• BMB Reports
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• v.51 no.1
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• pp.45-53
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• 2018

Mammalian target of rapamycin complex 1 (mTORC1) plays a major role in cell growth, proliferation, polarity, differentiation, development, and controls transitioning between anabolic and catabolic states of the cell. It collects almost all extracellular and intracellular signals from growth factors, nutrients, and maintains cellular homeostasis, and is involved in several pathological conditions including, neurodegeneration, Type 2 diabetes (T2D), obesity, and cancer. In this review, we summarize current knowledge of upstream signaling of mTORC1 to explain etiology of T2D and hypertriglyceridemia, in which state, the role of telomere attrition is explained. We discuss if chronic inhibition of mTORC1 can reverse adverse effects resulting from hyperactivation. In conclusion, we suggest the regulatory roles of telomerase (TERT) and hexokinase II (HKII) on mTORC1 as possible remedies to treat hyperactivation. The former inhibits mTORC1 under nutrient-rich while the latter under starved condition. We provide an idea of TOS (TOR signaling) motifs that can be used for regulation of mTORC1.

• Journal of the Korean Society of Costume
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• v.60 no.9
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• pp.106-119
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• 2010

The purpose of this study is to examine American students' perceptions of contemporary fashion design that incorporates Korean traditional costume. The findings, which are based on a survey of American students' aesthetic response to the fashion designs, are as follows. First, the impressions of American students about the fashion designs were affected by two major factors, Tradition and Trend. The Tradition factor was related to the impressions traditional, formal, elegant, classic, romantic, gorgeous, and natural, but was correlated negatively to the impressions dynamic, modern, and casual. The Trend factor was related to the impressions chic, trendy, and clear but not dandy. Designs with elongated shape had a positive score for the Tradition factor and designs with curvy line had a positive score for the Trend factor. Second, American students gave visual priority to the aspects of shape such as garment type and silhouette when they evaluated the designs. Color was less important than the aspect of shape in their fashion image perception. Therefore, they categorized the designs by similarity of garment types, and then sub-categorized them by color. The meaning of Korean traditional motifs or details was not significant to American students. Third, American students showed the tendency that the more they evaluated the designs to be gorgeous or trendy, the more they liked the designs. Furthermore, they liked the designs which have a positive score for the Trend factor.

• Journal of architectural history
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• v.16 no.2
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• pp.7-22
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• 2007

${\ddot{O}}d{\ddot{o}}n$ Lechner has been known as an architect who incorporates Hungarian folk motifs in creating a highly original Hungarian national style. Nevertheless, his work has been surprisingly neither exposed nor familiar to Korean audiences. This article attempts to reveal the unique characteristics of Lechner's architectural thought and ideas along with his buildings in Budapest. First of all, this article presents the evolution of Lechner's architectural thought by dividing his career into four marking periods. They are in chronological order to serve as a record of his architectural career. The authors then discuss his concern on the Hungarian ethnography in architecture while turing away from orthodox classicism. Subsequently, this article analyzes Lechner's three major buildings located at Budapest. By doing so, it attempts to expose his underlying design ideas and to shed light on the most elegant works of the architect. Finally, it marks out Lechner's influences on young Hungarian architects.

• The Research Journal of the Costume Culture
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• v.18 no.4
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• pp.640-654
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• 2010

The purpose of this study is to design neckties that are motivated by Christmas symbol images that have been known to public most widely in the basis of Day marketing so as to develop the competitive commodities closed to consumers' emotion in the fashion industry. As a method of this study were to use Adobe Illustrator CS2, which is one of the vector graphic programs, to present the motif design such as Santa Claus, trees, presents and letters among Christmas symbols, and are to apply to neckties by giving a change with striped pattern, all over pattern and one point pattern. The results are as follows; Firstly, Santa Claus image was expressed by color contrast with red and white, which was perceived by red, green and white that are mostly used in Christmas. Secondly, tree images are expressed abstractly with color contrast where red and green are contrasted, and color way change was given for symbol color of Christmas. Third, in the image of gift, the image of share and image of colorfulness were considered for expression by making motifs of three dimensional hexahedron shape. Fourthly, in the image of type, motif was expressed by giving a change in horizontal and vertical writing types.

• The Research Journal of the Costume Culture
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• v.20 no.1
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• pp.121-127
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• 2012

When people are asked to described certain textiles, they frequently refer to the expressions of its properties such as attractiveness, uniqueness, shininess, robustness, comfortability, and so on. It shows how senses play important role in it. Human employs their senses when interacting with textiles, most notably visual and tactile/ haptic to absorb its expressive properties. Yet, our sensorial experiences may amplify when interacting with those of traditional textiles, such as batik, as we can entice sensations when seeing its motifs and patterns, smelling its materials, and touching its surfaces. The multi-sensorial importance of seeing, smelling, and touching in the interaction with and experience of textiles suggests that one should address senses in a systematic way when evaluating users' perception on traditional textiles. To address this issue, the paper proposes the incorporation of Kansei Engineering (KE) approach for identifying multi-sensorial experiences on the expressive properties of traditional textiles, using batik as a case of study. KE approach address person's psychological understanding when observing things in order to analyze and study the inherent relationship between person's perceptual knowledge and objects evaluated. This paper outlines the use of KE approach in correlating sensorial perceptions when experience with traditional textiles and ultimately expose users' preferences toward them. Background of KE approach on textiles will be explored and its application for the multi-sensorial investigation of traditional textiles will be discussed.

• Molecules and Cells
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• v.41 no.2
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• pp.103-109
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• 2018

Calcium ions are involved in the regulation of diverse cellular processes. Fourteen genes encoding calcium binding proteins have been identified in Dictyostelium. CBP7, one of the 14 CBPs, is composed of 169 amino acids and contains four EF-hand motifs. Here, we investigated the roles of CBP7 in the development and cell migration of Dictyostelium cells and found that high levels of CBP7 exerted a negative effect on cells aggregation during development, possibly by inhibiting chemoattractant-directed cell migration. While cells lacking CBP7 exhibited normal development and chemotaxis similar that of wild-type cells, CBP7 overexpressing cells completely lost their chemotactic abilities to move toward increasing cAMP concentrations. This resulted in inhibition of cellular aggregation, a process required for forming multicellular organisms during development. Low levels of cytosolic free calcium were observed in CBP7 overexpressing cells, which was likely the underlying cause of their lack of chemotaxis. Our results demonstrate that CBP7 plays an important role in cell spreading and cell-substrate adhesion. cbp7 null cells showed decreased cell size and cell-substrate adhesion. The present study contributes to further understanding the role of calcium signaling in regulation of cell migration and development.

• Journal of Fashion Business
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• v.22 no.1
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• pp.20-40
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• 2018

The purpose of this study is to examine the concept of surrealism and its expression technique and to develop creative and artistic women's coat design based on the analysis of various expression techniques of surrealistic artists and designers. To this end, literature review was done and design and actual works of women's coats were made. Surrealism was applied to fashion by Schiaparelli in the 1930s and it has constantly been applied by many fashion designers. The examples used in fashion were examined by shape of body parts or natural objects, metaphor and transformation of objects, position change and optical illusion. Based on this examination, motifs were drawn from paintings of Rene Magritte, Salvador Dali, Vladimir Kush, and Rafal Olbinski, who most inspired contemporary fashion designers with their works. The creative and artistic sense of five women's coats for 20's and 30's were designed using surrealistic paintings and fashion design expression techniques in a view of social problems. This study has a significance in that it expanded the expression techniques of fashion design and its field with original design which is inspired by surrealistic formativeness and expression technique with social criticism. It is also possible for this study to contribute to the development of fashion design if various designs are presented through grafting various artistic expression techniques onto fashion.

• Journal of Microbiology
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• v.45 no.3
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• pp.193-198
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• 2007

A marine bacterium was isolated from Mai Po Nature Reserve of Hong Kong and identified as Vibrio cholerae MP-1. It contains a small plasmid designated as pVC of 3.8 kb. Four open reading frames (ORFs) are identified on the plasmid, but none of them shows homology to any known protein. Database search indicated that a 440 bp fragment is 96% identical to a fragment found in a small plasmid of another V. cholerae. Further experiments demonstrated that a 2.3 kb EcoRI fragment containing the complete ORF1, partial ORF4 and their intergenic region could self-replicate. Additional analyses revealed that sequence upstream of ORF1 showed the features characteristic of theta type replicons. Protein encoded by ORF1 has two characteristic motifs existed in most replication initiator proteins (Rep): the leucine zipper (LZ) motif located at the N-terminal region and the alpha helix-turn-alpha helix motif (HTH) located at the C-terminal end. The results suggest that pVC replicates via the theta type mechanism and is likely a novel type of theta replicon.

• Proceedings of the Korean Information Science Society Conference
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• 2005.07b
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• pp.235-237
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• 2005

마이크로 어레이(micro array)로 표현되는 유전자 발현 패턴(gene expression pattern)들과 해당 유전자의 upstream에 위치한 DNA 서열 요소(motif)들은 유전자 발현에 밀접한 관련을 맺고 있는데 이들간의 매핑관계를 알아내는 것은 생물전산학 분야에서 중요한 문제 중 하나이다. 본 고에서는 유전자 발현 패턴 데이터와 해당 DNA에 포함된 것으로 알려진 모티프 프로파일에 대해 대응분석(correspondence analysis)을 수행하고 2차원 평면에 매핑하여 특정 유전자 발현과 밀접하게 관련된다고 여겨지는 후보 모티프를 시각적으로 직관적으로 동정하는 방법을 제시한다. 또한 유전자 발현 패턴은 일정한 길이로 나누어 가능한 모든 패턴에 대해 클러스터링을 행하여 이에 대한 인덱스로 데이터를 표현하여 패턴의 인식성과 발현 순차성을 높이는 반면 복잡도를 줄이도록 하였다. 실험에서 두가지 형태의 모티프 프로파일과 효모 Saccharomyces cerevisiae 포자형성 데이터 집합에 대하여 대응 분석을 통한 시각화된 결과를 이용해 유전자 발현과 깊게 관련되는 것으로 알려진 모티프들이 대응 유전자 발현과의 상관성이 잘 동정되고 있음을 알 수가 있다.

• Journal of the Korean Society of Clothing and Textiles
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• v.24 no.2
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• pp.214-225
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• 2000

The objective of this study was to investigate images of Korean traditional patterns. The subjects consisted of 369 male and 356 female undergraduate students. The experimental materials used in this study were 48 stimuli and questionnaires, composed of 7-point semantic differential scales of 23 bipolar adjectives. Twelve motifs selected from 3 groups of Korean patterns were used as motif stimuli. Twelve repeated patterns were constructed from them to be applied on a CAD-simulated dress. The data was analyzed by factor analysis, ANOVA, Duncan's multiple range test. The major findings were as follows: 1. Four dimensions were emerged accounting for the dimensional structure of the images of Korean traditional patterns. These dimensions were 'simplicity', 'quality', 'interest', and 'modernity' dimension. Among them, 'simplicity' and 'quality' were the major dimensions. 2. Category, interpretation type, composition type, and application object of motif had significant effects on the images of above-mentioned dimensions. The application object had a significant effect on 'simplicity' and 'modernity' image, and the composition type on 'quality' and 'interest' image.