• 대한간호학회지
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• 제44권5호
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• pp.525-533
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• 2014

Purpose: This study was done to propose and test a predictive model that would explain and predict fall prevention behaviors in postmenopausal women. The health belief model was the theoretical basis to aid development of a nursing intervention fall prevention program. Methods: Data for 421 postmenopausal women were selected from an original data set using a survey design. The structural equation model was tested for 3 constructs: modifying factors, expectation factors, and threat factors. Expectation factors were measured as relative perceived benefit (perceived benefit minus perceived barrier), self-efficacy, and health motivation; threat factors, as perceived susceptibility (fear of falling) and perceived severity (avoiding activity for fear of falling); and modifying factors: level of education and knowledge about fall prevention. Data were analyzed using SPSS Windows and AMOS program. Results: Mean age was 55.7 years (range 45-64), and 19.7% had experienced a fall within the past year. Fall prevention behaviors were explained by expectation and threat factors indicating significant direct effects. Mediating effect of health beliefs was significant in the relationship between modifying factors and fall prevention behaviors. The proposed model explained 33% of the variance. Conclusion: Results indicate that fall prevention education should include knowledge, expectation, and threat factors based on health belief model.

• 식품기술
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• 제15권4호
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• pp.29-35
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• 2002

To prevent the incidence of type food allergies, removal of food allergens by excluding all foodstuffs containing the allergen(s) or disruption of allergen(s) using proteases has been employed. Though allergen- specific digestion with a protease worked well in the preparation of low allergenic goods, it is often difficult to destroy allergenicity without adversely affecting the nutritive value, taste and rheological properties of foods. In the present study, we represented that herbs component contained both allergy- enhancing and inhibiting factors, in addition to llergens. We also reported that herbal component such as epigallocatechingallate (EGCG) and epicatechingallate (ECG) is possible to be allergy- inhibiting factors, but the exact mechanism by which they alleviate allergic response is left to be clarifying. Document of allergy enhancing factors and enrichment of allergy inhibiting factors may provide a new approach to diminish allergenicity of various foodstufffs. Clarification of the allergic reaction modifying mechanism of food components and optimization of the intake of allergy modifying factor are necessary for decrement of allergenicity of conventional food and prevention of incidents of allergic response

• 한국생태학회:학술대회논문집
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• 한국생태학회 1999년도 국제 Symposium 및 '99 춘계 공동 학술 발표대회
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• pp.65-65
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• 1999

• 성인간호학회지
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• 제27권6호
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• pp.624-633
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• 2015

Purpose: This study was to develop and test a theoretical model based on the revised health belief model explaining osteoporosis prevention behaviors among postmenopausal women under 65. Methods: This secondary data analysis included 342 postmenopausal women under 65 from original data sources of a total of 734 women. The measured instruments were scales for osteoporosis awareness, osteoporosis health belief scale (benefit, barrier, susceptibility, severity, and health motivation), self-efficacy, and osteoporosis prevention behaviors. Data were analyzed using SPSS/WIN 20.0 and AMOS 20.0. Results: The mean age of the subjects was 55.2 years and the mean age of menopause was 51.10. The hypothetical model of osteoporosis prevention behaviors was relatively fit. Osteoporosis prevention behaviors were significantly explained up to 62% by expectation factors (relative benefit, self-efficacy, health motivation) and modifying factors(knowledge only). Expectation factors of health belief had a mediation effect between modifying factors and prevention behaviors. Conclusion: This study partially supported the revised health belief model for explaining osteoporosis prevention behaviors. It provides a basis for developing an educational program focusing on expectation factors and knowledge with the aim of behavioral changes for osteoporosis prevention.

• 한국공작기계학회논문집
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• 제10권2호
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• pp.64-72
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• 2001

Weld line is one of serious troubles which are observed in a plastic part manufactured by a injection molding process. This is caused by many process factors, which are molding pressure, temperature, velocity, location of a injection gate, mold geometry and material properties. investigation on the effects of these process factors to the appearance of a weld line was carried out using a finite element method. Filling and packing analyses were carried out by modifying both the configuration of the injection gates and cavity thickness. Proper locations of the injection gates could be determined by considering molding pressure, temperature, velocity and frozen layer, and whereby the weld line was controled. In order to make a weak appearance of the weld line, flow velocity and flow front in a cavity were also investigated by modifying a cavity thickness. As a result, flow front was extended around the corner in the cavity by changing the flow velocity and hence the appearance of the weld line was much weakened.

• 한국정보통신학회논문지
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• 제18권3호
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• pp.706-712
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• 2014

본 논문은 2-점 보간 필터에 대한 효과적인 가중치 설정에 대한 방법을 제안한다. 2-점 보간법은 선형 보간 필터에 변형 함수를 적용함으로써 구현된다. 여기서 변형 함수를 적용할 때 적절한 가중치를 설정해야하는 문제가 발생한다. 기존 방법에서는 보간 커널 함수의 c1-연속성을 활용하여 설정하였다. 하지만 이러한 설정 방법은 변형 함수의 특성을 활용하지 못하는 부분이 존재한다. 논문에서는 변형 함수와 영상 신호에 대한 주파수 해석을 바탕으로 실험적으로 가중치 결정 기법을 제공한다. 이를 확인하기 위해서 다양한 실험을 진행한다. 실험결과는 변형 함수에 따라서 서로 다른 최적인 가중치가 결정됨을 확인할 수 있고 이전 방법보다 더 우수한 성능을 보여주는 것을 확인해 준다.

• 한국균학회소식:학술대회논문집
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• 한국균학회 2018년도 춘계학술대회 및 임시총회
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• pp.19-19
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• 2018

Fungal pathogens have huge impact on health and economic wellbeing of human by causing life-threatening mycoses in immune-compromised patients or by destroying crop plants. A key determinant of fungal pathogenesis is their ability to undergo developmental change in response to host or environmental factors. Genetic pathways that regulate such morphological transitions and adaptation are therefore extensively studied during the last few decades. Given that epigenetic as well as genetic components play pivotal roles in development of plants and mammals, contribution of microbial epigenetic counterparts to this morphogenetic process is intriguing yet nearly unappreciated question to date. To bridge this gap in our knowledge, we set out to investigate histone modifications among epigenetic mechanisms that possibly regulate fungal adaptation and processes involved in pathogenesis of a model plant pathogenic fungus, Magnaporthe oryzae. For functional and comparative analysis of histone modifications, a web-based database (dbHiMo) was constructed first to archive and analyze histone modifying enzymes from eukaryotic species whose genome sequences are available. Based on the database entries, we carried out functional analysis of genes encoding histone modifying enzymes. Here I provide examples of such analyses that show how histone acetylation and methylation is implicated in regulating important aspects of fungal pathogenesis. Current analysis of histone modifying enzymes is followed by ChIP-seq and RNA-seq experiments to pinpoint the genes that are controlled by particular histone modifications. We anticipate that our work will provide not only the significant advances in our understanding of epigenetic mechanisms operating in microbial eukaryotes but also basis to expand our perspective on regulation of development in fungal pathogens.

• 한국미생물·생명공학회지
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• 제47권4호
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• pp.651-661
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• 2019

Targeting the pathogen viability using drugs is associated with development of drug resistance due to selective pressure. Hence, there is an increased interest in developing agents that target bacterial virulence. In this study, the inhibitory effect of ciclopirox, an antifungal agent with iron chelation potential, on the microbial virulence factors was evaluated in 26 clinical MDR Pseudomonas aeruginosa isolates collected from Alexandria Main University Hospital, a tertiary hospital in Egypt. Treatment with 9 ㎍/ml ciclopirox inhibited the hemolytic activity in 70% isolates, reduced pyocyanin production, decreased protease secretion in 46% isolates, lowered twitching and swarming motility, and decreased biofilm formation by 1.5- to 4.5-fold. The quantitative real-time PCR analysis revealed that treatment with ciclopirox downregulated the expression levels of alkaline protease (aprA) and pyocyanin (phzA1). Ciclopirox is used to treat hematological malignancies and the systemic administration of ciclopirox is reported to have adequate oral absorption with a satisfactory drug safety profile. It is important to calculate the appropriate clinical dose and therapeutic index to reposition ciclopirox from a topical antifungal agent to a promising virulence-modifying agent agent against P. aeruginosa, a problematic Gram-negative pathogen.

• The Journal of Korean Physical Therapy
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• 제15권2호
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• pp.157-167
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• 2003

Falls are a leading cause of injury, disability and death among people older than 65. Even without injury, falls cause a loss of confidence that results in reduced physical activity, increased dependency and social withdrawal. Fall prevention in the eldery people is a multifaced task that includes both the identification of risk factors and their modification strategies. Fall risk factors have been identified as both intrinsic and extrinsic. Intrinsic factors are those related to the physical and cognitive function of the person. Extrinsic factors are those which are included in the environmental hazards of everyday life. Combinations of interventions aimed at modifying both intrinsic and extrinsic risk factors can result in significant fall prevention in the geriatric population. This article selectively reviews the literature reporting exercise intervention to improve strength, balance and mobility.

• 드라이브 ㆍ 컨트롤
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• 제17권1호
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• pp.1-12
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• 2020

This study was to develop a simulation model of a compound planetary gear reducer for the final driving shaft using a gear analysis software (KISSsoft, Version 2017, KISSsoft AG, Switzerland). The aim of this study is to analyze transmission error and the tooth load distribution through micro-geometry using the simulation model. The tip and root relief were modified with Micro-geometry in the profile direction, and crowning was modified with Micro-geometry in the lead direction. The transmission error was analyzed using the PPTE (Peak to Peak Transmission Error) value, and the tooth load distribution was analyzed for the concentrated stress on the tooth surface. As a result of modifying tip and relief in the profile direction, the transmission error was reduced up to 40.7%. In the case of modifying crowning in the lead direction, the tooth load was more evenly distributed than before and decreased the stress on the tooth surface. After modifying the profile direction for the 1st and 2nd planetary gear train, the bending and contact safety factors were increased by 31.7% and 17%, and 18.3% and 12.5% respectively. Moreover, the bending and safety factors after modifying lead direction were increased by 59.5% and 32.7%, respectively for the 1st planetary gear train, and 59.6% and 43.6%, respectively for the 2nd planetary gear train. In future studies, the optimal design of a compound planetary gear reducer for the final driving shaft is needed considering both the transmission error and tooth load distribution.