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Health Promoting Properties of Natural Flavor Substances  

Jun, Mi-Ra (Department of Food Science, Rutgers, The State University of New Jersey)
Jeon, Woo-Sik (Division of Applied Biology & Chemistry, Kyungpook National University)
Ho, Chi-Tang (Department of Food Science, Rutgers, The State University of New Jersey)
Publication Information
Food Science and Biotechnology / v.15, no.3, 2006 , pp. 329-338 More about this Journal
Abstract
The study of health promoting and disease preventing compounds in food or by themselves, so called nutraceuticals or functional foods, has become a major field of research in food science. Natural flavor compounds are usually present in food, essential oils, spices, and herbs. These compounds can produce aroma, not only by themselves, but also in combination with other compounds. Today, however, greater interest is being paid to the health promoting properties of natural flavor substances rather than their flavoring properties. In fact, a number of naturally occurring flavor compounds that possess health promoting and disease preventing properties have been extensively studied and identified. The beneficial properties of natural volatile flavor compounds as well as non-volatile substances in spices and herbs discussed in this review include antioxidant, anticarcinogenic, anti-inflammatory, and immune enhancing activities.
Keywords
flavor; herb; spice; antioxidant; anticancer; anti-inflammatory; immune-enhancing;
Citations & Related Records
Times Cited By KSCI : 4  (Citation Analysis)
Times Cited By Web Of Science : 12  (Related Records In Web of Science)
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1 Burdock GA. Fenaroli's handbook of flavor ingredients. 3rd ed. CRC press, Inc., Boca Ranton, FL, USA. pp. 1-2 (1995)
2 Risch SJ. Spices: Sources, processing, and chemistry. pp. 2-6. In: Spices: Flavor Chemistry and Antioxidant Properties. ACS symposium series 660. Risch SJ, Ho CT (eds). American Chemical Society, Washington, DC, USA (1997)
3 McCall MR, Frei B. Can antioxidant vitamins materially reduce oxidative damage in human? Free Radical Bio. Med. 26: 1034-1053 (1999)   DOI   ScienceOn
4 Prior RL, Cao G. In vivo total antioxidant capacity: comparison of different analytical methods. Free Radical Bio. Med. 27: 1173-1181 (1999)   DOI   ScienceOn
5 Rabinkov A, Miron T, Konstantinovski L, Wilchek M, Mirelman D, Weiner L. The mode of action of allicin: trapping of radicals and interaction with thiol containing proteins. Biochim. Biophys. Acta 1379: 233-244 (1998)   DOI   ScienceOn
6 Kim KM, Chun SB, Koo MS, Choi WJ, Kim TW, Kwon YG, Chung HT, Billiar TR, Kim YM. Differential regulation of NO availability from macrophages and endothelial cells by the garlic component S-allyl cysteine. Free Radical Bio. Med. 30: 747-756 (2001)   DOI   ScienceOn
7 Huang CN, Hong JS, Yin MC. Antioxidative and antiglycative effects of six organosulfur compounds in low-density lipoprotein and plasma. J. Agric. Food Chem. 52: 3674-3678 (2004)   DOI   ScienceOn
8 Wang CC, Chen LG, Lee LT, Yang LL. Effects of 6-gingerol, an antioxidant from ginger, on inducing apoptosis in human leukemic HL-60 cells. In Vivo 17: 641-645 (2003)
9 Tsuda H, Ohshima Y, Nomoto H, Fujita K, Matsuda E, Iigo M, Takasuka N, Moore MA. Cancer prevention by natural compounds. Drug Metab. Pharmacokinet. 19: 245-263 (2004)   DOI   ScienceOn
10 Surh YJ. Anti-tumor promoting potential of selected spice ingredients with antioxidative and anti-inflammatory activities: a short review. Food Chem. Toxicol. 40: 1091-1097 (2002)   DOI   ScienceOn
11 Lee EJ, Kim KS, Jung HY, Kim DH, Jang HD. Antioxidant activities of garlic (Allium sativum 1.) with growing districts. Food Sci. Biotechnol. 14: 123-130 (2005)
12 Tepe B, Daferera D, Sokmen M, Polissiou M, Sokmen A. In vitro antimicrobial and antioxidant activities of the essential oils and various extracts of Thymus eigii M. Zohary et P.H. Davis. J. Agric. Food Chem. 52: 1132-1137 (2004)   DOI   ScienceOn
13 Nagababu E, Lakshmaiah N. Inhibitory effect of eugenol on non-enzymatic lipid peroxidation in rat liver mitochondria. Biochem. Pharmacol. 43: 2393-2400 (1992)   DOI   ScienceOn
14 Crowell PL. Chemoprevention and therapy of cancer by d-limonene. Crit. Rev. Oncog. 5: 1-22 (1994)   DOI   ScienceOn
15 Chen Q, Shi H, Ho CT. Effects of rosemary extracts and major constituents on lipid oxidation and soybean lipoxygenase activity. J. Am. Oil Chem. Soc. 69: 999-1002 (1992)   DOI
16 Inatani R, Nakatani N, Fuwa H. Antioxidative effect of the constituents of rosemary (Rosmarinus officinalis L.) and their derivatives. Agric. Biol. Chem. 47: 521-528 (1983)   DOI
17 Cuvelier ME, Richard H, Berset C. Antioxidant constituents in sage (Salvia officinalis). J. Agric. Food Chem. 42: 665-669 (1994)   DOI   ScienceOn
18 Burke YD, Ayoubi AS, Werner SR, McFarland BC, Heilman DK, Ruggeri BA, Crowell PL. Effects of the isoprenoids perillyl alcohol and farnesol on apoptosis biomarkers in pancreatic cancer chemoprevention. Anticancer Res. 22: 3127-3134 (2002)
19 Greenwald P. Clinical trials in cancer prevention: current results and perspectives for the future. J. Nutr. 134: 3507S-3512S (2004)
20 Ho CT, Wang M, Wei GJ, Huang TC, Huang MT. Chemistry and antioxidative factors in rosemary and sage. Biofactors 13: 161-166 (2000)   DOI
21 Singletary K, MacDonald C, Wallig M. Inhibition by rosemary and carnosol of 7,12-dimethylbenz[a]anthracene (DMBA)-induced rat mammary tumorigenesis and in vivo DMBA-DNA adduct formation. Cancer Lett. 104: 43-48 (1996)   DOI   ScienceOn
22 Conney AA, Lou YR, Xie JG, Osawa T. Newmark HL. Liu Y, Chang RL. Huang MT. Some perspectives on dietary inhibitors of carcinogenesis; studies with curcumin and tea. P. Soc. Exp. Biol. Med. 216: 234-245 (1997)
23 Belman S. Onion and garlic oils inhibit tumor promotion. Carcinogenesis 4: 1063-1065 (1983)   DOI   ScienceOn
24 Duvoix A, Blasius R, Delhalle S, Schnekenburger M, Morceau F, Henry E, Dicato M, Diederich M. Chemopreventive and therapeutic effects of curcumin. Cancer Lett. 223: 181-190 (2005)   DOI   ScienceOn
25 Hong J, Bose M, Ju J, Ryu J, Chen X, Sang S, Lee M, Yang CS. Modulation of arachidonic acid metabolism by curcumin and related ${\beta}$-diketone derivatives: effects on cytosolic phospholipase $A_{2}$, cycloxygenases and 5-lipoxygenase. Carcinogenesis 25: 1671-1679 (2004)   DOI   ScienceOn
26 Wargovich MJ. New dietary anticarcinogens and prevention of gastrointestinal cancer. Dis. Colon Rectum 31: 72-75 (1988)   DOI
27 Sigounas G, Hooker J, Anagnostou A, Steiner M. S-Allylmercapto-cysteine inhibits cell proliferation and reduces the viability of erythroleukemia, breast, and prostate cancer cell lines. Nutr. Cancer 27: 186-191 (1997)   DOI   ScienceOn
28 Hageman GJ, van Herwijnen MH, Schilderman PA, Rhijnsburger EH, Moonen EJ, Kleinjans JC. Reducing effects of garlic constituents on DNA adduct formation in human lymphocytes in vitro. Nutr. Cancer 27: 177-185 (1997)   DOI   ScienceOn
29 Aggarwal BB, Shishodia S. Suppression of the nuclear factor-kappaB activation pathway by spice-derived phytochemicals: reasoning for seasoning. Ann. NY Acad. Sci. 1030: 434-441 (2004)   DOI   ScienceOn
30 Pestka JJ, Witt MF. An Overview of Immune Functions. Food Technol.-Chicago 39: 83-90 (1985)
31 Kyo E, Uda N, Kasuga S, Itakura Y. Immunomodulatory effects of aged garlic extract. J. Nutr. 131: 1075S-1079S (2001)
32 Joe B, Rao UJSP, Lokesh BR. Presence of an acidic glycoprotein in the serum of arthritic rats; modulation by capsaicin and curcumin. Mol. Cell Biochem. 169: 125-134 (1997)   DOI   ScienceOn
33 Park KK, Chun KS, Lee JM, Lee SS, Surh YJ. Inhibitory effects of [6]-gingerol, a major pungent principle of ginger, on phorbol ester-induced inflammation, epidermal ornithine decarboxylase activity and skin tumor promotion in ICR mice. Cancer Lett. 129: 139-144 (1998)   DOI   ScienceOn
34 Lamm DL, Riggs DR. Enhanced immunocompetence by garlic: role in bladder cancer and other malignancies. J. Nutr. 131: 1067S-1070S (2001)
35 Jeong WS, Kim IW, Hu R, Kong AN. Modulatory Properties of Various Natural Chemopreventive Agents on the Activation of NF-kB Signaling Pathway. Pharm. Res. 21: 661-670 (2004)   DOI   ScienceOn
36 Burke YD, Stark MJ, Roach SL, Sen SE, Crowell PL. Inhibition of pancreatic cancer growth by the dietary isoprenoids farnesol and geraniol. Lipids 32: 151-156 (1997)   DOI
37 Lagouri V, Boskou D. Screening for antioxidant activity of essential oils obtained from spices. pp. 869-879. In: Food Flavors: Generation, Analysis and Process Influence. Charalambous G (ed). Elsevier, Amsterdam, Netherlands (1995)
38 Ray A. Cancer preventive role of selected dietary factors. Indian J. Cancer 42: 15-24 (2005)   DOI   ScienceOn
39 Corticchiato M, Tomi F, Bernardini AF, Casanova J. Composition and infraspecific variability of essential oil from Thymus herba barona Lois. Biochem. Syst. Ecol. 26: 915-932 (1998)   DOI   ScienceOn
40 Madsen HL, Bertelsen G, Skibsted LH. Antioxidative activity of spices and spice extracts. pp. 176-187. In: Spices: Flavor Chemistry and Antioxidant Properties. ACS symposium series 660. Risch SJ, Ho CT (eds). American Chemical Society, Washington, DC, USA (1997)
41 Sharma JN, Srivastava KC, Gan EK. Suppressive effects of eugenol and ginger oil on arthritic rats. Pharmacology 49: 314-318 (1994)   DOI
42 Bruck R, Aeed H, Brazovsky E, Noor T, Hershkoviz R. Allicin, the active component of garlic, prevents immune-mediated, concanavalin A-induced hepatic injury in mice. Liver Int. 25: 613-621 (2005)   DOI   ScienceOn
43 Huang MT, Ma W, Lu YP, Chang RL, Fisher C, Manchand PS, Newmark HL, Conney AH. Effects of curcumin, demethoxy-curcumin, bisde-methoxycurcumin and tetrahydrocurcumin on 12-O-tetradecanoylphorbol-13-acetate-induced tumor promotion. Carcinogenesis 16: 2493-2497 (1995)   DOI   ScienceOn
44 Thapliyal R, Maru G.B. Inhibition of cytochrome P450 isozymes bycurcumins in vitro and in vivo. Food Chem. Toxicol. 39: 541-547 (2001)   DOI   ScienceOn
45 Cho JW, Park K, Kweon GR, Jang BC, Baek WK, Suh MH, Kim CW, Lee KS, Suh SI. Curcumin inhibits the expression of COX-2 in UVB-irradiated human keratinocytes (HaCaT) by inhibiting activation of AP-1: p38 MAP kinase and JNK as potential upstream targets. Exp. Mol. Med. 37: 186-192 (2005)   DOI   ScienceOn
46 Santos FA, Silva RM, Campos AR, De Araujo RP, Lima Junior RC, Rao VS. 1,8-Cineole (eucalyptol), a monoterpene oxide attenuates the colonic damage in rats on acute TNBS-colitis. Food Chem. Toxicol. 42: 579-584 (2004)   DOI   ScienceOn
47 Maklad YA, Aboutabl EA, el-Sherei MM, Meselhy KM. Bioactivity studies of Salvia transsylvanica (Schur ex Griseb) grown in Egypt. Phytother. Res. 13: 147-150 (1999)   DOI   ScienceOn
48 Kwon YK, Jun JM, Shin SW, Cho JW, Suh SI. Curcumin decreases cell proliferation rates through BTG2-mediated cyelin D1 down-regulation in U937 cells. Int. J. Oncol. 26: 1597-1603 (2005)
49 Brand C, Ferrante A, Prager RH, Riley TV, Carson CF, Finlay-Jones JJ, Hart PH. The water-soluble components of the essential oil of Melaleuca alternifolia (tea tree oil) suppress the production of superoxide by human monocytes, but not neutrophils, activated in vitro. Inflamm. Res. 50: 213-219 (2001)   DOI
50 Cuvelier ME, Richard H, Berset C. Antioxidant activity and phenolic composition of pilot-plant and commercial extracts of sage and rosemary. J. Am. Oil Chem. Soc. 73: 645-652 (1996)   DOI
51 Lagouri V, Blekas G, Tsimidou M, Kokkini S, Boskou D. Composition and antioxidant activity of essential oils from Oregano plants grown in Greece. Z. Lebensm. Unters. For. 197: 20-23 (1993)   DOI
52 Naidu KA. Eugenol-an inhibitor of lipoxygenase-dependent lipid peroxidation. Prostag. Leukot. Ess. 53: 381-383 (1995)   DOI   ScienceOn
53 Houlihan CM, Ho CT, Chang SS. The structure of rosmariquinone, a new antioxidant isolated from Rosmarinus officinalis L. J. Am. Oil Chem. Soc. 63: 96-98 (1985)
54 Chen CW, Lee TC, Ho CT. Antioxidative effect and kinetics study of capsanthin on the chlorophyll-sensitized photooxidation of soybean oil and selected flavor compounds. pp. 188-198. In: Spices: Flavor Chemistry and Antioxidant Properties. ACS symposium series 660. Risch SJ, Ho CT (eds). American Chemical Society, Washington, DC, USA (1997)
55 Yuri T, Danbara N, Tsujita-Kyutoku M, Kiyozuka Y, Senzaki H, Shikata N, Kanzaki H, Tsubura A. Perillyl alcohol inhibits human breast cancer cell growth in vitro and in vivo. Breast Cancer Res. Tr. 84: 251-260 (2004)   DOI   ScienceOn
56 Huang MT, Ma W, Yen P, Xie JG, Han J, Frenkel K, Grunberger D. Conney AH. Inhibitory effects of topical application of low doses of curcumin on 12-O-tetradecanoylphorbol-13-acetate-induced tumor promotion and oxidized DNA bases in mouse epidermis. Carcinogenesis 18: 83-88 (1997)   DOI   ScienceOn
57 Lo AH, Liang YC, Lin-Shiau SY, Ho CT, Lin JK. Carnosol, an antioxidant in rosemary, suppresses inducible nitric oxide synthase through down-regulating nuelear factor-kappaB in mouse macrophages. Carcinogenesis 23: 983-991 (2002)   DOI   ScienceOn
58 Ranjan D, Johnston TD, Wu G, Elliott L, Bondada S, Nagabhushan M. Curcumin blocks cyelosporine A-resistant CD 28 costimulatory pathway of human T-cell proliferation. J. Surg. Res. 77: 174-178 (1998a)   DOI   ScienceOn
59 Deby-Dupont G, Mouithys-Mickalad A, Serteyn D, Lamy M, Deby C. Resveratrol and curcumin reduce the respiratory burst of Chlamydia-primed THP-1 cells. Biochem. Bioph. Res. Co. 333: 21-27 (2005)   DOI   ScienceOn
60 Kamat JP, Ghosh A, Devasagayam TPA. Vanillin as an antioxidant in rat liver mitochondria: inhibition of protein oxidation and lipid peroxidation induced by photosensitization. Mol. Cell Biochem. 209: 47-53 (2000)   DOI   ScienceOn
61 Pinto JT, Rivlin RS. Garlic and prevention of prostate cancer. pp. 177-187. In: Nutraceuticals, Designer Foods III Garlic. Soy, and Licorice. Lachance PA (ed). Food & Nutrition Press, Inc., Trumbull. CT, USA (1997)
62 Chen X, Yano Y, Hasuma T, Yoshimata T, Yinna W, Otani S. Inhibition of farnexyl protein transferase and P21 rase membrane association by d-limonene in human pancreas tumor cells in vitro. Chin. Med. Sci. J. 14: 138-144 (1999)
63 Gali-Muhtasib HU, Affara NI. Chemopreventive effects of sage oil on skin papillomas in mice. Phytomedicine 7: 129-136 (2000)   DOI   ScienceOn
64 Dorai T, Aggarwal BB. Role of chemopreventive agents in cancer therapy. Cancer Lett. 215: 129-140 (2004)   DOI   ScienceOn
65 Kumar SS, Priyadarsini KI, Sainis KB. Inhibition of peroxynitrite-mediated reactions by vanillin. J. Agric. Food Chem. 52: 139-145 (2004)   DOI   ScienceOn
66 Aeschbach R, Loliger J, Scott BC, Murcia A, Butler J, Halliwell B, Aruoma OI. Antioxidant actions of thymol, carvacrol, 6-gingerol, zingerone and hydroxytyrosol. Food Chem. Toxicol. 32: 31-36 (1994)   DOI   ScienceOn
67 Wang M, Li J, Ho GS, Peng X, Ho CT. Isolation and identification of antioxidative flavonoid glycosides from thyme (Thymus vulgaris L.). J. Food Lipids 5: 313-321 (1998)   DOI   ScienceOn
68 Fukao T, Hosono T, Misawa S, Seki T, Ariga T. The effects of allyl sulfides on the induction of phase II detoxification enzymes and liver injury by carbon tetrachloride. Food Chem. Toxicol. 42: 743-749 (2004)   DOI   ScienceOn
69 Brieskorn CH, Domling HJZ. Carnosic acid as an antioxidant in rosemary and sage leaves. Z. Lebensm. Unters. For. 141: 10-16 (1969)
70 Reddy AC, Lokesh SR. Studies on anti-inflammatory activity of spice principles and dietary n-3 polyunsaturated fatty acids on carrageenan-induced inflammation in rats. Ann. Nutr. Metabol. 38: 349-358 (1994)   DOI
71 Santos FA, Rao VS. Antiinflammatory and antinociceptive effects of 1,8-cineole a terpenoid oxide present in many plant essential oils. Phytother. Res. 14: 240-244 (2000)   DOI   ScienceOn
72 Fukushima S, Takada N, Wanibuchi H, Hori T, Min W, Ogawa M. Suppression of chemical carcinogenesis by water-soluble organosulfur compounds. J. Nutr. 131: 1049S-1053S (2001)
73 Maltzman T, Hurt L, Elson C, Tanner M, Gould M. The prevention of nitrosomethylurea-induced mammary tumors by d-limonene and orange oil. Carcinogenesis 10: 781-783 (1989)   DOI
74 Liu CT. Effect of garlic oil on hepatic arachidonic acid content and immune response in rats. J. Agric. Food Chem. 46: 4642-4647 (1998)   DOI   ScienceOn
75 Unnikrishnan MC, Kuttan R. Tumour reducing and anticarcinogenic activity of selected spices. Cancer Lett. 51: 85-89 (1990)   DOI   ScienceOn
76 Takada N. Matsuda T, Otoshi T, Yano Y, Otani S, Hasegawa T. Nakae D, Konishi Y, Fukushima S. Enhancement by organosulfur compounds from garlic and onions of diethylnitrosamine-induccd glutathione S-transferase positive foci in the rat liver. Cancer Res. 54:2895-2899 (1994). Erratum in: Cancer Res. 55:2484 (1995)
77 Ranjan D, Siquijor A, Johnston TD, Wu G, Nagabhuskahn M. The effect of curcumin on human B-cell immortalization by Epstein-Barr virus. Am. Surgeon 64: 47-51 (1998b)
78 Offord EA, Guillot F, Aeschbach R, Loliger J, Pfeifer AMA. Antioxidant and biological properties of rosemary components: Implications for food and health. pp. 88-96. In: Natural Antioxidants: Chemistry, Health Effects, and Application. Shahidi F (ed). AOCS Press, Champaign, IL, USA (1997)
79 Kawamori T, Lubet R, Steele VE, Kelloff GJ, Kaskey RB, Rao CV, Reddy BS. Chemopreventive effect of curcumin, a naturally occurring anti-inflammatory agent, during the promotion/progression stages of colon cancer. Cancer Res. 59: 597-601 (1999)
80 Juergens UR, Stober M, Schmidt-Schilling L, Kleuver T, Vetter H. Anti-inflammatory effects of eucalyptol (1,8-cineole) in bronchial asthma: inhibition of arachidonic acid metabolism in human blood monocytes in vitro. Eur. J. Med. Res. 17: 508-510 (1998)
81 Masuda Y, Kikuzaki H, Hisamoto M, Nakatani N. Antioxidant properties of gingerol related compounds from ginger. Biofactors 21: 293-296 (2004)   DOI
82 Nishimura H, Higuchi O, Tateshita K. Antioxidative activity of sulfur-containing compounds in Allium species for human LDL oxidation in vitro. Biofactors 21: 277-280 (2004)   DOI
83 Ray A. Cancer preventive role of selected dietary factors. Indian J. Cancer. 42: 15-24 (2005)   DOI   ScienceOn
84 Jung EM, Lim JH, Lee TJ, Park JW, Choi KS, Kwon TK. Curcumin sensitizes tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis through reactive oxygen species-mediated up-regulation of death receptor 5 (DR5). Carcinogenesis 26: 1905-1913 (2005)   DOI   ScienceOn
85 Joe B, Lokesh BR. Effect of curcumin and capsaicin on arachidonic acid metabolism and lysosomal enzyme secretion by rat peritoneal macrophages. Lipids 32: 1173-1180 (1997)   DOI   ScienceOn
86 Mo SJ, Son EW, Rhee DK, Pyo S. Modulation of TNF-alpha-induced ICAM-1 expression, NO and H2O2 production by alginate, allicin and ascorbic acid in human endothelial cells. Arch. Pharm. Res. 26: 244-251 (2003)   DOI   ScienceOn
87 Reuter HD, Heinrich PK, Lawson LD. Therapeutic effects and applications of garlic and its preparation. pp. 135-212. In: Garlic: The Science and Therapeutic Application of Allium sativum L. and Related Species. Koch HP, Lawson LD (eds). Williams & Wilkins. Baltimore, MD, USA (1996)
88 Hong JY, Wang ZY, Smith T, Zhou S. Shi S, Pan J, Yang CS. Inhibitory effects of diallyl sulfide on the metabolism and tumorigenecity of the tobacco-specific carcinogen 4-(methyl-nitrosamino )-1-(3-pyridyl)-1-butanone (NNK) in A/J mouse lung. Cancinogenesis 13: 901-904 (1992)   DOI
89 Kim SO, Kundu JK, Shin YK, Park JH, Cho MH, Kim TY, Surh YJ. [6]-Gingerol inhibits COX-2 expression by blocking the activation of p38 MAP kinase and NF-kappaB in phorbol esterstimulated mouse skin. Oncogene 24: 2558-2567 (2005)   DOI   ScienceOn
90 Mazumder A, Raghavan K, Weinstein J, Kohn KW, Pommier Y. Inhibition of human immunodeficiency virus type-1 integrase by curcumin. Biochem. Pharmacol. 49: 1165-1170 (1995)   DOI   ScienceOn
91 Zheng GQ, Kenney PM. Lam LK. Sesquiterpenes from clove (Eugenia caryophyllala) as potential anticarcinogenic agents. J. Nat. Prod. 55: 999-1003 (1992)   DOI
92 Huang MT, Ho CT, Wang ZY, Ferraro T, Lou YR, Stauber K. Ma W, Georgiadis C, Laskin JD, Conney AH. Inhibition of skin tumorigenesis by rosemary and its constituents carnosol and ursolic acid. Cancer Res. 54: 701-708 (1994a)
93 Stoner GD, Mukhtar H. Polyphenols as cancer chemopreventive agents. J. Cell Biochem. 22: 169-180 (1995)
94 Horie T, Awazu S, Itakura Y, Fuwa T. Identified diallyl polysulfides from an aged garlic extract which protects the membranes from lipid peroxidation. Planta Med. 58: 468-469 (1992)   DOI   ScienceOn
95 Prasad K, Laxdal VA, Yu M, Raney BL. Antioxidant activity of allicin, an active principle in garlic. Mol. Cell Biochem. 148: 183-189 (1995)   DOI
96 Huang SC, Ho CT, Lin-Shiau SY, Lin JK. Carnosol inhibits the invasion of B16/F10 mouse melanoma cells by suppressing metalloproteinase-9 through down-regulating nuclear factor-kappa B and C-Jun. Biochem. Pharmacol. 69: 221-232 (2005)   DOI   ScienceOn
97 Chung MS. Volatile compounds of Zanthoxylum piperitum A.P.DC. Food Sci. Biotechnol. 14: 529-532 (2005)
98 Craig WJ. Health-promoting properties of common herbs. Am. J. Clin. Nutr. 70: 491s-499s (1999)   DOI
99 Nagashima K. Inhibitory effect of eugenol on $Cu^{2+}$ - catalyzed lipid peroxidation in human erythrocyte membranes. Int. J. Biochem. 21: 745-749 (1989)   DOI   ScienceOn
100 Yanishlieva NV, Marinova EM, Gordon MH, Raneva VG. Antioxidant activity and mechanism of action of thymol and carvacrol in two lipid systems. Food Chem. 64: 9-66 (1999)
101 Nakatani N, Inatani R. Structure of rosmanol, a new antioxidant from rosemary (Rosmarinus officinalis L.). Agric. Biol. Chem. 45: 2385-2386 (1981)   DOI
102 Duncan RE, Lau D, El-Sohemy A, Archer MC. Geraniol and beta-ionone inhibit proliferation, cell cycle progression, and cyclin-dependent kinase 2 activity in MCF-7 breast cancer cells independent of effects on HMG-CoA reductase activity. Biochem. Pharmacol. 68: 1739-1747 (2004)   DOI   ScienceOn
103 Cha JD, Jeong MR. Lee YE. Induction of Apoptosis in Human Oral Epidermoid Carcinoma Cells by Essential Oil of Chrysanthemum boreale Makino. Food Sci. Biotechnol. 14: 350-354 (2005)
104 Fukushima S, Takada N, Hori T, Wanibuchi H. Cancer prevention by organosulfur compounds from garlic and onion. J. Cell Biochem. 27: 100-105 (1997)
105 al-Zuhair H, el-Sayeh B, Ameen HA, Al-Shoora H. Pharmacological studies of cardamom oil in animals. Pharmacol. Res. 34: 79-82 (1996)   DOI   ScienceOn
106 Childs NM, Poryzees GH. Food that help prevent disease: consumer attitudes and public policy implications. Brit. Food J. 100: 419-426 (1998)   DOI   ScienceOn
107 Burri J, Graf M, Lambelet P, Loliger J. Vanillin: more than a flavoring agent-a potent antioxidant. J. Sci. Food Agric. 48: 49-56 (1989)   DOI
108 Houlihan CM, Ho CT, Chang SS. Elucidation of the chemical structure of a novel antioxidant, rosmaridiphenol, isolated from rosemary. J. Am. Oil Chem. Soc. 61: 1036-1039 (1984)   DOI
109 Camesecchi S, Bras-Goncalves R, Bradaia A, Zeisel M, Gosse F, Poupon MF, Raul F. Geraniol, a component of plant essential oils, modulates DNA synthesis and potentiates 5-fluorouracil efficacy on human colon tumor xenografts. Cancer Lett. 215: 53-59 (2004)   DOI   ScienceOn
110 Shimizu M, Weinstein IB. Modulation of signal transduction by tea catechins and related phytochemicals. Mutat. Res. 591: 147-160 (2005)   DOI
111 Lang A, Lahav M, Sakhnini E, Barshack I, Fidder HH, Avidan B, Bardan E, Hershkoviz R, Bar-Meir S, Chowers Y. Allicin inhibits spontaneous and TNF-alpha induced secretion of proinflammatory cytokines and chemokines from intestinal epithelial cells. Clin. Nutr. 23: 1199-1208 (2004)   DOI   ScienceOn
112 Surh YJ. More than spice: capsaicin in hot chili peppers makes tumor cells commit suicide. J. Natl. Cancer Inst. 94: 1263-1265 (1999)
113 Elegbede JA, Flores R, Wang RC. Perillyl alcohol and perillaldehyde induced cell cycle arrest and cell death in BroTo and A549 cells cultured in vitro. Life Sci. 73: 2831-2840 (2003)   DOI   ScienceOn
114 Chen C, Pung D, Leong V, Hebbar V, Shen G, Nair S, Li W, Kong AN. Induction of detoxifying enzymes by garlic organosulfur compounds through transcription factor Nrf2: effect of chemical structure and stress signals. Free Radical Bio. Med. 37: 1578-1590 (2004)   DOI   ScienceOn
115 Arora A, Shykla Y. Induction of apoptosis by diallyl sulfide in DMBA-induced mouse skin tumors. Nutr. Cancer 44: 89-94 (2002)   DOI   ScienceOn
116 Caragay AB. Cancer-preventive foods and ingredients. Food Technol.-Chicago 46: 65-68 (1992)
117 Inatani R, Nakatani N, Fuwa H, Seto H. Structure of a new antioxidative phenolic diterpene isolated from rosemary (Rosmarinus officinalis L.). Agric. Biol. Chem. 46: 1661-1666 (1982)   DOI
118 Azuma Y, Ozasa N, Ueda Y, Takagi N. Pharmacological studies on the anti-inflammatory action of phenolic compounds. J. Dental Res. 65: 53-56 (1986)   DOI   ScienceOn
119 Salem ML, Hossain MS. Protective effect of black seed oil from Nigella sativa against murine cytomegalovirus infection. Int. J. Immunopharmacol. 22: 729-740 (2000)   DOI   ScienceOn
120 Bagchi D, Bagchi M, Stohs SJ, Das DK, Ray SD, Kuszynski CA, Joshi SS, Pruess HG. Free radicals and grape seed proanthocyanidin extract: importance in human health and disease prevention. Toxicology 148: 187-197 (2000)   DOI   ScienceOn
121 He L, Mo H, Hadisusilo S, Qureshi AA, Elson CE. Isoprenoids suppress the growth of murine B16 melanomas in vitro and in vivo. J. Nutr. 127: 668-674 (1997)
122 Moran AE, Carothers AM, Weyant MJ, Redston M, Bertagnolli MM. Carnosol inhibits beta-catenin tyrosine phosphorylation and prevents adenoma formation in the C57BL/6J/Min/+(Min/+) mouse. Cancer Res. 65: 1097-1104 (2005)
123 Sotelo-Felix JI, Martinez-Fong D, Muriel De la Torre P. Protective effect of carnosol on $CCl_{4}$-induced acute liver damage in rats. Eur. J. Gastroen. Hepat. 14:1001-1006 (2002)   DOI
124 Crowell PL. Prevention and therapy of cancer by dietary monoterpenes. J. Nutr. 129: 775s-778s (1999)   DOI
125 Joe B, Lokesh BR. Role of capsaicin, curcumin and dietary n-3 fatty acids in lowering the generation of reactive oxygen species in rat peritoneal macrophages. Biochim. Biophys. Acta 1224: 255-263 (1994)   DOI   ScienceOn
126 Ohnishi ST, Kojinra R. Antioxidant activities of aged garlic extracts and cancer chemotherapy. pp. 105-115. In: Nutraceuticals, Designer Foods III; Garlic, Soy, and Licorice. Lachance PA (ed). Food & Nutrition Press, Inc., Trumbull, CT, USA (1997)
127 McAnally JA, Jung M, Mo H. Famesyl-O-acetylhydroquinonc and geranyl-O-acetylhydroquinone suppress the proliferation of murine B16 melanoma cells, human prostate and colon adenocarcinoma cells, human lung carcinoma cells, and human leukemia cells. Cancer Lett. 202: 181-192 (2003)   DOI   ScienceOn
128 Pinto JT, Rivlin RS. Antiproliferative effects of allium derivatives from garlic. J. Nutr. 131: 1058S-1060S (2001)
129 Moldao-Martins M, Palavra A, Beirao da Costa ML, Bernardo-Gil MG. Supercritical $CO_{2}$ extraction of Thymus zygis J. subsp. sylvestris aroma. J. Supercrit. Fluid 18: 25-34 (2000)   DOI   ScienceOn
130 Nakatani N, Inatani R. Two antioxidative diterpenes from rosemary (Rosmarinus officinalis L.) and a revisal structure of rosmanol. Agric. Biol. Chem. 48: 2081-2085 (1984)   DOI
131 Carnesecchi S, Bradaia A, Fischer B, Coelho D, Scholler-Guinard M, Gosse F, Raul F. Perturbation by geraniol of cell membrane permeability and signal transduction pathways in human colon cancer cells. J. Pharmacol. Exp. Ther. 303: 711-715 (2002)   DOI   ScienceOn
132 Huang MT. Thomas F, Ho CT. Cancer chemoprevention by phytochemicals in fruits and vegetables. pp. 2-16. In: Food Phytochemicals for Cancer Prevention I. Huang MT, Osawa T, Ho CT. Rosen RT (eds). American Chemical Society, Washington, DC, USA (1994b)
133 Apitz-Castro R, Badimon JJ, Badimon L. Effect of ajoene, the major antiplatelet compound trom garlic, on platelet thrombus formation. Thromb. Res. 68: 145-155 (1992)   DOI   ScienceOn
134 Chan MM, Ho CT, Huang HI. Effects of three dietary phytochemicals from tea, rosemary and turmeric on inflammation-induced nitrite production. Cancer Lett. 1: 23-29 (1995)