• CELLMED
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• v.6 no.4
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• pp.22.1-22.19
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• 2016

The biologically active compounds derived from different natural organisms such as animals, plants, and microorganisms like algae, fungi, bacteria and merine organisms. These natural compounds possess diverse biological activities like anthelmintic, antibacterial, antifungal, antimalarial, antiprotozoal, antituberculosis, and antiviral activities. These biological active compounds were acted by variety of molecular targets and thus may potentially contribute to several pharmacological classes. The synthesis of natural products and their analogues provides effect of structural modifications on the parent compounds which may be useful in the discovery of potential new drug molecules with different biological activities. Natural organisms have developed complex chemical defense systems by repelling or killing predators, such as insects, microorganisms, animals etc. These defense systems have the ability to produce large numbers of diverse compounds which can be used as new drugs. Thus, research on natural products for novel therapeutic agents with broad spectrum activities and will continue to provide important new drug molecules.

• Proceedings of the Plant Resources Society of Korea Conference
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• 2019.04a
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• pp.34-34
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• 2019

About 60% of the present drugs were developed from natural products with unique chemical diversity and biological activities. Hence, discovery of new bioactive compounds from natural products is still important for the drug development. On the other hand, breakthrough made in synthetic biology has also begun to supply us with many useful compounds through manipulation of biosynthetic gene for secondary metabolites. Theoretically, this approach can also be exploited to generate new unnatural compounds by intermixing genes from different biosynthetic pathway. Considering the potential, we are studying about bioactive compounds in natural sources, as well as the biosynthesis of natural products including engineering of the secondary metabolite enzymes to make new compounds in order to construct the methodological basis of the synthetic biology. In this symposium, engineering of secondary metabolite enzymes that are involved in the biosynthesis of plant polyketides to generate new compounds in our laboratory will be mainly introduced.

• Food Science and Biotechnology
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• v.15 no.3
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• pp.329-338
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• 2006

The study of health promoting and disease preventing compounds in food or by themselves, so called nutraceuticals or functional foods, has become a major field of research in food science. Natural flavor compounds are usually present in food, essential oils, spices, and herbs. These compounds can produce aroma, not only by themselves, but also in combination with other compounds. Today, however, greater interest is being paid to the health promoting properties of natural flavor substances rather than their flavoring properties. In fact, a number of naturally occurring flavor compounds that possess health promoting and disease preventing properties have been extensively studied and identified. The beneficial properties of natural volatile flavor compounds as well as non-volatile substances in spices and herbs discussed in this review include antioxidant, anticarcinogenic, anti-inflammatory, and immune enhancing activities.

• Natural Product Sciences
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• v.23 no.2
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• pp.139-145
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• 2017

Seven flavonoid compounds, kaempferol (1), quercetin (2), quercetin-3-O-${\beta}$-D-glucopyranoside (3), kaempferol-3-O-${\beta}$-D-glucopyranoside (4), kaempferol-3-O-${\alpha}$-L-rhamnoside (5), quercetin-3-O-sophoroside (6) and quercetin-3-O-rutinoside (7), were isolated from the methanolic extract of leaves of Kalanchoe prolifera. Compounds 1-7 were isolated for first time from this plant. These compounds were evaluated their cytotoxic activity against P-388 murine leukimia cells in vitro. Among those compounds kaempferol (1) and quercetin (2) showed strongest cytotoxic activity with $IC_{50}$ values of $4.45{\pm}0.05$ and $6.28{\pm}0.02{\mu}g/mL$, respectively.

• Archives of Pharmacal Research
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• v.25 no.6
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• pp.725-746
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• 2002

The demand for new alternative "low calorie" sweeteners for dietetic and diabetic purposes has increased worldwide. Although the currently developed and commercially used highly sweet sucrose substitutes are mostly synthetic compounds, the search for such compounds from natural sources is continuing. As of mid-2002, over 100 plant-derived sweet compounds of 20 major structural types had been reported, and were isolated from more than 25 different families of green plants. Several of these highly sweet natural products are marketed as sweeteners or flavoring agents in some countries as pure compounds, compound mixtures, or refined extracts. These highly sweet natural substances are reviewed herein.

• Biomedical Science Letters
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• v.25 no.1
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• pp.1-6
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• 2019

The hydroxylation of estradiol results in the formation of catechol estrogens such as 2-hydroxyestradiol ($2-OHE_2$) and 4-hydroxyestradiol ($4-OHE_2$). These catechol estrogens are further oxidized to quinone metabolites by peroxidases or cytochrome P450 (CYP450) enzymes. Catechol estrogens contribute to hormone-induced carcinogenesis by generating DNA adducts or reactive oxygen species (ROS). Interestingly, many of the natural products found in living organisms have been reported to show protective effects against carcinogenesis induced by catechol estrogens. Although some compounds have been reported to increase the activity of catechol estrogens via oxidation to quinone metabolites, many natural products decreased the activity of catechol estrogens by inhibiting DNA adduct formation, ROS production, or oxidative cell damage. Here we focus specifically on the chemopreventive effects of these natural compounds against carcinogenesis induced by catechol estrogens.

• Korean Chemical Engineering Research
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• v.45 no.2
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• pp.155-159
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• 2007

A series of new dimesogenic compounds having two identical, terminal Schiff base type mesogens and a central tetramethylene spacer were synthesized. Their thermotropic and mesomorphic properties of the compounds were investigated by differential scanning calorimetry and polarizing microscopy. The compounds with X= -F, -Cl, -Br, -CN and $-OCH_3$ were enantiotropically nematic liquid crystal. In contrast, the compounds with X= -I and $-CF_3$ were non-liquid crystal. The nematic forming efficiency of the groups was in the order of -CN > $-OCH_3$ > -Br > -Cl > -F.

• Textile Coloration and Finishing
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• v.28 no.2
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• pp.118-123
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• 2016

The use of natural organic dyes obtained from renewable resources such as plants and trees has the potential for not only preserving petrochemicals but also all-endangered environment for coming next generations. In spite of inferior fastness, natural dyes can be employed in the colouration of natural as well as synthetic fibers. Recently, the potentiality of using natural dyes in colouration with additional UV-protection and antimicrobial properties has been reported. This study is aimed to investigate the effect of Zinc compounds compared to another metallic compounds as mordants on the dyeing properties of natural dye extracted from mulberry leaves and coffee. In this study, the results showed Zinc compounds was expose that is more similar than other mordants in washing fastness through a repeated experiment. Also, Zinc is the environmental impact is less material compared with other mordants, essential edibility minerals ingredient that is necessary in human body.

• Food Science and Biotechnology
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• v.17 no.4
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• pp.846-849
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• 2008

This study employed high performance liquid chromatography (HPLC) coupled to an on-line $ABTS^+$ radical scavenging detection (RSD) system along with HPLC-electro spin impact/mass spectrometry (ESI/MS), to rapidly determine and identify antioxidant compounds occurring in blueberry extract. The extract was separated by HPLC, and then the radical scavenging activities of the separated compounds were evaluated by the on-line coupled $ABTS^+$-RSD system. The negative peaks of the $ABTS^+$-RSD system, which indicates the presence of antioxidant activity, were monitored by measuring the decrease in absorbance at 734 nm. The active components in the blueberry extract were identified by HPLC-ESI/MS using their MS spectra and retention times. According to the data acquired from the on-line HPLC-$ABTS^+$-based assay and HPLC-ESI/MS systems, the antioxidant compounds detected in the blueberry extract were identified as chlorogenic acid and 11 anthocyanins.

• Korean Journal of Pharmacognosy
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• v.40 no.4
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• pp.326-333
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• 2009

Fourteen compounds were isolated from the 70% ethanol extract of Lonicera Caulis (Caprifoliaceae) and their structures were identified as seven aliphatic compounds [long-chain alcohols (1, 2), trilinolein (3), hexacosanol (4), fatty acids (6), 9,12,13-trihydroxyoctadeca-10(E),15(Z)-dienoic acid (10), and pinellic acid (11)] and seven phenolics [bis(2-ethylhexyl) phthalate (dioctylphthalate, DOP) (5), coniferaldehyde (7), caffeic acid docosanoyl ester (8), caffeic acid (9), coniferyl aldehyde 4-O-glucoside (12), linarin (13), and coniferin (14)]. The chemical structures of these compounds were identified on the basis of spectroscopic methods and comparison with literature values. All the compounds except for caffeic acid (9) were isolated from this plant parts for the first time.