• BMB Reports
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• v.48 no.8
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• pp.454-460
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• 2015

Naturally occurring reoviruses are live replication-proficient viruses that specifically infect human cancer cells while sparing their normal counterpart. Since the discovery of reoviruses in 1950s, they have shown various degrees of safety and efficacy in pre-clinical or clinical applications for human anti-cancer therapeutics. I have recently discovered that cellular tumor suppressor genes are also important in determining reoviral tropism. Carcinogenesis is a multi-step process involving the accumulation of both oncogene and tumor suppressor gene abnormalities. Reoviruses can exploit abnormal cellular tumor suppressor signaling for their oncolytic specificity and efficacy. Many tumor suppressor genes such as p53, ataxia telangiectasia mutated (ATM), and retinoblastoma associated (RB) are known to play important roles in genomic fidelity/maintenance. Thus, a tumor suppressor gene abnormality could affect host genomic integrity and likely disrupt intact antiviral networks due to the accumulation of genetic defects which in turn could result in oncolytic reovirus susceptibility. This review outlines the discovery of oncolytic reovirus strains, recent progresses in elucidating the molecular connection between oncogene/tumor suppressor gene abnormalities and reoviral oncotropism, and their clinical implications. Future directions in the utility of reovirus virotherapy is also proposed in this review. [BMB Reports 2015; 48(8): 454-460]

• Journal of Korea Port Economic Association
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• v.17 no.2
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• pp.1-28
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• 2001

Korea has been at the forefront of efforts to enhance international cooperation in transport and communications within Northeast Asia. This effort is driven not only by the benefits that could accrue to the Korean Peninsula but also to all nations in the region. Mutual cooperation within Northeast Asia would reduce transport and communications costs and provide the basis for a regional transport and logistics network. Before progress can be made towards an integrated transport and communications system in Northeast Asia, however, there is a need to evaluate its prospects, outline a visionary plan, and detail a preferred strategy. The strategy to develop the Korean Peninsula as the gateway for Northeast Asia should harmonize with the region's common transport (and communications) policy The strategy adopted by South Korea is focused primarily on the development of an improved logistics infrastructure that would be extended to North Korea upon reunification. The seaport and airport developments In Korea will have to be supported by improved access to planned high-speed railways, expressways and freight distribution centers that, in turn, are to be integrated with new telecommunications and computer technologies. The benefits from these improvements will be lost unless existing government monopolies controlling seaport, airport, rail, road and expressway developments are commercialized to ensure that the price of transport reflects its actual cost. Technical harmonization between different modes should be promoted to facilitate efficient intermodal transport between the Korean Peninsula and the rest of Northeast Asia.

• The Transactions of the Korean Institute of Electrical Engineers P
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• v.61 no.1
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• pp.23-28
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• 2012

The market of domestic Power Plant Generator Protection and Control System (GPCS) is narrow and required the high reliability, and technology. So, it is still operated as turn-key. In recent years, digital relays has evolved into IED can perform the control and monitoring functions without central monitoring based on IEC61850 international standards communications, and attention for advancement of smart grid and ECMS has been increased in South Korea. The increasing attention on multi-function IED, DGPS(digital generator protection system), for internal fault protection of large generator results in starting a national project in South Korea, the IED prototype development for next-generation power units. The voltage restrained overcurrent relay have been used as back-up overcurrent protection for generators. In this paper, voltage restrained overcurrent relay is one of the back-up protective factors in generator protection IED was presented. For evaluation performance of the voltage restrained overcurrent relay, the data of ATPDraw5.7p4 modeling was used.

• The Journal of Information Systems
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• v.17 no.4
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• pp.301-319
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• 2008

The display market has been replaced by the FPD (Flat Panel Display) from the CRT (Cathode-Ray Tube) since the late 1990s. In the FPD production line, the most equipment has high price. Thus, when the equipment has multi-function, the repetitive process is arranged for the equipment. However, such disposition of equipment results in more complicated process flow owing to repetitive operations. This reduces the production capacity and increases lead-time in turn. In this paper, we develop an AutoMod simulation system that derives to information about the quantity, production lead-time, utilities of facilities, and occupation rates of racks. In this simulation system, we consider the situation where the equipment might be broken and suspended randomly. For the developed system, we first evaluate a production plan with current layout and then, propose a revised alternative plan. Using the same simulation scheme, we investigate comparing the production quantity and lead-time with the two plans. In addition, for a proposed alternative, we try to forecast the most adequate rule between the two job dispatching rules which are FOR (Fewest Operation Remaining) and FCFS (First Come First Serve) through simulation.

• Korean Journal of Materials Research
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• v.17 no.3
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• pp.173-178
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• 2007

Carbon nanotube cathodes(CNT cathodes) with a trench structure similar to gated structure of triode-type cathode were fabricated by a screen printing method using multi-walled carbon nanotubes. The effects of surface treatments on CNT cathodes were investigated for high efficiency field emission displays(FEDs). A liquid method easily removed the organic residue and protruded the CNTs. Field emission properties were measured by using a diode-type mode. The liquid method produced a turn-on field of $1.4V/{\mu}m$. The emission current density was measured about $3.1mA/cm^{2}$ at the electric field of $3V/{\mu}m$. The liquid method showed a high potential applicable to the surface treatment for triode-type FEDs.

• Proceedings of the KIEE Conference
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• 2002.11d
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• pp.263-266
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• 2002

In this paper, It is indicating that an issues of the conventional boost converter for high frequency induction heating. To improve those issues, it is proposed, simulated and analyzed that the current resonant circuit, simulated. As the result, we knew that the proposed circuit has a good point to improve the waveform of input current and to make high efficiency. On the other side, in the inverter for the high current power supply, it is proposed that the high frequency inverter of the half bridge topology, be done the circuit analysis to extract the optimal circuit parameter. It is making sure of the soft switching operating by the inductor to reverse parallel connected on the inverter main switch, decreasing the surge voltage when the switch is turn-off by compulsion, and repressing the switch current and bringing the high current amplitude operation by the multi resonance.

• Proceedings of the KIEE Conference
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• 1999.11d
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• pp.860-862
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• 1999

we have grown vertically aligned carbon nanotubes on a large area of Co-Ni codeposited Si substrates by thermal chemical vapor deposition using $C_{2}H_{2}$ gas. The carbon nanotubes grown by the thermal chemical vapor deposition are multi-wall structure, and the wall solace of nanotubes is covered with defective carbons or carbonaceous particles. The carbon nanotubes range from 50 to 120nm in diameter and about $130{\mu}m$ in length at $950^{\circ}C$. The turn-on voltage was about $0.8V/{\mu}m$ with a current density of $0.1{\mu}A/cm^2$ and emission current reveals the Fowler-Nordheim mode.

• Journal of Information Processing Systems
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• v.14 no.5
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• pp.1114-1135
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• 2018

A multiple classification system based on a new boosting technique has been approached utilizing different biometric traits, that is, color face, iris and eye along with fingerprints of right and left hands, handwriting, palm-print, gait (silhouettes) and wrist-vein for person authentication. The images of different biometric traits were taken from different standard databases such as FEI, UTIRIS, CASIA, IAM and CIE. This system is comprised of three different super-classifiers to individually perform person identification. The individual classifiers corresponding to each super-classifier in their turn identify different biometric features and their conclusions are integrated together in their respective super-classifiers. The decisions from individual super-classifiers are integrated together through a mega-super-classifier to perform the final conclusion using programming based boosting. The mega-super-classifier system using different super-classifiers in a compact form is more reliable than single classifier or even single super-classifier system. The system has been evaluated with accuracy, precision, recall and F-score metrics through holdout method and confusion matrix for each of the single classifiers, super-classifiers and finally the mega-super-classifier. The different performance evaluations are appreciable. Also the learning and the recognition time is fairly reasonable. Thereby making the system is efficient and effective.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.19 no.1
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• pp.24-34
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• 1994

In most computer networks, each node needs to have correct routing information for finding shortest paths to forward data packets. In a distributed environment, however, it is very difficult to keep consistent routing information throughout the whole network at all times. The presence of out-dated routing information can cause loop-forming which in turn causes the significant degradation of network performance. In this paper, a new class of routing algorithm for loop detection and resolution is discussed. The proposed algorithm is based on the distributed Bellman-Ford algorithm which is popularly adopted for routing in computer network. The proposed algorithm detects and resolves all kinds( two-node and multi-node) of loop in a distributed environment within finite time while maintaining the simplicity of the distributed Bellman-Ford algorithm.

• Journal of the Korean Society of Clothing and Textiles
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• v.23 no.8
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• pp.1110-1118
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• 1999

This study was to examine the effects of garment types on thermal insulation using a thermal manikin. cotton polyester wool silk and rayon were selected as outer wears like a blouse a skirt slacks and one-piece for this study Acetate was chosen as a lining. Brief and upper innerwear with long sleeves(cotton) were also chosen as the innerwear. The results were as follows: 1. The thermal insulation of the garment of single layer was in proportion to the covering area of garment in all types of clothing. 2. On adding the innerwear or the lining or both the thermal insulation of the each garment of single layer were showed a different trends by garment types. The thermal manikin insulations of one-piece dress adding the innerwear was higher than those of blouse-skirt suits. The thermal insulation of one-piece dress adding the innerwear and lining was lower than those of blouse-skirt suits. 3. The increasing rates of thermal insulation of multi-layered garments had different value by garment types but garment made of rayon and silk were showed very high increasing rates of thermal insulation. 4. The increasing rates of the thermal insulation of one-piece dress added the lining the innerwear or both except polyester showed the highest value and then blouse-slacks suits' turn came ound Blouse-skirt suits had the lowest the increasing rates of thermal insualition value.