• The Korean Journal of Cytopathology
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• v.15 no.2
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• pp.75-80
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• 2004

To analyze the accuracy and usefulness of sputum cytology as a screening method, 103 cases of histologically proven lung cancer registered from 1998 to 2000 at Kangbuk Samsung Hospital were retrospectively examined. We reviewed the original cytologic and surgical diagnoses for the cases, and the cytology slides of all cytologically negative cases. The overall sensitivity of sputum cytology was 0.83 ; the sensitivity of prebronchoscopy sputum cytology for bronchogenic carcinoma was 0.87. Central tumor location (P=0.002), tumor size (>2.4 cm), (P=0.027) and the number of sputum samples $(\geq3)$ (P=0.001) were associated with a positive cytologic diagnosis. Of the 18 cytologically negative cases, 9 cases(38% of smears) were determined to be insufficient for diagnosis, due strictly to low cellularity and saliva. After a review of the cytology slides of cytologically negative cases, we identified several atypical clusters in one case of bronchioloalveolar carcinoma. This negativity was thus attributed to an interpretation error (1/18, 5.6%). Our results suggest that its sensitivity is more strongly related to the specimen adequacy and the times of sampling than to interpretation error. In terms of sensitivity, specificity, accessibility, cost, and morbidity associated with the screening tests, sputum cytology was found to be an accurate effective screening method for lung cancer.

• The Journal of the Acoustical Society of Korea
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• v.34 no.3
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• pp.234-239
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• 2015

Non-Negative Matrix Factorization (NMF) is a method for updating dictionary and gain in alternating manner. Due to ease of implementation and intuitive interpretation, NMF is widely used to detect and separate overlapping sound events. However, NMF that utilizes non-negativity constraints generates parts-based representation and this distinct property leads to a dictionary containing fragmented acoustic events. As a result, the presence of shared basis results in performance degradation in both separation and detection tasks of overlapping sound events. In this paper, we propose a new method that utilizes K-Singular Value Decomposition (K-SVD) based dictionary to address and mitigate the part-based representation issue during the dictionary learning step. Subsequently, we calculate the gain using NMF in sound event detection step. We evaluate and confirm that overlapping sound event detection performance of the proposed method is better than the conventional method that utilizes NMF based dictionary.

• The Journal of the Korea Contents Association
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• v.16 no.5
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• pp.375-383
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• 2016

The purpose of this study is to consider the impact on the degree of turnover of the professional self-concept and the emotional labor. This study were subjected to empirical analysis on female children's hospital nurses. The results of the analysis, only emotional labor and task satisfaction among the components of the professional self-concept became statistically significant results. The relationship between professional pride and task satisfaction have a significant effect on turnover. The relationship only of surface acting and turnover between those of emotional labor and turnover became significant. Based on the research results, it should be preferred to nurse specialists in the women's hospital, in order to lower the turnover of nurses. Management strategies of the organization should be sought to improve operational feeling of satisfaction, and Also the approach should be applied to ease the negativity of surface acting.

• The Journal of the Korea Contents Association
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• v.20 no.9
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• pp.238-248
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• 2020

This study examines the feelings of positivity and negativity generated through upward social comparison and explores the impact of the results of the emotions on SNS users' posting behavior. In particular, this study aims to systematically identify the influence of upward social comparison on SNS followers and uploaders' SNS usage behavior and the structural principle of social network circulation in which followers become uploaders again. According to the analysis, interaction-oriented followers made negative upward social comparison and positive upward social comparison, while negative upward social comparison reduced the publication of independence tendency. However, positive upward social comparison has been shown to increase both independent and interactive postings. The results of this study are meaningful in that SNS has expanded the results of prior studies, in which social comparison theories were biased toward negative upward comparisons, to positive upward comparisons. In addition, this study suggested a practical strategy for SNS platform operators on how SNS users would not deviate from other platforms.

• Journal of Convergence for Information Technology
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• v.10 no.10
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• pp.318-324
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• 2020

The present study was conducted to investigate the influences of emotion priming and the number of negation words on the task of sentential predicate reasoning in groups with or without anxiety symptoms. 3 types of primed emotions and 2 types of stimulus and 3 conditions of negation words were used as a within-subject variable. The subjects were instructed to make facial expressions that match the directions, and were asked to choose the correct answer from the given examples. Mixed repeated measured ANOVA analyses on reaction time first showed main effects for the variables of emotion, stimulus, number of negation words and anxiety level, and the interaction effects for the negation words x anxiety combination. These results are presumably suggested to reflect that externally intervening emotion works on language comprehension in a way that anxiety could delay task processing speed regardless of the emotion and stimulus type, meanwhile the number of negation words can slower language processing only in a anxiety group. Implications and limitations were discussed for the future work.

• Korean journal of communication and information
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• v.81
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• pp.40-74
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• 2017

Drawn upon the analysis of Seoul community media, this study make six points. The generation of community is not essentially determined but has singularity and differences. Historical context, social conditionality, cultural orientation, and the subjects' will and anticipation bring out certain forms of community. Various power relations and desires are engaged in the formation of community. The process of the construction of community is necessarily and simultaneously mediated with collective acts of communication and sharing. Community is not so much cultivated within society as articulated with precariousness, negativity and limit. Community is able to create its own cultural sensibility and language to express it. Thereby community is a dynamics between articulation and disarticulation, convergency and divergency, similitude and difference living in our actual society.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.3
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• pp.1077-1082
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• 2016

Background: The three standard biomarkers used in breast cancer are the estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2). The Ki-67 index, a proliferative marker, has been shown to be associated with a poorer outcome, and despite absence of standardization of pathological assessment, is widely used for therapy decision making. We aim to study the role of the Ki-67 index in a group of Asian women with breast cancer. Materials and Methods: A total of 450 women newly diagnosed with Stage 1 to 3 invasive breast cancer in a single centre from July 2013 to Dec 2014 were included in this study. Univariable and multivariable logistic regression was used to determine the association between Ki-67 (positive defined as 14% and above) and age, ethnicity, grade, mitotic index, ER, PR, HER2, lymph node status and size. All analyses were performed using SPSS Version 22. Results: In univariable analysis, Ki -67 index was associated with younger age, higher grade, ER and PR negativity, HER2 positivity, high mitotic index and positive lymph nodes. However on multivariable analysis only tumour size, grade, PR and HER2 remained significant. Out of 102 stage 1 patients who had ER positive/PR positive/HER2 negative tumours and non-grade 3, only 5 (4.9%) had a positive Ki-67 index and may have been offered chemotherapy. However, it is interesting to note that none of these patients received chemotherapy. Conclusions: Information on Ki67 would have potentially changed management in an insignificant proportion of patients with stage 1 breast cancer.

• Archives of Plastic Surgery
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• v.40 no.6
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• pp.748-753
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• 2013

Background Nasal reconstruction is one of the most difficult challenges for the head and neck surgeon, especially in the case of complex full thickness defects following malignant skin tumor resection. Full-thickness defects require demanding multi-step reconstruction. Methods Seven patients underwent surgical reconstruction of full-thickness nasal defects with a bi-pedicled forehead flap shaped appropriately to the defect. Patients were aged between 58 and 86 years, with a mean age of 63.4 years. All of the tumors were excised using traditional surgery, and in 4 of the patients, reconstruction was performed simultaneously following negativity of fresh frozen sections of the margins under general anesthesia. Results Nasal reconstruction was well accepted by all of the patients suffering non-melanoma skin tumors with acceptable cosmetic outcomes. The heart-shaped forehead flap was harvested in cases of subtotal involvement of the nasal pyramid, while smaller defects were reconstructed with a wing-shaped flap. No cartilaginous or osseous support was necessary. Conclusions This bi-pedicled forehead flap was a valid, versatile, and easy-to-implement alternative to microsurgery or multi-step reconstruction. The flap is the best indication for full-thickness nasal defects but can also be indicated for other complex facial defects in the orbital (exenteratio orbitae), zygomatic, and cheek area, for which the availability of a flap equipped with two thick and hairless lobes can be a valuable resource.

• Journal of Gastric Cancer
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• v.20 no.1
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• pp.106-114
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• 2020

Breast metastases of extramammary malignant neoplasms are rare, with an incidence of 0.3%-2.7% among all malignant mammary tumors. Breast metastases from gastric carcinoma are very rare (<0.1%), and this event is even rarer during pregnancy. Herein, we describe a 39-year-old Caucasian woman with a history of an Epstein-Barr virus-associated gastric carcinoma (EBVaGC) that was characterized by prominent tumor infiltrating lymphocytes. Three years after undergoing radical surgery, the patient developed bilateral breast nodules during her pregnancy. A breast biopsy was performed, and histology confirmed a diagnosis of EBVaGC; tumor cells showed positivity for cytokeratin 8/18 and E-cadherin, and negativity for cytokeratin 7, cytokeratin 20, cytokeratin 5/6, caudal type homebox 2, androgen receptor, mammaglobin, gross cystic disease fluid protein-15, and estrogen and progesterone receptors. We also discuss the main diagnostic pitfalls. To our knowledge, this is the first report of an EBVaGC with lymphoid stroma that developed breast metastases during pregnancy.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.1
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• pp.327-332
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• 2015

Background: Gastric cancer is one of the frequently seen cancers in the world and it is the second most common reason for death due to cancer. The prognostic role of expression of p53 detected by immunohistochemistry in gastric cancer remains controversial. This meta-analysis aimed to explore any association between overexpression and survival outcomes. Materials and Methods: We systematically searched for studies investigating the relationships between expression of p53 detected by immunohistochemistry and prognosis of gastric cancer patients. Study quality was assessed using the Newcastle-Ottawa Scale. After careful review, survival data were extracted from eligible studies. A meta-analysis was performed to generate combined hazard ratios for overall survival and disease-free survival. Results: A total of 4.330 patients from 21 studies were included in the analysis. Our results showed tissue p53 overexpression in patients with gastric cancer to be associated with poor prognosis in terms of overall survival (HR, 1.610; 95% CI, 1.394 -5.235; p:<0.001). Pooled hazard ratio for disease free survival showed that p53 positivity or negativity were not statitistically significant (HR, 1.219; 95%CI, 0.782-1.899; p:0.382). Conclusions: The present meta-analysis indicated overexpression of p53 detected by immunohistochemistry to be associated with a poor prognosis in patients with gastric cancer.