• Title/Summary/Keyword: natural sources

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Development of New Antitumor Drugs from Natural Sources , with Guida (항종양활성 Screening을 지표로 한 천연물의약품의 개발연구와 그 생약소재의 품질평가에 대하여(抗腫瘍活性スクリ-ニングを指標とした天然物醫藥品の開發硏究とその生約素材の品質評價について))

  • Takeya, Koichi
    • Proceedings of the Plant Resources Society of Korea Conference
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    • 1993.08a
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    • pp.14-20
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    • 1993
  • We in anticancer drug development from natural resources have conceived and used a wide variety of experimental screening systems to support our efforts during the past 20 tears. Screens have been devided to address targets at the molecular, biochemical and cellular levels, both in vivo and in vitro. Screens have been essential for the experimental evaluation of the products from natural sources. In this congress, antitumor screening methods for deveol[ment of new drugs from natural sources and evaluation of their crude drugs are discussed.

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The Effects of Carbon Sources on the Biosynthesis of the Phospholipid and the Fatty Acid Composition of Mitochondria in Chlorella ellipsoidea

  • Yoon, Seung-Hee;Jang, Jae-Seon;Lee, Chong-Sam
    • BMB Reports
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    • v.29 no.4
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    • pp.343-352
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    • 1996
  • The biosynthesis of phospholipid and the composition of fatty acid were analyzed in mitochondria isolated from Chlorella ellipsoidea treated with carbon sources (glucose, sucrose, raffinose) during the culture. The growth of Chlorella and total lipid contents in mitochondria treated with various carbon sources was increased to compare with the control. When Chlorella mitochondria was treated with various carbon sources, four kinds of phospholipid were increased predominantly. The major fatty acids utilized for the biosynthesis of the phospholipid were analyzed linoleic acid (average 25.18%) and stearic acid (average 10.52%) in the control. But, it was shown that the major fatty acids in Chlorella mitochondria treated with glucose were stearic acid (average 30.93%), palmitic acid (average 17.47%) and stearic acid (average 20.31%), linoleic acid (average 16.68%) in sucrose treatment and oleic acid (average 17.17%), palmitic acid (average 15.64%) in raffinose treatment.

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Natural Convection in a Rectangular Enclosure with Heat Sources at the Bottom (밑면에 열원이 존재하는 밀폐공간에서의 자연대류)

  • Kwon, Y.I.;Kim, S.J.;Kwon, S.S.
    • Korean Journal of Air-Conditioning and Refrigeration Engineering
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    • v.3 no.3
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    • pp.197-205
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    • 1991
  • A numerical study has been performed to investigate two dimensional natural convection heat transfer in a rectangular enclosure with heat sources of constant temperature at the bottom. Calculations were made for various dimensionless heat source lengths, W/L=0.1-0.5, and positions of heat sources at $Gr=2.57{\times}10^6$, Pr=0.71 and Ks/Kf=28.98. For various positions of heat sources, the maximum local Nusselt numbers generally show X=0.81-0.85 at the bottom and X=0.23 at the top. For various dimensionless heat source lengths, the maximum local Nusselt numbers at the bottom show W/L=0.4 for one heat source, W/L=0.2 for two heat sources with fixed centers, W/L=0.5 for two heat sources with moved centers. Finally the maximum heat transfer at the bottom exhibits in condition of W/L=0.4 for two heat sources with moved centers.

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Development of protein tyrosine phosphatase 1B (PTPIB) Inhibitors from marine sources and other natural products-Future of Antidiabetic Therapy : A Systematic Review

  • KAUR, Kulvinder Kochar;ALLAHBADIA, Gautam;SINGH, Mandeep
    • The Korean Journal of Food & Health Convergence
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    • v.5 no.3
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    • pp.21-33
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    • 2019
  • The incidence of both obesity and Type 2 Diabetes Mellitus( DM) is increasing proportionately so that causes of deaths from these has overtaken from that of malnourishment. Hence it has been recommended to treat the 2 in parallel considering the role of diabesity on health. Important causes of T2DM are insulin resistance (IR) and /or inadequate insulin secretion. Protein tyrosine phosphatase 1B(PTPIB) has a negative impact in insulin signaling pathways and hence plays crucial role inT2DM,since its overexpression might induce IR. Thus PTPIB is considered a therapeutic target for both obesity and T2DM, there has been a search for novel ,promising natural inhibitors. We conducted a pubmed search for articles related to PTPIB inhibitors from natural causes be it marine sources or other natural sources. Out of 988 articles we selected 100 articles for review. Thus various bioactive molecules isolated from marine organisms that can acts as PTPIB Inhibitors and thus possess antidiabetic activity both in vitro/ in vivo studies ,besides products from fruits like Chinese raspberry or curcumin used as routine spices are described with their chemical classes, structure-activity relationships and potency as assessed by IC 50 values are discussed. More work is required to make this a reality.

The Influence of Luminous Source Affecting on the Perception of Textile Color (직물색의 지각에 미치는 광원의 영향)

  • Choi, Na-Young;Yang, Lee-Na;Lee, Jong-Sook
    • The Research Journal of the Costume Culture
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    • v.15 no.2 s.67
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    • pp.214-220
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    • 2007
  • The purpose of this study is to derive the use of the luminous source corresponding to the intention and contribute to product display by visually evaluating the relations between luminous source and colors, analyzing and reviewing the subjective perceptions depending on the luminous source, and clarifying the colors of artificial luminous source that look close to natural lights by each color. Hence, the researcher objectified the subjective evaluation for which they used sensory evaluation method with four colors of luminous sources(natural colors, 2800K, 4200K, and 6500K) and five colors of textiles(purple, blue, green, yellow, and red) by quantifying the evaluation. As a result, we could obtain the conclusion as follows. As for the temperature of textile colors under artificial luminous sources that appeared most close to the colors of textiles under natural luminous sources, 6500K was most frequent, and the temperature of the luminous sources that appeared most different was 2800K. However, as there were also 4200K colors that looked most close to the textile colors under natural light source, it was observed that the temperature differs depending on the textile colors. In addition, less glossy textiles exhibited more visual changes by luminous source colors than comparatively more glossy textiles, and it was observed that the most influenced color was purple, as purple has shown the largest difference among colors.

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Effect of nitrogen sources on production of exopolymer by Pseudomonas elodea ATCC 31461

  • Lee, Nam-Gyu;Kim, Hyeon-Suk;Seo, Hyeong-Pil;Jeong, Dae-Yeong;Kim, Ji-Mo;Lee, Jin-U
    • 한국생물공학회:학술대회논문집
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    • 2000.04a
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    • pp.247-250
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    • 2000
  • Extracellular polysaccharide was produced by Pseudomonas elodea ATCC 31461 under aerobic condition. Nitrogen sources in medium affected cell growth and production of exopolymer. Ammonium nitrate limitation was found to be essential for higher production of exopolymer. Conversion rate of exopolymer from glucose under ammonium nitrate limitation was about 5 times higher than with ammonium nitrate.

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Production of curdlan with agro-industrial byproduct by Agrobacterium sp. ATCC 31749

  • Jeong, Dae-Yeong;Kim, Hyeon-Suk;Seo, Hyeong-Pil;Lee, Nam-Gyu;Kim, Ji-Mo;Lee, Jin-U
    • 한국생물공학회:학술대회논문집
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    • 2000.04a
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    • pp.251-254
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    • 2000
  • Effect of carbon sources including agro-industrial byproduct on cell growth and production of curdlan by Agrobacterium sp. ATCC 31749 was investigated. Maximal production of curdlan was obtained when the carbon source was sucrose. The conversion rate of curdlan from 2% (w/v) sucrose was 59%. Glucose, mannose and maltose were also found to be good carbon sources for production of curdlan. Production of curdlan increased up to 3% (w/v) glucose as the carbon source and then decrease as the concentration of glucose increased. The major components of agro-industrial byproduct (AIB) were glucose, maltose, and maltose, and maltotriose. Agrobacterium sp.ATCC 31749 utilized up to 25% (v/v) AIB and produced curdlan with 29.8g/1.

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Oyster Shell waste is alternative sources for Calcium carbonate (CaCO3) instead of Natural limestone

  • Ramakrishna, Chilakala;Thenepalli, Thriveni;Nam, Seong Young;Kim, Chunsik;Ahn, Ji Whan
    • Journal of Energy Engineering
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    • v.27 no.1
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    • pp.59-64
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    • 2018
  • In this paper, we investigated the alternative sources of limestone. Oyster shell waste originated from aquaculture that causes a major disposal landfill problem in coastal sectors in southeast Korea. Their inadequate disposal causes a significant environmental problems araised. Bio mineralization leads to the formation of oyster shells and consists $CaCO_3$ as a major phase with a small amount of organic matter. It is a good alternative material source instead of natural lime stone. The utilization of oyster shell waste for industrial applications instead of natural limestone is major advantage for conservation of natural limestone. The present work describes the limestone and oyster shells hydraulic activity and chemical composition and characteristics are most similar for utilization of oyster shell waste instead of natural limestone.