• Title/Summary/Keyword: model studies

Search Result 16,600, Processing Time 0.046 seconds

Ginsenoside Rg1 treatment protects against cognitive dysfunction via inhibiting PLC-CN-NFAT1 signaling in T2DM mice

  • Xianan Dong ;Liangliang Kong ;Lei Huang ;Yong Su ;Xuewang Li;Liu Yang;Pengmin Ji ;Weiping Li ;Weizu Li
    • Journal of Ginseng Research
    • /
    • v.47 no.3
    • /
    • pp.458-468
    • /
    • 2023
  • Background: As a complication of Type II Diabetes Mellitus (T2DM), the etiology, pathogenesis, and treatment of cognitive dysfunction are still undefined. Recent studies demonstrated that Ginsenoside Rg1 (Rg1) has promising neuroprotective properties, but the effect and mechanism in diabetes-associated cognitive dysfunction (DACD) deserve further investigation. Methods: After establishing the T2DM model with a high-fat diet and STZ intraperitoneal injection, Rg1 was given for 8 weeks. The behavior alterations and neuronal lesions were judged using the open field test (OFT) and Morris water maze (MWM), as well as HE and Nissl staining. The protein or mRNA changes of NOX2, p-PLC, TRPC6, CN, NFAT1, APP, BACE1, NCSTN, and Ab1-42 were investigated by immunoblot, immunofluorescence or qPCR. Commercial kits were used to evaluate the levels of IP3, DAG, and calcium ion (Ca2+) in brain tissues. Results: Rg1 therapy improved memory impairment and neuronal injury, decreased ROS, IP3, and DAG levels to revert Ca2+ overload, downregulated the expressions of p-PLC, TRPC6, CN, and NFAT1 nuclear translocation, and alleviated Aβ deposition in T2DM mice. In addition, Rg1 therapy elevated the expression of PSD95 and SYN in T2DM mice, which in turn improved synaptic dysfunction. Conclusions: Rg1 therapy may improve neuronal injury and DACD via mediating PLC-CN-NFAT1 signal pathway to reduce Aβ generation in T2DM mice.

A Study on Factors Affecting Usage Intention of Metaverse Services in the Work Environment (업무환경에서의 메타버스 사용의도에 대한 영향요인 연구)

  • Wonsang Cho;Hyunchul Ahn
    • Knowledge Management Research
    • /
    • v.23 no.4
    • /
    • pp.251-273
    • /
    • 2022
  • Metaverse is one of the most frequently used words recently, with digitalization accelerated by the COVID-19 pandemic that started in 2019 and the development of information and communication technology. It is expected to bring a new revolution in our life as a whole in user experience. In particular, as telecommuting was adopted in the business area, interest in virtual office services such as digital video conferencing and remote offices, which are similar to the metaverse, has also increased. In this study, a study on the intention to use the metaverse service used in the work environment was applied to the Unified Theory of Acceptance and Use of Technology 2(UTAUT2). External variables for metaverse characteristics, such as self-presentation, telepresence, and technostress, were analyzed and discussed. In this study, PC-based Gather.town and VR-based Facebook Horizon, currently the most well-known and considered usable in work environments, were introduced to potential users and conducted a survey. This study has academic implications in that the research has examined the factors that affect the technology acceptance intention of users who want to apply the metaverse as a work environment based on the UTAUT2 model, unlike previous studies that have been mainly researched on the general metaverse. In practice, it may be helpful to suggest factors that should be considered when firms adopt the metaverse for business purposes.

Analysis of Relative Importance of Board Game Development Models (보드게임 개발 모형의 상대적 중요도 분석)

  • Kim, Ji-Hye;Ho, Ryu Seuc
    • Journal of Digital Convergence
    • /
    • v.20 no.1
    • /
    • pp.257-263
    • /
    • 2022
  • In the current era of Corona, the positive potential of board games is emerging as the 'untact' is accelerating. This situation can be seen as an opportunity to have a positive impact on the development of the board game industry depending on how to develop board games in a more interesting, high-quality and educational way than before. To this end, this study intends to present a methodology for deriving the relative importance of important factors in board game development among the preceding studies and methodologies for more advanced board game development by board game developers and experts. This study is to derive the relative importance of important factors in board game development. To this end, important factors in board game development for board game developers and experts were derived through the Delphi method, and the Delphi method in the ranking format was used to rank the relative importance of the derived factors. This study focused on the development model of playing cards among board games. Priority analysis result, development and planning composition, prior research analysis, draft production, production, validation, application, and review in order of importance were derived(were derived in the order of importance). The results of this study are expected to provide practical guidelines for companies to prioritize and utilize development according to their importance when developing board games.

A Study on the Introduction of Library Services Based on Blockchain (블록체인 기반의 도서관 서비스 도입 및 활용방안에 관한 연구)

  • Ro, Ji-Yoon;Noh, Younghee
    • Journal of the Korean BIBLIA Society for library and Information Science
    • /
    • v.33 no.1
    • /
    • pp.371-401
    • /
    • 2022
  • If the blockchain means storing information in a distributed environment that cannot be forged or altered, it is mentioned that this is similar to what librarians collect, preserve, and share authoritative information. In this way, this study examined blockchain technology as a way to collect and provide reliable information, increase work efficiency inside and outside the library, and strengthen cooperative networks. This study attempted to propose various ways to utilize blockchain technology in book relations based on literature surveys and case studies in other fields. To this end, this study first analyzed the field and cases of blockchain application to confirm the possibility and value of blockchain application in the library field, and proposed 12 ways to utilize it based on this. The utilization model was proposed by dividing it into operation and service sectors. In the operation sector, it is a digital identity-based user record storage and authentication function, transparent management and traceable monitoring function, voting-based personnel and recruitment system, blockchain governance-based network efficiency function, and blockchain-based next-generation device management and information integration function. The service sector includes improved book purchase and sharing efficiency due to simplification of intermediaries, digital content copyright protection and management functions, customized service provision based on customer behavior analysis, blockchain-based online learning platforms, sharing platforms, and P2P-based reliable information sharing platforms.

Deep Learning based Estimation of Depth to Bearing Layer from In-situ Data (딥러닝 기반 국내 지반의 지지층 깊이 예측)

  • Jang, Young-Eun;Jung, Jaeho;Han, Jin-Tae;Yu, Yonggyun
    • Journal of the Korean Geotechnical Society
    • /
    • v.38 no.3
    • /
    • pp.35-42
    • /
    • 2022
  • The N-value from the Standard Penetration Test (SPT), which is one of the representative in-situ test, is an important index that provides basic geological information and the depth of the bearing layer for the design of geotechnical structures. In the aspect of time and cost-effectiveness, there is a need to carry out a representative sampling test. However, the various variability and uncertainty are existing in the soil layer, so it is difficult to grasp the characteristics of the entire field from the limited test results. Thus the spatial interpolation techniques such as Kriging and IDW (inverse distance weighted) have been used for predicting unknown point from existing data. Recently, in order to increase the accuracy of interpolation results, studies that combine the geotechnics and deep learning method have been conducted. In this study, based on the SPT results of about 22,000 holes of ground survey, a comparative study was conducted to predict the depth of the bearing layer using deep learning methods and IDW. The average error among the prediction results of the bearing layer of each analysis model was 3.01 m for IDW, 3.22 m and 2.46 m for fully connected network and PointNet, respectively. The standard deviation was 3.99 for IDW, 3.95 and 3.54 for fully connected network and PointNet. As a result, the point net deep learing algorithm showed improved results compared to IDW and other deep learning method.

An Exploratory Study on Food Psychology (음식 심리학에 대한 탐색적 고찰)

  • Kim, Sei-Kyung
    • The Journal of the Korea Contents Association
    • /
    • v.22 no.5
    • /
    • pp.393-403
    • /
    • 2022
  • This study tried to derive implications by analyzing the literature related to food psychology to understand the psychological and emotional influence of food. The results of an exploratory study on food psychology are as follows. First, it was found that the perception of taste is related to an individual's state of mind. Second, as the theories for understanding the psychological aspects of food intake, the eating inhibition theory, the emotion regulation theory, and the escape model for binge eating based on the narcissistic theory were confirmed. Third, it was found that tools that can measure symptoms related to binge eating occupy a large portion of food-related diagnostic tools. Fourth, research on food-related psychological disorders was conducted on food cravings, binge eating disorder, bulimia nervosa, eating inhibition, and healthy food obsession. Fifth, it was found that studies related to the treatment of food-related psychological disorders were focused on the cognitive behavioral therapy approach. This study will serve as a basis for understanding and intervening in the emotional impact of food and psychological problems related to food.

Deep-learning-based GPR Data Interpretation Technique for Detecting Cavities in Urban Roads (도심지 도로 지하공동 탐지를 위한 딥러닝 기반 GPR 자료 해석 기법)

  • Byunghoon, Choi;Sukjoon, Pyun;Woochang, Choi;Churl-hyun, Jo;Jinsung, Yoon
    • Geophysics and Geophysical Exploration
    • /
    • v.25 no.4
    • /
    • pp.189-200
    • /
    • 2022
  • Ground subsidence on urban roads is a social issue that can lead to human and property damages. Therefore, it is crucial to detect underground cavities in advance and repair them. Underground cavity detection is mainly performed using ground penetrating radar (GPR) surveys. This process is time-consuming, as a massive amount of GPR data needs to be interpreted, and the results vary depending on the skills and subjectivity of experts. To address these problems, researchers have studied automation and quantification techniques for GPR data interpretation, and recent studies have focused on deep learning-based interpretation techniques. In this study, we described a hyperbolic event detection process based on deep learning for GPR data interpretation. To demonstrate this process, we implemented a series of algorithms introduced in the preexisting research step by step. First, a deep learning-based YOLOv3 object detection model was applied to automatically detect hyperbolic signals. Subsequently, only hyperbolic signals were extracted using the column-connection clustering (C3) algorithm. Finally, the horizontal locations of the underground cavities were determined using regression analysis. The hyperbolic event detection using the YOLOv3 object detection technique achieved 84% precision and a recall score of 92% based on AP50. The predicted horizontal locations of the four underground cavities were approximately 0.12 ~ 0.36 m away from their actual locations. Thus, we confirmed that the existing deep learning-based interpretation technique is reliable with regard to detecting the hyperbolic patterns indicating underground cavities.

Comparison of Muscle Activities in Upper Extremity Muscles During the Knee-flexed and Standard Push-ups With Different Hand Shape (무릎 팔굽혀펴기와 표준 팔굽혀펴기 시 손 모양에 따른 어깨 근육의 근활성도 비교)

  • Jeong, Sang-jin;Kim, Ji-hye;Kong, Hae-jin;Cho, Min-ji;Baek, Hyeon-ji;Kim, Su-jin
    • Physical Therapy Korea
    • /
    • v.29 no.2
    • /
    • pp.117-123
    • /
    • 2022
  • Background: Push-up are effective exercises for shoulder stability. Previous studies have documented the effects of support plane and hand position and width on muscle activities during a push-up. Objects: This study aimed to investigate the changes in muscle activities in the upper extremity when performing the standard and the knee-flexed push-up with different hand shapes. Methods: A total of twenty-six healthy males participated in this study. Three different hand shapes (finger abduction, finger adduction, and fists) and two types of push-up posture (standard and knee-flexed push-up) were set as the independent variables. Electrograms were used to measure the muscle activity of the upper trapezius (UT), triceps brachii (TB), pectoralis major (PM), and serratus anterior (SA). Each participant performed the randomly assigned push-up to the sound of the metronome. The mixed-effect linear regression model was used to detect the changes in muscle activities after changing the hand shape and push-up posture. Statistical significance was set at α = 0.05. Results: The UT muscle activity was statistically significantly higher when performing push-up with fists than finger abduction (p = 0.035) or finger adduction (p = 0.044). During the standard push-up, the muscle activity in all muscles was that the push-up with fists showed the highest muscle activity compared to the finger abduction (p < 0.01) and finger adduction (p < 0.01). Regardless of the shape of the hand, UT had the lowest muscle activity compared to other muscles (p < 0.001). In contrast, the SA muscle had the highest muscle activity among four muscles during the standard push-up. Conclusion: Based on the results of this study, we suggest hand shape is related to the difficulty level of push-up either in the standard or the knee-flexed push-up, especially in the push-up with fists. In addition, knee push-up can be recommended as shoulder muscle-strengthening exercises for individuals with low shoulder muscle strength.

The Impact of Intellectual Properties on Foreign Direct Investment (지적재산권이 해외직접투자에 미치는 영향)

  • Kim, Seok-Chin;Yim, Jeong-Dae;Kang, Sang-Il
    • Korea Trade Review
    • /
    • v.42 no.1
    • /
    • pp.165-188
    • /
    • 2017
  • Foreign direct investment is the means for companies to enter the overseas market and strengthen their competitiveness. The holding of intellectual properties, representing advantages of firms, may affect foreign direct investment. By expanding previous studies, we define intellectual properties as including trademarks and design as well as patents. Using a random-effect panel data model, we examine the effects of both intellectual properties of Korea and host countries on Korea's foreign direct investment in 128 countries from 1981 to 2014. The results are as follow. First, the coefficients of Korea's intellectual properties, patent, trademark, and design are significantly positive. This implies that Korean firms may invest abroad to take their advantages of technologies, brand value, and the capability of product differentiation. Second, except for patents, intellectual properties of host countries have a positive impact on foreign direct investment. In other words, foreign direct investment to acquire the ability of branding or product design from host countries may occur. Third, the coefficients of Korea's intellectual properties are significantly greater than those of host countries' properties. Foreign direct investment to take advantages of the firms' capabilities overseas is greater than one to acquire knowledge of host countries. Finally, Korea's intellectual properties have a greater positive impact on foreign direct investment in high growth countries than in low growth countries. It is interpreted that Korean firms are more motivated to exploit their intellectual properties in developing countries with a high growth than developed countries. Overall, it is confirmed that Korea's foreign direct investment not only to utilize some advantages but also to seek the brand value or product differentiation ability from host countries can occur. Our findings provide the contribution that some innovative activities in firms and R&D investments policies which encourage the possession of intellectual properties can improve foreign direct investment.

  • PDF

A Study on the Buddha's Life Relief in the Gupta Period at Sarnath, India (인도 굽타시대 사르나트 불전도에 대한 일고찰)

  • KOH, Jeong Eun
    • SUVANNABHUMI
    • /
    • v.1 no.2
    • /
    • pp.21-41
    • /
    • 2009
  • The Art of the Buddha's Life which depicts the life and before-life of Buddha flourished in Sanci and Bharhut in the ancient India and in Gandhara during the Kushan period. More than one hundred scenes from Buddha's life were represented in the form of relief sculpture or wall painting. They are found in Gandhara and Mathura during the Kushan period, Amaravati and Nagarjunakonda during the Satavahana period, in Mathura and Sarnath during the Gupta period, and during the Pala Period. They unfolded in various forms and styles according to the text(Buddhist scripture), layout, and expressive technique. In Mathura, where the Evolution of the Buddha image was made about the same time as in Gandhara during the Kushan period, the Buddha's life was presented in a number of scenes related to the sacred sites; in four or eight scenes. In the case of the Eight Great Events of the Buddha's Life, the four scenes out of eight were different from those that were represented in Sarnath during the Gupta period, manifesting a transitional period. The Gupta period is widely known as the time when the classic artistic style was established. The art of Buddha's Life was produced only in Sarnath during this period, and it was the time when the Eight Great Events of the Buddha's Life was established as iconography, providing a model for those of the Pala period. Also, it was the time when the single image of Buddha was produced such as the 'Buddha delivering his first sermon,' 'Buddha's Enlightenment,' and 'Buddha's Death,' thus showing the emergence of the single Buddha image from the narrative Buddha's life image. In this paper, a general introduction of the relief sculpture of the Buddha's life from Sarnath during the Gupta period was given. The art of Buddha's life gave great influences on that of China, Korea, Japan and Southeast Asia, and can be emphasized as an important subject in understanding the development of the Buddhist art in East Asia. A further study will be made on the art of Buddha's Life of Southeast Asia in the future, which will enhance the understanding of the art of Buddha's Life in East Asia as a whole.

  • PDF