• 대한치과교정학회지
• /
• 제44권4호
• /
• pp.177-183
• /
• 2014

Objective: To determine the unique contribution of geometrical design characteristics of orthodontic mini-implants on maximum insertion torque while controlling for the influence of cortical bone thickness. Methods: Total number of 100 cylindrical orthodontic mini-implants was used. Geometrical design characteristics of ten specimens of ten types of cylindrical self-drilling orthodontic mini-implants (Ortho Easy$^{(R)}$, Aarhus, and Dual Top$^{TM}$) with diameters ranging from 1.4 to 2.0 mm and lengths of 6 and 8 mm were measured. Maximum insertion torque was recorded during manual insertion of mini-implants into bone samples. Cortical bone thickness was measured. Retrieved data were analyzed in a multiple regression model. Results: Significant predictors for higher maximum insertion torque included larger outer diameter of implant, higher lead angle of thread, and thicker cortical bone, and their unique contribution to maximum insertion torque was 12.3%, 10.7%, and 24.7%, respectively. Conclusions: The maximum insertion torque values are best controlled by choosing an implant diameter and lead angle according to the assessed thickness of cortical bone.

• 한국항해항만학회지
• /
• 제31권6호
• /
• pp.537-543
• /
• 2007

다기준 의사결정 문제에서 요인간의 가중치 계산과 계산된 요인의 평가값 종합화는 매우 중요하다. 본 연구에서는 다기준 의사결정 문제에 있어서 의사결정자의 의사전략 결합기법과 다기준의사결정 문제로의 적용을 연구하였다. 복잡한 환경에서 의사결정을 할 때 발생되는 모호함을 해결하기 위해 주관적 의견을 결합한 퍼지지합 이론을, 다기준 문제의 요인을 퍼지값으로 계층화하기 위해 계층분석법을 적용하였다. 또한, 의사결정자의 의사전략을 결합하기 위해 순위 가중치평균법을 이용하였다. 순위가 있는 가중치 평균방법은 퍼지집합의 orness 특성을 이용하여 의사결정자의 주관적 의지를 반영할 수 있는 기법으로, 순위가중치평균(OWA) 연산자에 따른 낙관적 혹은 비관적인 정도에 따라 주관적인 의도를 반영할 수 있는 방법이다. 다기준의사결정 문제의 적용사례로서 해상교통안전을 위한 대기정박지의 위치분석 문제를 본 연구에서 제시한 방법에 따라 적용하였다.

• Smart Structures and Systems
• /
• 제22권4호
• /
• pp.481-493
• /
• 2018

Ultrasonic guided waves have attracted increasing attention for non-destructive testing (NDT) and structural health monitoring (SHM) of bridge cables. They offer advantages like single measurement, wide coverage of acoustical field, and long-range propagation capability. To design defect detection systems, it is essential to understand how guided waves propagate in cables and how to select the optimal excitation frequency and mode. However, certain cable characteristics such as multiple wires, anchorage, and polyethylene (PE) sheath increase the complexity in analyzing the guided wave propagation. In this study, guided wave modes for multi-wire bridge cables are identified by using a semi-analytical finite element (SAFE) technique to obtain relevant dispersion curves. Numerical results indicated that the number of guided wave modes increases, the length of the flat region with a low frequency of L(0,1) mode becomes shorter, and the cutoff frequency for high order longitudinal wave modes becomes lower, as the number of steel wires in a cable increases. These findings were used in design of transducers for defect detection and selection of the optimal wave mode and frequency for subsequent experiments. A magnetostrictive transducer system was used to excite and detect the guided waves. The applicability of the proposed approach for detecting and locating wire breakages was demonstrated for a cable with 37 wires. The present ultrasonic guided wave method has been found to be very responsive to the number of brokenwires and is thus capable of detecting defects with varying sizes.

• Molecules and Cells
• /
• 제43권7호
• /
• pp.619-631
• /
• 2020

In this study, we describe a novel function of TNNC1 (Troponin C1, Slow Skeletal and Cardiac Type), a component of actin-bound troponin, as a tumor suppressor of lung adenocarcinoma (LUAD). First, the expression of TNNC1 was strongly down-regulated in cancer tissues compared to matched normal lung tissues, and down-regulation of TNNC1 was shown to be strongly correlated with increased mortality among LUAD patients. Interestingly, TNNC1 expression was enhanced by suppression of KRAS, and ectopic expression of TNNC1 in turn inhibited KRAS^G12D-mediated anchorage independent growth of NIH3T3 cells. Consistently, activation of KRAS pathway in LUAD patients was shown to be strongly correlated with down-regulation of TNNC1. In addition, ectopic expression of TNNC1 inhibited colony formation of multiple LUAD cell lines and induced DNA damage, cell cycle arrest and ultimately apoptosis. We further examined potential correlations between expression levels of TNNC1 and various clinical parameters and found that low-level expression is significantly associated with invasiveness of the tumor. Indeed, RNA interference-mediated down-regulation of TNNC1 led to significant enhancement of invasiveness in vitro. Collectively, our data indicate that TNNC1 has a novel function as a tumor suppressor and is targeted for down-regulation by KRAS pathway during the carcinogenesis of LUAD.