then, both groups received a total of 20 training sessions at 30 minutes per session, five times a week for four weeks. Results : A statistically significant difference was found in cognitive function between before and after the cognitive training for both the experimental group and the control group. For the FIM scores, statistically significant differences were observed after intervention in the categories of handling personal matters and social cognition, and in the total score. The average scores of the remaining items also improved. Conclusion : The results of this study showed that both the computerized cognition rehabilitation program and the traditional occupational therapy had a positive effect on the improvement of cognitive function in stroke patients.