• Proceedings of the Korean Vacuum Society Conference
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• 2014.02a
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• pp.401-401
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• 2014

In this study, graphene, the most attractive material today, has been applied to the wavelength-modulated surface plasmon resonance (SPR) sensor. The optical fiber sensor technology is the most fascinating topic because of its several benefits. In addition to this, the SPR phenomenon enables the detection of biomaterials to be label-free, highly sensitive, and accurate. Therefore, the optical fiber SPR sensor has powerful advantages to detect biomaterials. Meanwhile, Graphene shows superior mechanical, electrical, and optical characteristics, so that it has tremendous potential to be applied to any applications. Especially, grapheme has tighter confinement plasmon and relatively long propagation distances, so that it can enhance the light-matter interactions (F. H. L. Koppens, et al., Nano Lett., 2011). Accordingly, we coated graphene on the optical fiber probe which we fabricated to compose the wavelength-modulated SPR sensor (Figure 1.). The graphene film was synthesized via thermal chemical vapor deposition (CVD) process. Synthesized graphene was transferred on the core exposed region of fiber optic by lift-off method. Detected analytes were biotinylated double cross-over DNA structure (DXB) and Streptavidin (SA) as the ligand-receptor binding model. The preliminary results showed the SPR signal shifts for the DXB and SA binding rather than the concentration change.

• International Journal of Fluid Machinery and Systems
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• v.2 no.4
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• pp.346-352
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• 2009

The objective of the present work is to improve numerical predictions of unsteady turbulent swirling flows in the draft tubes of hydraulic power plants. We present Large Eddy Simulation (LES) results on a simplified draft tube consisting of a straight conical diffuser. The basis of LES is to solve the large scales of motion, which contain most of the energy, while the small scales are modeled. LES strategy is here preferred to the average equations strategies (RANS models) because it resolves directly the most energetic part of the turbulent flow. LES is now recognized as a powerful tool to simulate real applications in several engineering fields which are more and more frequently found. However, the cost of large-eddy simulations of wall bounded flows is still expensive. Bypass methods are investigated to perform high-Reynolds-number LES at a reasonable cost. In this study, computations at a Reynolds number about 2 $10^5$ are presented. This study presents the result of a new near-wall model for turbulent boundary layer taking into account the streamwise pressure gradient (adverse or favorable). Validations are made based on simple channel flow, without any pressure gradient and on the data base ERCOFTAC. The experiments carried out by Clausen et al. [1] reproduce the essential features of the complex flow and are used to develop and test closure models for such flows.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.27 no.2
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• pp.327-333
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• 2003

Most of shape defects in steel strip are originated from the structure of rolling mill itself. For instance, strip crown occurs when the work roll is deformed by the bending moment induced on roll chocks. To get rids of the shape defects, it is necessary to increase the stiffness of rolling mill. The structure change of back-up roll is one of alternative ways to increase the mill stiffness without facility revamping from 4 high mill to 6 high mill. In this research work, the new back-up roll was developed and can be used in any type of 4 high mill to reduce the strip shape defects. The developed back-up roll consists of sleeve, arbor and phase angle adjusting system for arbor. The circumference of arbor is specially machined to adapt the strip width change during rolling. The experimental cold rolling test was done to prove the effectiveness of newly developed back-up roll. The experimental rolling results show that the new back-up roll has more powerful performance in reducing the shape defects than conventional back-up roll. It was also found that the new back-up roll has higher stability for shape control. In addition to, the only sleeve surface needs to be reground and changed in most cases, so that the maintenance cost can be greatly reduced.

• Journal of Nutrition and Health
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• v.46 no.6
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• pp.503-510
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• 2013

Breast cancer is the most common malignancy in women, both in the developed and developing countries. Anthocyanins are natural coloring of a multitude of foods, such as berries, grapes or cherries. Glycosides of the aglycons delphinidin represent the most abundant anthocyanins in fruits. Delphinidin has recently been reported to inhibit the growth of human tumor cell line. Also, delphinidin is a powerful antioxidant that reportedly exerts beneficial effects in patients with advanced cancer by reducing the level of reactive oxygen species and increasing glutathion peroxidase activity. This study investigates the effects of delphinidin on protein ErbB2, ErbB3 and Akt expressions associated with cell proliferation and Bcl-2, Bax protein associated with cell apoptosis in MDA-MB-231 human breast cancer cell line. MDA-MB-231 cells were cultured with various concentrations (0, 5, 10, and $20{\mu}mol/L$) of delphinidin. Delphinidin inhibited breast cancer cell growth in a dose dependent manner (p < 0.05). ErbB2 and ErbB3 expressions were markdly lower $5{\mu}mol/L$ delphinidin (p < 0.05). In addition, total Akt and phosphorylated Akt levels were decreased dose-dependently in cells treated with delphinidin (p < 0.05). Futher, Bcl-2 levels were dose-dependently decreased and Bax expression was significantly increased in cells treated with delphinidin (p < 0.05). In conclusion, I have shown that delphinidin inhibits cell growth, proliferation and induces apoptosis in MDA-MB-231 human breast cancer cell lines.

• Journal of Microbiology and Biotechnology
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• v.20 no.5
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• pp.950-957
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• 2010

Serratiopeptidase (SRP), a 50 kDa metalloprotease produced from Serratia marcescens species, is a drug with potent anti-inflammatory property. In this study, a powerful statistical design, evolutionary operation (EVOP), was applied to optimize the media composition for SRP production in shake-flask culture of Serratia marcescens NRRL B-23112. Initially, factors such as inoculum size, initial pH, carbon source, and organic nitrogen source were optimized using one factor at a time. The most significant medium components affecting the production of SRP were identified as maltose, soybean meal, and $K_2HPO_4$. The SRP so produced was not found to be dependent on whey protein, but rather was notably induced by most of the organic nitrogen sources used in the study and free from other concomitant protease contaminant, as revealed by protease inhibition study. In addition, experiments were performed using different sets of EVOP design with each factor varied at three levels. The experimental data were analyzed with a standard set of statistical formula. The EVOP-optimized medium, with maltose 4.5%, soybean meal 6.5%, $K_2HPO_4$ 0.8%, and NaCl 0.5% (w/v), gave a SRP production of 7,333 EU/ml, which was 17-fold higher than the unoptimized media. The application of EVOP resulted in significant enhancement of SRP production.

• Preventive Nutrition and Food Science
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• v.12 no.4
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• pp.267-272
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• 2007

The objective of this study was to investigate antioxidant activities of Panax ginseng extracted with various solvents including n-hexane, chloroform, EtOAC, n-butanol and water. Among the various ginseng extracts, ethyl acetate (EtOAC) extracts showed the most powerful scavenging activities against DPPH radicals. Among the other solvent extracts, the butanol extract seemed relatively more effective in scavenging activity, followed by chloroform, water and hexane extracts. Moreover, the highest reducing power and ferrous ion chelating activity were found in the EtOAC extract followed by other extracts of ginseng. EtOAC extracts, which exhibited the best antioxidant activities of all solvent extracts of ginseng, possessed higher concentrations of total phenolics (777.61 mg/100 g) than other extracts. These results suggest that EtOAC extracts of ginseng (P. ginseng C.A. Meyer) have the most effective antioxidant capacity compared to n-hexane, chloroform, n-butanol and water tested in this study, and has important applications for the pharmaceutical and food industries.

• Korean Journal of Social Welfare
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• v.49
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• pp.319-342
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• 2002

The nuclear family is no longer the typical Korean Family. In recent years, stepfamilies have been of the most rapidly growing family forms in Korea. Census Bureau data show that 5.9% of marriage were in 1980, 8.0% in 1990, 10.3% in 1995, 18.0% in 2000. Especially it is remarkable that women's remarriage have been increased. In spite of the fact, the stepfamily is not an urgent issue of social welfare in Korea. The stepfamily is more vulnerable than the first-marriage family in many reasons such as vague family rules, boundary ambiguity, and stepparent role ambiguity, which provides rationale for social welfare services. This study categorizes determinants of psychological distress in remarried mothers into individual, family, and environment level and tries to prove the relationships between psychological distress and determinants. Also, it explores the degree of psychological distress in remarried mothers using Zung's Self-Rating Depression Scale. The respondents of survey research are 62 cases. The result shows relatively severe level of depression among the subjects. 46.8% of them are clinically diagnosed as mild, moderate, severe depression. Our findings suggest that the variables of marriage satisfaction, ex-wife's remarriage, role strains, marriage experience, and income are significantly associated with the level of psychological distress in remarried mothers. The most powerful predictor of psychological distress is the variable of marriage satisfaction. According to the result, it is desperately needed to pay attention to social welfare services or programs for stepfamilies.

• ETRI Journal
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• v.37 no.4
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• pp.824-832
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• 2015

Heart sounds are the main obstacle in lung sound analysis. To tackle this obstacle, we propose a diagnosis algorithm that uses singular spectrum analysis (SSA) and frequency features of heart and lung sounds. In particular, we introduce a frequency coefficient that shows the frequency difference between heart and lung sounds. The proposed algorithm is applied to a synthetic mixture of heart and lung sounds. The results show that heart sounds can be extracted successfully and localizations for the first and second heart sounds are remarkably performed. An error analysis of the localization results shows that the proposed algorithm has fewer errors compared to the SSA method, which is one of the most powerful methods in the localization of heart sounds. The presented algorithm is also applied in the cases of recorded respiratory sounds from the chest walls of five healthy subjects. The efficiency of the algorithm in extracting heart sounds from the recorded breathing sounds is verified with power spectral density evaluations and listening. Most studies have used only normal respiratory sounds, whereas we additionally use abnormal breathing sounds to validate the strength of our achievements.

• Korean Journal of Occupational Health Nursing
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• v.24 no.2
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• pp.114-121
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• 2015

Purpose: The purpose of this study was to assess the psychosocial work environment of hospital nurses to identify influences of psychosocial work environment on stress, depression, sleep disorder, and burnout. Methods: A total of 219 nurses working in one hospital were surveyed by using the Korean version of the Copenhagen Psychosocial Questionnaire (COPSOQ-K) mental health and psychosocial work environment. The impact of the psychosocial work environment on mental health was analyzed using multiple regression. Results: Mental health variables are correlated with each other. The psychosocial work environment variables and mental health variables are mostly correlated. To assess the psychosocial work environment that affects mental health the most, multiple regression was used. Work-family conflict was the most powerful explanation of all the mental health variables. Work pace, social community at work, mutual trust among employees, predictability, and influence were found to be affecting some mental health variables. Conclusion: To improve the mental health of nurses, it is necessary to consider work pace, social community at work, mutual trust among employees, predictability, influence focus on work-family conflict.

• Smart Structures and Systems
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• v.14 no.2
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• pp.159-189
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• 2014

One of the most important requirements in the evaluation of existing structural systems and ensuring a safe performance during their service life is damage assessment. Damage can be defined as a weakening of the structure that adversely affects its current or future performance which may cause undesirable displacements, stresses or vibrations to the structure. The mass and stiffness of a structure will change due to the damage, which in turn changes the measured dynamic response of the system. Damage detection can increase safety, reduce maintenance costs and increase serviceability of the structures. Artificial Neural Networks (ANNs) are simplified models of the human brain and evolved as one of the most useful mathematical concepts used in almost all branches of science and engineering. ANNs have been applied increasingly due to its powerful computational and excellent pattern recognition ability for detecting damage in structural engineering. This paper presents and reviews the technical literature for past two decades on structural damage detection using ANNs with modal parameters such as natural frequencies and mode shapes as inputs.