• Clinical Psychopharmacology and Neuroscience
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• v.16 no.4
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• pp.481-488
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• 2018

Preliminary studies have claimed that short term fasting would negatively affect school performance and cognition. In contrast some other studies have reported not important decline in cognition and executive function as a result of fasting. Also limited attention was generally devoted to dietetic regimens, nutritional status and body weight. Yet neuroscience and neuro-cognitive aspects of acute hunger on the electroencephalogram and differences between obese and non-obese cases is not well understood. Hence, we decided to design and perform a case study in a more controlled situation similar to reality. Therefore, we performed several examinations including subjective tests (for eating status) and objective tests (cognitive tests such as Stroop effect and Sternberg search and electroencephalogram measures such as steady-state visual evoked potential and auditory steady-state responses) for an obese and a non-obese academic case before and after a simple breakfast. The results showed that the breakfast effects on the neuro-cognitive functions depend on either obesity status, nutritional status of the case or the type of cognitive task (visual or auditory). This paper would open a new insight to answer some important questions about the neuro-cognitive implications of fasting and feeding in obese and non-obese human cases.

• Proceedings of the Korean Society for Cognitive Science Conference
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• 2006.06a
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• pp.39-41
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• 2006

A modifiedPosner cue-target paradigm in which neutral, positive and negative (threat) words were presented in peripheral location for cue was used to investigate the difference of engagement component of attention across emotional valence and anxiety level of participants. Results showed an interaction effect between anxiety level of participants and emotional valence of cue in valid trial. This indicates that the engage component of attention is not encapsulated and influenced by anxiety level of participant.

• Annual Conference on Human and Language Technology
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• 2004.10d
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• pp.229-231
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• 2004

본 연구는 다(多)음절 한국어 단어재인에서의 어휘접근단위(unit of lexical access)를 알아보고자 했다. 이를 위해 Taft(1987)가 영어 어휘접근단위를 알아보고자 했을 때 사용한 실험 패러다임을 이용하였다. 실험 결과 반응시간에서는 조건간 통계적으로 유의미한 차이를 보이지 않았지만, BOSS 조건의 반응시간이 짧은 경향성을 보였고, 반응률에 있어서도 BOSS를 지지하는 결과를 보여주었다. 물론, 반응 오류가 많은 등 Taft(1987)의 패러다임을 한국어에 적용하기에 부적절했던 점이 있었지만, 적어도 다음절 단어 어휘접근 시 BOSS가 역할을 하고 있다는 것은 알아 볼 수 있었다.

• Journal of the Korea Convergence Society
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• v.12 no.11
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• pp.161-168
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• 2021

Recently, many cognitive training programs based on digital contents have been presented, but few digital contents have been produced for children with intellectual disabilities among children with developmental disabilities. Digital contents based training programs are needed to apply remotely untact training programs rather than face-to-face apprenticeship classes for improving the cognition of children with intellectual disabilities. This study was attempted to present the new cognitive training program by analyzing concurrent validity, which was analyzed by the correlation between items by comparing with subtests of K-WISC-IV and items of game based Neuro-World cognitive training program. It was found that there are some validity by analyzing correlation between the subtests of K-WISC-IV and the items of Neuro-World program, which means that it has concurrent validity of some items of Neuro-World program. In terms of reliability, the Cronbach alpha value was 0.794, indicating that game performance of children with intellectual disabilities and the degree of level increase in each game were somewhat reliable. This is considered to be a significant result in future studies for clinical trials of cognitive training tools.

• Molecules and Cells
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• v.42 no.5
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• pp.418-425
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• 2019

Multicistronic elements, such as the internal ribosome entry site (IRES) and 2A-like cleavage sequence, serve crucial roles in the eukaryotic ectopic expression of exogenous genes. For utilization of multicistronic elements, the cleavage efficiency and order of elements in multicistronic vectors have been investigated; however, the dynamics of multicistronic element-mediated expression remains unclear. Here, we investigated the dynamics of encephalomyocarditis virus (EMCV) IRES- and porcine teschovirus-1 2A (p2A)-mediated expression. By utilizing real-time fluorescent imaging at a minute-level resolution, we monitored the expression of fluorescent reporters bridged by either EMCV IRES or p2A in two independent cultured cell lines, HEK293 and Neuro2a. We observed significant correlations for the two fluorescent reporters in both multicistronic elements, with a higher correlation coefficient for p2A in HEK293 but similar coefficients for IRES-mediated expression and p2A-mediated expression in Neuro2a. We further analyzed the causal relationship of multicistronic elements by convergent cross mapping (CCM). CCM revealed that in all four conditions examined, the expression of the preceding gene causally affected the dynamics of the subsequent gene. As with the cross correlation, the predictive skill of p2A was higher than that of IRES in HEK293, while the predictive skills of the two multicistronic elements were indistinguishable in Neuro2a. To summarize, we report a significant temporal correlation in both EMCV IRES- and p2A-mediated expression based on the simple bicistronic vector and real-time fluorescent monitoring. The current system also provides a valuable platform to examine the dynamic aspects of expression mediated by diverse multicistronic elements under various physiological conditions.

• PNF and Movement
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• v.10 no.3
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• pp.45-52
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• 2012

Purpose : This study examines the relationship between the Mini Mental State Examination-Korean Version(MMSE-K) and the Neuro-behavioral Cognitive Status Examination(NCSE) in Stroke Patients. Methods : We studied sixteen people with stroke(7 males, 9 females) who were admitted to occupational therapy a participants were tested with the MMSE-K, the NCSE. Results : Correlation between the NCSE and the MMSE-K was significant in p<.05, p<.01. The result was orientation r=.652, memory r=.514, attention r=.417, calculation r=.839, comprehension r=.676, repetition r=.960, naming r=.683, construction r=.961, judgement r=.616. Conclusion : The MMSE-K and the NCSE are valid and useful measurement tools evaluating cognitive function of persons with stroke in Korea.

• Advances in robotics research
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• v.1 no.2
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• pp.155-169
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• 2014

Study results in the last decades show that amount and quality of physical exercises, then the active participation, and now the cognitive involvement of patient in rehabilitation training are known of crux to enhance recovery outcome of motor dysfunction patients after stroke. Rehabilitation robots mainly have been developing along this direction to satisfy requirements of recovery therapy, or focusing on one or more of the above three points. Therefore, neuro-machine interaction based active rehabilitation robot has been proposed for assisting paralyzed limb performing designed tasks, which utilizes motor related EEG, UCSDI (Ultrasound Current Source Density Imaging), EMG for rehabilitation robot control and feeds back the multi-sensory interaction information such as visual, auditory, force, haptic sensation to the patient simultaneously. This neuro-controlled and perceptual rehabilitation robot will bring great benefits to post-stroke patients. In order to develop such kind of robot, some key technologies such as noninvasive precise detection of neural signal and realistic sensation feedback need to be solved. There are still some grand challenges in solving the fundamental questions to develop and optimize such kind of neuro-machine interaction based active rehabilitation robot.

• Korean Journal of Cognitive Science
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• v.17 no.4
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• pp.375-398
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• 2006

Humans learn by observing, hearing, imitating, doing, and feeling. The brain(cortex) is the central tore of this process. The recent rapid progress of brain science and the active interdisciplinary collaboration between brain science and cognitive science opens a new possibility. That is a new research Held called 'Brain-Based learning Science', 'Edutational Neuroscienre', or 'NeuroEduration' This study reviews the nature and basic assumptions of brain-based learning science, current directions in educational neuroscience research, the neuro-myths, educational implications of neuroscience, and a possibility of making a meaningful connection between brain science and education. Also the future prospects and limitations of the brain-based learning science are discussed.

• Investigative Magnetic Resonance Imaging
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• v.24 no.2
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• pp.76-84
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• 2020

Background: Determination of inter-method differences between clinically available volumetry methods are essential for the clinical application of brain volumetry in a wider context. Purpose: The purpose of this study was to examine the inter-method reliability and differences between the Siemens morphometry (SM) software and the NeuroQuant (NQ) software. Materials and Methods: MR images of 86 subjects with subjective or objective cognitive impairment were included in this retrospective study. For this study, 3D T1 volume images were obtained in all subjects using a 3T MR scanner (Skyra 3T, Siemens). Volumetric analysis of the 3D T1 volume images was performed using SM and NQ. To analyze the inter-method difference, correlation, and reliability, we used the paired t-test, Bland-Altman plot, Pearson's correlation coefficient, intraclass correlation coefficient (ICC), and effect size (ES) using the MedCalc and SPSS software. Results: SM and NQ showed excellent reliability for cortical gray matter, cerebral white matter, and cerebrospinal fluid; and good reliability for intracranial volume, whole brain volume, both thalami, and both hippocampi. In contrast, poor reliability was observed for both basal ganglia including the caudate nucleus, putamen, and pallidum. Paired comparison revealed that while the mean volume of the right hippocampus was not different between the two software, the mean difference in the left hippocampus volume between the two methods was 0.17 ml (P < 0.001). The other brain regions showed significant differences in terms of measured volumes between the two software. Conclusion: SM and NQ provided good-to-excellent reliability in evaluating most brain structures, except for the basal ganglia in patients with cognitive impairment. Researchers and clinicians should be aware of the potential differences in the measured volumes when using these two different software interchangeably.

• Journal of Korean Society of Forest Science
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• v.104 no.2
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• pp.277-284
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• 2015

This study aims to evaluate the impact of forest therapy on neuro-cognitive, psychosocial, and physiological aspect of adolescent internet addiction risk group. We have classified potential and high risk user group as internet addiction risk group according to the criteria of Korean Internet Addiction Proneness Scale(K Scale). Based on the results of k-scale from the adolescents in metropolitan area from May to July 2013, 25 people were selected as Internet addiction risk group. We have randomized 13 participants joining forest therapy camp and 12 participants not joining one, and analyzed the change of the two groups with Continuous Performance, Kimberly S. Young, Connor-Davidson Resilience, Relationship Change Scale, heart rate variability and cortisol. Statistically significant changes were observedd in neuro-cognitive, psychosocial, and physiological variables, Through this study, we can consider that the therapy healing may relieve the level of internet addiction and can be an alternative to control emotional stability and impulsive behavior.