• The KIPS Transactions:PartD
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• v.13D no.4 s.107
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• pp.501-512
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• 2006

XML is the most popular platform-independent data expression which is used to communicate between loosely coupled heterogeneous systems such as B2B Applications or Workflow systems. The powerful query language XQuery has been developed to support diverse needs for querying XML documents. XQuery is designed to configure results from diverse data sources into a uniquely structured query result. Therefore, it became the standard for the XML query language. Although the latest XQuery supports heavy search functions including iterations, the grouping mechanism for data is too primitive and makes the query expression difficult and complex. Therefore, this work is focused on supporting the groupby clause in the query expression to process XQuery grouping. We suggest it to be a more efficient way to process grouping for restructuring and aggregation functions on XML data. We propose an XQuery EBNF that includes the groupby clause and implemented an XQuery processing system with grouping functions based on the eXist Native XML Database.

• KSBB Journal
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• v.30 no.5
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• pp.230-238
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• 2015

Abnormal glycosylation can significantly affect the intrinsic functions (i.e., stability and solubility) of proteins and the extrinsic protein interactions with other biomolecules. For example, recombinant glycoprotein therapeutics needs proper glycosylation for optimal drug efficacy. Therefore, there has been a strong demand for rapid, sensitive and high-through-put glycomics tools for real-time monitoring and fast validation of the biotherapeutics glycosylation. Although liquid chromatography tandem mass spectrometry (LC-MS/MS) is one of the most powerful tools for the characterization of glycan structures, it is generally time consuming and requires highly skilled personnel to collect the data and analyze the results. Recently, as an alternative method, matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-MS), which is a fast, robust and easy-to-use instrumentation, has been used for quantitative glycomics with various chemical derivatization techniques. In this review, we highlight the recent advances in MALDI-MS based quantitative glycan analysis according to the chemical derivatization strategies. Moreover, we address the application of MALDI-MS for high-throughput glycan analysis in many fields of clinical and biochemical engineering.

• Journal of KIISE:Computer Systems and Theory
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• v.33 no.12
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• pp.885-893
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• 2006

The Bayesian network(BN) has emerged in recent years as a powerful technique for handling uncertainty iii complex domains. Parameter learning of BN to find the most proper network from given data set has been investigated to decrease the time and effort for designing BN. Off-line learning needs much time and effort to gather the enough data and since there are uncertainties in real world, it is hard to get the complete data. In this paper, we propose an online learning method of Bayesian network parameters from incomplete data. It provides higher flexibility through learning from incomplete data and higher adaptability on environments through online learning. The results of comparison with Voting EM algorithm proposed by Cohen at el. confirm that the proposed method has the same performance in complete data set and higher performance in incomplete data set, comparing with Voting EM algorithm.

• Journal of KIISE:Databases
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• v.41 no.4
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• pp.242-248
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• 2014

With the rapidly growing amount of information represented in RDF format, efficient querying of RDF graph has become a fundamental challenge. SPARQL is one of the most widely used query languages for retrieving information from RDF dataset. SPARQL is not only simple in its syntax but also powerful in representation of graph pattern queries. However, users need to make a lot of efforts to understand the ontology schema of a dataset in order to compose a relevant SPARQL query. In this paper, we propose a graph query formulation and processing scheme based on ontology schema information which can be obtained by summarizing RDF graph. In the context of the proposed querying scheme, a user can interactively formulate the graph queries on the graphic user interface without making efforts to understand the ontology schema and even without learning SPARQL syntax. The graph query formulated by a user is transformed into a set of class paths, which are stored in a relational database and used as the constraint for search space reduction when the relational database executes the graph search operation. By executing the LUBM query 2, 8, and 9 over LUBM (10,0), it is shown that the proposed querying scheme returns the complete result set.

• Asian Oncology Nursing
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• v.12 no.1
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• pp.84-91
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• 2012

Purpose: The purpose of this study was to identify relationships between quality of sleep, symptom cluster, depression, environmental disorder, and quality of life among hospitalized cancer patients. Methods: The subjects were 114 patients who underwent chemotherapy for colon cancer, gastric cancer, gynecologic cancer and breast cancer. They were recruited from the cancer center of a university hospital. Data were collected from August 4th to 30th, 2011. The questionnaires included the Korean sleep scale A (quality of sleep), MDASI-K (symptom cluster), the environmental sleep disturbing scale, Zung's depression scale, and the Korean version of EORTC QLQ-C30. The collected data was analyzed by t-test, ANOVA, multiple regression analysis using the SPSS 19.0 program. Results: Functional QOL was negatively associated with symptom QOL (r=-.798, p<.001). Symptom cluster, depression, & spouse (46.3%) were the most powerful predictors for functional QOL (46.3%) and symptom QOL (53.4%). Conclusion: It is evident that oncology nurses need to evaluate two dimensions of quality of life for cancer patients, for example, functional and symptom QOL. We recommend nurses develop specific protocols for relieving physical symptoms and alleviating depression, and furthermore test the effectiveness of them.

• Journal of Microbiology and Biotechnology
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• v.20 no.3
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• pp.550-557
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• 2010

Escherichia coli (E. coli) heat-labile enterotoxin B subunit (LTB) was regarded as one of the most powerful mucosal immunoadjuvants eliciting strong immunoresponse to coadministered antigens. In the research, the high-level secretory expression of functional LTB was achieved in P. pastoris through high-density fermentation in a 5-1 fermentor. Meanwhile, the protein was expressed in E. coli by the way of inclusion body, although the gene was cloned from E. coli. Some positive yeast and E. coli transformants were obtained respectively by a series of screenings and identifications. Fusion proteins LTB-6$\times$His could be secreted into the supernatant of the medium after the recombinant P. pastoris was induced by 0.5% (v/v) methanol at $30^{\circ}C$, whereas E. coli transformants expressed target protein in inclusion body after being induced by 1 mM IPTG at $37^{\circ}C$. The expression level increased dramatically to 250-300 mg/l supernatant of fermentation in the former and 80-100 mg/l in the latter. The LTB-6$\times$His were purified to 95% purity by affinity chromatography and characterized by SDS-PAGE and Western blot. Adjuvant activity of target protein was analyzed by binding ability with GMI gangliosides. The MW of LTB-6$\times$His expressed in P. pastoris was greater than that in E. coli, which was equal to the expected 11 kDa, possibly resulted from glycosylation by P. pastoris that would enhance the immunogenicity of co-administered antigens. These data demonstrated that P. pastoris producing heterologous LTB has significant advantages in higher expression level and in adjuvant activity compared with the homologous E. coli system.

• Journal of the Korean Society for information Management
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• v.34 no.2
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• pp.159-180
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• 2017

This study analyzed changes to copyright policies in KCI journals comparatively using the previous 2 research results published in 2008 and 2016 and then gave insight into the meaning of the changes. The results of the study are as follows: Journals making the subject of copyright public had increased from 34% in 2008 to 67% in 2016. Journals transferring copyright from authors remained almost the same, with only a slight increase from 90% to 91% in the same period. Journals using the term 'publication rights' instead of 'copyright' had decreased; on the other hand, journals using the term 'reproduction right' and 'right of transmission' had increased. Use of copyright transfer agreement had increased from 25% to 50%; on the other hand, self archiving policy remained almost the same, decreasing slightly from 13% to 12%. This study argues that these changes mean the establishment of copyright industrialization for Korean journals and that the publishing bodies appear to be the most powerful main agent among stakeholders participating in scholarly publishing in this process.

• Microbiology and Biotechnology Letters
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• v.9 no.3
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• pp.145-152
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• 1981

Microorganisms from the waste water of starch industry, were isolated and a strain, Y-124, possessing a powerful enzymic activity was selected and identified as a member of the genus Bacillus. The ideal cultural condition for the formation of $\alpha$-amylase form Bacillus Y-124 and its preservation was investigated in connection with the biotechnological and industrial approach to the bulk enzyme production. High yield of $\alpha$-amylase was observed in medium containing casein as well as calcium pantothenate in this work. Calcium ions were found to have an effect in forming this particular enzyme. Ammonium phosphate dibasic was an important inorganic nitrogen source for the formation of $\alpha$-amylase. And preservation of this enzyme was greatly affected by calcium or sodium salts. The addition of calcium carbonate or sodium sulfate presented the most effective result for the prevention of its denaturation to various factors. The above data was obtained with crude enzyme preparation.

• Journal of the Korean Society of Fashion and Beauty
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• v.5 no.3
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• pp.111-117
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• 2007

Essential oils aims to rejuvenate and beautify medical skin care the body through the use of essential oils, and generally to improve our outward appearance. Much of this section fouses on the different methods by which essential oils can be used to improve the complexion or to treat specific medical care skin conditions. Beauty, however, is not just skin-deep. The condition of the medical care express the overall health of an individual. A relaxed attitude, together with a well-balanced diet, enough exercise, and a daily intake of plenty of spring water or herbal teas, all help to keep the system in top condition. Essential oils is a healing art which has powerful effects on both mind and body. The vital element in essential oils is the pure oils which are extracted from various part of different plants. The key to medical aromatherapy care lies in its dual use of essential oils and medical care massage, thus masking full use of two of our most important senses-smell and touch. Medical aromatherapy care is holistic, working mainly on the nervous system and including the head and body as part of the same treatment. Using pressure points along the spine, Medical aromatherapy care on the autonomic nervous system and has an immediate effect of relexation. In directly it also acts on mood. Many of the medical massage movements help lymphatic drainage. Essential oils have many different qualities; they can be relaxing or invigorating and are generally antisepic and antibacterial. Medical aromatherapy care can have psychological benefits. The power of essences in healing has been recognized in the treatment of insect bites. Clove, thyme, sandalwood, and lavender are a few of the essences that have antiseptic. Essential oils effect the dry skin for small visual pores, dull matte finish, rough sandy feeling, tantskin. Essential oils effect the mature/sun damaged skin for some red or couperose areas, loose saggy skin, exposure to a lot of ultraviolet light. Essential oils effect the medical care nomal skin good elasticity, healthy color(good circulation), smooth terture.

• Tunnel and Underground Space
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• v.23 no.1
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• pp.54-65
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• 2013

The LCM (Linear Cutting Machine) test is one of the most powerful and reliable methods for designing the disc cutter and for predicting the TBM (Tunnel Boring Machine) performance. It has an advantage to predict the actual load on disc cutter from the laboratory test on the real-size large rock samples, however, it also has a disadvantage to transport and/or prepare the large rock samples and to need an extra cost for experiment. In order to overcome this problem, lots of numerical studies have been performed. In this study, the PFC3D (Particle Flow Code in 3 Dimension) has been adopted for numerical analysis on optimum cutter spacing and failure aspects of Busan Tuff. The optimum cutting condition with s/p ratio of 16 and minimum specific energy of $14MJ/m^3$ was derived from numerical analyses. The cutter spacing for Busan Tuff had the good agreements with those of LCM test and numerical analysis by finite element method.