• American Studies
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• v.41 no.1
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• pp.99-131
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• 2018

The United States of America is privileged in that social stratification is not directly linked to the division of powers. Nonetheless, America endured the devastating Civil War only to consolidate her national identity when a nation was not defined. In fact, state governments preexisted as a sovereign long before the federal government came into existence as a national government. As a consequence, intergovernmental relations have persistently been contested long after the Civil War ended. In contrast, the European Union was founded on the political will to establish regional integration such that her member states would never repeat the bloodshed in catastrophic wars. Since the principle of subsidiarity precipitated political endeavor in regional integration, the EU developed into a bifurcated system of transnational and international organizations. In this paper, I evaluate the US and the EU by applying the perspective of federalism in which separation and integration are perennially at tension.

• Molecules and Cells
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• v.46 no.2
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• pp.106-119
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• 2023

With the increased number of single-cell RNA sequencing (scRNA-seq) datasets in public repositories, integrative analysis of multiple scRNA-seq datasets has become commonplace. Batch effects among different datasets are inevitable because of differences in cell isolation and handling protocols, library preparation technology, and sequencing platforms. To remove these batch effects for effective integration of multiple scRNA-seq datasets, a number of methodologies have been developed based on diverse concepts and approaches. These methods have proven useful for examining whether cellular features, such as cell subpopulations and marker genes, identified from a certain dataset, are consistently present, or whether their condition-dependent variations, such as increases in cell subpopulations in particular disease-related conditions, are consistently observed in different datasets generated under similar or distinct conditions. In this review, we summarize the concepts and approaches of the integration methods and their pros and cons as has been reported in previous literature.

• Journal of Microbiology and Biotechnology
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• v.25 no.11
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• pp.1863-1870
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• 2015

Fibrinolytic enzyme genes (aprE2, aprE176, and aprE179) were introduced into the Bacillus subtilis 168 chromosome without any antibiotic resistance gene. An integration vector, pDG1662, was used to deliver the genes into the amyE site of B. subtilis 168. Integrants, SJ3-5nc, SJ176nc, and SJ179nc, were obtained after two successive homologous recombinations. The integration of each fibrinolytic gene into the middle of the amyE site was confirmed by phenotypes (Amy-, Spec^S) and colony PCR results for these strains. The fibrinolytic activities of the integrants were higher than that of B. subtilis 168 by at least 3.2-fold when grown in LB broth. Cheonggukjang was prepared by inoculating each of B. subtilis 168, SJ3-5nc, SJ176nc, and SJ179nc, and the fibrinolytic activity of cheonggukjang was 4.6 ± 0.7, 10.8 ± 0.9, 7.0 ± 0.6, and 8.0 ± 0.2 (U/g of cheonggukjang), respectively at 72 h. These results showed that construction of B. subtilis strains with enhanced fibrinolytic activities is possible by integration of a strong fibrinolytic gene via a marker-free manner.

• Journal of the Korean Statistical Society
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• v.33 no.4
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• pp.435-447
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• 2004

In additive nonparametric regression, Linton and Nielsen (1995) showed that the marginal integration when applied to the local linear smoother produces a rate-optimal estimator of each univariate component function for the case where the dimension of the predictor is two. In this paper we give new formulas for the bias and variance of the marginal integration regression estimators which are valid for boundary areas as well as fixed interior points, and show the local linear marginal integration estimator is in fact rate-optimal when the dimension of the predictor is less than or equal to four. We extend the results to the case of the local polynomial smoother, too.

• Journal of Distribution Science
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• v.11 no.9
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• pp.25-29
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• 2013

Purpose - This study aimed to examine how the integration of IT systems was applied in the merger and acquisition (M&A) process in a Korean retail industry, based on the conceptual framework of a combination of related, existing literature. Research design, data, methodology - We employed the case study method, which involved literature reviews and interviews. We conducted a documentary survey and interviews regarding the M&A case for company A. Results - Company A had an integration strategy and plan with IT expertise before it began integrating both IT systems in D-Day. The IT integration of both systems was completed efficiently and effectively. Company A utilized not just one but all integration options, which was done in stages and according to situation. Conclusions - Companies should develop an integration strategy and have a clear integration plan with IT expertise in order to achieve successful integration. Companies trying to integrate IT systems during an M&A process can utilize all integration options in consideration of their business context and IT system conditions.

• The Journal of Asian Finance, Economics and Business
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• v.4 no.1
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• pp.51-58
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• 2017

The aim of the study is to assess the asymmetry of influence of factors of economic growth of national economies, which are included in the integration. Unlike previous research, the scientific significance of the obtained results consists in the use of a new method of study - external demand as a factor of economic growth, disaggregated into two components. The first is net exports mutual trade in goods within integration associations. The second is net exports of foreign trade in goods outside the integration. By use of these methods we have evaluated the contribution of these factors on economic growth of the Customs Union and the Common Economic Space (CU/CES), as well as Kazakhstan, Russia and Belarus. In the conducted analysis of scientific research was based on the fact that the economies of the member (CU/CES) are very different in scale, economic potential and volume of foreign trade. Based on this research we conclude: integration is developing successfully and efficiently only with the rise of the national economies of the member countries; to enhance economic growth and competitiveness of the countries of the Eurasian integration it is necessary to increase the volume of mutual trade of member countries of this integration.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.24 no.11
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• pp.2804-2811
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• 2000

A Nordsick form opf the multirate integration scheme has been proposed for flexible multibody dynamic systems. It is assumed that vibrational modal coordinates in the equations of motion are treated as fast variables, whereas the relative joint coordinates are treated as slow variables. In the multirate integration, the fast variables are integrated with small step-size, and the slow variables are integrated with larger step-size. The proposed multirate integration method is based on the Adams-Bashforth-Moulton predictor-corrector method and implemented in the Nordsieck vector form. The Nordsieck form of multrate integration method provides effective step-size control and at the same time, inherits the efficiency from the Adams integration method. Simulations of a flexible gun and turret system of the military tank have been carried out to show the effectiveness and efficiency of the proposed method.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 1998.04a
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• pp.407-412
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• 1998

In this work, a new time integration method is proposed using the generalized derivative concept to simulate the dynamic phenomena having sudden constraint occurring in dynamic contact/impact problems. By the adoption of the generalized derivative concept and jump assumption, discontinuity can be incorporated in time integration and as a result, the algorithm does not need any other special consideration of jumps in dynamic field variables due to sudden constraint like dynamic contact-release conditions. To observe the characteristics of the proposed time integration method, the stability and convergence analyses are carried out. In numerical tests, several dynamic contact/impact problems are analyzed by straightforward application of the proposed time integration method with the exterior penalty method.

• Journal of Fisheries and Marine Sciences Education
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• v.20 no.3
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• pp.462-472
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• 2008

Education is a field that has tried to make use of the advantages of computers since they were introduced to the world. Intelligent Tutoring System and multimedia have become methods of teaching students of Computer Science, Education, Psychology, and Cognitive Science. Until now, they have been designed and produced only on the basis of a very specific domain and format. However, in the education field, most learners ask for integrated service that is practical, realizable, and sensitive to technological change. Therefore, in this study, we would like to present the technological and formal integration model as an ITS model which acknowledges changes in the fields of technology and education. As a technological integration model, the integration model of traditional Symbolic Artificial Intelligence and Artificial Neural Networks was presented. As a formal integration model, three integration models were presented according to (a) the process of learning diagnosis (b) learners' action behaviors (c) intelligence service respectively.

• Journal of Microbiology and Biotechnology
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• v.11 no.1
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• pp.61-64
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• 2001

Delta-integration vectors were constructed for the purpose of achieving homologous integration of the hirudin expression cassette into the chromosome of Saccharomyces cerevisiae. A double $\delta$ system truncated with the unnecessary bacterial genes, and consequently having a reduced insert size for integration, showed a four-fold increase in transformation efficiency at given DNA concentrations, and as a result, the constructed recombinant yeast strain had a 1.3-fold enhancement in hirudin expression level compared with a single $\delta$ system.