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http://dx.doi.org/10.20307/nps.2017.23.2.139

Flavonoid Compounds from the Leaves of Kalanchoe prolifera and Their Cytotoxic Activity against P-388 Murine Leukimia Cells  

Aisyah, Lilis Siti (Department of Chemistry, Faculty of Mathematics and Natural Sciences, Jenderal Achmad Yani, University)
Yun, Yenny Febriani (Department of Chemistry, Faculty of Mathematics and Natural Sciences, Jenderal Achmad Yani, University)
Herlina, Tati (Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran)
Julaeha, Euis (Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran)
Zainuddin, Achmad (Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran)
Nurfarida, Ida (Central Laboratory of Universitas Padjadjaran)
Hidayat, Ace Tatang (Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran)
Supratman, Unang (Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran)
Shiono, Yoshihito (Department of Food, Life, and Environmental Science, Faculty of Agriculture, Yamagata University)
Publication Information
Natural Product Sciences / v.23, no.2, 2017 , pp. 139-145 More about this Journal
Abstract
Seven flavonoid compounds, kaempferol (1), quercetin (2), quercetin-3-O-${\beta}$-D-glucopyranoside (3), kaempferol-3-O-${\beta}$-D-glucopyranoside (4), kaempferol-3-O-${\alpha}$-L-rhamnoside (5), quercetin-3-O-sophoroside (6) and quercetin-3-O-rutinoside (7), were isolated from the methanolic extract of leaves of Kalanchoe prolifera. Compounds 1-7 were isolated for first time from this plant. These compounds were evaluated their cytotoxic activity against P-388 murine leukimia cells in vitro. Among those compounds kaempferol (1) and quercetin (2) showed strongest cytotoxic activity with $IC_{50}$ values of $4.45{\pm}0.05$ and $6.28{\pm}0.02{\mu}g/mL$, respectively.
Keywords
Flavonoids; Kalanchoe prolifera; Crassulaceae; P-388 murine leukimia cell;
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1 Heyne, K. The useful Indonesian plants: Research and Development Agency; Ministry of Forestry: Indonesia, 1987, pp 845-846.
2 Hutapea, J. R. Inventory of Indonesian Medicinal Plants Vol: Research and Development Agency; Ministry of Health: Indonesia, 1994, pp 117-118.
3 Capon, R. J.; Macleod, J. K.; Oelrichs, P. B. Aust. J. Chem, 1986, 39, 1711-1715.
4 Yamagishi, T.; Haruna, M.; Yan, X. Z.; Chang, J. J.; Lee, K. H. J. Nat. Prod, 1989, 52, 1071-1079.   DOI
5 Gaind, K. N.; Singla, A. K.; Boar, R. B.; Copsey, D. B. Phytochemistry 1976, 15, 1999-2000.   DOI
6 Costa, S. S.; Jossang, A.; Bodo, B. J. Nat. Prod. 1996, 59, 327-329.   DOI
7 Liu, K. C. S.; Yang, S. L.; Robert, M. F.; Phillipson, J. D. Phytochemistry 1989, 28, 2813-2818.   DOI
8 Liu, K. C. S.; Yang, S. L.; Robert, M. F.; Phillipson, J. D. J. Nat. Prod. 1989, 52, 970-974.   DOI
9 Almeida, A. P.; Da Silva, S. A.; Souza, M. L. M.; Lima, L. M.; Rossi-Bergmann, B.; de Moraes, V. L.; Costa, S. S. Planta Med. 2000, 66, 134-137.   DOI
10 Wu, P. L.; Hsu, Y. L.; Wu, T. S.; Bastow, K. F.; Lee, K. H. Org. Lett. 2006, 8, 5207-5210.   DOI
11 Supratman, U.; Fujita, T.; Akiyama, K.; Hayashi, H. Phytochemistry 2001, 58, 311-314.   DOI
12 Supratman, U.; Fujita, T.; Akiyama, K.; Hayashi, H.; Murakami, A.; Sakai, H.; Koshimizu, K.; Ohigashi, H. Biosci. Biotechnol. Biochem. 2001, 65, 947-949.   DOI
13 Toker, G.; Memisoglu, M.; Yesilada, E.; Aslan, M. Turk. J. Chem, 2004, 28, 745-749.
14 Supratman, U.; Fujita, T.; Akiyama, K.; Hayashi, H. Biosci. Biotechnol. Biochem. 2000, 64, 1310-1312.   DOI
15 Markam, H. M. Techiques of Flavonoid Identification; Academic Press: London, 1982, pp 41-47.
16 Guvenalp, Z.; Demirezer, L. O. Turk. J. Chem. 2005, 29, 163-169.
17 Chaturvedula, V. S. P.; Prakash, I. J. Chem. Pharm. Res., 2011, 3, 799-804.
18 Kim, J. W.; Kim, T. B.; Yang, H.; Sung, S. H. Nat. Prod. Sci. 2016, 22, 117-121.   DOI
19 Lin, L. J.; Huang, X. B.; Lv, Z. C. Springerplus, 2016, 5, 1649.   DOI
20 Aisyah, L. S.; Yun, Y. F.; Julaeha, E.; Herlina, T.; Zainuddin, A.; Hermawan, W.; Supratman, U.; Hayashi, H. Open Chemistry Journal. 2015, 2, 36-39.   DOI
21 Ross, S. A.; ElSohly, M. A.; Sultana, G. N.; Mehmedic, Z.; Hossain, C. F.; Chandra, S. Pyhtochem. Anal. 2005, 16, 45-48.   DOI
22 Islam, M.; Al-Amin, Md.; Siddiqi, M. M. A.; Akter, S.; Haque, M. M.; Sultana, N.; Chowdhury, A. M. S. Dhaka Univ. J. Sci. 2012, 60, 11-14.
23 Si, C. L.; Du, Z. G.; Fan, S.; An, L. L. Chem. Nat. Comp. 2016, 52, 794-797.   DOI
24 Furusawa, M.; Tanaka, T.; Ito, T.; Nakaya, K.; Iliya, I.; Ohyama, M.; Iinuma, M.; Murata, H.; Inatomi, Y.; Inada, A.; Nakanishi, T.; Matsushita, S.; Kubota, Y.; Sawa, R.; Takahashi, Y. Chem. Pharm. Bull. 2005, 53, 591-593.   DOI
25 Li, H.; Liu, Y.; Yi, Y.; Miao, Q.; Liu, S.; Zhao, F.; Cong, W.; Wang, C.; Xia, C. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 2017, 1048, 56-63.   DOI
26 Zhang, S.; Tao, Z. M.; Zhang, Y.; Shen, Z. W.; Qin, G. W. Chin. J. Nat. Med. 2010, 8, 21-24.   DOI
27 Ganbaatar, C.; Gruner, M.; Mishig, D.; Duger, R.; Schmidt, A. W.; Knolker, H. J. The Open Natural Products Journal 2015, 8, 1-7.   DOI
28 Alley, M. C.; Scudiero, D. A.; Monks, A.; Hursey, M. L.; Czerwinski, M. J.; Fine, D. L.; Abbott, B. J.; Mayo, J. G.; Shoemaker, R. H.; Boyd, M. R. Cancer Res. 1988, 48, 589-601.
29 Hakim, E. H.; Juliawaty, L. D.; Syah, Y. M.; Din, L. B.; Ghisalberti, E. L.; Latip, J.; Said, I. M.; Achmad, S. A. Z. Naturforsch. C 2005, 60, 723-727.
30 Harneti, D.; Tjokronegoro, R.; Safari, A.; Supratman, U.; Loong, X. M.; Mukhtar, M. R.; Mohamad, K.; Awang, K.; Hayashi, H. Phytochem. Lett. 2012, 5, 496-499.   DOI
31 Hakim, E. H.; Achmad, S. A.; Juliawaty, L. D.; Makmur, L.; Syah, Y. M.; Aimi, N.; Kitajima, M.; Takayama, H.; Ghisalberti, E. L. J. Nat. Med. 2007, 61, 229-236.   DOI