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http://dx.doi.org/10.9799/ksfan.2019.32.1.027

The Effect of Selaginella tamariscina on Inhibition of Pancreatic Lipase and Lipid Accumulation  

Kim, Gun-Hee (Plant Resources Research Institute, Duksung Women's University)
Lee, Shin-Young (Plant Resources Research Institute, Duksung Women's University)
Lee, Ae-Rang (Dept. of Food and Nutrition, SoongEui Women's College)
Publication Information
The Korean Journal of Food And Nutrition / v.32, no.1, 2019 , pp. 27-32 More about this Journal
Abstract
The objective of this study was to evaluate novel usability as natural anti-obesity supplement of Selaginella tamariscina extract. The total phenol contents and total flavonoid contents were $60.29{\pm}3.11GAE\;mg/g$ and $14.90{\pm}0.34QE\;mg/g$, respectively. To evaluate anti-obesity activity of Selaginella tamariscina extract, pancreatic lipase inhibition activity as well as its inhibition effect of lipid accumulation in adipocytes were conducted by Oil Red O staining and lipolysis assay. The result of pancreatic lipase inhibition activity of S. tamariscina extract showed a wide range between 40 and 73% dose dependently. While the incubation of 3T3-L1 cells with S. tamariscina extract inhibited differentiation of preadipocytes and reduced lipid accumulation, the level of released free glycerol into culturing medium was increased in multiple concentrations. These results showed that S. tamariscina extract inhibit adipogenesis and pancreatic lipase activity. Thus, S. tamariscina extract can be a candidate for regulating lipid accumulation in obesity.
Keywords
Selaginella tamariscina; pancreatic lipase; lipid accumulation; lipolysis;
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Times Cited By KSCI : 3  (Citation Analysis)
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