• Journal of Electrical Engineering and Technology
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• 제9권3호
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• pp.1060-1071
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• 2014

Signals of the Electroencephalogram (EEG) can reflect the electrical background activity of the brain generated by the cerebral cortex nerve cells. This has been the mostly utilized signal, which helps in effective analysis of brain functions by supervised learning methods. In this paper, an approach for improving the accuracy of EEG signal classification is presented to detect epileptic seizures. Moreover, Independent Component Analysis (ICA) is incorporated as a preprocessing step and Short Time Fourier Transform (STFT) is used for denoising the signal adequately. Feature extraction of EEG signals is accomplished on the basis of three parameters namely, Standard Deviation, Correlation Dimension and Lyapunov Exponents. The Artificial Neural Network (ANN) is trained by incorporating Levenberg-Marquardt(LM) training algorithm into the backpropagation algorithm that results in high classification accuracy. Experimental results reveal that the methodology will improve the clinical service of the EEG recording and also provide better decision making in epileptic seizure detection than the existing techniques. The proposed EEG signal classification using feed forward Backpropagation Neural Network performs better than to the EEG signal classification using Adaptive Neuro Fuzzy Inference System (ANFIS) classifier in terms of accuracy, sensitivity, and specificity.

• Molecules and Cells
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• 제37권9호
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• pp.650-655
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• 2014

Mesenchymal stem cells (MSCs) can differentiate into neural cells to treat nervous system diseases. Magnetic resonance is an ideal means for cell tracking through labeling cells with superparamagnetic iron oxide (SPIO). However, no studies have described the neural differentiation ability of SPIO-labeled MSCs, which is the foundation for cell therapy and cell tracking in vivo. Our results showed that bone marrow-derived mesenchymal stem cells (BM-MSCs) labeled in vitro with SPIO can be induced into neural-like cells without affecting the viability and labeling efficiency. The cellular uptake of SPIO was maintained after labeled BM-MSCs differentiated into neural-like cells, which were the basis for transplanted cells that can be dynamically and non-invasively tracked in vivo by MRI. Moreover, the SPIO-labeled induced neural-like cells showed neural cell morphology and expressed related markers such as NSE, MAP-2. Furthermore, whole-cell patch clamp recording demonstrated that these neural-like cells exhibited electrophysiological properties of neurons. More importantly, there was no significant difference in the cellular viability and $[Ca^{2+}]_i$ between the induced labeled and unlabeled neural-like cells. In this study, we show for the first time that SPIO-labeled MSCs retained their differentiation capacity and could differentiate into neural-like cells with high cell viability and a good cellular state in vitro.

• Annals of Clinical Neurophysiology
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• 제1권2호
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• pp.160-167
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• 1999

Although somatosensory evoked potentials(SSEPs) have been utilized as the useful diagnostic tools in evaluating the wide variety of pathological conditions, such as focal lesions affecting the somatosensory pathways, demyelinating diseases, and detecting the clinically occult abnormality, their neural generators is still considerably uncertain. To appreciate the basis for uncertainties about the origins of SSEPs, consider criteria that must be met to establish a causal relationship between activity in a neural structure and a spine/ scalp-recorded potential. Electrode locations and channel derivations for SSEPs recordings are based on two principles:(1) the waveforms are best recorded from electrode sites on the body surface closest to the presumed generator sources along the somatosensory pathways, and(2) studies of the potential-field distribution of each waveform of interest dictate the best techniques to be used. In this article, authors will describe followings focused on ;(1) the concepts of near field potentials(NFPs) and far field potentials(FFPs) - the voltage of NFPs is highly dependent upon recording electrode position, FFPs are unlike NFPs in that they are widely distributed, their latencies and amplitudes are independent of recording electrode.(2) appropriate montage settings to detect the significant potentials in the median nerve and posterior tibial nerve SSEPs(3) neural generators of various potentials(P9, N13, P14, N18, N20, P37) and their clinical significance in interpretating the results of SSEPs. Especially, Characteristics of N18(longduration, small superimposed inflection) suggested that N18 is a complex wave with multiple generators including brainstem structures and thalamic nuclei. And N18 might be used as the parameter of braindeath. Precise understanding on these facts provide an adequate basis utilizing SSEPs for numerous clinical purposes.

• 한국정밀공학회지
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• 제22권5호
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• pp.80-86
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• 2005

Optical performance evaluation results and an interference fringe pattern analysis of alignment errors for an optical head of a near-field receding (NFR) system are presented. The focusing unit is an optical head of a NFR system and is composed of a solid immersion lens (SIL) and an objective lens (OL). Generally, the size of the focusing unit is smaller than that of the conventional optical recording head. Hence there are difficulties to assemble the small focusing unit precisely. We composed an evaluation system with an interferometer and evaluated some focusing unit samples aligned and assembled by manual and present the obtained results. Using the conventional optical tool, Code V, a tolerance analysis of the alignment error between the SIL and the objective lens and an interference pattern analysis for the assembly error are executed. Then, through an analysis of the simulation results, the conceptual auto-alignment methodology using a neural network approach is considered.

• 대한의용생체공학회:학술대회논문집
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• 대한의용생체공학회 1997년도 추계학술대회
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• pp.31-34
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• 1997

A semiconductor microelectrode array has been successfully used in obtaining single unit recordings from medial giant nerve of clay fish, rat saphenous nerve and abdominal ganglia of aplysia. The recording device fabricated using silicon microfabrication techniques is a depth-probe type and, previously, has been mostly used to record from central nerve system of vertebrates. From invertebrates, and also from peripheral nerves of vertebrates, however, the quality of the recorded signal depends heavily on the recording conditions, such as the proximity of the electrode site to the nerve cells and the size of the neuron. We have modeled the signal to noise ratio as unctions of these parameters and compared the experimental data with the calculated values thus obtained.

• 센서학회지
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• 제24권1호
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• pp.22-28
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• 2015

This study demonstrates a polyimide nerve cuff electrode with a conductive polymer for improving recording signal quality at peripheral nerve. The nerve cuff electrodes with platinum (Pt), iridium oxide (IrOx), and poly(3,4-ethylenedioxythiophene): p-toluene sulfonate (PEDOT:pTS) were fabricated and investigated their electrical characteristics for improving recorded nerve signal quality. The fabricated nerve cuff electrodes with Pt, IrOx, and PEDOT:pTS were characterized their impedance and CDC by using electrochemical impedance spectroscopy (EIS) and cyclic voltammetry. The impedance of PEDOT:pTS measured at 1 kHz was $257{\Omega}$, which was extremely lower than the value of the nerve cuff electrodes with IrOx ($15897{\Omega}$) and Pt ($952{\Omega}$), respectively. Furthermore, the charge delivery capacity (CDC) of the nerve cuff electrode with PEDOT:pTS was dramatically increased to 62 times than the nerve cuff electrode with IrOx. In ex-vivo test using extracted sciatic nerve of spaque-dawley rat (SD rat), the PEDOT:pTS group exhibited higher signal-to-interference ratio than IrOx group. These results indicated that the nerve cuff electrode with PEDOT:pTS is promising for effective implantable nerve signal recording.

• 한국음향학회지
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• 제38권5호
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• pp.568-573
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• 2019

폐질환 진단에서 청진은 다른 진단 방식에 비해 단순하고, 폐음을 이용하여 폐질환 환자식별뿐 아니라 폐음과 관련된 질병을 예측할 수 있다. 따라서 본 논문에서는 다양한 합성곱 신경방 방식을 기반으로 폐음을 이용하여 폐질환 환자를 식별하고, 소리특성에 따른 폐음을 분류하여 각 신경망 방식의 분류 성능을 비교한다. 먼저 폐질환 소견을 갖는 흉부 영역에서 단채널 폐음 녹음기기를 이용하여 폐음 데이터를 수집하고, 수집된 시간축 신호를 스펙트럼 형태의 특징값으로 추출하여 각 분류 신경망 방식에 적용한다. 폐 사운드 분류 방식으로는 일반적인 합성곱 신경망, 병렬 구조, 잔류학습이 적용된 구조의 합성곱 신경망을 사용하고 실험을 통해 각 신경망 모델의 폐음 분류 성능을 비교한다.

• Computers and Concrete
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• 제25권5호
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• pp.433-445
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• 2020

A method is proposed in this paper to estimate the workability of self-compacting concrete (SCC) in different mixing conditions with different mixers and mixing volumes by recording the mixing process based on deep learning (DL). The SCC mixing videos were transformed into a series of image sequences to fit the DL model to predict the SF and VF values of SCC, with four groups in total and approximately thirty thousand image sequence samples. The workability of three groups SCC whose mixing conditions were learned by the DL model, was estimated. One additionally collected group of the SCC whose mixing condition was not learned, was also predicted. The results indicate that whether the SCC mixing condition is included in the training set and learned by the model, the trained model can estimate SCC with different workability effectively at the same time. Our goal to estimate SCC workability in different mixing conditions is achieved.

• Korean Journal of Acupuncture
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• 제35권4호
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• pp.187-202
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• 2018

Objectives : Non-invasive transcranial electrical stimulation is one of therapeutic interventions to change in neural excitability of the cortex. Transcranial electro-acupuncture (TEA) can modulate brain functions through changes in cortical excitability as a model of non-invasive transcranial electrical stimulation. Some composites of fermented Scutellaria baicalenis (FSB) can activate intercellular signaling pathways for activation of brain-derived neurotrophic factor that is critical for formation of neural plasticity in stroke patients. This study was aimed at evaluation of combinatory treatment of TEA and FSB on behavior recovery and cortical neural excitability in rodent focal stroke model. Methods : Focal ischemic stroke was induced by photothrombotic injury to the motor cortex of adult rats. Application of TEA with 20 Hz and $200{\mu}A$ in combination with daily oral treatment of FBS was given to stroke animals for 3 weeks. Motor recovery was evaluated by rotating bean test and ladder working test. Electrical activity of cortical pyramidal neurons of stroke model was evaluated by using multi-channel extracellular recording technique and thallium autometallography. Results : Compared with control stroke group who did not receive any treatment, Combination of TEA and FSB treatment resulted in more rapid recovery of forelimb movement following focal stroke. This combination treatment also elicited increase in spontaneous firing rate of putative pyramidal neurons. Furthermore expression of metabolic marker for neural excitability was upregulated in peri-infract area under thallium autometallography. Conclusions : These results suggest that combination treatment of TEA and FSB can be a possible remedy for motor recovery in focal stroke.

• 센서학회지
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• 제22권5호
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• pp.309-314
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• 2013

Glass micropipettes are widely used for drug injection in neurological studies. To enable these devices to monitor neural activity simultaneously with drug injection, an electrode such as Ag/AgCl must be located near or inserted into the glass micropipette to detect electrical signals in vivo. Here, we report carbon-nanotube-modified glass micropipettes (CNGs), which have excellent electrochemical properties such as low impedance and large electrochemical surface area suited for neural recording. In addition, using a standard pressure pump, CNGs can deliver drugs to the target region without bending. Because they are based on standard glass micropipettes, CNGs can readily be applied to traditional equipment, creating opportunities to monitor precisely the drug-injected area.