• Proceedings of the SAREK Conference
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• 2009.06a
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• pp.148-153
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• 2009

This paper considers the age of air in a ventilated space with multiple supply inlets. The local mean age of air at a point from one supply inlet is different from those from the other supply inlets. It is the purpose of the present paper to investigate theoretically the relations between the LMA's from each supply and overall combined LMA whether or not to trace the origins of supply air. Transient concentration distributions are calculated with a step-up injection of tracer gas at each supply inlet, and at both inlets simultaneously. The steady state concentration with a continuous tracer injection at a supply inlet works as a weighting factor for the corresponding LMA in calculating the average overall LMA from multiple inlets.

• Brain Tumor Research and Treatment
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• v.6 no.2
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• pp.68-72
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• 2018

We report a rare case of arachnoid granulations mimicking multiple osteolytic bone lesions. A 66-year-old woman was admitted to a local clinic for a regular checkup. Upon admission, brain CT showed multiple osteolytic lesions in the occipital bone. These needed to be differentiated from multiple osteolytic bone tumor. Subsequent brain MRI revealed that the osteolytic lesions were isointense to cerebrospinal fluid, hyperintense on T2-weighted image, hypointense on T1-weighted image, and with subtle capsules around the osteolytic lesions that were visible after gadolinium injection. A bone scan revealed no radiotracer uptake. The lesions were in both the transverse sinuses and the torcular herophili. With typical radiological appearances of the lesions, the osteolytic lesions were diagnosed as multiple arachnoid granulations. No further treatment was planned. A 1-year follow-up brain CT scan revealed no change. We should consider the possibility of arachnoid granulations when multiple osteolytic lesions are observed in the occipital bone.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.9
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• pp.5371-5374
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• 2013

Objective: Photodynamic therapy (PDT) is an emerging therapeutic procedure suitable for the treatment of cervical cancer. However, the side effects of PDT are severe, including skin ulceration, so we designed an experiment to examine the effects of multiple low-dose photodynamic therapy of 5, 10, 15, 20-tetrakis(1-methylpyridinium-4-yl) porphyrin (Tmpyp4) on tumour growth by utilizing a model in nude mice implanted with Hela cervical cancer cells. Materials and Methods: Female BALB/c nude mice (aged 5-6 weeks, weighing 18-20 g) were used. Hela cervical cancer cells were injected subcutaneously ($1{\times}10^7cells/200{\mu}L$). Ten days after injection, the mice were divided into three groups (n=6), the A group of controls without any treatment, the B group receiving a single-treatment with Tmpyp4 (10 mg/kg, intratumor injection) and irradiation (blue laser, $108J/cm^2$), and the C group given three-treatments with Tmpyp4 (10 mg/kg, intratumor injection) and irradiation at intervals of two days. After starting treatment, tumours were measured every two days, to assess growth. At 2 weeks after the last treatment of C group, tumour tissue and organs were collected from each mouse to evaluate tumor histology and organ damage. Results: Tumour growth in C group was significantly inhibited compared with A and B groups (P<0.05), without any injury to the skin and internal organs. Conclusion: Our novel findings demonstrated that multiple low-dose photodynamic therapy of Tmpyp4 could inhibit cervical cancer growth significantly with no apparent side effects.

• Journal of the Korean Society of Safety
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• v.37 no.5
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• pp.80-88
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• 2022

The Korean nuclear industry had developed the SPACE (Safety and Performance Analysis Code for nuclear power plants) code, which adopts a two-fluid, three-field model that is comprised of gas, continuous liquid and droplet fields and has the capability to simulate three-dimensional models. According to the revised law by the Nuclear Safety and Security Commission (NSSC) in Korea, the multiple failure accidents that must be considered for the accident management plan of a nuclear power plant was determined based on the lessons learned from the Fukushima accident. Generally, to improve the reliability of the calculation results of a safety analysis code, verification is required for the separate and integral effect experiments. Therefore, the goal of this work is to verify the calculation capability of the SPACE code for multiple failure accidents. For this purpose, an experiment was conducted to simulate a Control Element Drive Mechanism (CEDM) break with a safety injection failure using the ATLAS test facility, which is operated by Korea Atomic Energy Research Institute (KAERI). This experiment focused on the comparison between the experiment results and code calculation results to verify the performance of the SPACE code. The results of the overall system transient response using the SPACE code showed similar trends with the experimental results for parameters such as the system pressure, mass flow rate, and collapsed water level in component. In conclusion, it can be concluded that the SPACE code has sufficient capability to simulate a CEDM break with a safety injection failure accident.

• Journal of ILASS-Korea
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• v.20 no.2
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• pp.88-94
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• 2015

Recently, exhaust gas regulation has been gradually strengthened due to depletion of fossil fuels and environmental problem like a global warming. Due to this global problem, the demand for eco-friendly vehicle development is rapidly increasing. A clean diesel vehicle is considered as a realistic alternative. The common-rail fuel injection system, which is the key technology of the clean diesel vehicle, has adopted injection strategies such as high pressure injection, multiple injection for better atomization of the fuel. In addition, the emission regulations in the future is expected to be more stringent, which a conventional engine is difficult to deal with. One of the way for actively proceeding is the study of alternative fuels. Among them, the bio-diesel has been attracted as an alternative of diesel. So, in this study, spray characteristics of bio-diesel was analyzed in the common-rail fuel injection system with three injectors driven by different operating mechanism.

• Journal of the Korean Society of Manufacturing Process Engineers
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• v.14 no.5
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• pp.1-7
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• 2015

Cleaning by injecting dry ice and water is a generally adopted trend these days to clean molds (injection, diecasting foundry, press, rubber mold, etc). This cleaning method is performed manually, or by installing multiple high pressure spray nozzles. We have manufactured a turbine cleaning module device that is able to clean diecasting modules at any position and angle in the space by mounting an articulated robot instead of the existing pipe type injection nozzle, to minimize lead time and enhance working yield of the cleaning process. In this paper, we analyzed process factors that are required to design the turbine module by reviewing number of revolution, and results according to different blade angles and thicknesses of the mold release injection turbine module, using computational fiuid dynamics (CFD).

• Journal of Aerospace System Engineering
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• v.12 no.4
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• pp.81-89
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• 2018

In the present study, a numerical investigation was conducted to analyze the effect of the distance between the adjacent injectors on the characteristics of flow structure, fuel penetration, and air/fuel mixing. Numerical results were validated with experimental data using a single injection. Subsequently, the same injector geometry and properties were applied on a non-reacting flow simulation with multiple injectors. Total pressure loss, penetration height, and mixing efficiency were compared with the distance between the injectors. The results showed that each injected gas merged into a single stream, resulting in the 2D-like flow fields under the condition of short distance and lower mixing efficiency along with higher total pressure loss. When the distance between the injectors increased, total pressure loss reduced and mixing efficiency increased due to the weakening of interactions between the injected gases.

• YAKHAK HOEJI
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• v.42 no.4
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• pp.431-436
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• 1998

The pharmacokinetics of CKD-602, a new camptothecin anticancer derivative, were studied in mice, rats and dogs following a single or multiple intravenous administration, and the following results were obtained. The blood levels of CKD-602 declined in biphasic fashions with peak plasma levels $(C_0)$ of $2.63{\mu}g/ml$ in mice, $2.27{\mu}g/ml$ in tumor bearing mice, $2.84{\mu}g/ml$ in rats at a dose of 20mg/kg, and of 0.02mcg/ml in dogs at a dose of 0.5mg/kg. The plasma half-lives $(t_{1/2}{\beta})$ were 9.55hr in mice, 9.94hr in tumor bearing mice, 9.98hr in rats and 12.75hr in dogs. AUC of CKD-602 was increased linearly with the dose at a range from 5 to 20mg/kg. Moreover, Cltot and Vdss were also not significantly changed with increasing the dose. On the other hand, after 5 daily intravenous bolus injection of CKD-602 (5mg/kg) in rats, $t_{1/2}{\beta}$, AUC and MRT of CKD-602 were 11.90hr, $3.19{\mu}g{\cdot}hr/ml$, and 11.61hr, respectively, which were slightly higher than after the single bolus injection.

• Transactions of the Korean Society of Automotive Engineers
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• v.14 no.5
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• pp.32-38
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• 2006

Currently, due to the serious world-wide air pollution by substances emitted from vehicles, emission control is enforced more firmly and it is expected that the regulation requirements for emission will become more severe. A new concept combustion technology that can reduce the NOx and PM in relation to combustion is urgently required. Due to such social requirement, technologically advanced countries are making efforts to develop an environment-friendly vehicle engine at the nation-wide level in order to respond to the reinforced emission control. As a core combustion technology among new combustion technologies for the next generation engine, the homogenous charge compression ignition(HCCI) is expanding its application range by adopting multiple combustion mode, catalyst, direct fuel injection and partially premixed combustion. This study used a 2-staged injection method in order to apply the HCCI combustion method without significantly altering engine specifications in the aspect of multiple combustion mode and practicality by referring to the results of studies on the HCCI engine. In addition, this study confirmed the possibility of securing optimum fuel economy emission reduction in the IMEP 8bar range(which could not be achieved with existing partially premixed combustion) through forced charging, exhaust gas recirculation(EGR), compression ratio change and application of DOC catalyst.

• Journal of the Korean Society of Combustion
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• v.17 no.3
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• pp.46-52
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• 2012

3D DNS is performed for n-heptane spray turbulent jet combustion. Diesel-like conditions are considered including single and multiple injections. Conditional statistics are obtained for multiple Lagrangian flame groups of sequentially evaporating fuel. Each fuel group represents the conditional statistics of an independent Lagrangian flame group. Sequentially evaporating fuel goes through different histories and residence times over the ignition delay period. Multiple flame groups are required for accurate description of combustion of a spray jet that goes through a long injection duration or multiple injections.