• Archives of Pharmacal Research
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• v.22 no.2
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• pp.124-129
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• 1999

The present study was undertaken to investigate the effect of biphenyl dimethyl idcarboxylate (PMC) on the humoral immunosuppression by ketoconazole (KCZ) in ICR mice. PMC at a dose of 6 mg/kg was administered orally to mice daily for 14 consecutive days. KCZ was suspended in RPMI 1640 medium and orally administered at 160 mg/kg/day 2 hrs after the administration of PMC. Mice were immunized an challenged with challenged red blood cells (SRBC). The results of the present study are summarized as follows; a gain of body weight and relative weights of spleen and liver were significantly increased by combination of PMC and KCZ, as compared with those in mice treated with KCZ alone. Splenic plaque forming cells (PFC) and hemagglutination (HA) titers to SRBC were greatly enhanced by the combination of PMC and KCZ, compared with treatment of KCZ alone. The elevation of serum glutamicpyruvic transminase (S-GPT) and total protein levels caused by KCZ were reduced to normal level by the combination of PMC and KCZ. In addition, lower serum albumin and A/G ratio were also increased to normal level. These findings indicate that PMC has a protective effect against KCZ-induced humoral immunosuppression.

• Journal of agriculture & life science
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• v.46 no.2
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• pp.115-127
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• 2012

Antioxidant and neuronal cell protective effects of aqueous extract from lotus (Nelumbo nucifera) leaf tea (LLTE) were investigated. The 2,2'-azino-bis (3-ethylbenzthiazoline-6-sulfonic acid) radical scavenging effect, ferric reducing antioxidant power, and malondialdehyde inhibition of LLTE were increased in a dose dependent manner. Intracellular reactive oxygen species accumulation resulting from hydrogen peroxide ($H_2O_2$) treatment was significantly reduced when LLTE were present in the media compared to PC12 cells treated with $H_2O_2$ only. In neuronal cell viability assay using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazoliumbromide (MTT), LLTE showed protective effect against $H_2O_2$-induced neurotoxicity. In addition, lactate dehydrogenase release into medium was also inhibited by LLTE (7.13-43.89%). Total phenolics of LLTE were 33.16 mg/g and a quercetin was identified as major phenolics (105.93 mg/100g). Therefore, above these data suggest that LLTE including quercetin may be useful in the natural antioxidant substance, and may reduce the risk of neurodegenerative disease.

• Korean Journal of Chemical Engineering
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• v.35 no.12
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• pp.2413-2420
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• 2018

Sida acuta, a common type of weed in Thailand, contains relatively high cellulose (42.7%) content. We pretreated NaOH to improve glucose recovery from S. acuta. The effect of pretreatment temperature and NaOH concentration was fundamentally investigated based on hydrolysis efficiency with recovery of solid fraction. The pretreatment condition was determined to be 3% NaOH at $60^{\circ}C$ for 9 h, which showed the highest glucose recovery. The hydrolysates obtained by enzymatic hydrolysis of S. acuta were applied to the fermentation of Saccharomyces cerevisiae K35, and a theoretical yield of 97.6% was achieved at 18 h. This indicated that the hydrolysates medium without detoxification had no negative effects on the fermentation. The production of biomass into bioethanol was evaluated based on the material balance of 1,000 g basis. Following this estimation, approximately 28 g and 110 g bioethanol could be produced by untreated and pretreated S. acuta, respectively, and this production was improved about 3.9-fold by NaOH pretreatment. These results again show the importance of pretreatment in biorefinery process.

• Journal of The Geomorphological Association of Korea
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• v.24 no.2
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• pp.1-13
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• 2017

Massive coastal sand dunes are distributed in Ui-island, Shinan-gun. The sand dunes in Ui-island is worth studying, in terms of preserving natural environment without anthropogenic impacts. In this study, we surveyed geomorphological processes of the sand dune based upon measuring of geometric properties, grain size analysis, and OSL(Optically Stimulated Luminescence) age dating. The sediments of the dune consist mainly of well sorted medium sand with about 250$\mu$m. Based on spatial distribution of sand dunes, we found that they are formed by northwest monsoon during winter, and sands are supplied from Seongchon area in northern UI-island. According to OSL age dating, the sand dunes were deposited from $0.07{\pm}0.01ka$ to $0.17{\pm}0.04ka$. This result shows that the transformation of the dune due to the sand movement by wind was active during the last 100-200 years. The aerial photograph indicates that the dimension of the largest sand dune has decreased since 1945. Further research is needed to get more detailed information on geomorphic changes of sand dunes in UI-island.

• Earthquakes and Structures
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• v.7 no.3
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• pp.349-365
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• 2014

The dynamic response of structures under extremely short duration dynamic loads is of great concern nowadays. This paper investigates structures' response as well as the associated structural damage to explosive loads considering and ignoring the supporting soil flexibility effect. In the analysis, buildings are modeled by two alternate approaches namely, (1) building with fixed supports, (2) building with supports accounting for soil-flexibility. A lumped parameter model with spring-dashpot elements is incorporated at the base of the building model to simulate the horizontal and rotational movements of supporting soil. The soil flexibility for various shear wave velocities has been considered in the investigation. In addition, the influence of variation of lateral natural periods of building models on the obtained response and peak response time-histories besides damage indices has also been investigated under blast loads with different peak over static pressures. The Dynamic response is obtained by solving the governing equations of motion of the considered building model using a developed Matlab code based on the finite element toolbox CALFEM. The predicted results expressed in time-domain by the building model incorporating SSI effect are compared with the corresponding model results ignoring soil flexibility effect. The results show that the effect of surrounding soil medium leads to significant changes in the obtained dynamic response of the considered systems and hence cannot be simply ignored in damage assessment and response time-histories of structures where it increases response and amplifies damage of structures subjected to blast loads. Moreover, the numerical results provide an understanding of level of damage of structure through the computed damage indices.

• Journal of Microbiology and Biotechnology
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• v.29 no.4
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• pp.538-547
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• 2019

The aim of the present study was to evaluate the effects of two well-known natural antioxidants, vitamin C (VC) and vitamin E (VE), on the antifungal activity of honokiol against Candida albicans. The broth microdilution method was employed to test the antifungal activities of honokiol with or without antioxidants in the medium against C. albicans strain. Intracellular reactive oxygen species and lipid peroxidation were determined by fluorescence staining assay. Mitochondrial dysfunction was assessed by detecting the mitochondrial DNA and the mitochondrial membrane potential. We observed that VC could significantly potentiate the antifungal activities of honokiol while VE reduced the effectiveness of honokiol against C. albicans. In addition, VC accelerated honokiol-induced mitochondrial dysfunction and inhibited glycolysis leading to a decrease in cellular ATP. However, VE could protect against mitochondrial membrane lipid peroxidation and rescue mitochondrial function after honokiol treatment. Our research provides new insight into the understanding of the action mechanism of honokiol and VC combination against C. albicans.

• Structural Engineering and Mechanics
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• v.71 no.5
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• pp.525-544
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• 2019

In the present study, buckling and free vibration analyses of annular thin sector plate made of functionally graded materials (FGMs) resting on visco-elastic Pasternak foundation, subjected to external radial, circumferential and shear in-plane loads is investigated. Material properties are assumed to vary along the thickness according to an power law with Poisson's ratio held constant. First, based on the classical plate theory (CPT), the governing equation of motion is derived using Hamilton's principle and then is solved using the generalized differential quadrature method (GDQM). Numerical results are compared to those available in the literature to validate the convergence and accuracy of the present approach. Finally, the effects of power-law exponent, ratio of radii, thickness of the plate, sector angle, and coefficients of foundation on the fundamental and higher natural frequencies of transverse vibration and critical buckling loads are considered for various boundary conditions. Also, vibration and buckling mode shapes of functionally graded (FG) sector plate have been shown in this research. One of the important obtained results from this work show that ratio of the frequency of FG annular sector plate to the corresponding values of homogeneous plate are independent from boundary conditions and frequency number.

• The Korean Journal of Food And Nutrition
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• v.32 no.1
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• pp.27-32
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• 2019

The objective of this study was to evaluate novel usability as natural anti-obesity supplement of Selaginella tamariscina extract. The total phenol contents and total flavonoid contents were $60.29{\pm}3.11GAE\;mg/g$ and $14.90{\pm}0.34QE\;mg/g$, respectively. To evaluate anti-obesity activity of Selaginella tamariscina extract, pancreatic lipase inhibition activity as well as its inhibition effect of lipid accumulation in adipocytes were conducted by Oil Red O staining and lipolysis assay. The result of pancreatic lipase inhibition activity of S. tamariscina extract showed a wide range between 40 and 73% dose dependently. While the incubation of 3T3-L1 cells with S. tamariscina extract inhibited differentiation of preadipocytes and reduced lipid accumulation, the level of released free glycerol into culturing medium was increased in multiple concentrations. These results showed that S. tamariscina extract inhibit adipogenesis and pancreatic lipase activity. Thus, S. tamariscina extract can be a candidate for regulating lipid accumulation in obesity.

• Food Science and Industry
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• v.51 no.2
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• pp.148-156
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• 2018

Structured lipids are lipids in which the composition and/or positional distribution of fatty acids have been chemically or enzymatically modified from their natural biosynthetic form. Because structured lipids have desired nutritional, physicochemical, textural or physiological properties for applications in processed foods, functional foods, or nutraceuticals, many research activities have been aimed at their commercialization. The enzymatic production of structured lipids using lipases as the biocatalysts has a big potential in the future market due to the specificity or selectivity of the lipases. This article introduced some examples of specialty structured lipids that have been enzymatically produced and have been utilized as commercialized products. The commercialized products include medium- and long-chain triacylglycerols, human milk fat substitutes, cocoa butter equivalents, trans-free plastic fats, low-calorie fats/oils, and health-beneficial fatty acid-rich oils.

• International journal of advanced smart convergence
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• v.10 no.2
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• pp.151-157
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• 2021

Livestock farmers are using animal carcasses to dispose of the carcasses of livestock that have died of natural causes or disease. Most of the existing livestock carcass processors are mechanical in their structure without considering the environment. It has a function of sterilizing dead bodies at high pressure after processing them and causes environmental problems such as carbon monoxide emissions. If livestock carcasses occur, livestock farmers have to purchase their own livestock carcasses or entrust them to the outside world, which is costly. For this reason, the possibility of environmental pollution, infectious diseases, and spread has been increased recently by frequent dumping of dead bodies. The carcass of livestock mixed with manure not only serves as a medium for infectious diseases but also needsto be buried on a large scale as foot-and-mouth disease and avian influenza spread. As a result, the possibility of environmental pollution, such as contamination of groundwater, is increasing, so research is needed to protect and improve the environment. We aim to improve the process of processing livestock carcasses and purify the agricultural environment through development results on the form, structure and function of eco-friendly livestock carcasses. Its shape is applied with naturalshapessuch asstones and seeds. The material used in the dead body processis a brown beggar biocouple and is applied with an eco-friendly industrial animal recycling process. As a result of the study, it is expected to improve odors and the environment, and to be used as data to improve and help the livestock industry in the future.