• 한국한의학연구원논문집
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• 제13권1호통권19호
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• pp.37-42
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• 2007

As the cholera was spread over the Joseon dynasty at 1821, Hwang Doyeon investigated the symptoms like diarrhea, vomiting, muscle cramp and so on, and he presented the cause of cholera as the damage of Primordial-gi caused by abnormal climate and Damp-heat made by taking inadequate foods. He regarded as of great importance the ordinary health condition by guessing the prognosis of the disease, and proposed how to make a diagnosis of dehydration by observing nails and toenails. To treat cholera, he presented the methods of Sipseon-bloodletting and Singwol-moxacautery, and mentioned compound herb remedies and single herbs like garlic etc. He wrote down Mulberry leaves and Argyi wormwood leaves as the preventor of cholera to emphasize the importance of prevention, and mentioned food contraindication in addition to keep from getting worse.

• 셀메드
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• 제7권1호
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• pp.1.1-1.10
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• 2017

Minerals are individual of the components of foods and are not produced in the body but essential for best possible health. Several essential metals are vital for the appropriate performance of various enzymes, transcriptional factors and proteins that are essential in various biochemical paths. Metals like zinc (Zn), magnesium (Mg), and manganese (Mn) are cofactors of hundreds of enzymes. Zn is involved in the synthesis and secretion of insulin from the pancreatic ${\beta}-cells$. Chromium (Cr) increases the insulin receptors activity on target tissues, mainly in muscle cells. Insulin hormone is required to maintain the blood glucose amount in normal range. Continual increase of blood serum glucose level leads to marked chronic hyperglycemia or diabetes mellitus. Deficiency of insulin or its resistance, blood glucose level exceeds the upper limit of the common range of 126 mg/dl. Poor glucose control and diabetes changes the levels of essential trace elements such as Zn, Mg, Mn, Cr, iron etc. by rising urinary excretion and their related decrease in the blood. The aim of this article to discusses the important roles of essential trace elements in particular perspective of type 2 diabetes.

• 한국축산식품학회지
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• 제30권6호
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• pp.879-885
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• 2010

Conjugated linoleic acid (CLA) isomers are found naturally in foods, such as milk, milk products, beef and others, from biohydrogenation of vegetable oils. They are heterogenous group of isomers of linoleic acid in the family of polyunsaturated fatty acids. Among the isomers of linoleic acid cis9, trans11- CLA (c9, t11-CLA) and trans10, cis12- CLA (t10, c12-CLA) are found to be biologically active isomers. These biologically active isomers either individual or combined found to be health beneficial in various diseases, such as cancer, diabetes, obesity, and atherosclerosis, conclusive participation in physiological processes are necessary. This review focused on the current study of CLA in prevention of disease, such as cancer, diabetes and atherosclerosis, and their effective function in body fat reduction, improvement of bone and muscle mass at a cellular, clinical and systematic level.

• Journal of Korean Biological Nursing Science
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• 제1권1호
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• pp.1-24
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• 1999

The purpose of this study was to define the content of requisite human structure and function knowledge needed for clinical knowledge of nursing practice. Subjects of human structure and function were divided into 10 units, and each unit was further divided into 21 subunits, resulting in a total of 90 items. Contents of knowledge of human structure and function were constructed from syllabus of basic nursing subjects in 4 college of nursing, and textbooks published by nurse scholars prepared with basic nursing sciences. The degree of need of 90 items was measured with a 4 point scale. The subjects of this study were college graduated 136 nurses from seven university hospitals in Seoul and three university hospitals located in Chonnam Province, Kyungbook Province, and Inchon. They have been working at internal medicine ward, surgical ward, intensive care unit, obstetrics and gynecology ward, pediatrics ward, opthalmology ward, ear, nose, and throat ward, emergency room, rehabilitation ward, cancer ward, hospice ward, and their working period was mostly under 5 years. The results were as follows: 1. The highest scored items of human structure and function knowledge necessary for nursing practice were electrolyte balance, blood clotting mechanism and anticoagulation mechanism, hematopoietic function, body fluid balance, function of plasma, and anatomical terminology in the order of importance. The lowest scored items of human structure and function knowledge necessary for nursing practice was sexual factors of genetic mutation. 2. The highest order of need according to unit was membrane transport in the living unit, anatomical terminology in movement and exercise unit, mechanism of hormone function in regulation and integration unit, component and function of blood in oxygenation function unit, structure and function of digestive system in digestive and energy metabolism unit, temperature regulation in temperature regulation unit electrolyte balance in body fluid and electrolyte unit, concept of immunity in body resistance unit, and genetics terminology in genetics unit. The highest order of importance according to subunit was membrane transportation in cell subunit, classification of tissues in tissue unit, function of skin and skin in skin subunit, anatomical derivatives of the skeleton subunit, classification of joints in joint subunit, an effect of exercise on muscles in muscle subunit, function of brain in nervous system subunit, special sense in sensory subunit mechanism of hormone function in endocrine subunit, structure and function of female reproductive system in reproductive system unit, structure and function of blood in blood unit, structure of heart, electrical and mechanical function in cardiovascular system unit, structure of respiratory system in respiratory system subunit, structure and function of digestive system in digestive system subunit, hormonal regulation of metabolism in nutrition and metabolism subunit, function of kidney in urologic system subunit, electolyte balance in body fluid, electolyte and acid-base balance subunit. 3. The common content of human structure and function knowledge need for all clinical areas in nursing was structure and function of blood, hematopoietic function, function of plasm, coagulation mechanism and anticoagulation mechanism, body fluid, electrolyte balance, and acid-base balance. However, the degree of need of each human structure and function knowledge was different depending on clinical areas. 4. Significant differences in human structure and function knowledge necessary for nursing practice such as skin and derivatives of the skin, growth and development of bone, classification of joint, classification of muscle, structure of muscle, function of muscle, function of spinal cord, peripheral nerve, structure and function of pancrease, component and function of blood, function of plasma, structure and function of blood, hemodynamics, respiratory dynamics, gas transport, regulation of respiration, chemical digestion of foods, absorption of foods, characteristics of nutrients, metabolism and hormonal regulation, body energy balance were demonstrated according to the duration of work. 5. Significant differences in human structure and function knowledge necessary for nursing practice such as classification of tissue, classification of muscles, function of muscles, muscle metabolism, classification of skeletal muscles, classification of nervous system, neurotransmitters, mechanism of hormone function, pituitary and pituitary hormone, structure and function of male reproductive organ, structure and function of female reproductive organ, component and function of blood, function of plasma, coagulation mechanism and anticoagulation mechanism, gas exchange, gas transport, regulation of respiration, characteristics of nutrients, energy balance, function of kidney, concept of immunity, classification and function of immunity were shown according to the work area. Based on these findings, all the 90 items constructed by Korean Academic Society of Basic Nursing Science should be included as contents of human structure and function knowledge.

• 한국양식학회지
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• 제19권4호
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• pp.254-260
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• 2006

본 연구에서는 국내에서 가장 많이 양식되고 있는 넙치에 있어서 단백질 사료원들의 단백질과 인소화율을 측정을 통해 저오염 사료 개발을 위한 사료원을 선택하는데 그 목적이 있다. 본 실험에 사용된 9가지 동 식물성 단백질원들은 $BAIFA-M^{TM}$(어분대체품), 어분(White fish meal, WFM), 넙치근육분(Flounder muscle powder, FMP), 오징어간분(Squid liver powder, SLP), 수지박(Leather meal, LM), 대두박(Soybean meal, SM), 콘글루텐밀(Corn gluten meal, CGM), 가금부산물(Poultry by-product PBP), 그리고 난단백질(Egg albumin) 이였다. 실험결과, 각 사료원의 단백질 소화율은 FMP, 94%; SLP, 92%; WFM, 86%; SM, 82%; CGM, 75%; LM, 72%; PBP, 72%; $BAIFA-M^{TM}$, 71%; EA, 30%로 나타났다. 각 사료원의 인 소화율은 FMP, 77%; SLP, 72%; $BAIFA-M^{TM}$, 65%; LM, 55%; WFM, 54%; PBP, 50%; CGM, 20%; EA, 20%; SM, 17%로 나타났다.

• 한국식품과학회지
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• 제52권1호
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• pp.81-88
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• 2020

PGSE의 혈당조절 효과를 평가하기 위하여 제2형 당뇨 동물모델을 이용하여 8주간의 동물실험을 진행한 결과, 고농도 PGSE(600 mg/kg)의 투여는 경구 포도당 내성 및 혈당 수준을 유의적으로 감소시켰으며(p<0.05), 당화혈색소도 유의적으로 낮은 수준을 유지시켰다(p<0.05). 또한, 혈청 인슐린과 렙틴 농도 역시 대조군과 비교하여 PGSE 고농도 처리군에서 유의적으로 감소하였다(p<0.05). PGSE 투여는 db/db 마우스의 골격근에서 인슐린 의존적 세포신호전달경로를 유의적으로 활성화시켰으며, AMPK 인산화를 촉진시키고, 골격근내 포도당 흡수를 위한 GLUT4의 세포막으로의 전이를 대조군 대비 약 1.7배 증가시켰다. 이러한 결과를 근거로 할 때 PGSE는 항 당뇨병 치료제로서의 잠재적 가능성을 가진 것으로 판단된다.

• Journal of Nutrition and Health
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• 제10권3호
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• pp.10-24
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• 1977

The effects of dietary cellulose to utilize the intake nutrients in the albino rats were investigated by the two consecutive experiments in this study. The author wanted to observe the effects of the age of animals and different level of dietary cellulose, high and low in the first experiment and the effects of dietary cellulose from three different sources, rice bran, vegetable and pure-cellulose at high level in the second experiment. The results were summarized as follows. (1) The obvious effect of dietary cellulose caused to increase feces weight. Consequently apparent digestibilities of intake nutrients in the diet decreased. It was noteworthy that fecal glucose excretion was significantly affected by cellulose intake. Since three nutrients, protein, fat and carbohydrate serve as energy sources in the body, this result can be interpreted to be lowered in the efficiency of energy utilization out of intake from the diet. (2) The nutrients loss due to dietary cellulose resulted in reduction of skeletal muscle and bone weights which lead eventually to affect in reduction of body weight. (3) The effects of dietary cellulose showed differently according to the amount of cellulose ingested, dietary nutrients composition, the kinds of dietary cellulose supplemented and the age of experimental animals. When the intake diet was proportionately imbalanced in three different energy sources, carbohydrate, fat and protein, the cellulose intake was adversely affected in the utilization of the nutrients in the body. Cellulose from rice bran decreased body weight gain, cellulose from vegetable maintained medium level in body weight and pure-cellulose increased body weight. Growing rats showed more sensitive effects of cellulose tolerance in the body than grown rats in every concerns of this experiment.

• Journal of Nutrition and Health
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• 제57권2호
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• pp.261-274
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• 2024

Purpose: Recently, high-protein diets have become highly popular, and the market for protein products has steadily increased in Korea together with the development of various types of such products. However, there is limited information on the consumption of protein supplements (PS) or protein-fortified foods (PF). Thus, this study aimed to evaluate the use of PS/PF among young adults in Jeju. Methods: A total of 350 adults (140 men and 210 women) aged 19-39 years voluntarily participated in this study from June 2022 to May 2023. PS/PF use was measured using a questionnaire. Dietary intake was assessed using a 24-hour dietary recall. Results: Approximately 31.4% of the participants (n = 110) had consumed PS/PF for more than 2 weeks during the past year and 71.8% of them (n = 79) were still consuming these products (PS/PF consumers). The PS/PF consumers tended to be male and physically active (p < 0.05 for all). The most frequent reason for PS/PF use was muscle gain (59.5%), followed by protein supplementation (19.0%) and body fat loss (13.9%), and the most frequent type of PS/PF consumed was powders (70.6%), followed by drinks (17.7%) and bars (8.8%). The PS/PF consumers tended to consume a high-protein low-carbohydrate diet compared to the non-consumers. The prevalence of consuming dietary protein less than the estimated average requirement (EAR) was significantly lower in PS/PF consumers (13.9%) compared to non-consumers (25.4%; p = 0.0316). Conclusion: These findings indicate that the necessity of protein supplementation should be determined based on the current dietary protein intake and individual requirements. The study also provides the basic information for establishing guidelines for appropriate protein intake.

• 생명과학회지
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• 제20권4호
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• pp.535-542
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• 2010

경남지역 모 대학교에 재학 중인 여자 대학생 212명을 대상으로 인체 계측과 건강에 관련된 습관에 대하여 설문 조사를 실시하였다. 총대상자의 평균 연령은 20.7 세, 신장은 161.8 cm, 체중은 53.5 kg이었으며, 비만도는 98.4%이었으며 체질량 지수는 $20.6\;kg/m^2$이었고 허리-엉덩이 둘레 비율은 0.80이었다. 이와 같은 신체 계측치는 한국인의 정상 범위에 속하는 것이지만, 조사 대상자의 63.7%가 상체가 하체에 비하여서 불균형적으로 약한 체형인 것으로 나타났다. 이들 대상자를 불균형적으로 상체가 약한 군(UU, n=135)으로 하고 대조군으로써 상 하체가 균형인 군(BU, n=77)의 두 군으로 나누어서 측정 결과치를 비교 분석하였다. 체중, 비만도, 체질량지수, 허리-엉덩이 둘레비가 BU군에 비하여서 UU군이 유의적으로 낮았다. 체단백질, 체지방, 체무기질량도 역시 UU군에서 유의적으로 낮았다. 상완근육 둘레를 측정한 결과, UU군이 BU군에 비하여 유의적으로 낮았다. 운동의 규칙적 수행 여부를 알아본 결과 UU군의 1.5%, BU군에서 7.8%가 '운동을 규칙적으로 하고 있다'고 답하였다. 한편 '운동을 전혀 하고 있지 않다'라고 답한 비율이 UU군과 BU군에서 각각 55.5%, 31.2%로써, 운동을 하지 않는 경우가 UU군에서 1.8배 정도 많았다. 운동을 할 경우에 얼마나 오래하는지에 대한 질문에 UU군의 38.4%와 BU군의 35.8%가 30분 이하로 운동을 한다고 답하여서, 여자 대학생이 운동을 한다 하더라도 운동 시간이 충분하지 않은 것으로 사료된다. 본 연구 조사 결과, 상체가 하체에 비하여서 불균형적으로 약한 여자 대학생이 총 조사 대상자의 63.7%이나 되었으며, 이들의 운동 습관에 문제가 있는 것으로 나타나서 운동을 습관화하여 꾸준히 하고 특히 상체와 팔 근육을 발달시키는 운동을 실천하는 것이 필요하다고 사료된다. 아울러 여자 대학생만을 대상으로 하여 체형의 올바른 인식을 위한 교육의 필요성이 절실하며, 신체 부위의 균형을 고려한 운동 프로그램 개발이 시급하다고 생각한다.

• 대한의생명과학회지
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• 제13권4호
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• pp.263-272
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• 2007

Nebulin is a giant actin binding protein (600-900 kDa) which is specific to skeletal muscle. This protein is known to regulate thin filaments length in sarcomere as a molecular template. The C-terminus of nebulin is located in the Z-disc of muscle sarcomere and is bound to other proteins such like myopalladin, titin, archvillin, and desmin. The N-terminus of nebulin binds to tropomodulin at the pointed ends of the thin filaments. In recent research, nebulin not only found in brain but also expressed in heart, stomach, and liver. So, the roles of nebulin in non-muscle tissue have been studied. However, lack of information or studies on nebulin binding proteins and nebulin function in brain are available so far. Therefore, the current study have investigated a novel binding partner of Nebulin C-terminus by using yeast two-hybrid screening with human brain cDNA library. Nebulin C-terminus, containing simple repeats, serine rich and SH3 domain, interacts with osteonectin C-terminal region. The specific interaction of nebulin and osteonectin were confirmed in vitro by using GST pull-down assay and reconfirmed in vivo by using transfected COS-7 cells with EGFP-tagged nebulin and DsRed-tagged osteonectin. Consequently, this study identified SH3 domain in nebulin C-terminus specifically binds to extracellular Ca-binding (EeC domain in osteonectin. Also, nebulin C-terminus fusion protein colocalized with osteonectin EC domain fusion protein in transfected COS-7 cells. The current study found the interaction between nebulin and osteonectin in human brain for the first time and suggested the nebulin in brain may be associated with osteonectin, as a regulator of cell cycle progression and mitosis.