• KSII Transactions on Internet and Information Systems (TIIS)
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• v.7 no.4
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• pp.632-650
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• 2013

The paper considers a spectrum sharing cognitive radio (CR) network coexisting with a primary network under the average interference power constraint. In particular, the secondary user (SU) is assumed to carry delay-sensitive services and thus shall satisfy a given delay quality-of-service (QoS) constraint. The secondary receiver is also assumed to be equipped with multiple antennas to perform maximal ratio combining (MRC) to enhance SU performance. We investigate the effective capacity of the SU with MRC diversity under aforementioned constraints in Nakagami fading environments. Particularly, we derive the optimal power allocation to achieve the maximum effective capacity of the SU, and further derive the effective capacity in closed-form. In addition, we further obtain the closed-form expressions for the effective capacities under three widely used power and rate adaptive transmission schemes, namely, optimal simultaneous power and rate adaptation (opra), truncated channel inversion with fixed rate (tifr) and channel inversion with fixed rate without truncation (cifr). Numerical results supported by simulations are presented to consolidate our studies. The impacts on the effective capacity of various system parameters such as the number of antennas, the average interference power constraint and the delay QoS constraint are investigated in detail. It is shown that MRC diversity can significantly improve the effective capacity of the SU especially for cifr transmission scheme.

• Molecules and Cells
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• v.27 no.1
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• pp.15-19
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• 2009

Notch signaling is controlled at multiple levels. In particular, stabilized Notch receptor activation directly affects the transcriptional activations of Notch target genes. Although some progress has been made in terms of defining the regulatory mechanism that alters Notch stability, it has not been determined whether Notch1/NICD stability is regulated by $GSK-3{\alpha}$. Here, we show that Notch1/NICD levels are significantly regulated by $GSK-3{\beta}$ and by $GSK-3{\alpha}$. Treatment with LiCl (a specific GSK-3 inhibitor) or the overexpression of the kinase-inactive forms of $GSK-3{\alpha}/{\beta}$ significantly increased Notch1/NICD levels. Endogenous NICD levels were also increased by either $GSK-3{\alpha}/{\beta}$- or $GSK-3{\alpha}$-specific siRNA. Furthermore, it was found that $GSK-3{\alpha}$ binds to Notch1. Deletion analysis showed that at least three Thr residues in Notch1 (Thr-1851, 2123, and 2125) are critical for its response to LiCl, which increased not only the transcriptional activity of endogenous NICD but also Hes1 mRNA levels. Taken together, our results indicate that $GSK-3{\alpha}$ is a negative regulator of Notch1/NICD.

• Korean Institute of Interior Design Journal
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• v.14 no.2 s.49
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• pp.63-71
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• 2005

The dome structure has been treated in two layers among the techniques that have formed the space in Baroque architecture and the light used to be manipulated to create the openness of space and the fantasy of atmosphere. Such an expression technique has influenced on the expression of space in the architecture of New York Five in the 1960s to 1970s and the concept of multiple space embellished with various layers has appeared in the architectural concept of New York Five; meanwhile, the common meaning with the technique of double layers and the ways of phenomenal expressions that have recognized the existence of space in the Baroque period has been achieved through the light, immaterial organism. It means that the existing concept of light limited simply to the plane elements of brightness and darkness has been treated as a formative element that has defined and adjusted the visual expansion and reduction of the space Itself and special existence and has been used as an element of the media of spatial structure. In addition, these elements have been treated as another solution for the emotional aspects of space. Therefore, this study compares the plastic and formative meaning of the Baroque architecture with that of New York Five in terms of the relation between space and light and examines them; in doing so, it will give a clue to understand various and new space expression techniques to many architects and space designers who have led modern architecture.

• International Journal of Industrial Entomology and Biomaterials
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• v.14 no.1
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• pp.33-36
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• 2007

To improve insecticidal activity of B. thuringiensis 2385-1 (Bt 2385-1), a recombinant plasmid, pHT1K-1Ac, was introduced into lepidopteran toxic Bt 2385-1 by electroporation. The presence of the recombinant plasmid in Bt 2385-1 after electroporation was confirmed by PCR. Bt 2385-1 transformant was named as Bt pHT1K-1Ac/2385-1 (1K-1Ac/2385-1). The 1K-1Ac/2385-1 transformant produced bipyramidal-shaped parasporal inclusion as like the wild-type strain, Bt 2385-1, and showed an 130 kDa band of Cry1Ac protein. The insecticidal activity of 1K-lAc/2385-1 against S. exigua was similar to that of Bt 2385-1 but the $LC_{50}$ value of transformant against P. xylostella was 1.8 times lower. Through these bioassay results, it was confirmed that toxicity of Bt 2385-1 transformant showed synergistic effect by introducing Cry1Ac. These results suggested that the multiple expressions of Cry proteins in a promising Bt strain may interact synergistically in insect midgut, resulting in increase of toxicity and expansion of host spectrum.

• Proceedings of the Korean Society of Applied Pharmacology
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• 2004.11a
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• pp.124-128
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• 2004

We have assessed amyloid ${\beta}-peptide$ $(A{\beta})-induced$ neurotoxicity in primary neurons and organotypic hippocampal slice cultures (OHC) in rat. Exposing cultured hippocampal and cerebellar granule neurons to $A{\beta}$ resulted in a decrease of MTT reduction, and in destruction of neuronal integrity. Treatment of these neurons with tunicamycin, an inhibitor of N-glycosylation in the endoplasmic reticulum (ER), also decreased MTT reduction in these neurons. S-allyl-L-cysteine (SAC), an active organosulfur compound in aged garlic extract, protected hippocampal but not cerebellar granule neurons against $A{\beta}$- or tunicamycin-induced toxicity. In the hippocampal neurons, protein expressions of casapse-12 and GRP 78 were significantly increased after $A{\beta}_{25-35}$ or tunicamycin treatment. The increase in the expression of caspase-12 was suppressed by simultaneously adding $1{\mu}M$ SAC in these neurons. In contrast, in the cerebellar granule neurons, the expression of caspase-12 was extremely lower than that in the hippocampal neurons, and an increase in the expression by $A{\beta}_{25-35}$ or tunicamycin was not detected. In OHC, ibotenic acid (IBO), a NMDA receptor agonist, induced concentration-dependent neuronal death. When $A{\beta}$ was combined with IBO, there was more intense cell death than with IBO alone. SAC protected neurons in the CA3 area and the dentate gyrus (DG) from the cell death induced by IBO in combination with $A{\beta}$, although there was no change in the CA1 area. Although protein expression of casapse-12 in the CA3 area and the DG was significantly increased after the simultaneous treatment of AI3 and IBO, no increase in the expression was observed in the CA1 area. These results suggest that SAC could protect against the neuronal cell death induced by the activation of caspase-12 in primary cultures and OHC. It is also suggested that multiple mechanisms may be involved in neuronal death induced by AI3 and AI3 in combination with IBO.

• Journal of Science Education
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• v.41 no.3
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• pp.480-498
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• 2017

This study analyzed the errors of 6th graders of elementary school in problem solving process of the measurement domain. By analyzing the errors that students make in solving difficult problems, this study tried to draw implications for teaching and learning that can help students reach their achievement standards. First, though the students were given enough time to deal with problems, the fact that about 30~60% of students, based upon the problems given, can't solve them show that they are struggling with a part of measurement domain. Second, it was confirmed that students' understanding of the unit of measurement, such as relationship between units, was low. Third, the students have a low understanding in terms of the fact that once the base is set in a triangle then the height can be set accordingly and from which multiple expressions, in obtaining the area of the triangle, can be driven.

• Journal of Communications and Networks
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• v.10 no.3
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• pp.316-330
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• 2008

This paper proposes a novel method for transporting various types of user traffic effectively over the next generation network called integrated services digital network 3 (ISDN3) (or quantum network) using quantum packets. Basically, a quantum packet comprises one or more 53-byte quanta as generated by a "quantumization" process. While connection-oriented traffic is supported by fixed-size quantum packets each with one quantum to emulate circuit switching, connectionless traffic (e.g., IP packets and active packets) is carried by variable-size quantum packets with multiple quanta to support store-and-forward switching/routing. Our aim is to provide frame-like or datagram-like services while enabling cell-based multiplexing. The quantum packet method also establishes a flexible and extensible framework that caters for future packetization needs while maintaining backward compatibility with ATM. In this paper, we discuss the design of the quantum packet method, including its format, the "quantumization" process, and support for different types of user traffic. We also present an analytical model to evaluate the consumption of network resources (or network costs) when quantum packets are employed to transfer loss-sensitive data using three different approaches: cut-through, store-and-forward and ideal. Close form mathematical expressions are obtained for some situations. In particular, in terms of network cost, we discover two interesting equivalence phenomena for the cut-through and store-and-forward approaches under certain conditions and assumptions. Furthermore, analytical and simulation results are presented to study the system behavior. Our analysis provides valuable insights into the. design of the ISDN3/quantum network.

• Korean Journal of Cognitive Science
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• v.6 no.2
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• pp.47-79
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• 1995

Since the early age of computer graphics, facial animation has been applied to various fields, and nowadays it has found several novel applications such as virtual reality(for representing virtual agents), teleconference, and man-machine interface.When we want to apply facial animation to the system with multiple participants connected via network, it is hard to animate facial expression as we desire in real-time because of the size of information to maintain an efficient communication.This paper's major contribution is to adapt 'Level-of-Detail'to the facial animation in order to solve the above problem.Level-of-Detail has been studied in the field of computer graphics to reperesent the appearance of complicated objects in efficient and adaptive way, but until now no attempt has mode in the field of facial animation. In this paper, we present a systematic scheme which enables this kind of adaptive control using Level-of-Detail.The implemented system can generate speech synchronized facial expressions with various types of user input such as text, voice, GUI, head motion, etc.

• Journal of Integrative Natural Science
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• v.12 no.4
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• pp.133-141
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• 2019

Mesenchymal stem cells (MSCs) are known to differentiate into multiple lineages, making neurogenic differentiation an important target in the clinical field. In the present study, we induced the neurogenic differentiation of cells using histone deacetylase (HDAC) inhibitors and studied their mechanisms for further differentiation in vitro. We treated cells with the HDAC inhibitors, MS-275 and NaB; and found that the cells had neuron-like features such as distinct bipolar or multipolar morphologies with branched processes. The mRNA expressions encoding for NEFL, MAP2, TUJ1, OLIG2, and SYT was significantly increased following HDAC inhibitors treatment compared to without HDAC inhibitors; high protein levels of MAP2 and Tuj1 were detected by immunofluorescence staining. We examined the mechanisms of differentiation and found that the Wnt signaling pathway and downstream mitogen-activate protein kinase were involved in neurogenic differentiation of MSCs. Importantly, Wnt4, Wnt5a/b, and Wnt11 protein levels were highly increased after treatment with NaB; signals were activated through the regulation of Dvl2 and Dvl3. Interestingly, NaB treatment increased the levels of JNK and upregulated JNK phosphorylation. After MS-275 treatment, Wnt protein levels were decreased and GSK-3β was phosphorylated. In this cell, HDAC inhibitors controlled the non-canonical Wnt expression by activating JNK phosphorylation and the canonical Wnt signaling by targeting GSK-3β.

• Journal of Educational Research in Mathematics
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• v.23 no.1
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• pp.17-35
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• 2013

The purpose of this study was to analyze the extendibility of division algorithm and Euclid algorithm for integers to algorithms for rational numbers based on word problems of fraction division. This study serviced to upgrade professional development of elementary and secondary mathematics teachers. In this paper, fractions were used as expressions of rational numbers, and they also represent rational numbers. According to discrete context and continuous context, and measurement division and partition division etc, divisibility was classified into two types; one is an abstract algebraic point of view and the other is a generalizing view which preserves division algorithms for integers. In the second view, we raised some contextual problems that can be used in school mathematics and then we discussed division algorithm, the greatest common divisor and the least common multiple, and Euclid algorithm for fractions.