• Biomolecules & Therapeutics
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• v.21 no.6
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• pp.470-475
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• 2013

Ultraviolet (UV) radiation is a major environmental factor that leads to acute and chronic reactions in the human skin. UV exposure induces wrinkle formation, DNA damage, and generation of reactive oxygen species (ROS). Most mechanistic studies of skin physiology and pharmacology related with UV-irradiated skin have focused on proteins and their related gene expression or single-targeted small molecules. The present study identified and analyzed the alteration of skin metabolites following UVB irradiation and topical retinyl palmitate (RP, 5%) treatment in hairless mice using direct analysis in real time (DART) time-of-flight mass spectrometry (TOF-MS) with multivariate analysis. Under the negative ion mode, the DART ion source successfully ionized various fatty acids including palmitoleic and linolenic acid. From DART-TOF-MS fingerprints measured in positive mode, the prominent dehydrated ion peak (m/z: 369, M+H-$H_2O$) of cholesterol was characterized in all three groups. In positive mode, the discrimination among three groups was much clearer than that in negative mode by using multivariate analysis of orthogonal partial-least squares-discriminant analysis (OPLS-DA). DART-TOF-MS can ionize various small organic molecules in living tissues and is an efficient alternative analytical tool for acquiring full chemical fingerprints from living tissues without requiring sample preparation. DART-MS measurement of skin tissue with multivariate analysis proved to be a powerful method to discriminate between experimental groups and to find biomarkers for various experiment models in skin dermatological research.

• Journal of Korean Society on Water Environment
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• v.21 no.6
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• pp.651-658
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• 2005

The Non-parametric Analysis is powerful in data test especially for the non- normality water quality data. The data at three monitoring stations of the Tam-Jin River were evaluated for their normality using Skewness, Q-Q plot and Shapiro-Willks tests. Various constituent of water quality data including temperature, pH, DO, SS, BOD, COD, TN and TP in the period of January 1994 to December 2004 were used as dataset. Shapiro-Willks normality test was carried out for a test 5% significance level. Most water quality data except DO at monitoring stations 1 and 2 showed that data does not normally distributed. It is indicating that non-parametric method must be used for a water quality data. Therefore, a homogeneity was conducted by Mann-Whitney U test (p<0.05). Two stations were paired in three pairs of such stations. Differences between stations 1, 2 and stations 1, 3 for pH, BOD, COD, TN and TP were meaningful, but Tam-Jin 2 and 3 stations did not meaningful. In addition, a narrow gap of the water quality ranges is not a difference. Categories in which all three pairs of stations (1 and 2, 2 and 3, 1 and 3) in the Tam-Jin River showed difference in water quality were analyzed on TN and TP. The results of in this research suggest a right analysis in the homogeneity test of water quality data and a reasonable management of pollutant sources.

• Journal of Korean Society on Water Environment
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• v.32 no.6
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• pp.589-599
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• 2016

Implemented since 2004, TPLC (Total Pollution Load Control) is the most powerful water-quality protection program. Recently, uncertainty of prediction using steady state model increased due to changing water environments, and necessity of a dynamic state model, especially the watershed model, gained importance. For application of watershed model on TPLC, it needs to be feasible to adjust the relationship (mass-balance) between discharged loads estimated by technical guidance, and arrived loads based on observed data at the watershed outlet. However, at HSPF, simulation is performed as a semi-distributed model (lumped model) in a sub-basin. Therefore, if the estimated discharged loads from individual pollution source is directly entered as the point source data into the RCHRES module (without delivery ratio), the pollutant load is not reduced properly until it reaches the outlet of the sub-basin. The hypothetic RCHRES generated using the HSPF BMP Reach Toolkit was applied to solve this problem (although this is not the original application of Reach Toolkit). It was observed that the impact of discharged load according to spatial distribution of pollution sources in a sub-basin, could be expressed by multi-segmentation of the hypothetical RCHRES. Thus, the discharged pollutant load could be adjusted easily by modification of the infiltration rate or characteristics of flow control devices.

• Proceedings of the Korean Vacuum Society Conference
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• 1999.07a
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• pp.135-135
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• 1999

It is well known that Raman spectroscopy is powerful tool in analysis of sp3/sp3 bonding fraction in diamond-like carbon(DLC) films. Raman spectra of DLC film is composed of D-peak centered at 1350cm-1 and G-peak centered at 1530cm-1. The sp3/sp3 fraction is qualitatively acquired by deconvolution method. However, in case of DLC film, it is generally observed that G-peak position shifts toward low wavenumber as th sp3 fraction increases. However, opposite results were frequently observed in ta-C films. ta-C film has much higher residual compressive stress due to its high sp3 fraction compared to the DLC films deposited by CVD method. Effect of residual stress on G-peak position is most recommendable parameter in Raman analysis of ta-C, due to its smallest fitting error among many parameters acquired by peak deconvolution of symmetric spectra. In current study, the effect of residual stress on Raman spectra was quantitatively evaluated by free-hang method. ta-C films of different residual stress were deposited on Si-wafer by modifying DC-bias voltage during deposition. The variation of the G-peak position along the etching depth were observed in the free-hangs of 20~30${\mu}{\textrm}{m}$ etching depth. Mathematical result based on Airy stress function, was compared with experimental results. The more reliable analysis excluding stress-induced shift was possible by elimination of the Raman shift due to residual compressiove stress.

• The Bulletin of The Korean Astronomical Society
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• v.35 no.2
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• pp.38.2-38.2
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• 2010

We present ultraviolet (UV) color-magnitude relations (CMRs) of early-type dwarf galaxies in the Virgo cluster, based on Galaxy Evolution Explorer (GALEX) UV and Sloan Digital Sky Survey (SDSS) optical imaging data. We find that dwarf lenticular galaxies (dS0s), including peculiar dwarf elliptical galaxies (dEs) with disk substructures and blue centers, show a surprisingly distinct and tight locus separated from that of ordinary dEs, which is not clearly seen in previous CMRs. The dS0s in UV CMRs follow a steeper sequence than dEs and show bluer UV-optical color at a given magnitude. We also find that the UV CMRs of dEs in the outer cluster region are slightly steeper than that of their counterparts in the inner region, due to the existence of faint, blue dEs in the outer region. We explore the observed CMRs with population models of a luminosity-dependent delayed exponential star formation history. We confirm that the feature of delayed star formation of early-type dwarf galaxies in the Virgo cluster is strongly correlated with their morphology and environment. The observed CMR of dS0s is well matched by models with relatively long delayed star formation. Our results suggest that dS0s are most likely transitional objects at the stage of subsequent transformation of late-type progenitors to ordinary red dEs in the cluster environment, In any case, UV photometry provides a powerful tool to disentangle the diverse subpopulations of early-type dwarf galaxies and uncover their evolutionary histories.

• Journal of Technologic Dentistry
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• v.22 no.1
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• pp.145-152
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• 2000

In order to select an effective antibiotic substance against oral resident bacteria, we were isolated from soil and texonomically analyzed. Seven hundred and eighteen strains were isolated on humic acid- vitamin agar(HV agar) and 220 strains were on methanol medium from three each paddy forest, field and riverside soil samples. So, during the screening of antibiotics from soil, we isolated microorganisms showing powerful antagonistic activity against oral resident bacteria. Microorganism was tested against 25 strains of bacteria, yeast and fungi. Among them, No. 248 strain exhibited the most strongly growth inhibition. So, the taxonomical analysis the isolated strain was found to be unknown Actinomyces sp. and was named No 248. A production of the antibiotics from No. 248 begins at the early exponential phase developed at the 72th hour under the optinum conditions. The property of No. 248 antimicrobial compound was very stable under acid(pH 3.0) and alkali(pH 10.0) treatment, but it was instable in heat treatment at $120^{\circ}C$. For the improvement of antibiotic activity, two mutants were isolated from strain No. 248 by the treatment of mutagenic agents, NTG and hydroxylamine. As a result, the mutant strains excreted the potent antibiotics to inhibit the growth of Candida albicans.

• The Korean Journal of Emergency Medical Services
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• v.16 no.1
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• pp.91-101
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• 2012

Purpose: This study aims to assess the influencing factors on the level of satisfaction with clinical training and to provide basic data for more efficient clinical training. Method: The study was conducted on 402 paramedic students who have experienced clinical training from September 6 until October 12 in 2011. The questionnaires consisted of 40 questions. We used SPSS 18.0 frequency analysis, technical statistics, t-test, ANOVA, Pearson's correlation coefficients and multiple regression analysis. Result: 1. The level of satisfaction with clinical training showed significant difference between the frequency (F=8.837, p=.000) and clinical training managers (F=5.418, p=.001). 2. The level of satisfaction with clinical training showed the strongest positive correlation with the satisfaction of clinical training hospitals (r=.694, p=.000). 3. Multiple regression analysis revealed the most powerful predictor for satisfaction with clinical training was the satisfaction level of clinical training hospitals(48.2%) and the frequency of clinical training experiences(.8%), the preparation before the clinical training(5.4%), the total duration of clinical training(.7%), and the satisfaction of emergency department education(1.0%). These five variables accounted for 56.1% of the satisfaction of clinical training among paramedic students. Conclusion: As student's satisfaction of the clinical training increases, the quality of paramedics is expected to improve in the future. As a result, the future paramedics can be nurtured to be highly skilled in on-the-scene emergency situations after graduation.

• The Journal of Information Technology
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• v.5 no.1
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• pp.157-171
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• 2002

The evolution of transaction-based business model is upon us. The business models of many e-Marketplace in their early stages have typically been based on transaction fees. Many e-Marketplaces have even called out transaction revenues as a core element of their business plans. The transaction business represents the most simple of business models, but it does not provide a long-term sustain able advantage. For buyer's convenience, wide selection and test price hold appeal. For suppliers, the extended global market reach and direct access to customers and consortiums of customers is powerful. To maxmize leverage of these new e-marketplace, you must from both a buyer perspective as well as a supplier perspective. Also required is a strategy that takes in account all of the various e-Marketplace transaction standards and one that allows the easy accomodation to new e-marketplace as the market change. These new e-marketplace will need to be factored into the sales channel strategies. To be successful, integration with these e-marketplaces should occur at a complete business process level. This study explored independent and industry-backed current and future business models that are emerging in the B2B electronic market industry, as well as value -added service models for the Net market maker industry. E-Marketplaces will evolve into digital work environments in which real industry collaboration can occur.

• Earthquakes and Structures
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• v.14 no.3
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• pp.215-227
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• 2018

Supplemental passive control devices are widely considered as an important tool to mitigate the dynamic response of a building under seismic excitation. Nevertheless, a systematic method for strategically placing dampers in the buildings is not prescribed in building codes and guidelines. Many deterministic and stochastic methods have been proposed by previous researchers to investigate the optimum distribution of the viscous dampers in the steel frames. However, the seismic performances of the retrofitted buildings that are under large earthquake intensity levels or near collapse state have not been evaluated by any seismic research. Recent years, an increasing number of studies utilize genetic algorithms (GA) to explore the complex engineering optimization problems. GA interfaced with nonlinear response history (NRH) analysis is considered as one of the most powerful and popular stochastic methods to deal with the nonlinear optimization problem of damper distribution. In this paper, the effectiveness and the efficiency of GA on optimizing damper distribution are first evaluated by strong ground motions associated with the collapse failure. A practical optimization framework using GA and NRH analysis is proposed for optimizing the distribution of the fluid viscous dampers within the moment resisting frames (MRF) regarding the improvements of large drifts under intensive seismic context. Both a 10-storey and a 20-storey building are involved to explore higher mode effect. A far-fault and a near-fault earthquake environment are also considered for the frames under different seismic intensity levels. To evaluate the improvements obtained from the GA optimization regarding the collapse performance of the buildings, Incremental Dynamic Analysis (IDA) is conducted and comparisons are made between the GA damper distribution and stiffness proportional damping distribution on the collapse probability of the retrofitted frames.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.1
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• pp.117-123
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• 2016

Taxol (paclitaxel) is a powerful anti-cancer drug widely used against several types of malignant tumors. Because Taxol may exert several side effects, a variety of formulations have been developed. One of these features liposomes, regarded as one of the most promising drug carriers, biocompatible and best able to reduce drug toxicity without changing efficacy against tumor cells. Eruca sativa seed extract (SE) is considered a promising natural product from cruciferous vegetables against breast cancer, increasing chemotherapeutic and eliminating harmful side effects. The effects of Taxol-encapsulated liposomes (T) alone and in combination between Eruca sativa seed extract on nuclear factor kappa B (NF-${\kappa}B$), cyclooxygenase-2 (COX-2) and B-cell lymphoma-2 (Bcl-2) gene expression levels were investigated in rat mammary gland carcinogenesis induced by 7,12 dimethylbenz(${\alpha}$) anthracene (DMBA) using qRT-PCR. The results showed that DMBA increased NF-${\kappa}B$, COX-2 and Bcl-2 gene expression levels and lipid peroxidation (LP), while decreasing glutathione-S-transferase (GST) and superoxide dismutase (SOD) activities and total antioxidant concentration (TAC) compared to the control group. T and T-SE treatment reduced NF-${\kappa}B$, COX-2 and Bcl-2 gene expression levels and LP. Hence, T and T-SE treatment appeared to reduce inflammation and cell proliferation, while increasing apoptosis, GST and SOD activities and TAC.